Heparan sulfate: Lessons from knockout mice

Journal of Clinical Investigation

Volumn 108, Issue 2, 2001, Pages 175-180

  Forsberg, Erik ^a   Kjellen, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 O SULFOTRANSFERASE; GENE PRODUCT; GLYPICAN; HEPARAN SULFATE; PROTEIN EXT1; PROTEIN EXT2; SULFOTRANSFERASE; SYNDECAN; UNCLASSIFIED DRUG;

BIOSYNTHESIS; CELL FUNCTION; ENZYME DEFICIENCY; ENZYME SYNTHESIS; GASTRULATION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; KIDNEY AGENESIS; KNOCKOUT MOUSE; MAST CELL; MOUSE; MUTATION; NONHUMAN; PHENOTYPE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SKELETON MALFORMATION;

AMIDOHYDROLASES; ANIMALS; BONE DISEASES, DEVELOPMENTAL; CELL MEMBRANE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HEPARAN SULFATE PROTEOGLYCANS; HEPARITIN SULFATE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MODELS, CHEMICAL; MUTATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYMERS; PROTEIN BINDING; PROTEOGLYCANS; SULFOTRANSFERASES;

EID: 0034956917     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200113561     Document Type: Review

References (44)

1. Molecular diversity of heparan sulfate
2. Functions of cell surface heparan sulfate proteoglycans
3. Cell surface heparan sulfate proteoglycans: Selective regulators of ligand-receptor encounters
4. Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?
5. Heparan sulfate: Growth control with a restricted sequence menu
6. Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
7. Regulated diversity of heparan sulfate
8. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/N-sulfotransferase: Structure and activity of the fourth member, NDST4
9. Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1
10. Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice
11. Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice
12. Heparin is essential for the storage of specific granule proteases in mast cells
13. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
14. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
15. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate
16. Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality, due to failure of endoderm differentiation
17. Dystroglycan is essential for early embryonic development: Disruption of Reichert's membrane in Dag1-null mice
18. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
19. The link between heparan sulfate and hereditary bone disease: Finding a function for the EXT family of putative tumor suppressor proteins
20. Mast cells and basophils
21. Altered processing of fibronectin in mice lacking heparin. A role for heparin-dependent mast cell chymase in fibronectin degradation
22. Perlecan maintains the integrity of cartilage and some basement membranes
23. Perlecan is essential for cartilage and cephalic development
24. Supramolecular assembly of basement membranes
25. The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7
26. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core
27. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)
28. Still more complexity in mammalian basement membranes
29. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
30. Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena
31. Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice
32. Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
33. The elusive functions of proteoglycans: In vivo veritas
34. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome
35. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
36. Glypicans: Proteoglycans with a surprise
37. Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
38. Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
39. Syndecans: Synergistic activators of cell adhesion
40. Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth
41. Specificities of heparan sulphate proteoglycans in developmental processes
42. Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice
43. 3-OST-1 deficient mice lack an obvious procoagulant phenotype
44. Matrix proteoglycans: From molecular design to cellular function