Miracle nutrient

International Journal of Pharmacy and Technology

Volumn 3, Issue 2, 2011, Pages 1140-1164

  Kopparapu, Nagamani ^a  

^a ACHARYA AND B M REDDY COLLEGE OF PHARMACY   (India)

Author keywords

Antioxidant; Ascorbic acid; Vitamin C

Indexed keywords

ASCORBIC ACID; INSULIN; REACTIVE OXYGEN METABOLITE;

ADENOCARCINOMA; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ASTHMA; BACTERIAL INFECTION; BIOCHEMISTRY; CARDIOVASCULAR DISEASE; CATARACT; CIGARETTE SMOKING; COLON CANCER; DESMOPLASTIC SMALL ROUND CELL TUMOR; DRUG BLOOD LEVEL; DRUG EFFECT; ESOPHAGUS CANCER; GOUT; HUMAN; LEUKEMIA; LIVER CELL CARCINOMA; LUNG CANCER; MESOTHELIOMA; MOUTH CANCER; MULTIPLE MYELOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT AVAILABILITY; NUTRITIONAL PARAMETERS; OSTEOARTHRITIS; PANCREAS CANCER; PHARYNX CANCER; PREGNANCY; RECOMMENDED DIETARY ALLOWANCE; REVIEW; SARCOMA; SCURVY; STOMACH CANCER; VIRUS INFECTION; WEIGHT REDUCTION; WERNER SYNDROME;

EID: 79960114370     PISSN: None     EISSN: 0975766X     Source Type: Journal    
DOI: None     Document Type: Review

References (142)

1. Printed by Sands, Murray and Cochran for Kincaid A and Donaldson, A. Edinburgh. Lind J: A treatise of scurvy.1753.
2. Svirbely JL, Szent-Gyorgyi A: The chemical nature of vitamin C. Biochem J 1932, 26865-870.
3. Waugh WA, King CG: Isolation and identification of vitamin C. J Biol Chem 1932, 97:325-331.
4. Haworth WN, Hirst EL: Synthesis of ascorbic acid. J Soc Chem Ind (London) 1933, 52:645-647.
5. Anitra C Carr and Balz Frei. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am J Clin Nutr 1999;69:1086-107.
6. Nishikimi M, Fukuyama R, Minoshima S, Shimizu N, Yagi K: Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for Lascorbic acid biosynthesis missing in man. J Biol Chem 269: 13685-13688, 1994.
7. Nishikimi M, Yagi K: Biochemistry and molecular biology of ascorbic acid biosynthesis. Subcell Biochem 25:17-39, 1996.
8. Buettner GR, Moseley PL: EPR spin trapping of free radicals produced by bleomycin and ascorbate. Free Radic Res Commun 19:S89-S93, 1993.
9. Bielski BH, Richter HW, Chan PC: Some properties of the ascorbate free radical. Ann N Y Acad Sci 258:231-237, 1975.
10. Mandl A, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol. 2009; 157:1097-1110.
11. Toth I, Bridges KR. Ascorbic acid enhances ferritin mRNA translation by an IRP/aconitase switch. J Biol Chem. 1995;270: 19540-19544.
12. Neuzil J, Thomas SR, Stocker R: Requirement for, promotion, or inhibition by alpha- tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radic Biol Med 22: 57-71, 1997.
13. McCall MR, Frei B. Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med 1999; 26:1034-53.
14. Frei B, Yamamoto Y, Niclas D, Ames BN. Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. Anal Biochem 1988; 175:120-30
15. Mark Levine, Sebastian J. Padayatty, and Michael Graham. Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries Adv. Nutr. 2: 78-88, 2011; doi:10.3945/an.110.000109.
16. Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Eng J Med. 1986;314:892-902.
17. Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr. 986;6:365-406.
18. Rebouche C. Ascorbic acid and carnitine biosynthesis. Am J Clin Nutr. 1991; 54:1147-1152.
19. Wimalasena K, Wimalasena DS. The reduction of membranebound dopamine beta- onooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extra granular reducing equivalents? J Biol Chem. 1995;270: 27516-27524.
20. Oldham CD, Girard PR, Nerem RM, May SW. Peptide amidating enzymes are present in cultured endothelial cells. Biochem Biophys Res Commun. 1992;184:323-329.
21. Morrow JD: The isoprostanes: their quantification as an index of oxidant stress status in vivo. Drug Metab Rev 32:377-385, 2000.
22. Pratico D: F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo. Atherosclerosis 147:1-10, 1999.
23. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts 2nd LJ: Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med 332:1198-1203, 1995.
24. Steinberg FM, Chait A: Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am J Clin Nutr 68:319-327, 1998.
25. Porkkala-Sarataho E, Salonen JT, Nyyssonen K, Kaikkonen J, Salonen R, Ristonmaa U, Diczfalusy U, Brigelius-Flohe R, Loft S, Poulsen HE: Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2α-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler Thromb Vasc Biol 20:2087-2093, 2000.
26. Dietrich M, Block G, Hudes M, Morrow JD, Norkus EP, Traber MG, Cross CE, Packer L: Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers. Cancer Epidemiol Biomarkers Prev 11:7-13, 2002.
27. Chevion M, Berenshtein E, Stadtman ER: Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res 33(Suppl):S99-S108, 2000.
28. Carty JL, Bevan R, Waller H, Mistry N, Cooke M, Lunec J, Griffiths HR: The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochem Biophys Res Commun 273:729-735, 2000.
29. Huang HY, Helzlsouer KJ, Appel LJ: The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 9:647- 652, 2000.
30. Jacobson JS, Begg MD, Wang LW, Wang Q, Agarwal M, Norkus E, Singh VN, Young TL, Yang D, Santella RM: Effects of a 6-month vitamin intervention on DNA damage in heavy smokers. Cancer Epidemiol Biomarkers Prev 9:1303-1311, 2000.
31. Lee BM, Lee SK, Kim HS: Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). Cancer Lett 132:219-227, 1998.
32. Johnston CD, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am Coll Nutr. 1996;15:586-591.
33. Atanasova BD, Li AC, Bjarnason I, Tzatchev KN, Simpson RJ. Duodenal ascorbate and ferric reductase in human iron deficiency. Am J Clin Nutr. 2005;81:130-133.
34. Hallberg L, Brune M, Rossander L. Effect of ascorbic acid on iron absorption from different types of meals. Studies with ascorbic acid-rich foods and synthetic ascorbic acid given in different amounts with different meals. Human Nutr: Appl Nutr. 1986; 40A:97-113.
35. Hoffman KE, Yanelli K, Bridges KR. Ascorbic acid and iron metabolism: alterations in lysosomal function. Am J Clin Nutr. 1991; 54:1188-1192.
36. Weber P, Bendich A, Schalch W. Vitamin C and human health-a review of recent data relevant to human requirements. Int J Vitam Nutr Res 1996;66:19-30.
37. Enstrom JE. Vitamin C in prospective epidemiological studies. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. New York: Marcel Dekker Inc, 1997:381-98
38. Gey KF. Vitamins E plus C and interacting co-nutrients required for optimal health. Biofactors 1998; 7:113-74
39. Pletsity and KD. Vopr Pitan. Role of ascorbic acid in regulating immunological reactions 1979 Jul-Aug;(4):18-27ascorbic acid in regulating immunological reactions
40. Fred R. Klenner M.D., Reidsville. The Use of Vitamin C as an Antibiotic. N.C.Journal of Applied Nutrition, 1953, Vol. 6, pp. 274-278
41. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. Gorton HC, Jarvis K. Manipulative Physiol Ther. 1999 Oct;22(8):530-3.
42. Vitamin C as an Antiviral: It's All About Dose Andrew W. Saul, Ph.D., Orthomolecular Medicine News Service, Jan11, 2011
43. Murata A, Oyadomari R, Ohashi T, Kitagawa K. (1975) Mechanism of inactivation of bacteriophage deltaA containing single-stranded DNA by ascorbic acid. J Nutr Sci Vitaminol (Tokyo). 21:261-269.
44. Harakeh S, Jariwalla RJ, Pauling L (1990) Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proc Natl Acad Sci USA. 87:7245-7249.
45. White LA, Freeman CY, Forrester BD, Chappell WA (1986) In vitro effect of ascorbic acid on infectivity of herpes viruses and paramyxo viruses. J Clin Microbiol. 24:527-531.
46. Douglas RM, Hemila H, D'Souza R, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2004 Oct 18;(4)
47. Audera C, Patulny RV, Sander BH, Douglas RM. Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial. Med J Aust. 2001 Oct 1; 175(7):359-62.
48. Mc Elhaney JE, Goel V, Toane B, Hooten J, Shan JJ. J. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. Altern Complement Med. 2006 Mar; 12(2):153-7.
49. Winkler P, de Vrese M, Laue Ch, Schrezenmeir. Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters. J.Int J Clin Pharmacol Ther. 2005 Jul; 43(7):318-26.
50. Hemilä H.Scand. Does vitamin C alleviate the symptoms of the common cold?--a review of current evidence. J Infect Dis. 1994;26(1):1-6.
51. Hemilä H, Herman ZS. Vitamin C and the common cold: a retrospective analysis of Chalmers' review. J Am Coll Nutr. 1995 Apr;14(2):116-23.
52. LaForce C, Man CY, Henderson FW, McElhaney JE, Hampel FC Jr, Bettis R, Kudule L, Harris J, Yates P, Tisdale M, Webster A. Efficacy and safety of inhaled zanamivir in the prevention of influenza in community-dwelling, high-risk adult and adolescent subjects: a 28-day, multicenter, randomized, double-blind, placebo-controlled trial. Clin Ther. 2007 Aug;29(8):1579-90; discussion 1577-8.
53. Hemilä H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep; 3(9):756-61.
54. Mizoguchi H, Wilson A, Jerdack GR, Hull JD, Goodale M, Grender JM, Tyler BA. Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. Int J Clin Pharmacol Ther. 2007 Apr; 45(4):230-6.
55. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Baird IM, Hughes RE, Wilson HK, Davies JE, Howard AN. Am J Clin Nutr. 1979 Aug; 32(8):1686-90.
56. Hemilä H. Vitamin C, the placebo effect, and the common cold: a case study of how preconceptions influence the analysis of results. J Clin Epidemiol.1996 Oct;49(10):1079-84; discussion 1085, 1087.
57. J, Hansson LO, Tibbling G, Ludvigsson, Scand. Vitamin C as a preventive medicine against common colds in children. J Infect Dis. 1977;9 (2):91-8.
58. Hemilä H, Kaprio J, Albanes D, Heinonen OP, Virtamo J Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers. Epidemiology. 2002 Jan;13(1):32-7.
59. Hemilä H. Vitamin C intake and susceptibility to the common cold.Br J Nutr. 1997 Jan;77(1):59-72.
60. Heimer KA, Hart AM, Martin LG, Rubio-Wallace S. Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold. J Am Acad Nurse Pract. 2009 May; 21(5):295-300.
61. Levy TE (2002) Curing the Incurable: Vitamin C, Infectious Diseases, and Toxins. ISBN-13: 9781401069636
62. Hickey S, Saul AW (2008) Vitamin C: The Real Story, the Remarkable and Controversial Healing Factor. ISBN-13: 9781591202233
63. Klenner FR. The significance of high daily intake of ascorbic acid in preventive medicine, in: Physician's Handbook on Orthomolecular Medicine, Third Edition, 1979, Roger Williams, PhD, ed., p 51-59.
64. Cathcart, R.F. Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). Medical Hypotheses, 14(4):423-433, Aug 1984.
65. Anderson R, Dittrich OC (1979) Effects of ascorbate on leucocytes: Part 4. Increased neutrophil function and clinical improvement after oral ascorbate in 2 patients with chronic granulomatous disease. S Afr Med J. 1; 56476-80
66. Li W, Maeda N, Beck MA. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo- /- mice. J Nutr. 2006 Oct; 136(10):2611-6.
67. Taylor A, Dorey CK, Nowell T. Oxidative stress and ascorbate in relation to risk for cataract and age-related maculopathy. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. New York: Marcel Dekker Inc, 1997:231-64.
68. Rose RC, Richer SP, Bode AM. Ocular oxidants and antioxidant protection. Proc Soc Exp Biol Med 1998; 217:397-407.
69. Delcourt, C., Cristol, J. P., Leger, C. L., Descomps, B. & Papoz, L. (1999) Associations of antioxidant enzymes with cataract and age-related macular degeneration: the POLA study. Ophthalmology 106: 215-222
70. Maria Pastor Valero, Astrid E. Fletcher, Bianca L. De Stavola, Jesus, Vioque and Vicente Chaque s Alepuz. Vitamin C Is Associated with Reduced Risk of Cataract in a Mediterranean Population. J. Nutr. 132: 1299-1306, 2002.
71. Shanmugasundaram KR, Kumar SS, Rajajee S. Excessive free radical generation in the blood of children suff erring from asthma. Clin Chim Acta 2001;305:107-114.
72. Vural H, Uzun K. Serum and red blood cell antioxidant status in patient with bronchial asthma. Can Respir J 2000; 7:476-480
73. Kelly FJ, Mudway I, Blomberg A, Frew A, Sandstrom T. Altered lung antioxidant in patients with mild asthma. Lancet 1999; 354:482-483.
74. McDermoth JH. Antioxidant nutrients: current dietary recommendations and research update. J Am Pharm Assoc 2000;40:785-799.
75. Hatch GE. Asthma, inhaled oxidants, and dietary antioxidants. Am J Clin Nutr 995;61:625S-630S.
76. Graziano Riccioni, 1 Mancini Barbara, 1 Tonino Bucciarelli, Carmine diIlioand Nicolantonio D Orazio 1. Antioxidant Vitamin Supplementation in Asthma Annals of Clinical & Laboratory Science, 96 vol. 37, no. 1, 2007.
77. Huang SL, Pan WH. Dietary fats and asthma: analyses of the First Nutrition and Health Survey in Taiwan (NAHSIT). Clin Exp Allergy 2001; 31:1875-1880
78. P. H. Canter, B. Wider and E. Ernst. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology 2007; 46: 1223-1233
79. Henrotin Y, Deby-Dupont G, Deby C, Debruin M, Lamy M, Franchimont P. Production of active oxygen species by isolated human chondrocytes. Br J Rheumatol 1993;32:562-7.
80. McAlindon TE, Jaques P, Zhang Y et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthr Rheum 1996;39:648-56.
81. Kaiki G, Tsuji H, Yonezawa T et al. Osteoarthrosis induced by intraarticular hydrogen peroxide injection and running load. J Orthop Res 1990; 8:731-40.
82. Tiku ML, Shah R, Allison GT. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J Biol Chem 2000;275: 20069-76.
83. Black J, Shadle CA, Parsons JR, Brighton CT. Articular cartilage preservation and storage. Arthr Rheum 1979; 22:1102-8.
84. Hitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Res Ther 2004; 6:265-78.
85. Kowsari B, Finnie SK, Carter RL et al. Assessment of the diet of patients with rheumatoid arthritis and osteoarthritis. J Am Diet Assoc 1983; 82:657-9
86. Hertz Jensen N. [Reduced pain from osteoarthritis in hip joint or knee joint during treatment with calcium ascorbate. A randomized, placebo-controlled cross-over trial in general practice. Ugeskr Laeger 2003; 165:2563- 6.
87. K. G. Oldroyd and P. T. Dawes. Clinically significant vitamin c deficiency in rheumatoid arthritis Rheumatology (1985) 24 (4): 362-363.
88. Stein HB, et al. Ascorbic acid-induced uricosuria: a consequence of megavitamin therapy. Anna of Internal Medicine 1976; 84:385-8
89. Sutton JL, et al. Effect of large doses of ascorbic acid in man on some nitrogenous components of urine. Human Nutrition-Applied Nutrition 1983; 37:136-40
90. Berger L, et al. The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. American Journal of Medicine 1977; 62:71-6
91. Mitch WE, et al. Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects. Clinical Pharmacology & Therapeutics 1981; 29:318-21
92. Choi HK, et al. Vitamin C intake and the risk of gout in men: a prospective study. Archives of Internal Medicine 2009; 169(5): 502-7
93. Huang HY, et al. The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial. Arthritis & Rheumatism 2005; 52(6): 1843-7
94. Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JM, Franklin B, Sanderson B, Southard D. Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation.2007;115:2675-82.
95. Lynch SM, Gaziano JM, Frei B. Ascorbic acid and atherosclerotic cardiovascular disease. In: Harris JR, ed. Ascorbic acid: biochemistry and biomedical cell biology. New York: Plenum Press, 1996:331-67.
96. Simon JA. Vitamin C and cardiovascular disease: a review. J Am Coll Nutr 1992; 11:107-25.
97. Anderson D, Phillips BJ, Yu T, Edwards AJ, Ayesh R, Butterworth KR. The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with "low" or "high" cholesterol levels. Environ Mol Mutagen 1997; 30:161-74.
98. Li Y, Schellhorn HE. Can ageing-related degenerative diseases be ameliorated through administration of vitamin C at pharmacological levels? Med Hypotheses. 2007;68:1315-7
99. Ness AR, Khaw KT, Bingham S, Day NE. Vitamin C status and serum lipids. Eur J Clin Nutr 1996; 50:724-9.
100. Woodward M, Lowe GD, Rumley A, et al. Epidemiology of coagulation factors, inhibitors and activation markers: the third Glasco MONICA survey. Br J Haematol 1997; 97:785-97.
101. Khaw KT, Woodhouse P. Interrelation of vitamin C, infection, hemostatic factors, and cardiovascular disease. BMJ 1995; 310:1559-63.
102. Frei B. Vitamin C as an antiatherogen: mechanisms of action. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. New York: Marcel Dekker Inc, 1997:163-82.
103. Woodhouse PR, Meade TW, Khaw KT. Plasminogen activator inhibitor-1, the acute phase response and vitamin C. Atherosclerosis 1997;133:71-6.
104. Toohey L, Harris MA, Allen KG, Melgy CL. Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African- Americans. J Nutr 1996;126:121-8.
105. Jacques PF. Effects of vitamin C on high-density lipoprotein cholesterol and blood pressure. J Am Coll Nutr 1992;11:139-44.
106. Moran JP, Cohen L, Greene JM, et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993;57:213-7.
107. Jacques PF. A cross-sectional study of vitamin C intake and blood pressure in the elderly. Int J Vitam Nutr Res 1992;62:252-5.
108. Ness AR, Khaw KT, Bingham S, Day NE. Vitamin C status and blood pressure. J Hypertens 1996; 14:503-8.
109. Levine GL, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996; 93:1107-13.
110. Ichim et al. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? Journal of Translational Medicine 2011 9.25.
111. Nina A Mikirova, Joseph J Casciari and Neil H Riordan. Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo. Journal of angiogenesis Research 2010 2.2
112. Mayland CR, Bennett MI, Allan K: Vitamin C deficiency in cancer patients. Palliat Med 2005, 19:17-20.
113. Bodansky O, Wroblewski F, Markardt B: Concentrations of ascorbic acid in plasma and white blood cells of patients with cancer and noncancerous chronic disease. Cancer 1952, 5:678-684.
114. Fraenkel-Conrat J, Stoy T, Tsai SF: Investigation of ascorbic acid levels in blood of cancer patients compared to normal subjects. Mo Med 1967, 64:1001-1002.
115. Meadows GG, Pierson HF, Abdallah RM. Ascorbate in the treatment of experimental transplanted melanoma. Am J Clin Nutr 1991; 54(Suppl):1284S-91S.
116. Tsao CS. Inhibiting effect of ascorbic acid on the growth of human mammary tumor xenografts. Am J Clin Nutr 1991; 54(Suppl):1274S-80S.
117. Prasad KN. Modulation of the effects of tumor therapeutic agents by vitamin C. Life Sci 1980;27(4):275-80
118. Leung PY, Miyashita K, Young M, Tsao CS. Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines. Anticancer Res 1993;13:475-80.
119. Henson DE, Block G, Levine M. Ascorbic acid: biologic functions and relation to cancer. J Natl Cancer Inst 1991;83(8):547-50.
120. Barinaga M. Vitamin C gets a little respect. Science 1991;254:374-6.
121. Shimpo K, Nagatsu T, Yamada K, Sato T, Niimi H, Shamoto M, et al. Ascorbic acid and adriamycin toxicity. Am J Clin Nutr 1991;54(Suppl):1298S-301S.
122. Cullen JJ. Ascorbate induces autophagy in pancreatic cancer. Autophagy. 2010 Apr;6(3):421-2. Epub 2010 Apr 15.
123. Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care. 2002;5:66-74.
124. Yiqing Song, Qun Xu, Yikyung Park. Multivitamins, Individual Vitamin and Mineral Supplements, and Risk of Diabetes Among Older U.S. Adults diabetes care, volume 34, number 1, january 2011.
125. Davie SJ, Gould BJ and Yudkin JS. Effect of vitamin C on glycosylation of proteins. Diabetes (1992) 41: 167-173
126. Oian M, Liu M and Eaton JW. Transition metals bind to glycated protein forming redox active glycochelates implications for the pathogenesis of certain diabetic complications. Biochem. Biophys. Res. Commun. (1998) 256: 385-389.
127. Mohammad Reza Safaria, Nasrin Sheikhb and Khosro Mani Kashanic. Study on the Effect of Vitamin C on the In Vitro Albumin Glycation Reaction. Iranian Journal of Pharmaceutical Research (2006) 4: 275-279
128. P L Mearkle and R G Brown. Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J J Cunningham, J Am Coll Nutr. 1994 Aug;13(4):344-50.
129. Relation between intake of vitamin C and E and risk of diabetic retinopathy in the Atheresclerosis risk in communities study Am J Clin Nutr May 1,2004 79:865-873
130. Antonio Ceriello MD, Katherine Esposito MD, Michael Ihnat PhD, Jessica Thorpe BS, and Dario Giugiano MD. Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes. The Journal of Clinical Endocrinology & Metabolism.
131. Laurent Massip, Chantal Garand, Eric R. Paquet, Victoria C. Cogger, Jennifer N. O'Reilly, Leslee Tworek, Avril Hatherell, Carla G. Taylor, Eric Thorin, Peter Zahradka, David G. Le Couteur, and Michel Lebel. Vitamin C restores healthy aging in a mouse model for Werner syndrome. The FASEB Journal, 2010; 24 (1): 158 DOI:10.1096/fj.09-137133
132. New Role Of Vitamin C In Skin Protection Revealed By Study Tiago Duarte, Marcus S. Cooke and G. Don Jones Free Radical Biology and Medicine. 10 Sep 2009
133. Vitamin C and wound healing Bartlett, M.K Jones New Eng Med 226.429,1942
134. Idem; Vitamin C and wound healing Bartlett New Eng Med 226.474,1942
135. American College of Obstetricians and Gynecologists Premature rupture of membranes. ACOG practice bulletin no. 80. Obstet Gynecol. 2007;109:1007-19.
136. Woods JR, Plessinger MA, Miller RK. Vitamins C and E: Missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynecol. 2001;185:5-10.
137. Siega-Riz AM, Promislow JHE, Savitz DA, Thorp JM, McDonald T. Vitamin C intake and the risk of preterm delivery. Am J Obstet Gynecol. 2003;189:519-25.
138. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med. 2006;354:1796-806.
139. Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ, Pearson GD, Wapner RJ, Varner MW, et al. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med. 2010;362:1282-91.
140. Padayatty SJ, Levine M. Vitamins C and E and the prevention of preeclampsia. N Engl J Med. 2006; 355:1065.
141. Pernille Tveden-Nyborg, Louise Kruse Johansen, Zindy Raida, Charlotte Krogh illumsen, Jytte Overgaard Larsen, and Jens Lykkesfeldt. Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. Am J Clin Nutr September 2009 vol. 90 no. 3 540-546.
142. Carol S. Johnston. Strategies for Healthy Weight Loss: From Vitamin C to the Glycemic Response. The American College of Nutrition page158-165.