Duodenal ascorbate and ferric reductase in human iron deficiency

American Journal of Clinical Nutrition

Volumn 81, Issue 1, 2005, Pages 130-133

  Atanasova, Bisera D ^b   Li, Andy C Y ^b   Bjarnason, Ingvar ^b   Tzatchev, Kamen N ^b   Simpson, Robert J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

Iron absorption; Iron nutrition; Vitamin C

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID; HEMOGLOBIN; NITROBLUE TETRAZOLIUM; OXIDOREDUCTASE; ANTIOXIDANT; FERRIC CITRATE IRON REDUCTASE; FLAVINE MONONUCLEOTIDE REDUCTASE; IRON;

ADULT; AGED; ARTICLE; ASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DUODENUM; DUODENUM BIOPSY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GASTROINTESTINAL ENDOSCOPE; HUMAN; IRON DEFICIENCY; MALE; VITAMIN BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; ENZYMOLOGY; INTESTINE ABSORPTION; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ANIMALIA;

ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; CASE-CONTROL STUDIES; DUODENUM; FEMALE; FMN REDUCTASE; HUMANS; INTESTINAL ABSORPTION; IRON; MALE; MIDDLE AGED;

EID: 13744254990     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/81.1.130     Document Type: Article

References (18)

1. Zoller H, Theurl I, Koch RO, Mckie AT, Vogel W, Weiss G. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. Gastroenterology 2003;125:746-54.
2. Raja KB, Pountney DJ, Bomford A, et al. A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis. Gut 1996;38:765-9.
3. Mckie AT, Barrow D, LatundeDada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 2001;291:1755-9.
4. Dupic F, Fruchon S, Bensaid M, et al. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology 2002;122:745-51.
5. Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-7.
6. LatundeDada GO, Van Der Westhuizen JP, Vulpe CD, Anderson G, Simpson RJ, Mckie AT. Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism. Blood Cells Mol Dis 2002;29:356-60.
7. Atanasova B, Mudway IS, Laftah AH, et al. Duodenal ascorbate levels are changed in mice with altered iron metabolism. J Nutr 2004;134:501-5.
8. Simpson RJ, Debnam E, Beaumont N, Bahram S, Schumann K, Srai S. Duodenal mucosal reductase in wild type and HFE knock-out mice on iron-adequate, iron-deficient and iron-rich feeding. Gut 2003;52:510-3.
9. Kampfenkel K, Van Montagu M, Inze D. Extraction and determination of ascorbate and dehydroascorbate from plant tissue. Anal Biochem 1995;225:165-7.
10. Okamura M. An improved method for determination of L-ascorbic acid and L-dehydroascorbic acid in blood plasma. Clin Chim Acta 1980;103:259-68.
11. Goldenberg H, Schweinzer E. Transport of vitamin C in animal and human cells. J Bioenerg Biomembr 1994;26:359-67.
12. Hung CR, Neu SL. Acid-induced gastric damage in rats is aggravated by starvation and prevented by several nutrients. J Nutr 1997;127:630-6.
13. Lynch SR, Cook JD. Interaction of vitamin C and iron. Ann N Y Acad Sci 1980;355:32-44.
14. Roeser HP. The role of ascorbic acid in the turnover of storage iron. Semin Hematol 1983;20:91-100.
15. Fleming DJ, Jacques PF, Dallal GE, Tucker KL, Wilson PW, Wood RJ. Dietary determinants of iron stores in a free-living elderly population: the Framingham Heart Study. Am J Clin Nutr 1998;67:722-33.
16. Reddy MB, Hurrell RF, Cook JD. Estimation of nonheme-iron bioavailability from meal composition. Am J Clin Nutr 2000;71:937-43.
17. Cook JD, Reddy MB. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 2001;73:93-8.
18. Schectman G, Byrd JC, Gruchow HW. The influence of smoking on vitamin C status in adults. Am J Public Health 1989;79:158-62.