The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with 'low' or 'high' cholesterol levels

Environmental and Molecular Mutagenesis

Volumn 30, Issue 2, 1997, Pages 161-174

  Anderson, D ^a   Phillips, B J ^a   Yu, Tian Wei ^a   Edwards, A J ^a   Ayesh, R ^a   Butterworth, K R ^a  

^a BIBRA INTERNATIONAL   (United Kingdom)

Author keywords

Chromosome aberrations; Comet assay; DNA damage; Human monitoring; Lymphocytes; Ras

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; CHOLESTEROL; OXYGEN RADICAL; PLACEBO; SANATOGEN; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME ABERRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; FEMALE; HUMAN; HUMAN EXPERIMENT; LYMPHOCYTE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION;

ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; BLEOMYCIN; CHOLESTEROL; CHROMOSOME ABERRATIONS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FREE RADICALS; GENETIC TECHNIQUES; HUMANS; LIPID PEROXIDATION; LYMPHOCYTES; MALE; MIDDLE AGED; OXYGEN; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 0030859382     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)30:2<161::AID-EM9>3.0.CO;2-Q     Document Type: Article

References (58)

1. Ames BN (1988a): Measuring oxidative damage in humans: Relation to cancer and ageing. In Bartsch H, Hemminki K, O'Neill IK (eds): "Methods for Detecting DNA Damaging Agents in Humans. Applications in Cancer Epidemiology and Prevention." IARC Scientific Publication no. 89. Lyon: International Agency for Research on Cancer, pp 407-416.
2. Ames BN (1988b): The measurement of oxidative damage in humans: Relation to cancer and ageing. In Yoshikawa T (ed): "Medical, Biochemical and Chemical Aspects of Free Radicals." Amsterdam: Elsevier.
3. Ames BN (1989): Endogenous DNA damage as related to cancer and ageing. Free Radic Res Commun 7:121-128.
4. Ames BN, Motchnik P, Fraga C, Helbock H (1992): Antioxidant prevention of birth defects and childhood cancer. Abstract from Conference on Male-mediated Developmental Toxicology. September 16-19, 1992, Pittsburgh, Pennsylvania.
5. Anderson D (1996): Antioxidant defences against reactive oxygen species causing genetic and other damage. Mutat Res 350:103-108.
6. Anderson D, Jenkinson PC, Dewdney RS, Francis AJ, Godbert P, Butterworth KR (1988): Chromosome aberrations, mitogen-induced blastogenesis and proliferative rate index in peripheral lymphocytes from 106 control individuals of the UK population. Mutat Res 204:407-420.
7. Anderson D, Francis AJ, Godbert P, Jenkinson PC, Butterworth KR (1991): Chromosome aberrations (CA), sister chromatid exchanges (SCE) and mitogen-induced blastogenesis in cultured peripheral lymphocytes from 48 control individuals sampled 8 times over 2 years. Mutat Res 250:467-476.
8. Anderson D, Yu T-W, Phillips BJ, Schmezer P (1994): The effects of various antioxidants and other modifying agents on oxygen radical generated DNA damage in human lymphocytes in the Comet assay. Mutat Res 307:261-271.
9. Anderson D, Yu T-W, Phillips BJ, Schmezer P, Edwards AJ, Butterworth K, Ayesh R (1995): The use of the Comet assay as a biomarker to measure the genetic effects of food chemicals and the protective effects of antioxidants administered in vitro and in vivo. In Crews HM, Hanley AB (eds): "Biomarkers in Food Chemical Risk Assessment." London: Royal Society Chemistry, pp 48-55.
10. Anderson D, Hughes JA, Cebulska-Wasilewska A, Nizankowska B, Graca B (1996): Ras oncoproteins in human plasma from lung cancer patients and healthy controls. Mutat Res 349:121-126.
11. Anderson D, Hughes JA, Nizankowska E, Graca B, Cebulska-Wasilewska A, Wierzewska A, Kasper E (1997): Factors affecting various biomarkers in untreated lung cancer patients and healthy donors. Environ Mol Mutagen 30:205-216.
12. Arnao MB, Cano A, Hernandezruiz J, Garciacanovas F, Acosta M (1996): Inhibition of L-ascorbic acid and other antioxidants of the ABTS oxidation catalysed by peroxidase: A new approach for determining total antioxidant status of foods. Anal Biochem 236:255-261.
13. Brandt-Rauf PW, Niman NL (1988): Serum screening for oncogene proteins in workers exposed to PCBs. Br J Med 45:689-693.
14. Brandt-Rauf PW, Smith S, Niman HL, Goldstein MD, Favata E (1989): Serum oncogene proteins in hazardous waste workers. J Soc Occup Med 39:141-143.
15. Brandt-Rauf PW, Niman HL, Smith ST (1990a): Correlation between serum oncogene protein expression and the development of neo-plastic disease in a worker exposed to carcinogens. J R Soc Med 83:594-595.
16. Brandt-Rauf PW, Smith S, Perera FP, Niman HL, Wohanan W, Hemminki K, Santella RM (1990b): Serum oncogene proteins in foundry workers. J Soc Occup Med 40:11-14.
17. Butler J, Hoey BM (1993): Redox cycling drugs and DNA damage. In Halliwell B, Aruoma OI (eds): "DNA and Free Radicals." New York, London: Ellis Horwood, pp 243-273.
18. Cerutti PA (1994): Oxy-radicals and cancer. Lancet 344:862-863.
19. Chakrabarty S, Nandi A, Mukhopadhyay CK, Chatterjee IB (1992): Protective role of ascorbic acid against lipid peroxidation and myocardial injury. Mol Cell Biochem 111:41-47.
20. Cheeseman K (1993): Lipid peroxidation and cancer. In Halliwell B, Aruoma OI (eds): "DNA and Free Radicals." New York, London: Ellis Horwood, pp 109-144.
21. Coghlan A (1991): Europe's search for a winning diet. New Scientist 30:29-30.
22. Committee on Medical Aspects of Food Policy (COMA) (1991): Report of the panel on dietary reference values for food energy and nutrients for the United Kingdom. Report on health and social subjects 41. Department of Health, HMSO, London.
23. Cross CE, Van der Vliet A, O'Neill CA, Eisenrich JP (1994): Reactive oxygen species and the lung. Lancet 344:930-932.
24. Dewdney RS, Lovell DP, Jenkinson PC, Anderson D (1986): Variation in sister chromatid exchange among 106 members of the general UK population. Mutat Res 171:43.
25. Diplock AT (1987): Dietary supplementation with antioxidants. Is there a case for exceeding the recommended dietary allowance? Free Radic Biol Med 14:303-311.
26. Diplock AT (1996): Antioxidants and disease prevention. Food Chem Toxicol 34:1013-1023.
27. Duthie GC, Wahle KWJ, James WPT (1989a): Oxidants, antioxidants and cardiovascular disease. Nutr Res Rev 2:51-61.
28. Duthie GC, Arthur JR, James WPT, Vint HM (1989b): Antioxidant status of smokers and non-smokers, effect of vitamin E supplementation. Ann NY Acad Sci 560:435-438.
29. Flagg EW, Coates RJ, Greenberg RS (1995): Epidemiological studies of antioxidants and cancer in humans. J Am Coll Nutr 14:419-427.
30. Frei B, England L, Ames BN (1989): Ascorbic acid is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86:6377-6381.
31. Gey KF (1986): On the antioxidant hypothesis with regard to arteriosclerosis. Bibl Nutr Dieta 37:53-91.
32. Gey KF, Brubacher GB, Stahelin HB (1987): Plasma levels of antioxidant vitamins in relation to ischaemic heart disease and cancer. Am J Clin Nutr 45:1368-1377.
33. Goldbourt V, Holtzman E, Neufeld NN (1985): Total and high density lipoprotein cholesterol in the serum and risk of mortality. Evidence of a threshold effect. Br Med J 290:1239-1243.
34. Grisham MB (1994): Oxidants and free-radicals in inflammatory bowel disease. Lancet 344:859-861.
35. 2 cholesterol. Am J Clin Nutr 60:100-105.
36. Halliwell B (1994): Free radicals, antioxidants and human disease: Curiosity, cause or consequence? Lancet 344:721-723.
37. Halliwell B, Gutteridge JMC (1989): "Free Radicals in Biology and Medicine," 2nd ed. Oxford: Clarendon Press.
38. Herbert V (1994): The antioxidant supplement myth. Am J Clin Nutr 60:157-158.
39. Jenner P (1994): Oxidative damage in neurodegenerative disease. Lancet 344:796-798.
40. Kannel WB, Castelli W, Gordon T, et al. (1971): Serum cholesterol, lipoproteins and risk of coronary heart disease. The Framingham Study. Ann Intern Med 74:1-12.
41. Liau LS, Lee BL, New AL, Ong CN (1993): Determination of plasma ascorbic acid by high-performance liquid chromatography with ultraviolet and electrochemical detection. J Chromatogr 29:63-70.
42. Margolin BH, Shelby MD (1988): Sister chromatid exchanges: A reexamination of the evidence for sex and race differences in humans. Environ Mutagen 7(Suppl. 4):63-72.
43. McCord JM (1974): Free radicals and inflammation. Protection of synovial fluid by superoxide dismutase. Science 185:529-531.
44. Meyers DG, Maloley PA (1993): The antioxidant vitamins. Impact on athereosclerosis. Pharmacology 13:547-582.
45. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A (1993): A method for measuring antioxidant capacity and application to monitoring the antioxidant status in premature neonates. Clin Sci 84:407-412.
46. Pauling L (1986): "How to Live Longer and Feel Better." New York: William H. Freeman.
47. Perera FP, Hemminki K, Gryzbowska E, Motykiewicz G, Michalska J, Santella RM, Young TL, Dickey C, Brandt-Rauf P, DeVivo I, Blaner W, Tsai WY, Chorazy M (1992): Molecular and genetic damage in humans from environmental pollution in Poland. Nature 360:256-258.
48. Phillips BJ, James TEB, Anderson D (1984): Genetic damage in CHO cells exposed to enzymically generated active oxygen species. Mutat Res 126:265-271.
49. Phillips BJ, Anderson D, Gangolli SD (1985): The respiratory burst of phagocyte cells as a potential source of mutagenic species. In Poli G, Cheeseman KH, Diazuni MU, Slater FF (eds): "Free Radicals in Liver Injury." Oxford: IRL Press, pp 21-25.
50. Retsky KL, Freeman MW, Frei B (1993): Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. J Biol Chem 268:1304-1309.
51. Rivers JM (1987): Safety of high-level vitamin C ingestion. Ann NY Acad Sci 498:445-453.
52. Schettler G, Nüssel E (1975): Maßnahmen zur prävention der arteriosklerose. Arbeitsmed Sozialmed Praventivmed 10:25-29.
53. Smith JL, Hodges RE (1987): Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and non-smokers. Ann NY Acad Sci 498:144-152.
54. Stadtman ER (1990): Metal ion-catalysed oxidation of proteins: Biochemical mechanisms and biological consequences. Free Radic Biol Med 9:315-325.
55. Stamler J, Wenworth D, Neaton J (1986): Is the relationship between serum cholesterol and risk of death from coronary heart disease continuous and graded? JAMA 256:2823-2828.
56. Stephens NE, Parson A, Schofield PM, Kelly F, Cheeseman K, Mitchison MJ (1996): Randomised controlled trial of Vitamin E in patients with coronary disease. Cambridge Heart Antioxidant Study (CHAOS): Lancet 347:781-785.
57. Witzum JL (1994): The oxidative hypothesis of atherosclerosis. Lancet 344:793-795.
58. Wollenberg P, Rummel W (1987): Dependence of intestinal ion absorption on the valency state of iron. Arch Pharmacol 336:578.