Vitamin C, the placebo effect, and the common cold: A case study of how preconceptions influence the analysis of results

Journal of Clinical Epidemiology

Volumn 49, Issue 10, 1996, Pages

  Hemilä, Harri ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Ascorbic acid; Common cold; Placebo effect; Viral infections; Vitamin C

Indexed keywords

ASCORBIC ACID; LACTOSE;

ARTICLE; COMMON COLD; CONTROLLED STUDY; DIET SUPPLEMENTATION; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SYMPTOM;

EID: 0030273104     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/0895-4356(96)00189-8     Document Type: Article

References (37)

1. 1. Ruskin SL. Calcium cevitamate in the treatment of acute rhinitis. Ann Otol Rhinol Laryngol 1938; 47: 502-511.
2. 2. Markwell NW. Vitamin C in the prevention of colds. Med J Aust 1947; 34: 777-778.
3. 3. Woolstone AS. Treatment of the common cold. (Letter.) Br Med J 1954; 2: 1290.
4. 4. Regnier E. The administration of large doses of ascorbic acid in the prevention and treatment of the common cold. II. Rev Allergy 1968; 22: 948-956.
5. 5. Luberoff BJ. Symptomectomy with vitamin C. A chat with Robert Cathcart. Chemtech 1978; 8: 76-86.
6. 6. Bee DM. The vitamin C controversy. (Letter.) Postgrad Med 1980; 67(2): 64.
7. 7. Cathcart RF. Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Med Hypotheses 1981; 7: 1359-1376.
8. 8. Gotzsche AL. Pernasal vitamin C and the common cold. (Letter.) Lancet 1989; 2: 1039.
9. 9. Pauling L. Vitamin C and the Common Cold. San Francisco: Freeman; 1970. (Reprinted in 1976 as Vitamin C, Common Cold, and the Flu.)
10. 10. Stone, I. The Healing Factor: Vitamin C against Disease. New York: Grosset and Dunlap; 1972.
11. 11. Pauling L. How to Live Longer and Feel Better. New York: Freeman; 1986.
12. 12. Gwaltney JM: The common cold. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 4th Ed. New York: Churchill Livingstone; 1995: 561-566.
13. 13. Rivers JM. Safety of high-level vitamin C ingestion. Ann NY Acad Sci 1987; 498: 445-454.
14. 14. Bendich A. Safety issues regarding the use of vitamin supplements. Ann NY Acad Sci 1992; 669: 300-312.
15. 15. Karlowski TR, Chalmers TC, Frenkel LD, Kapikian AZ, Lewis TL, Lynch JM. Ascorbic acid for the common cold. A prophylactic and therapeutic trial. JAMA 1975; 231: 1038-1042.
16. 16. Chalmers TC. Effects of ascorbic acid on the common cold. An evaluation of the evidence. Am J Med 1975; 58: 532-536.
17. 17. Dykes MHM, Meier P. Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity. JAMA 1975; 231: 1073-1079.
18. 18. Coulehan J. Ascorbic acid and the common cold. Reviewing the evidence. Postgrad Med 1979; 66(3): 153-160.
19. 19. Sperber SJ, Hayden FG. Chemotherapy of rhinovirus colds. Antimicrob Agents Chemother 1988; 32: 409-419.
20. 20. Hemilä H. Vitamin C and the common cold. Br J Nutr 1992; 67: 3-16.
21. 21. Hemilä H. Does vitamin C alleviate the symptoms of the common cold? - A review of current evidence. Scand J Infect Dis 1994; 26: 1-6.
22. 22. Hemilä H, Herman ZS. Vitamin C and the common cold - A retrospective analysis of Chalmers' review. J Am Coll Nutr 1995; 14: 116-123.
23. 23. Anderson TW, Reid DB, Beaton GH. Vitamin C and the common cold: A double-blind trial. Can Med Assoc J 1972; 107:503-508.
24. 24. Anderson TW, Beaton GH, Corey PN, Spero L. Winter illness and vitamin C: The effect of relatively low doses. Can Med Assoc J 1975; 112: 823-826.
25. 25. Lewis TL, Karlowski TR, Kapikian AZ, Lynch JM, Shaffer GW, George DA. A controlled clinical trial of ascorbic acid for the common cold. Ann NY Acad Sci 1975; 258: 505-512.
26. 26. Asfora J. Vitamin C in high doses in the treatment of the common cold. Int J Vitam Nutr Res 1977; Suppl. 16: 219-234.
27. 27. National Research Council. Recommended Dietary Allowances, 10th Ed. Washington, D.C.: National Academy Press; 1989; 115-124.
28. 28. Pauling L. Are recommended daily allowances for vitamin C adequate? Proc Natl Acad Sci USA 1974; 71: 4442-4446.
29. 29. Hughes RE. Recommended daily amounts and biochemical roles. In: Counsell JN, Hornig DH, eds. Vitamin C. London: Applied Science Publishers; 1981: 75-86.
30. 30. Hemilä H. Nutritional need versus optimal intake. Med Hypotheses 1984; 14: 135-139.
31. 31. Hemilä H. A re-evaluation of nutritional goals - Not just deficiency counts. Med Hypotheses 1986; 20: 17-27.
32. 32. Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med 1986; 314: 892-902.
33. 33. Ginter E. Ascorbic acid in cholesterol metabolism and in detoxification of xenobiotic substances: The problem of optimum vitamin C intake. Nutrition 1989; 5: 369-374.
34. 34. Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr 1986; 6: 365-406.
35. 35. Padh H. Cellular functions of ascorbic acid. Biochem Cell Biol 1990; 68: 1166-1173.
36. 36. Bergsten P, Amitai G, Kehrl J, Dhariwal KR, Klein HG, Levine M. Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. J Biol Chem 1990; 265: 2584-2587.
37. 37. Washko PW, Wang Y, Levine M. Ascorbic acid recycling in human neutrophils. J Biol Chem 1993; 268: 15531-15535.