Characterization of rhodamine-123, calcein and 5(6)-carboxy-2′, 7′-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells

European Journal of Pharmaceutical Sciences

Volumn 43, Issue 5, 2011, Pages 359-369

  Munić, Vesna ^a,b   Hlevnjak, Mario ^a   Eraković Haber, Vesna ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Galapagos Istraživački Centar Ltd ^*  (Croatia)

Author keywords

A549; Calcein; Drug drug interaction; MES SA; MRP2 (ABCC2); Rhodamine 123

Indexed keywords

5(6) CARBOXY 2',7' DICHLOROFLUORESCEIN; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; CYCLOSPORIN A; DICHLOROFLUORESCEIN; ELACRIDAR; FUMITREMORGIN C; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; RHODAMINE 123; UNCLASSIFIED DRUG; VERAPAMIL; VERLUKAST;

ARTICLE; ASSAY; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MEMBRANE VESICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL LINE; FLOW CYTOMETRY; FLUORESCEINS; GENE SILENCING; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODAMINE 123;

EID: 79959989458     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.05.003     Document Type: Article

References (40)

1. S.G. Aller, J. Yu, A. Ward, Y. Weng, S. Chittaboina, R. Zhuo, P.M. Harrell, Y.T. Trinh, Q. Zhang, I.L. Urbatsch, and G. Chang Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 323 2009 1718 1722
2. S.V. Ambudkar, I.W. Kim, and Z.E. Sauna The power of the pump: mechanisms of action of P-glycoprotein (ABCB1) Eur. J. Pharm. Sci. 27 2006 392 400 (Pubitemid 43363335)
3. E. Bakos, R. Evers, E. Sinko, A. Varadi, P. Borst, and B. Sarkadi Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions Mol. Pharmacol. 57 2000 760 768 (Pubitemid 30183717)
4. P. Borst, and R.O. Elferink Mammalian ABC transporters in health and disease Annu. Rev. Biochem. 71 2002 537 592 (Pubitemid 34800230)
5. L.M. Chan, S. Lowes, and B.H. Hirst The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability Eur. J. Pharm. Sci. 21 2004 25 51 (Pubitemid 38050202)
6. Z.S. Chen, T. Kawabe, M. Ono, S. Aoki, T. Sumizawa, T. Furukawa, T. Uchiumi, M. Wada, M. Kuwano, and S.I. Akiyama Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter Mol. Pharmacol. 56 1999 1219 1228
7. R.G. Deeley, C. Westlake, and S.P. Cole Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins Physiol. Rev. 86 2006 849 899 (Pubitemid 44033384)
8. M. Essodaigui, H.J. Broxterman, and A. Garnier-Suillerot Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein Biochemistry 37 1998 2243 2250 (Pubitemid 28119297)
9. A. Gupta, Y. Dai, R.R. Vethanayagam, M.F. Hebert, K.E. Thummel, J.D. Unadkat, D.D. Ross, and Q. Mao Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan Cancer Chemother. Pharmacol. 58 2006 374 383 (Pubitemid 43800742)
10. K. Heredi-Szabo, E. Kis, E. Molnar, A. Gyorfi, and P. Krajcsi Characterization of 5(6)-carboxy-2′,7′-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4 J. Biomol. Screen. 13 2008 295 301 (Pubitemid 351442761)
11. Z. Hollo, L. Homolya, C.W. Davis, and B. Sarkadi Calcein accumulation as a fluorometric functional assay of the multidrug transporter Biochim. Biophys. Acta 1191 2 1994 384 388 (Pubitemid 24183562)
12. Z. Hollo, L. Homolya, T. Hegedus, and B. Sarkadi Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells FEBS Lett. 383 1996 99 104 (Pubitemid 26093722)
13. Y. Honjo, C.A. Hrycyna, Q.W. Yan, W.Y. Medina-Perez, R.W. Robey, A. van de Laar, T. Litman, M. Dean, and S.E. Bates Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells Cancer Res. 61 2001 6635 6639 (Pubitemid 32896477)
14. J.H. Hooijberg, H.J. Broxterman, M. Kool, Y.G. Assaraf, G.J. Peters, P. Noordhuis, R.J. Scheper, P. Borst, H.M. Pinedo, and G. Jansen Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 Cancer Res. 59 1999 2532 2535 (Pubitemid 29269093)
15. M.T. Huisman, A.A. Chhatta, O. van Tellingen, J.H. Beijnen, and A.H. Schinkel MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid Int. J. Cancer 116 2005 824 829 (Pubitemid 41099717)
16. J. Konig, D. Rost, Y. Cui, and D. Keppler Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane Hepatology 29 1999 1156 1163 (Pubitemid 29168750)
17. J.S. Lagas, C.M. van der Kruijssen, K. van de Wetering, J.H. Beijnen, and A.H. Schinkel Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone Drug Metab. Dispos. 37 2009 129 136
18. H. Lage, and M. Dietel Effect of the breast-cancer resistance protein on atypical multidrug resistance Lancet Oncol. 1 2000 169 175
19. Y. Lai, L. Xing, G.I. Poda, and Y. Hu Structure-activity relationships for interaction with multidrug resistance protein 2 (ABCC2/MRP2): the role of torsion angle for a series of biphenyl-substituted heterocycles Drug Metab. Dispos. 35 2007 937 945 (Pubitemid 46798605)
20. C. Lechner, V. Reichel, U. Moenning, A. Reichel, and G. Fricker Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles Eur. J. Pharm. Biopharm. 75 2010 284 290
21. X. Liang, and Y. Huang Intracellular free calcium concentration and cisplatin resistance in human lung adenocarcinoma A549 cells Biosci. Rep. 20 2000 129 138
22. T. Litman, M. Brangi, E. Hudson, P. Fetsch, A. Abati, D.D. Ross, K. Miyake, J.H. Resau, and S.E. Bates The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2) J. Cell Sci. 113 Pt. 11 2000 2011 2021 (Pubitemid 30386505)
23. T. Litman, T.E. Druley, W.D. Stein, and S.E. Bates From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance Cell. Mol. Life Sci. 58 2001 931 959 (Pubitemid 32652819)
24. D.W. Loe, R.G. Deeley, and S.P. Cole Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) J. Pharmacol. Exp. Ther. 293 2000 530 538 (Pubitemid 30244104)
25. R. Masereeuw, S. Notenboom, P.H. Smeets, A.C. Wouterse, and F.G. Russel Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats J. Am. Soc. Nephrol. 14 2003 2741 2749 (Pubitemid 37305636)
26. P. Matsson, J.M. Pedersen, U. Norinder, C.A. Bergstrom, and P. Artursson Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs Pharm. Res. 26 2009 1816 1831
27. M.A. McAleer, M.A. Breen, N.L. White, and N. Matthews PABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells J. Biol. Chem. 274 1999 23541 23548
28. U. Muenster, B. Grieshop, K. Ickenroth, and M.J. Gnoth Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions Pharm. Res. 25 2008 2320 2326
29. V. Munic, Z. Kelneric, L. Mikac, and V. Erakovic Haber Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays Eur. J. Pharm. Sci. 41 2010 86 95
30. J.M. Pedersen, P. Matsson, C.A. Bergstrom, U. Norinder, J. Hoogstraate, and P. Artursson Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2) J. Med. Chem. 51 2008 3275 3287 (Pubitemid 351821886)
31. J. Pétriz, and J. García-López Flow cytometric analysis of P-glycoprotein function using rhodamine 123 Leukemia 11 7 1997 1124 1130 (Pubitemid 27345966)
32. R.W. Robey, Y. Honjo, A. van de Laar, K. Miyake, J.T. Regis, T. Litman, and S.E. Bates A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2) Biochim. Biophys. Acta 1512 2001 171 182 (Pubitemid 32530764)
33. G.L. Scheffer, M. Kool, M. Heijn, M. de Haas, A.C. Pijnenborg, J. Wijnholds, A. van Helvoort, M.C. de Jong, J.H. Hooijberg, C.A. Mol, M. van der Linden, J.M. de Vree, P. van der Valk, R.P. Elferink, P. Borst, and R.J. Scheper Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies Cancer Res. 60 2000 5269 5277
34. A.J. Smith, A. van Helvoort, G. van Meer, K. Szabo, E. Welker, G. Szakacs, A. Varadi, B. Sarkadi, and P. Borst MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping J. Biol. Chem. 275 2000 23530 23539 (Pubitemid 30624635)
35. E. Stehfest, A. Torky, F. Glahn, and H. Foth Non-destructive micromethod for MRP1 functional assay in human lung tumor cells Arch. Toxicol. 80 2006 125 133 (Pubitemid 43320255)
36. G. Szakacs, J.P. Annereau, S. Lababidi, U. Shankavaram, A. Arciello, K.J. Bussey, W. Reinhold, Y. Guo, G.D. Kruh, M. Reimers, J.N. Weinstein, and M.M. Gottesman Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells Cancer Cell 6 2004 129 137 (Pubitemid 39485685)
37. A.R. Torky, E. Stehfest, K. Viehweger, C. Taege, and H. Foth Immuno-histochemical detection of MRPs in human lung cells in culture Toxicology 207 2005 437 450 (Pubitemid 40138940)
38. M. Vezmar, L.W. Deady, L. Tilley, and E. Georges The quinoline-based drug, N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide, photoaffinity labels the multidrug resistance protein (MRP) at a biologically relevant site Biochem. Biophys. Res. Commun. 241 1997 104 111 (Pubitemid 28033546)
39. T. Yamasaki, K. Kawamura, A. Hatori, J. Yui, K. Yanamoto, Y. Yoshida, M. Ogawa, N. Nengaki, H. Wakisaka, T. Fukumura, and M.R. Zhang PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein Nucl. Med. Commun. 31 2010 985 993
40. N. Zelcer, M.T. Huisman, G. Reid, P. Wielinga, P. Breedveld, A. Kuil, P. Knipscheer, J.H. Schellens, A.H. Schinkel, and P. Borst Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) J. Biol. Chem. 278 2003 23538 23544 (Pubitemid 36830173)