Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 75, Issue 2, 2010, Pages 284-290

  Lechner, Christian ^a   Reichel, Valeska ^a   Moenning, Ursula ^b   Reichel, Andreas ^b   Fricker, Gert ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

ABC protein; ABCC2; Carboxydichlorofluorescein (CDF); Fluorescence assay; MRP2

Indexed keywords

5' NUCLEOTIDASE; ALKALINE PHOSPHATASE; BENZBROMARONE; COUMARIN; CYCLOSPORIN A; DICHLOROFLUORESCEIN; ESTRADIOL; ESTRADIOL 17 GLUCURONIDE; FUSIDATE SODIUM; GLYCOPROTEIN P; INDOMETACIN; IVERMECTIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PHENAZONE; PROBENECID; TESTOSTERONE; VERLUKAST;

ARTICLE; CELL ISOLATION; CENTRIFUGATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IC 50; IMMUNOFLUORESCENCE TEST; MEMBRANE VESICLE; MICHAELIS MENTEN KINETICS; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN TRANSPORT; WESTERN BLOTTING;

5'-NUCLEOTIDASE; ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; FLUORESCENT DYES; HUMANS; MICROSCOPY, ELECTRON; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TIME FACTORS;

EID: 77952955606     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.03.008     Document Type: Article

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