Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

European Journal of Neuroscience

Volumn 34, Issue 1, 2011, Pages 110-123

  Clausen, Fredrik ^a   Hånell, Anders ^a   Israelsson, Charlotte ^b   Hedin, Johanna ^a   Ebendal, Ted ^b   Mir, Anis K ^c   Gram, Hermann ^c   Marklund, Niklas ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Behavior; Cognition; Edema; Microglia; Traumatic brain injury

Indexed keywords

CHEMOKINE RECEPTOR CCR2; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA ANTIBODY; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN WATER; CELL ACTIVATION; COGNITION; CONTROLLED STUDY; GENE EXPRESSION; LEARNING; MALE; MAZE TEST; MEMORY CONSOLIDATION; MEMORY DISORDER; MICROGLIA; MOTOR PERFORMANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ROTAROD TEST; TRAUMATIC BRAIN INJURY; VISUOSPATIAL LEARNING;

ANIMALS; ANTIBODIES; BEHAVIOR, ANIMAL; BRAIN EDEMA; BRAIN INJURIES; CHEMOKINES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEARNING; MALE; MEMORY; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROPSYCHOLOGICAL TESTS; TREATMENT OUTCOME;

EID: 79959969839     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2011.07723.x     Document Type: Article

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