Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat

Journal of Neurotrauma

Volumn 18, Issue 8, 2001, Pages 821-832

  Marklund, Niklas ^a   Clausen, Fredrik ^a   Hillered, Lars ^a   McIntosh, Tracy K ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fluid percussion; Morris Water Maze; Neuroprotection; Nitrone scavengers; Rat; Reactive oxygen species; Traumatic brain injury (TBI)

Indexed keywords

2 SULFOPHENYL N TERT BUTYL NITRONE; ALPHA PHENYL N TERT BUTYL NITRONE; HALOTHANE; NITRONE DERIVATIVE; NITROUS OXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; BRAIN PROTECTION; COGNITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INFUSION; MALE; MAZE TEST; MEDICAL INSTRUMENTATION; MEMORY; NONHUMAN; PERCUSSION; PRESSURE MEASUREMENT; RAT; TREATMENT OUTCOME;

ANIMALS; BRAIN INJURIES; FREE RADICAL SCAVENGERS; INFUSIONS, INTRAVENOUS; MALE; MAZE LEARNING; MEMORY DISORDERS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECOVERY OF FUNCTION;

EID: 0034883444     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771501316919184     Document Type: Article

References (62)

1. Neuronal apoptosis in rats is accompanied by rapid impairment of cellular respiration and is prevented by scavengers of reactive oxygen species
2. 2 activity by oxygen-derived free radicals in isolated brain capillaries
3. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
4. Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events
5. Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-hutyl-alpha-phenylnitrone and vitamin E
6. Effect of cognitive rehabilitation on outcomes for persons with traumatic brain injury: A systematic review
7. Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats
8. Secondary insults increase injury after controlled cortical impact in rats
9. One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats
10. Free radicals in brain metabolism and pathology
11. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
12. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
13. N-Tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia
14. Free radicals and CNS injury
15. Lipid antioxidants in acute central nervous system injury
16. Inhibition of lipid peroxidation in central nervous system trauma and ischemia
17. Brain attack. Acute therapeutic interventions. Free radical scavengers and antioxidants
18. Generation and detection of hydroxyl radical following experimental head injury
19. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
20. The effect of postinjury administration of polyethylene glycol-conjugated superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in rats
21. Blood-brain barrier breakdown occurs early after traumatic brain injury and is not related to white blood cell adherence
22. Respiratory activity of isolated rat brain mitochondria following in vitro exposure to oxygen radicals
23. Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies
24. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
25. Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals
26. Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat
27. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat
28. Ventricular enlargement after closed head injury
29. Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat
30. Deferoxamine improves spatial memory performance following experimental brain injury in rats
31. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage
32. Glycerol as a marker for post-traumatic membrane phospholipid degradation in rat brain
33. α-Phenyl-tert-butyl-nitrone improves functional and morphological outcome after cortical contusion injury in the rat
34. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: Effect of neutrophil depletion on extracellular ascorbyl radical formation
35. Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model
36. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury: 1998
37. Superoxide dismutase improves posttraumatic cortical blood flow in rats
38. Standardized neurosurgical neurointensive therapy directed toward vasogenic edema after severe traumatic brain injury: Clinical results
39. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
40. 2+ levels following cortical compression contusion trauma in rats
41. Calcium movements in traumatic brain injury: The role of glutamate receptor-operated ion channels
42. Effects of the spin trap-alpha-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat
43. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage
44. Reduction of traumatic brain injury-induced cerebral oedema by a free radical scavenger
45. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN)
46. Regional patterns of blood-brain barrier breakdown following central and lateral fluid percussion injury in rodents
47. Involvement of free radicals in excitotoxicity in vivo
48. Rehabilitation and outcome after severe head injury
49. Alpha-phenyl-tert-butyl-nitrone inhibits free radical release in brain concussion
50. Oxidative stress in closed-head injury: Brain antioxidant capacity as an indicator of functional outcome
51. Free radicals and brain damage
52. Progressive atrophy and neuron death for one year following brain trauma in the rat
53. Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat
54. Phenyl-N-tert-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats
55. Breakdown of the blood-brain barrier after fluid percussion brain injury in the rat: Part 2: Effect of hypoxia on permeability to plasma proteins
56. Influences on first-year recovery from traumatic brain injury in children
57. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: A microdialysis study
58. Neurosurgical intensive care improves outcome after severe head injury
59. Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats
60. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury
61. Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats