Differences in cerebral extracellular response of interleukin-1β, interleukin-6, and interleukin-10 after subarachnoid hemorrhage or severe head trauma in humans

Neurosurgery

Volumn 68, Issue 1, 2011, Pages 12-19

  Mellergård, Pekka ^a   Åneman, Oscar ^a   Sjögren, Florence ^a   Säberg, Carina ^a   Hillman, Jan ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Interleukin 1; Interleukin 10; Interleukin 6; Interleukins; Microdialysis; Subarachnoid hemorrhage; Traumatic brain injury

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ARTICLE; BRAIN LEVEL; DISEASE SEVERITY; EXTRACELLULAR SPACE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SEX DIFFERENCE; SUBARACHNOID HEMORRHAGE; TRAUMATIC BRAIN INJURY;

BRAIN CHEMISTRY; BRAIN INJURIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR FLUID; FEMALE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MICRODIALYSIS; SUBARACHNOID HEMORRHAGE;

EID: 78650915504     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e3181ef2a40     Document Type: Article

References (32)

1. Beneviste H HP. Microdialysis: theory and application. Progr Neurobiol. 1990;35(3):195-215.
2. Ungerstedt U. Principles and application for studies in animal and man. J Intern Med. 1991;230:365-373.
3. Bellander BM, Cantais E, Enblad P, et al. Consensus meeting on microdialysis in neurointensive care. Intensive Care Med. 2004;30(12):2166-2169.
4. Ao X, Stenken JA. Microdialysis sampling of cytokines. Methods. 2006;38(4):331-341.
5. Hillman J,Aneman O, Persson M, Andersson C, Dabrosin C, Mellergard P. Variations in the response of interleukins in neurosurgical intensive care patients monitored using intracerebral microdialysis. J Neurosurg. 2007;106(5):820-825.
6. Stoll G, Jander S, Schroeter M. Detrimental and beneficial effects of injuryinduced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol. 2002;513:87-113.
7. Morganti-Kossman MC, Rancan M, Stahel PF, Kossman T. Inflammatory response in acute traumatic brain injury: a double-edged sword. Curr Opin Crit Care. 2002;8(2):101-105.
8. Kriz J. Inflammation in ischemic brain injury: timing is important. Crit Rev Neurobiol. 2006;18(1-2):145-157.
9. Mellergard P, Aneman O, Sjögren F, Pettersson P, Hillman J. Changes in extracellular concentrations of some cytokines, chemokines, and neurotrophic factors after insertion of intracerebral microdialysis catheters in neurosurgical patients. Neurosurgery. 2008;62(1):151-157.
10. Rothwell NJ, Hopkins SJ. Cytokines and the nervous system. II: actions and mechanisms of action. Trends Neurosci. 1995;18(3):130-136.
11. Hayakata T, Tasaki O, Ikegawa H, et al. Changes in CSF S100 and cytokine concentrations in early-phase severe traumatic brain injury. Shock. 2004;22(2):102-107.
12. Holmin S, Hojeberg B. In situ detection of intracerebral cytokine expression after human brain contusion. Neurosci Lett. 2004;369(2):108-114.
13. Shiozaki T, Tasaki O, Hosotubo H, et al. Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury. Shock. 2005;23(5):406-410.
14. Hutchinson PJ, Rothwell NJ, Hopkins SJ, et al. Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma. 2007;24(10):545-557.
15. Liu S, Xu GY, Johnson KM, et al. Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection. Brain Res. 2008;1231:63-74.
16. Sturnegk P, Mellergard P, Yonas H, Theodorsson A, Hillman J. Potential use of quantitative bedside CBF monitoring (Xe-CT) for decision making in neurosurgical intensive care. Br J Neurosurg. 2007;21(4):332-339.
17. Asgeirsson B, Grande P, Nordstrom C. A new therapy of post-trauma brain oedema based on haemodynamic principles for brain volume regulation. Intensive Care Med. 1994;20(4):260-267.
18. Grande P, Asgeirsson B, Nordstrom C. Volume-targeted therapy of increased intracranial pressure: the Lund concept unifies surgical and non-surgical treatments. Acta Anaesthesiol Scand. 2002;46(8):929-941.
19. Hillman J, Aneman O, Anderson C, Sjögren F, Säberg C, Mellergard P. A microdialysis technique for routine measurement of macromolecules in the injured human brain. Neurosurgery. 2005;56(6):1264-1268.
20. Fulwyler M, McHugh T. Flow microsphere immunoassay for the quantitative and simultaneous detection ofmultiple soluble analytes. Methods Cell Biol. 1990;33:613-629.
21. Kemeny D. Titration of antibodies. J Immunol Methods. 1992;150:57-76.
22. Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol. 2006;66(3):232-245.
23. Chiaretti A, Aloe L, Antonelli A, Piastra M, Polidori G, Di Rocco C. Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv Syst. 2005;21(3):185-193.
24. Winter CD PA, Clough GF, Church MK. Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain. 2004;127(Pt 2):315-320.
25. Tarkowski E, Blomstrand C, Wikkelso C, Jensen C, Ekholm S, Tarkowski A. Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke. 1995;26(8):1393-1398.
26. Woiciechowsky C, Cobanov J, Lanksch WR, Volk HD, Docke WD. Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients. J Trauma. 2002;52(2):339-345.
27. Moore KW de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765.
28. Couper KN, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008;180(9):5771-5777.
29. Kirchhoff C, Bogner V, Stegmaier J, et al. Cerebrospinal IL-10 concentration is elevated in non-survivors as compared to survivors after severe traumatic brain injury. Eur J Med Res. 2008;13(10):464-468.
30. Maier B, Mautes A, Holanda M, Muller M, Steudel WI, Marzi I. Differential release of interleukines 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury. Shock. 2001;15(6):421-426.
31. Waelgaard L, Pharo A, Tønnessen TI, Mollnes TE. Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions. Scand J Immunol. 2006;64(3): 345-352.
32. Helmy A, Carpenter KL, Skepper JN, Kirkpatrick PJ, Pickard JD, Hutchinson PJ. Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma. 2009;26(4):549-561.