Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway

Neuropharmacology

Volumn 61, Issue 4, 2011, Pages 677-686

  Rau, Thomas F ^a   Kothiwal, Aakriti ^a   Zhang, Li ^b   Ulatowski, Sarah ^a   Jacobson, Saskia ^a   Brooks, Diane M ^a   Cardozo Pelaez, Fernando ^a   Chopp, Michael ^b,c   Poulsen, David J ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

Dopamine; Methamphetamine; Neuroprotection; Stroke

Indexed keywords

CASPASE 3; METHAMPHETAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN EMBOLISM; BRAIN SLICE; CONTINUOUS INFUSION; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STROKE;

ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MALE; METHAMPHETAMINE; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SIGNAL TRANSDUCTION; STROKE;

EID: 79959953794     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.05.010     Document Type: Article

References (56)

1. F. Amenta, E. Bronzetti, F. Cantalamessa, D. El-Assouad, L. Felici, A. Ricci, and S.K. Tayebati Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes J. Neuroimmunol. 117 2001 133 142 (Pubitemid 32595500)
2. F. Amenta, F. Mignini, A. Ricci, M. Sabbatini, D. Tomassoni, and S.K. Tayebati Age-related changes of dopamine receptors in the rat hippocampus: a light microscope autoradiography study Mech. Ageing Dev. 122 2001 2071 2083 (Pubitemid 32925115)
3. K.C. Arden FoxO: linking new signaling pathways Mol. Cell 14 2004 416 418 (Pubitemid 38648793)
4. J.M. Beaulieu, T.D. Sotnikova, W.D. Yao, L. Kockeritz, J.R. Woodgett, R.R. Gainetdinov, and M.G. Caron Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade Proc. Natl. Acad. Sci. U S A 101 2004 5099 5104 (Pubitemid 38469209)
5. J.M. Beaulieu, R.R. Gainetdinov, and M.G. Caron Akt/GSK3 signaling in the action of psychotropic drugs Annu. Rev. Pharmacol. Toxicol. 49 2009 327 347
6. J. Behr, T. Gloveli, D. Schmitz, and U. Heinemann Dopamine depresses excitatory synaptic transmission onto rat subicular neurons via presynaptic D1-like dopamine receptors J. Neurophysiol. 84 2000 112 119 (Pubitemid 30490035)
7. A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor Cell 96 1999 857 868 (Pubitemid 29165088)
8. A. Brunet, S.R. Datta, and M.E. Greenberg Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway Curr. Opin. Neurobiol. 11 2001 297 305 (Pubitemid 32524094)
9. J.L. Cadet, and I.N. Krasnova Molecular bases of methamphetamine-induced neurodegeneration Int. Rev. Neurobiol. 88 2009 101 119
10. J.L. Cadet, I.N. Krasnova, S. Jayanthi, and J. Lyles Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms Neurotox. Res. 11 2007 183 202
11. F. Cardozo-Pelaez, S. Song, A. Parthasarathy, C. Hazzi, K. Naidu, and J. Sanchez-Ramos Oxidative DNA damage in the aging mouse brain Mov. Disord. 14 1999 972 980
12. F. Cardozo-Pelaez, D.P. Cox, and C. Bolin Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development Gene Expr. 12 2005 315 323 (Pubitemid 41729062)
13. N.H. Chehab, A. Malikzay, E.S. Stavridi, and T.D. Halazonetis Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage Proc. Natl. Acad. Sci. U S A 96 1999 13777 13782
14. P.C. Chen, C.L. Lao, and J.C. Chen Dual alteration of limbic dopamine D1 receptor-mediated signalling and the Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitization J. Neurochem. 100 2007 225 241
15. S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M.E. Greenberg Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241 (Pubitemid 27456390)
16. A. Dhanasekaran, S.K. Gruenloh, J.N. Buonaccorsi, R. Zhang, G.J. Gross, J.R. Falck, P.K. Patel, E.R. Jacobs, and M. Medhora Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia Am. J. Physiol. Heart Circ. Physiol. 294 2008 H724 H735
17. G. Fiskum, R.E. Rosenthal, V. Vereczki, E. Martin, G.E. Hoffman, C. Chinopoulos, and A. Kowaltowski Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress J. Bioenerg. Biomembr. 36 2004 347 352 (Pubitemid 39619839)
18. P.E. Gold, R.L. Delanoy, and J. Merrin Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine Brain Res. 305 1984 103 107 (Pubitemid 14117849)
19. G.R. Hanson, J.W. Gibb, R.R. Metzger, J.M. Kokoshka, and A.E. Fleckenstein Methamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences? Ann. N. Y Acad. Sci. 844 1998 103 107 (Pubitemid 28367799)
20. R. Honda, H. Tanaka, and H. Yasuda Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett. 420 1997 25 27 (Pubitemid 28037193)
21. S.J. Jeong, A. Dasgupta, K.J. Jung, J.H. Um, A. Burke, H.U. Park, and J.N. Brady PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells Virology 370 2008 264 272 (Pubitemid 350199679)
22. V. Junker, A. Becker, R. Huhne, M. Zembatov, A. Ravati, C. Culmsee, and J. Krieglstein Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection Eur. J. Pharmacol. 446 2002 25 36 (Pubitemid 34722554)
23. L.M. Katz, G. Lotocki, Y. Wang, S. Kraydieh, W.D. Dietrich, and R.W. Keane Regulation of caspases and XIAP in the brain after asphyxial cardiac arrest in rats Neuroreport 12 2001 3751 3754 (Pubitemid 33105164)
24. J.G. Kiang, and K.T. Tsen Biology of hypoxia Chin. J. Physiol. 49 2006 223 233
25. T. Kihara, S. Shimohama, H. Sawada, K. Honda, T. Nakamizo, R. Kanki, H. Yamashita, and A. Akaike Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade J. Neurosci. Res. 70 2002 274 282 (Pubitemid 35222362)
26. T. Kita, I. Miyazaki, M. Asanuma, M. Takeshima, and G.C. Wagner Dopamine-induced behavioral changes and oxidative stress in methamphetamine- induced neurotoxicity Int. Rev. Neurobiol. 88 2009 43 64
27. J. Klisch, K.M. Bode-Greuel, E. Horvath, C. Klisch, and T. Els Additive neuroprotective effect of ketanserin and ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil Neurosci. Lett. 342 2003 25 28 (Pubitemid 36513901)
28. P.O. Koh, J.H. Cho, C.K. Won, H.J. Lee, J.H. Sung, and M.O. Kim Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway Neurosci. Lett. 436 2008 62 66
29. I.N. Krasnova, and J.L. Cadet Methamphetamine toxicity and messengers of death Brain Res. Rev. 60 2009 379 407
30. D.S. Kwon, C.H. Kwon, J.H. Kim, J.S. Woo, J.S. Jung, and Y.K. Kim Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells Eur. J. Cell Biol. 85 2006 1189 1199 (Pubitemid 44548871)
31. F.J. Lee, S. Xue, L. Pei, B. Vukusic, N. Chery, Y. Wang, Y.T. Wang, H.B. Niznik, X.M. Yu, and F. Liu Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor Cell 111 2002 219 230 (Pubitemid 35292442)
32. C.M. Lim, S.W. Kim, J.Y. Park, C. Kim, S.H. Yoon, and J.K. Lee Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect J. Neurosci. Res. 87 2009 1037 1045
33. X.Y. Liu, X.P. Chu, L.M. Mao, M. Wang, H.X. Lan, M.H. Li, G.C. Zhang, N.K. Parelkar, E.E. Fibuch, M. Haines, K.A. Neve, F. Liu, Z.G. Xiong, and J.Q. Wang Modulation of D2R-NR2B interactions in response to cocaine Neuron 52 2006 897 909 (Pubitemid 44828444)
34. L. Martinsson, and S. Eksborg Drugs for stroke recovery:the example of amphetamines Drugs Aging 21 2004 67 79 (Pubitemid 38293787)
35. J.F. Nash, and B.K. Yamamoto Effect of D-amphetamine on the extracellular concentrations of glutamate and dopamine in iprindole-treated rats Brain Res. 627 1993 1 8 (Pubitemid 23309592)
36. J. Noraberg, B.W. Kristensen, and J. Zimmer Markers for neuronal degeneration in organotypic slice cultures Brain Res. Brain Res. Protoc. 3 1999 278 290 (Pubitemid 29023528)
37. K. O'Phelan, D.L. McArthur, C.W. Chang, D. Green, and D.A. Hovda The impact of substance abuse on mortality in patients with severe traumatic brain injury J. Trauma 65 2008 674 677
38. N.J. Patel, M.J. Chen, and A.A. Russo-Neustadt Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons Eur. J. Pharmacol. 633 2010 1 9
39. D.R. Plas, S. Talapatra, A.L. Edinger, J.C. Rathmell, and C.B. Thompson Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology J. Biol. Chem. 276 2001 12041 12048
40. M.S. Quinton, and B.K. Yamamoto Causes and consequences of methamphetamine and MDMA toxicity AAPS J. 8 2006 E337 E347
41. A.J. Ramos, M.D. Rubio, C. Defagot, L. Hischberg, M.J. Villar, and A. Brusco The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization Brain Res. 1030 2004 201 220 (Pubitemid 39574953)
42. J.V. Selkirk, L.M. Nottebaum, A.M. Vana, G.M. Verge, K.B. Mackay, T.H. Stiefel, G.S. Naeve, J.E. Pomeroy, R.E. Petroski, J. Moyer, J. Dunlop, and A.C. Foster Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus Eur. J. Neurosci. 21 2005 3217 3228 (Pubitemid 40961417)
43. A. Shehadah, J. Chen, A. Zacharek, Y. Cui, M. Ion, C. Roberts, A. Kapke, and M. Chopp Niaspan treatment induces neuroprotection after stroke Neurobiol. Dis. 40 2010 277 283
44. K.J. Smith, T.R. Butler, M.M. Mullins, L. Ghayoumi, R.C. Holley, J.M. Littleton, and M.A. Prendergast Methamphetamine exposure antagonizes N-methyl-D-apsartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures Brain Res. 1157 2007 74 80 (Pubitemid 46938632)
45. B. Thrash, K. Thiruchelvan, M. Ahuja, V. Suppiramaniam, and M. Dhanasekaran Methamphetamine-induced neurotoxicity: the road to Parkinson's disease Pharmacol. Rep. 61 2009 966 977
46. T. Uchiyama, R.M. Engelman, N. Maulik, and D.K. Das Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning Circulation 109 2004 3042 3049 (Pubitemid 38808327)
47. Y. Wang, T. Hayashi, C.F. Chang, Y.H. Chiang, L.I. Tsao, T.P. Su, C. Borlongan, and S.Z. Lin Methamphetamine potentiates ischemia/reperfusion insults after transient middle cerebral artery ligation Stroke 32 2001 775 782
48. Q. Wang, L. Liu, L. Pei, W. Ju, G. Ahmadian, J. Lu, Y. Wang, F. Liu, and Y.T. Wang Control of synaptic strength, a novel function of Akt Neuron 38 2003 915 928 (Pubitemid 36782383)
49. X. Wang, C. Zhu, H. Hagberg, L. Korhonen, M. Sandberg, D. Lindholm, and K. Blomgren X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia Neurobiol. Dis. 16 2004 179 189 (Pubitemid 38569809)
50. L.L. Wang, C.C. Ou, and J.Y. Chan Receptor-independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of phosphatidylinositol 3-kinase/protein kinase Akt pathway in short-term cardiovascular actions of dexamethasone at the nucleus tractus solitarii of the rat Mol. Pharmacol. 67 2005 489 498 (Pubitemid 40216742)
51. 3H]YM-09151-2 in the rat hippocampus: characterization and autoradiographic distribution Brain Res. 681 1995 153 159
52. L. Zhang, Y. Qu, J. Tang, D. Chen, X. Fu, M. Mao, and D. Mu PI3K/Akt signaling pathway is required for neuroprotection of thalidomide on hypoxic-ischemic cortical neurons in vitro Brain Res. 1357 2010 157 165
53. R.L. Zhang, M. Chopp, Z.G. Zhang, Q. Jiang, and J.R. Ewing A rat model of focal embolic cerebral ischemia Brain Res. 766 1997 83 92 (Pubitemid 27431437)
54. Z. Zhang, R.L. Zhang, Q. Jiang, S.B. Raman, L. Cantwell, and M. Chopp A new rat model of thrombotic focal cerebral ischemia J. Cereb. Blood Flow Metab. 17 1997 123 135 (Pubitemid 27085835)
55. L. Zhang, Z.G. Zhang, X.S. Liu, A. Hozeska-Solgot, and M. Chopp The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat Arterioscler Thromb. Vasc. Biol. 27 2007 2470 2475 (Pubitemid 350203966)
56. S. Zou, L. Li, L. Pei, B. Vukusic, H.H. Van Tol, F.J. Lee, Q. Wan, and F. Liu Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity J. Neurosci. 25 2005 4385 4395 (Pubitemid 40628783)