PI3K/Akt signaling pathway is required for neuroprotection of thalidomide on hypoxic-ischemic cortical neurons in vitro

Brain Research

Volumn 1357, Issue , 2010, Pages 157-165

  Zhang, Li ^a   Qu, Yi ^a   Tang, Jun ^a   Chen, Dapeng ^a   Fu, Xuemei ^a   Mao, Meng ^a   Mu, Dezhi ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Hypoxia ischemia; Signaling pathway; Thalidomide

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; THALIDOMIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HYPOXIC CELL; IN VITRO STUDY; ISCHEMIA; NERVE CELL; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOXIA-ISCHEMIA, BRAIN; IN SITU NICK-END LABELING; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; THALIDOMIDE; TIME FACTORS;

RATTUS;

EID: 77957271408     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.08.007     Document Type: Article

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