The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 11, 2007, Pages 2470-2475

  Zhang, Li ^a   Zhang, Zheng Gang ^a   Liu, Xian Shuang ^a   Hozeska Solgot, Ann ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Atorvastatin; Plasminogen activator; Stroke; Tissue

Indexed keywords

ATORVASTATIN; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TISSUE PLASMINOGEN ACTIVATOR; VASCULOTROPIN; WORTMANNIN; AKT3 PROTEIN, RAT; EGR1 PROTEIN, HUMAN; FIBRINOLYTIC AGENT; HEPTANOIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN REGION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBRINOLYTIC THERAPY; GENE EXPRESSION REGULATION; LASER CAPTURE MICRODISSECTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; STROKE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG COMBINATION; DRUG POTENTIATION; METABOLISM; WISTAR RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BIOSYNTHETIC PATHWAYS; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EARLY GROWTH RESPONSE PROTEIN 1; FIBRINOLYTIC AGENTS; HEPTANOIC ACIDS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RATS; RATS, WISTAR; TISSUE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 36049028936     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.107.150748     Document Type: Article

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