A newly developed DNA Microarray is useful to assess induction of cytochromes P450 in the cynomolgus monkey

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 3, 2011, Pages 228-235

  Ise, Ryota ^a   Uehara, Shotaro ^a   Akiyama, Hideo ^b   Kondo, Satoshi ^b   Iwasaki, Kazuhide ^a   Nagata, Ryoichi ^a   Nobumasa, Hitoshi ^b   Yamazaki, Hiroshi ^c   Uno, Yasuhiro ^a  

^a SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cynomolgus monkey; Cytochrome P450; DNA microarray; Hepatocytes; Induction; Tissue expression

Indexed keywords

CYTOCHROME P450; OMEPRAZOLE; RIFAMPICIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOCHROME P450 2C43 GENE; CYTOCHROME P450 2C75 GENE; CYTOCHROME P450 3A5 GENE; CYTOCHROME P450 GENE; DNA MICROARRAY; ENZYME INDUCTION; GENE; GENE FUNCTION; GENE INDUCTION; GENE SEQUENCE; MACACA FASCICULARIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; VALIDATION PROCESS;

EID: 79959944260     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-099     Document Type: Article

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