메뉴 건너뛰기




Volumn 43, Issue 3, 2011, Pages 346-361

Macaque cytochromes P450: Nomenclature, transcript, gene, genomic structure, and function

Author keywords

African green monkey; Cynomolgus monkey; Drug metabolism; Genetic polymorphisms; Induction; Japanese monkey; Marmoset; Rhesus monkey; Synteny; Tissue expression pattern; Transcript variants

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2A; CYTOCHROME P450 2B; CYTOCHROME P450 2B17; CYTOCHROME P450 2B30; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 2C20; CYTOCHROME P450 2C43; CYTOCHROME P450 2C74; CYTOCHROME P450 2C75; CYTOCHROME P450 2C8; CYTOCHROME P450 2C83; CYTOCHROME P450 2C9; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; CYTOCHROME P450 2F; CYTOCHROME P450 2F1; CYTOCHROME P450 2F6; CYTOCHROME P450 2J; CYTOCHROME P450 3A21; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A64; CYTOCHROME P450 3A66; CYTOCHROME P450 3A8; CYTOCHROME P450 4F2; CYTOCHROME P450 4F45; UNCLASSIFIED DRUG;

EID: 79954557245     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2010.549492     Document Type: Review
Times cited : (103)

References (65)
  • 2
    • 0037232732 scopus 로고    scopus 로고
    • Nonhuman primate models of menopause workshop
    • DOI 10.1095/biolreprod.102.005215
    • Bellino, F. L., Wise, P. M. (2003). Nonhuman primate models of menopause workshop. Biol Reprod 68:10-18. (Pubitemid 36076312)
    • (2003) Biology of Reproduction , vol.68 , Issue.1 , pp. 10-18
    • Bellino, F.L.1    Wise, P.M.2
  • 3
    • 85027948581 scopus 로고    scopus 로고
    • Highlights of the "gene nomenclature across species" meeting
    • Bruford, E. A. (2010). Highlights of the "gene nomenclature across species" meeting. Hum Genomics 4:213-217.
    • (2010) Hum Genomics , vol.4 , pp. 213-217
    • Bruford, E.A.1
  • 5
    • 33747846229 scopus 로고    scopus 로고
    • Characterization of the rhesus monkey CYP3A64 enzyme: Species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes
    • DOI 10.1124/dmd.106.009977
    • Carr, B., Norcross, R., Fang, Y., Lu, P., Rodrigues, A. D., Shou, M., et al. (2006). Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specifcity and kinetics using baculovirus-expressed recombinant enzymes. Drug Metab Dispos 34:1703-1712. (Pubitemid 44427473)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1703-1712
    • Carr, B.1    Norcross, R.2    Fang, Y.3    Lu, P.4    Rodrigues, A.D.5    Shou, M.6    Rushmore, T.7    Booth-Genthe, C.8
  • 6
    • 0035135258 scopus 로고    scopus 로고
    • cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450
    • Domanski, T. L., Finta, C., Halpert, J. R., Zaphiropoulos, P. G. (2001). cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol 59:386-392. (Pubitemid 32108573)
    • (2001) Molecular Pharmacology , vol.59 , Issue.2 , pp. 386-392
    • Domanski, T.L.1    Finta, C.2    Halpert, J.R.3    Zaphiropoulos, P.G.4
  • 8
    • 33847652196 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta
    • Ferguson, B., Street, S. L., Wright, H., Pearson, C., Jia, Y., Tompson, S. L., et al. (2007). Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics 8:43.
    • (2007) BMC Genomics , vol.8 , pp. 43
    • Ferguson, B.1    Street, S.L.2    Wright, H.3    Pearson, C.4    Jia, Y.5    Tompson, S.L.6
  • 17
    • 0031105836 scopus 로고    scopus 로고
    • Marmoset liver cytochrome P450s: Study for expression and molecular cloning of their cDNAs
    • DOI 10.1006/abbi.1996.9852
    • Igarashi, T., Sakuma, T., Isogai, M., Nagata, R., Kamataki, T. (1997). Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs. Arch Biochem Biophys 339:85-91. (Pubitemid 27199757)
    • (1997) Archives of Biochemistry and Biophysics , vol.339 , Issue.1 , pp. 85-91
    • Igarashi, T.1    Sakuma, T.2    Isogai, M.3    Nagata, R.4    Kamataki, T.5
  • 18
    • 70349567244 scopus 로고    scopus 로고
    • Cynomolgus monkey CYPs: A comparison with human CYPs
    • Iwasaki, K., Uno, Y. (2009). Cynomolgus monkey CYPs: a comparison with human CYPs. Xenobiotica 39:578-581.
    • (2009) Xenobiotica , vol.39 , pp. 578-581
    • Iwasaki, K.1    Uno, Y.2
  • 19
    • 13844316753 scopus 로고    scopus 로고
    • Cytochrome P450 activation of arylamines and heterocyclic amines
    • DOI 10.1146/annurev.pharmtox.45.120403.100010
    • Kim, D., Guengerich, F. P. (2005). Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol 45:27-49. (Pubitemid 40261797)
    • (2005) Annual Review of Pharmacology and Toxicology , vol.45 , pp. 27-49
    • Kim, D.1    Guengerich, F.P.2
  • 20
    • 73149087257 scopus 로고    scopus 로고
    • Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction
    • Kim, S., Dinchuk, J. E., Anthony, M. N., Orcutt, T., Zoeckler, M. E., Sauer, M. B., et al. (2010). Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction. Drug Metab Dispos 38:16-24.
    • (2010) Drug Metab Dispos , vol.38 , pp. 16-24
    • Kim, S.1    Dinchuk, J.E.2    Anthony, M.N.3    Orcutt, T.4    Zoeckler, M.E.5    Sauer, M.B.6
  • 21
    • 0036786382 scopus 로고    scopus 로고
    • Interindividual variability and tissue-specifcity in the expression of cytochrome P450 3A mRNA
    • Koch, I., Weil, R., Wolbold, R., Brockmöller, J., Hustert, E., Burk, O., et al. (2002). Interindividual variability and tissue-specifcity in the expression of cytochrome P450 3A mRNA. Drug Metab Dispos 30:1108-1114.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1108-1114
    • Koch, I.1    Weil, R.2    Wolbold, R.3    Brockmöller, J.4    Hustert, E.5    Burk, O.6
  • 22
    • 0026593854 scopus 로고
    • Molecular cloning of monkey P450 1A1 cDNA and expression in yeast
    • Komori, M., Kikuchi, O., Kitada, M., Kamataki, T. (1992a). Molecular cloning of monkey P450 1A1 cDNA and expression in yeast. Biochim Biophys Acta 1131:23-29.
    • (1992) Biochim Biophys Acta , vol.1131 , pp. 23-29
    • Komori, M.1    Kikuchi, O.2    Kitada, M.3    Kamataki, T.4
  • 24
    • 33750471638 scopus 로고    scopus 로고
    • Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism
    • DOI 10.1016/j.ejphar.2006.09.006, PII S0014299906010041
    • Lee, A. M., Joshi, M., Yue, J., Tyndale, R. F. (2006a). Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism. Eur J Pharmacol 552:151-158. (Pubitemid 44648078)
    • (2006) European Journal of Pharmacology , vol.552 , Issue.1-3 , pp. 151-158
    • Lee, A.M.1    Joshi, M.2    Yue, J.3    Tyndale, R.F.4
  • 25
    • 33746060489 scopus 로고    scopus 로고
    • Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein
    • DOI 10.1038/sj.bjp.0706787, PII 0706787
    • Lee, A. M., Miksys, S., Tyndale, R. F. (2006b). Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein. Br J Pharmacol 148:786-794. (Pubitemid 44079408)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.6 , pp. 786-794
    • Lee, A.M.1    Miksys, S.2    Tyndale, R.F.3
  • 26
    • 33747839122 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African green monkeys: Induction by chronic nicotine treatment
    • DOI 10.1124/dmd.106.010363
    • Lee, A. M., Yue, J., Tyndale, R. F. (2006c). In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African green monkeys: induction by chronic nicotine treatment. Drug Metab Dispos 34:1508-1515. (Pubitemid 44285392)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.9 , pp. 1508-1515
    • Lee, A.M.1    Yue, J.2    Tyndale, R.F.3
  • 27
    • 41849091509 scopus 로고    scopus 로고
    • Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies
    • DOI 10.1093/hmg/ddn002
    • Lee, A. S., Gutiérrez-Arcelus, M., Perry, G. H., Vallender, E. J., Johnson, W. E., Miller, G. M., et al. (2008). Analysis of copy number variation in the rhesus macaque genome identifes candidate loci for evolutionary and human disease studies. Hum Mol Genet 17:1127-1136. (Pubitemid 351494184)
    • (2008) Human Molecular Genetics , vol.17 , Issue.8 , pp. 1127-1136
    • Lee, A.S.1    Gutierrez-Arcelus, M.2    Perry, G.H.3    Vallender, E.J.4    Johnson, W.E.5    Miller, G.M.6    Korbel, J.O.7    Lee, C.8
  • 30
    • 33745743111 scopus 로고    scopus 로고
    • Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purification and characterization
    • DOI 10.1093/jb/mvj093
    • Mitsuda, M., Iwasaki, M., Asahi, S. (2006). Cynomolgus monkey cytochrome P450 2C43: cDNA cloning, heterologous expression, purifcation, and characterization. J Biochem 139:865-872. (Pubitemid 44014580)
    • (2006) Journal of Biochemistry , vol.139 , Issue.5 , pp. 865-872
    • Mitsuda, M.1    Iwasaki, M.2    Asahi, S.3
  • 31
    • 17644412364 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: Comparison with marmoset cytochrome P450 1A2
    • DOI 10.1016/j.cbi.2005.01.006
    • Narimatsu, S., Oda, M., Hichiya, H., Isobe, T., Asaoka, K., Hanioka, N., et al. (2005). Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2. Chem Biol Interact 152:1-12. (Pubitemid 40568627)
    • (2005) Chemico-Biological Interactions , vol.152 , Issue.1 , pp. 1-12
    • Narimatsu, S.1    Oda, M.2    Hichiya, H.3    Isobe, T.4    Asaoka, K.5    Hanioka, N.6    Yamano, S.7    Shinoda, S.8    Yamamoto, S.9
  • 33
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
    • DOI 10.1097/00008571-200401000-00001
    • Nelson, D. R., Zeldin, D. C., Hofman, S. M., Maltais, L. J., Wain, H. M., Nebert, D. W. (2004). Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes, and alternative-splice variants. Pharmacogenetics 14:1-18. (Pubitemid 38183957)
    • (2004) Pharmacogenetics , vol.14 , Issue.1 , pp. 1-18
    • Nelson, D.R.1    Zeldin, D.C.2    Hoffman, S.M.G.3    Maltais, L.J.4    Wain, H.M.5    Nebert, D.W.6
  • 34
    • 34548532926 scopus 로고    scopus 로고
    • Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes
    • Nishimura, M., Koeda, A., Suganuma, Y., Suzuki, E., Shimizu, T., Nakayama, M, et al. (2007). Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet 22:178-186.
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 178-186
    • Nishimura, M.1    Koeda, A.2    Suganuma, Y.3    Suzuki, E.4    Shimizu, T.5    Nakayama, M.6
  • 37
    • 77957116897 scopus 로고    scopus 로고
    • Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys
    • Ohtsuka, T., Yoshikawa, T., Kozakai, K., Tsuneto, Y., Uno, Y., Utoh, M., et al. (2010). Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys. Drug Metab Dispos 38:1806-1813.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1806-1813
    • Ohtsuka, T.1    Yoshikawa, T.2    Kozakai, K.3    Tsuneto, Y.4    Uno, Y.5    Utoh, M.6
  • 40
    • 0027533906 scopus 로고
    • Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: Transcriptional activation of the human CYP1A1 gene
    • Quattrochi, L. C., Tukey, R. H. (1993). Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol Pharmacol 43:504-508. (Pubitemid 23112725)
    • (1993) Molecular Pharmacology , vol.43 , Issue.4 , pp. 504-508
    • Quattrochi, L.C.1    Tukey, R.H.2
  • 41
    • 4444281969 scopus 로고    scopus 로고
    • Aging in rhesus monkeys: Relevance to human health interventions
    • DOI 10.1126/science.1102541
    • Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., Ingram, D. K. (2004). Aging in rhesus monkeys: relevance to human health interventions. Science 305:1423-1426. (Pubitemid 39167653)
    • (2004) Science , vol.305 , Issue.5689 , pp. 1423-1426
    • Roth, G.S.1    Mattison, J.A.2    Ottinger, M.A.3    Chachich, M.E.4    Lane, M.A.5    Ingram, D.K.6
  • 42
    • 0031752608 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of cynomolgus monkey CYP1A2
    • DOI 10.1016/S0006-2952(98)00100-2, PII S0006295298001002
    • Sakuma, T., Hieda, M., Igarashi, T., Ohgiya, S., Nagata, R., Nemoto, N., et al. (1998). Molecular cloning and functional analysis of cynomolgus monkey CYP1A2. Biochem Pharmacol 56:131-139. (Pubitemid 28477460)
    • (1998) Biochemical Pharmacology , vol.56 , Issue.1 , pp. 131-139
    • Sakuma, T.1    Hieda, M.2    Igarashi, T.3    Ohgiya, S.4    Nagata, R.5    Nemoto, N.6    Kamataki, T.7
  • 44
    • 0037222167 scopus 로고    scopus 로고
    • Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration
    • DOI 10.1124/mol.63.1.96
    • Schoedel, K. A., Sellers, E. M., Palmour, R., Tyndale, R. F. (2003). Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Mol Pharmacol 63:96-104. (Pubitemid 36043813)
    • (2003) Molecular Pharmacology , vol.63 , Issue.1 , pp. 96-104
    • Schoedel, K.A.1    Sellers, E.M.2    Palmour, R.3    Tyndale, R.F.4
  • 47
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., Guengerich, F. P. (1994). Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ter 270:414-423. (Pubitemid 24229655)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 48
    • 41149167691 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms (SNPs) are highly conserved in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques
    • Street, S. L., Kyes, R. C., Grant, R., Ferguson, B. (2007). Single nucleotide polymorphisms (SNPs) are highly conserved in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. BMC Genomics 8:480.
    • (2007) BMC Genomics , vol.8 , pp. 480
    • Street, S.L.1    Kyes, R.C.2    Grant, R.3    Ferguson, B.4
  • 51
    • 33846884645 scopus 로고    scopus 로고
    • Diclofenac hydroxylation in monkeys: Efficiency, regioselectivity, and response to inhibitors
    • DOI 10.1016/j.bcp.2006.11.016, PII S0006295206007842
    • Tang, C., Fang, Y., Booth-Genthe, C., Kuo, Y., Kuduk, S. D., Rushmore, T. H., et al. (2007). Diclofenac hydroxylation in monkeys: efciency, regioselectivity, and response to inhibitors. Biochem Pharmacol 73:880-890. (Pubitemid 46227332)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.6 , pp. 880-890
    • Tang, C.1    Fang, Y.2    Booth-Genthe, C.3    Kuo, Y.4    Kuduk, S.D.5    Rushmore, T.H.6    Carr, B.A.7
  • 52
    • 77955596754 scopus 로고    scopus 로고
    • A novel CYP2A26 identifed in cynomolgus monkey liver metabolizes coumarin
    • Uehara, S., Murayama, N., Yamazaki, H., Uno, Y. (2010). A novel CYP2A26 identifed in cynomolgus monkey liver metabolizes coumarin. Xenobiotica 40:621-629.
    • (2010) Xenobiotica , vol.40 , pp. 621-629
    • Uehara, S.1    Murayama, N.2    Yamazaki, H.3    Uno, Y.4
  • 53
    • 77950791816 scopus 로고    scopus 로고
    • Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes
    • Uno, Y., Fujino, H., Iwasaki, K., Utoh, M. (2010a). Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes. Curr Drug Metab 11:142-152.
    • (2010) Curr Drug Metab , vol.11 , pp. 142-152
    • Uno, Y.1    Fujino, H.2    Iwasaki, K.3    Utoh, M.4
  • 54
    • 33746238122 scopus 로고    scopus 로고
    • CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone
    • DOI 10.1124/mol.106.022673
    • Uno, Y., Fujino, H., Kito, G., Kamataki, T., Nagata, R. (2006). CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol 70:477-486. (Pubitemid 44092308)
    • (2006) Molecular Pharmacology , vol.70 , Issue.2 , pp. 477-486
    • Uno, Y.1    Fujino, H.2    Kito, G.3    Kamataki, T.4    Nagata, R.5
  • 55
    • 34548640569 scopus 로고    scopus 로고
    • Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: Is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
    • DOI 10.1016/j.abb.2007.07.003, PII S0003986107003487
    • Uno, Y., Hosaka, S., Matsuno, K., Nakamura, C., Kito, G., Kamataki, T., et al. (2007a). Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: Is CYP2C76 the only monkey-specifc CYP gene responsible for species diferences in drug metabolism? Arch Biochem Biophys 466:98-105. (Pubitemid 47405072)
    • (2007) Archives of Biochemistry and Biophysics , vol.466 , Issue.1 , pp. 98-105
    • Uno, Y.1    Hosaka, S.2    Matsuno, K.3    Nakamura, C.4    Kito, G.5    Kamataki, T.6    Nagata, R.7
  • 56
    • 33845741509 scopus 로고    scopus 로고
    • CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans
    • DOI 10.1080/00498250600968275, PII M4952L7855438L7U
    • Uno, Y., Kumano, T., Kito, G., Nagata, R., Kamataki, T., Fujino, H. (2007b). CYP2C76-mediated species diference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica 37:30-43. (Pubitemid 46009555)
    • (2007) Xenobiotica , vol.37 , Issue.1 , pp. 30-43
    • Uno, Y.1    Kumano, T.2    Kito, G.3    Nagata, R.4    Kamataki, T.5    Fujino, H.6
  • 57
    • 74749087979 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis
    • Uno, Y., Matsuno, K., Nakamura, C., Utoh, M., Yamazaki, H. (2009a). Cloning, expression, and characterization of CYP3A43 cDNA in cynomolgus macaque (Macaca fascicularis). Drug Metab Lett 3:228-233.
    • (2009) Drug Metab Lett , vol.3 , pp. 228-233
    • Uno, Y.1    Matsuno, K.2    Nakamura, C.3    Utoh, M.4    Yamazaki, H.5
  • 58
    • 73349142051 scopus 로고    scopus 로고
    • Identifcation and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis
    • Uno, Y., Matsuno, K., Nakamura, C., Utoh, M., Yamazaki, H. (2009b). Identifcation and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis). J Vet Med Sci 71:1653-1656.
    • (2009) J Vet Med Sci , vol.71 , pp. 1653-1656
    • Uno, Y.1    Matsuno, K.2    Nakamura, C.3    Utoh, M.4    Yamazaki, H.5
  • 59
    • 77649306676 scopus 로고    scopus 로고
    • Identifcation and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis
    • Uno, Y., Matsuno, K., Nakamura, C., Utoh, M., Yamazaki, H. (2010b). Identifcation and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis). J Vet Med Sci 72:225-228.
    • (2010) J Vet Med Sci , vol.72 , pp. 225-228
    • Uno, Y.1    Matsuno, K.2    Nakamura, C.3    Utoh, M.4    Yamazaki, H.5
  • 60
    • 76149140867 scopus 로고    scopus 로고
    • Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques
    • Uno, Y., Matsushita, A., Osada, N., Uehara, S., Kohara, S., Nagata, R., et al. (2010c). Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques. Drug Metab Dispos 38:209-214.
    • (2010) Drug Metab Dispos , vol.38 , pp. 209-214
    • Uno, Y.1    Matsushita, A.2    Osada, N.3    Uehara, S.4    Kohara, S.5    Nagata, R.6
  • 61
    • 58149478521 scopus 로고    scopus 로고
    • A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: A possible genetic tool for generation of a better animal model in drug metabolism
    • Uno, Y., Sakuraba, H., Uehara, S., Kumano, T., Matsuno, K., Nakamura, C., et al. (2009c). A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism. Drug Metab Dispos 37:14-17.
    • (2009) Drug Metab Dispos , vol.37 , pp. 14-17
    • Uno, Y.1    Sakuraba, H.2    Uehara, S.3    Kumano, T.4    Matsuno, K.5    Nakamura, C.6
  • 62
    • 38049021537 scopus 로고    scopus 로고
    • Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: A systematic identifcation of drug-metabolizing enzymes
    • Uno, Y., Suzuki, Y., Wakaguri, H., Sakamoto, Y., Sano, H., Osada, N., et al. (2008). Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: A systematic identifcation of drug-metabolizing enzymes. FEBS Lett 582:351-358.
    • (2008) FEBS Lett , vol.582 , pp. 351-358
    • Uno, Y.1    Suzuki, Y.2    Wakaguri, H.3    Sakamoto, Y.4    Sano, H.5    Osada, N.6
  • 63
    • 77956005186 scopus 로고    scopus 로고
    • Cynomolgus monkey CYP2D44, newly identifed in liver, metabolizes bufuralol and dextromethorphan
    • Uno, Y., Uehara, S., Kohara, S., Murayama, N., Yamazaki, H. (2010d). Cynomolgus monkey CYP2D44, newly identifed in liver, metabolizes bufuralol and dextromethorphan. Drug Metab Dispos 38:1486-1492.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1486-1492
    • Uno, Y.1    Uehara, S.2    Kohara, S.3    Murayama, N.4    Yamazaki, H.5
  • 64
    • 0033058613 scopus 로고    scopus 로고
    • A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man
    • DOI 10.1080/004982599238489
    • Weaver, R. J., Dickins, M., Burke, M. D. (1999). A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man. Xenobiotica 29:467-482. (Pubitemid 29245746)
    • (1999) Xenobiotica , vol.29 , Issue.5 , pp. 467-482
    • Weaver, R.J.1    Dickins, M.2    Burke, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.