Botanical flavonoids on coronary heart disease

American Journal of Chinese Medicine

Volumn 39, Issue 4, 2011, Pages 661-671

  Wang, Chong Zhi ^a   Mehendale, Sangeeta R ^a   Calway, Tyler ^a   Yuan, Chun Su ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cardiovascular Disease; Flavonoids; Grape Seed Proanthocyanidin; Ischemia Reperfusion Injury; Ischemic Heart Disease; Nitric Oxide; Reactive Oxygen Species; Scutellaria baicalensis

Indexed keywords

BAICALEIN; BAICALIN; CATECHIN; EPICATECHIN; EPICATECHIN GALLATE; FLAVONOID; HERBACEOUS AGENT; NITRIC OXIDE; PROANTHOCYANIDIN; PROCYANIDIN; REACTIVE OXYGEN METABOLITE; SCUTELLARIA BAICALENSIS EXTRACT; WOGONIN;

ANTIOXIDANT ACTIVITY; ARTICLE; FRUIT; HEALTH CARE COST; HEART DISEASE; HEART MUSCLE CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; ISCHEMIC PRECONDITIONING; NONHUMAN; QUALITY OF LIFE; VEGETABLE;

ANIMALS; CORONARY DISEASE; FLAVONOIDS; HUMANS; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; PROANTHOCYANIDINS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SCUTELLARIA BAICALENSIS; VITIS;

EID: 79959926613     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X1100910X     Document Type: Article

References (64)

1. Arts, I.C., P.C. Hollman, E.J. Feskens, H.B. Bueno de Mesquita and D. Kromhout. Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Am. J. Clin. Nutr. 74: 227-232, 2001. (Pubitemid 32702490)
2. Bagchi, D., A. Garg, R.L. Krohn, M. Bagchi, M.X. Tran and S.J. Stohs. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res. Commun. Mol. Pathol. Pharmacol. 95: 179-189, 1997. (Pubitemid 27147562)
3. Baxter, G.F. and P. Ferdinandy. Delayed preconditioning of myocardium: current perspectives. Basic Res. Cardiol. 96: 329-344, 2001. (Pubitemid 32700570)
4. Becker, L.B. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc. Res. 61: 461-470, 2004. (Pubitemid 38210152)
5. Bochorakova, H., H. Paulova, J. Slanina, P. Musil and E. Taborska. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother. Res. 17: 640-644, 2003. (Pubitemid 36781740)
6. Cai, Z., X. Li and Y. Katsumura. Interaction of hydrated electron with dietary flavonoids and phenolic acids: rate constants and transient spectra studied by pulse radiolysis. Free Radic. Biol. Med. 27: 822-829, 1999. (Pubitemid 29454585)
7. Chan, E., C.Y. Wong, C.W. Wan, C.Y. Kwok, J.H. Wu, K.M. Ng, C.H. So, A.L. Au, C.C. Poon, S.W. Seto, Y.W. Kwan, P.H. Yu and S.W. Chan. Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. Am. J. Chin. Med. 38: 815-827, 2010.
8. Chang, T.N., G.J. Huang, Y.L. Ho, S.S. Huang, H.Y. Chang and Y.S. Chang. Antioxidant and antiproliferative activities of Crossostephium chinensis (L.) Makino. Am. J. Chin. Med. 37: 797-814, 2009.
9. Chao, J., M.S. Lee, S. Amagaya, J.W. Liao, J.B. Wu, L.K. Ho and W.H. Peng. Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. Am. J. Chin. Med. 37: 1085-1097, 2009.
10. Choi, J., C.C. Conrad, C.A. Malakowsky, J.M. Talent, C.S. Yuan and R.W. Gracy. Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim. Biophys. Acta 1571: 201-210, 2002. (Pubitemid 34686922)
11. Da Silva, J.M.R., N. Darmon, Y. Fernandez and S. Mitjavila. Oxygen free radical scavenger capacity in aqueous models of different procyanidins from grape seeds. J. Agric. Food Chem. 39: 1549-1552, 1991.
12. Das, D.K., M. Sato, P.S. Ray, G. Maulik, R.M. Engelman, A.A. Bertelli and A. Bertelli. Cardio-protection of red wine: role of polyphenolic antioxidants. Drugs Exp. Clin. Res. 25: 115-120, 1999. (Pubitemid 29257603)
13. Duranteau, J., N.S. Chandel, A. Kulisz, Z. Shao and P.T. Schumacker. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J. Biol. Chem. 273: 11619-11624, 1998. (Pubitemid 28272061)
14. Fitzpatrick, D.F., B. Bing, D.A. Maggi, R.C. Fleming and R.M. O'Malley. Vasodilating procyanidins derived from grape seeds. Ann. N. Y. Acad. Sci. 957: 78-89, 2002. (Pubitemid 34721655)
15. Gao, D., K. Sakurai, J. Chen and T. Ogiso. Protection by baicalein against ascorbic acid-induced lipid peroxidation of rat liver microsomes. Res. Commun. Mol. Pathol. Pharmacol. 90: 103-114, 1995.
16. Gasiorowski, K., E. Lamer-Zarawska, J. Leszek, K. Parvathaneni, B.B. Yendluri, Z. Blach-Ols-zewska and G. Aliev. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS Neurol. Disord. Drug Targets 10: 184-191, 2011.
17. Gavagan, T. Cardiovascular disease. Prim. Care 29: 323-338, 2002. (Pubitemid 34760377)
18. Geleijnse, J.M., L.J. Launer, D.A. Van der Kuip, A. Hofman and J.C. Witteman. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam study. Am. J. Clin. Nutr. 75: 880-886, 2002. (Pubitemid 34441257)
19. Gonzalez-Paramas, A.M., S. Esteban-Ruano, C. Santos-Buelga, S. de Pascual-Teresa and J.C. Rivas-Gonzalo. Flavanol content and antioxidant activity in winery byproducts. J. Agric. Food Chem. 52: 234-238, 2004.
20. Hamada, H., M. Hiramatsu, R. Edamatsu and A. Mori. Free radical scavenging action of baicalein. Arch. Biochem. Biophys. 306: 261-266, 1993. (Pubitemid 23291312)
21. Heim, K.E., A.R. Tagliaferro and D.J. Bobilya. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem. 13: 572-584, 2002. (Pubitemid 35246546)
22. Hodnick, W.F., D.L. Duval and R.S. Pardini. Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. Biochem. Pharmacol. 47: 573-580, 1994. (Pubitemid 24071539)
23. Hosny, M. and J.P. Rosazza. Novel oxidations of (\+)-catechin by horseradish peroxidase and laccase. J. Agric. Food. Chem. 50: 5539-5545, 2002.
24. Huang, X., A. Kojima-Yuasa, S. Xu, D.O. Kennedy, T. Hasuma and I. Matsui-Yuasa. Combination of Zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL. Am. J. Chin. Med. 37: 169-179, 2009.
25. Huxley, R.R. and H.A. Neil. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur. J. Clin. Nutr. 57: 904-908, 2003. (Pubitemid 36987238)
26. Jovanovic, S.V., S. Steenken, M.G. Simic and Y. Hara. Antioxidant properties of flavonoids: reduction potentials and electron transfer reactions of flavonoid radicals. Antioxid. Health Dis. 7: 137-161, 1998.
27. Keli, S.O., M.G. Hertog, E.J. Feskens and D. Kromhout. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch. Intern. Med. 156: 637-642, 1996. (Pubitemid 26095013)
28. Kim, H., Y.S. Kim, S.Y. Kim and K. Suk. The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production. Neurosci. Lett. 309: 67-71, 2001. (Pubitemid 32728261)
29. Kimura, Y., H. Okuda, T. Tani and S. Arichi. Studies on Scutellaria Radix. VI. Effects of flavanone compounds on lipid peroxidation in rat liver. Chem. Pharm. Bull. 30: 1792-1795, 1982. (Pubitemid 12029656)
30. Konishi, Y., S. Kobayashi and M. Shimizu. Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. J. Agric. Food Chem. 51: 7296-7302, 2003.
31. Lai, M.Y., S.L. Hsiu, S.Y. Tsai, Y.C. Hou and P.D. Chao. Comparison of metabolic pharmacoki-netics of baicalin and baicalein in rats. J. Pharm. Pharmacol. 55: 205-209, 2003.
32. Li, J., H. Liu, S. Ramachandran, G.B. Waypa, J.J. Yin, C.Q. Li, M. Han, H.H. Huang, W.W. Sillard, T.L. Vanden Hoek and Z.H. Shao. Grape seed proanthocyanidins ameliorate doxorubicin-induced cardiotoxicity. Am. J. Chin. Med. 38: 569-584, 2010.
33. Lu, Y.X., Q. Zhang, J. Li, Y.X. Sun, L.Y. Wang, W.M. Cheng and X.Y. Hu. Antidiabetic effects of total flavonoids from Litsea Coreana leve on fat-fed, streptozotocin-induced type 2 diabetic rats. Am. J. Chin. Med. 38: 713-725, 2010.
34. Mann, G.E., D.J. Rowlands, F.Y. Li, P. de Winter and R.C. Siow. Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression. Cardiovasc. Res. 75: 261-274, 2007. (Pubitemid 46964821)
35. Mehendale, S., H. Aung, C.Z. Wang, R. Tong, A. Foo, J.T. Xie and C.S. Yuan. Scutellaria baica-lensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects. J. Pharm. Pharmacol. 59: 1567-1572, 2007. (Pubitemid 350057460)
36. Mendes, A., C. Desgranges, C. Cheze, J. Vercauteren and J.L. Freslon. Vasorelaxant effects of grape polyphenols in rat isolated aorta. Possible involvement of a purinergic pathway. Fundam. Clin. Pharmacol. 17: 673-681, 2003. (Pubitemid 37491554)
37. Mohazzab, H.K., P.M. Kaminski and M.S. Wolin. Lactate and PO2 modulate superoxide anion production in bovine cardiac myocytes: potential role of NADH oxidase. Circulation 96: 614-620, 1997. (Pubitemid 27329442)
38. Ostadal, B. The past, the present and the future of experimental research on myocardial ischemia and protection. Pharmacol. Rep. 61: 3-12, 2009.
39. Ray, S.D., H. Parikh, E. Hickey, M. Bagchi and D. Bagchi. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol. Cell Biochem. 218: 27-33, 2001. (Pubitemid 32294132)
40. Renaud, S. and M. de Lorgeril. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523-1526, 1992.
41. Rimm, E.B., E.L. Giovannucci, W.C. Willett, G.A. Colditz, A. Ascherio, B. Rosner and M.J. Stampfer. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338: 464-468, 1991.
42. Roychowdhury, S., G. Wolf, G. Keilhoff, D. Bagchi and T. Horn. Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress. Nitric Oxide 5: 137-149, 2001. (Pubitemid 34142737)
43. Sato, M., G. Maulik, P.S. Ray, D. Bagchi and D.K. Das. Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury. J. Mol. Cell. Cardiol. 31: 1289-1297, 1999. (Pubitemid 29276626)
44. Schulz, R., M. Kelm and G. Heusch. Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc. Res. 61: 402-413, 2004. (Pubitemid 38210147)
45. Shao, Z.H., T.L. Vanden Hoek, Y. Qin, L.B. Becker, P.T. Schumacker, C.Q. Li, L. Dey, E. Barth, H. Halpern, G.M. Rosen and C.S. Yuan. Baicalein attenuates oxidant stress in cardiomyocytes. Am. J. Physiol. Heart. Circ. Physiol. 282: 999-1006, 2002.
46. Shao, Z.H., L.B. Becker, T.L. Vanden Hoek, P.T. Schumacker, C.Q. Li, D. Zhao, K. Wojcik, T. Anderson, Y. Qin, L. Dey and C.S. Yuan. Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacol. Res. 47: 463-469, 2003a. (Pubitemid 36542924)
47. Shao, Z.H., T.L. Vanden Hoek, J. Xie, K. Wojcik, K.C. Chan, C.Q. Li, K. Hamann, Y. Qin, P.T. Schumacker, L.B. Becker and C.S. Yuan. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovasc. Toxicol. 3: 331-339, 2003b. (Pubitemid 38056000)
48. Shao, Z.H., K.R. Wojcik, A. Dossumbekova, C. Hsu, S.R. Mehendale, C.Q. Li, Y. Qin, W.W. Sharp, W.T. Chang, K.J. Hamann, C.S. Yuan and T.L. Hoek. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J. Cell Biochem. 107: 697-705, 2009.
49. Stein, J.H., J.G. Keevil, D.A. Wiebe, S. Aeschlimann and J.D. Folts. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100: 1050-1055, 1999. (Pubitemid 29416230)
50. Stohs, S.J. The role of free radicals in toxicity and disease. J. Basic Clin. Physiol. Pharmacol. 6: 205-228, 1995. (Pubitemid 26086168)
51. Tong, R., S.R. Mehendale, C.Z. Wang, Z. Shao and C.S. Yuan. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. Am. J. Chin. Med. 37: 621-623, 2009.
52. Vanden Hoek, T., L.B. Becker, Z.H. Shao, C.Q. Li and P.T. Schumacker. Preconditioning in cardio-myocytes protects by attenuating oxidant stress at reperfusion. Circ. Res. 86: 541-548, 2000. (Pubitemid 30165046)
53. Violi, F., R. Cangemi, G. Sabatino and P. Pignatelli. Vitamin E for the treatment of cardiovascular disease: is there a future? Ann. N. Y. Acad. Sci. 1031: 292-304, 2004. (Pubitemid 40361764)
54. Vivekananthan, D.P., M.S. Penn, S.K. Sapp, A. Hsu and E.J. Topol. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361: 2017-2023, 2003. (Pubitemid 36695043)
55. Vivier, M.A. and I.S. Pretorius. Genetically tailored grapevines for the wine industry. Trends Biotechnol. 20: 472-478, 2002. (Pubitemid 35292360)
56. Wang, W., Y. Zu, Y. Fu, J. Reichling, U. Suschke, S. Nokemper and Y. Zhang. In vitro antioxidant, antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr. from China. Am. J. Chin. Med. 37: 195-203, 2009.
57. Wollny, T., L. Aiello, D. Di Tommaso, V. Bellavia, D. Rotilio, M.B. Donati, G. de Gaetano and L. Iacoviello. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. Br. J. Pharmacol. 127: 747-755, 1999.
58. Xie, Y.W., P.M. Kaminski and M.S. Wolin. Inhibition of rat cardiac muscle contraction and mito-chondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygena-tion. Circ. Res. 82: 891-897, 1998. (Pubitemid 28234580)
59. Yamashita, S., T. Sakane, M. Harada, N. Sugiura, H. Koda, Y. Kiso and H. Sezaki. Absorption and metabolism of antioxidative polyphenolic compounds in red wine. Ann. N. Y. Acad. Sci. 957: 325-328, 2002. (Pubitemid 34721682)
60. Yin, Y.Y., W.P. Li, H.L. Gong, F.F. Zhu, W.Z. Li and G.C. Wu. Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats. Am. J. Chin. Med. 38: 517-527, 2010.
61. Yook, H.S., K.H. Kim, J.E. Park and H.J. Shin. Antioxidative and antiviral properties of flowering cherry fruits (Prunus serrulata L. var. spontanea). Am. J. Chin. Med. 38: 937-948, 2010.
62. Yu, T., Q.E. Chen, Z.W. Chen, Z. Xiong and M. Ye. Protective effects of total flavones of rhodo-dendra against global cerebral ischemia reperfusion injury. Am. J. Chin. Med. 37: 877-887, 2009.
63. Yune, T.Y., J.Y. Lee, C.M. Cui, H.C. Kim and T.H. Oh. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J. Neurochem. 110: 1276-1287, 2009.
64. Zweier, J.L., J.T. Flaherty and M.L. Weisfeldt. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA 84: 1404-1407, 1987. (Pubitemid 17027362)