Lactate and PO2 modulate superoxide anion production in bovine cardiac myocytes: Potential role of NADH oxidase

Circulation

Volumn 96, Issue 2, 1997, Pages 614-620

  Mohazzab H, Kamal M ^a   Kaminski, Pawel M ^a   Wolin, Michael S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Free radicals; Hypoxia; Myocytes; Oxygen

Indexed keywords

DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; LACTIC ACID; LUCIGENIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; XANTHINE OXIDASE; FREE RADICAL; MULTIENZYME COMPLEX; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATTLE; CELL ISOLATION; ENZYME BINDING; ENZYME INHIBITION; HEART MUSCLE CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN TENSION; PRIORITY JOURNAL; REOXYGENATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; HEART MUSCLE; METABOLISM;

ANIMALS; CATTLE; CELLS, CULTURED; FREE RADICALS; LACTIC ACID; MULTIENZYME COMPLEXES; MYOCARDIUM; NADH, NADPH OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 0030612345     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.2.614     Document Type: Article

References (32)

1. Granger DN. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol. 1988;255:H1269-H1275.
2. Hearse DG, Manning AS, Downey JM, Yellon DM. Xanthine oxidase: a critical mediator of myocardial injury during ischemia and reperfusion. Acta Physiol Scand Suppl. 1986;548:65-78.
3. Bolli R. Mechanism of myocardial 'stunning.' Circulation. 1990;82: 723-738.
4. Ambrosio G, Zweier JL, Duilio C, Kuppusamy P, Santoro G, Elia PP, Tritto I, Cirillo P, Condorelli M, Chiariello M, Flaherty JT. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem. 1993;268:18532-18541.
5. Shlafer M, Myers CL, Adkins S. Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia. J Mol Cell Cardiol. 1987;18: 1195-1206.
6. Turrens JF, Beconi M, Barilla J, Chavez UB, McCord JM. Mitochondrial generation of oxygen radicals during reoxygenation of the ischemic tissues. Free Radic Res Commun. 1991;12-13:681-689.
7. Kaminski PM, Wolin MS. Hypoxia increases superoxide anion production from bovine coronary microvessels, but not cardiac myocytes, via increased xanthine oxidase. Microcirculalion. 1994;1: 231-236.
8. Mohazzab-H KM, Wolin MS. Sites of superoxide anion production in calf pulmonary arterial smooth muscle. Am J Physiol. 1994;267: L815-L822.
9. 2 production via NADH-derived superoxide. Am J Physiol. 1996;270: H1044-H1053.
10. Mohazzab-H KM, Kaminski PM, Wolin MS. NADH-oxidoreductase is a major source of superoxide anion in bovine coronary endothelium. Am J Physiol. 1994;266:H2568-H2572.
11. 2 and cGMP. Am J Physiol. 1993;264:L141-L145.
12. Wolin MS, Burke-Wolin TM, Kaminski PM, Mohazzab-H KM. Reactive oxygen species and vascular oxygen sensors. In: Weir EK, Archer SL, Reeves JT, eds. Nitric Oxide and Radicals in the Pulmonary Vasculature. Armonk, NY: Futura Publishing Co; 1996:245-263.
13. 2 species. Circulation. 1990;82(suppl III):III-422. Abstract.
14. Turrens JF, Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J. 1980;191:421-427.
15. Forman HJ, Boveris A. Superoxide radical and hydrogen peroxide in mitochondria. In: Pryor WA, ed. Free Radicals in Biology, Vol 5. New York, NY: Academic Press; 1982:65-90.
16. Nohl H. A novel superoxide radical generator in heart mitochondria. FEBS Lett. 1987;214:269-273.
17. Schonheit K, Nohl H. Oxidation of cytosolic NADH via complex I of heart mitochondria. Arch Biochem Biophys. 1996;327:319-323.
18. 2 sensor. Am J Physiol. 1994;267:L823-L831.
19. 2-elicited responses. Am J Physiol. 1995;269:L637-L644.
20. Mohazzab-H KM, Wolin MS. Sites of superoxide anion production in calf pulmonary arterial smooth muscle. Am J Physiol. 1994;267: L815-L822.
21. Paky A, Michael JR, Burke-Wolin T, Wolin MS, Gurtner GH. Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors. J Appl Physiol. 1993;74:2868-2874.
22. Thorpe GHG, Kricka L. Enhanced chemiluminescent reactions catalyzed by horseradish peroxidase. Methods Enzymol. 1986; 133: 331-353.
23. Yia Y, Zweier JL. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J Biol Chem. 1995;270: 18797-18803.
24. Saugstad OS. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988;23:143-150.
25. Jarasch E-D, Bruder G, Heid HW. Significance of xanthine oxidase in capillary endothelial cells. Acta Physiol Scand Suppl. 1986;548: 39-46.
26. Cross AR, Jones OTG. Enzymatic mechanisms of superoxide production. Biochim Biophys Acta. 1991;1057:291-298.
27. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem. 1992;267:24173-24176.
28. Kukreja RC, Kontos HA, Hess ML, Ellis EF. PGH synthetase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res. 1986;59:612-619.
29. Rovetto MJ, Lamberton WF, Neely JR. Mechanisms of glycolytic inhibition in isolated rat hearts. Circ Res. 1975;37:742-751.
30. Neely JR, Crotyohann LW. Role of glycolytic products in damage to ischemic myocardium: dissociation of adenosine triphosphatc levels and recovery of function of reperfused ischemic hearts. Circ Res. 1984;55:816-824.
31. Mohazzab-H KM, Zhang X, Kichuk MR, Michler R, Kaley G, Wolin MS. Potential sites of changes of superoxide production in failing and non-failing human cardiac myocytes. Circulation. 1995; 92(suppl I):I-32. Abstract.
32. Mohazzab-H KM, Zhang X, Xu X, Hintze TH, Wolin MS. Evidence for an increase in superoxide anion generation in pacing-induced failing dog heart myocytes. FASEB J. 1996;10:A581. Abstract.