Critical amino acid residues in transmembrane span 7 of the serotonin transporter identified by random mutagenesis

Journal of Biological Chemistry

Volumn 273, Issue 43, 1998, Pages 28098-28106

  Penado, Kendall M Y ^a   Rudnick, Gary ^a   Stephan, Megan M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032561347     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.43.28098     Document Type: Article

References (36)

1. Uhl, G. R. (1992) Trends Neurosci. 15, 265-268
2. Rudnick, G., and Clark, J. (1993) Biochim. Biophys. Acta Rev. Bioenerg. 1144, 249-263
3. Blakely, R. D., De Felice, L. J., and Hartzell, H. C. (1994) J. Exp. Biol. 196, 263-281
4. Kanner, B. I. (1994) J. Exp. Biol. 196, 237-249
5. Fuller, R. W. (1991) J. Clin. Psych. 52, (suppl.) 52-57
6. Kuhar, M. J., Ritz, M. C., and Boja, J. W. (1991) Trends Neurosci. 14, 299-302
7. Woolverton, W. L., and Johnson, K. M. (1992) Trends Pharmacol. Sci. 13, 193-200
8. Owens, M. J. (1996) Depression Anxiety 4, 153-159
9. Buck, K. J., and Amara, S. G. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 12584-12588
10. Giros, B., Wang, Y. M., Suter, S., McLeskey, S. B., Pifl, C., and Caron, M. G. (1994) J. Biol. Chem. 269, 15985-15988
11. Buck, K. J., and Amara, S. G. (1995) Mol. Pharmacol. 48, 1030-1037
12. Kitayama, S., Shimada, S., Xu, H. X., Markham, L., Donovan, D. M., and Uhl, G. R. (1992) Proc. Natl Acad. Sci. U. S. A. 89, 7782-7785
13. Sarkar, G., and Sommer, S. S. (1990) BioTechniques 8, 404-407
14. Barik, S., and Galinski, M. S. (1991) BioTechniques 10, 489-490
15. Aiyar, A., and Leis, J. (1993) BioTechniques 14, 366-369
16. Tate, C. G., and Blakely, R. D. (1994) J. Biol. Chem. 269, 26303-26310
17. Blakely, R. D., Clark, J. A., Rudnick, G., and Amara, S. G. (1991) Anal. Biochem. 194, 302-308
18. Stephan, M. M., Chen, M. A., Penado, K. M., and Rudnick, G. (1997) Biochemistry 36, 1322-1328
19. Talvenheimo, J., Fishkes, H., Nelson, P. J., and Rudnick, G. (1983) J. Biol. Chem. 258, 6115-6119
20. Deisenhofer, J., and Michel, H. (1989) Science 245, 1463-1473
21. Chen, J. G., Sachpatzidis, A., and Rudnick, G. (1997) J. Biol. Chem. 272, 28321-28327
22. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinzawa-Itoh, K., Nakashima, R., Yaono, R., and Yoshikawa, S. (1995) Science 269, 1069-1074
23. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinzawa-Itoh, K., Nakashima, R., Yaono, R., and Yoshikawa, S. (1996) Science 272, 1136-1144
24. Pebay-Peyroula, E., Rummel, G., Rosenbusch, J. P., and Landau, E. M. (1997) Science 277, 1676-1681
25. Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77
26. Dougherty, D. A. (1996) Science 271, 163-168
27. Mecozzi, S., West, A. P., Jr., and Dougherty, D. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10566-10571
28. Hibert, M. F., Trumpp-Kallmeyer, S., Bruinvels, A., and Hoflack, J. (1991) Mol. Pharmacol. 40, 8-15
29. Sussman, J. L., Harel, M., and Silman, I. (1993) Chem. Biol. Interact. 87, 187-197
30. Bismuth, Y., Kavanaugh, M. P., and Kanner, B. I. (1997) J. Biol. Chem. 272, 16096-16102
31. Barker, E. L., Kimmel, H. L., and Blakely, R. D. (1994) Mol. Pharmacol. 46, 799-807
32. Barker, E. L., and Blakely, R. D. (1996) Mol. Pharmacol. 50, 957-965
33. Kleinberger-Doron, N., and Kanner, B. (1994) J. Biol. Chem. 269, 3063-3067
34. Mager, S., Kleinberger-Doron, N., Keshet, G. I., Davidson, N., Kanner, B. I., and Lester, H. A. (1996) J. Neurosci. 16, 5405-5414
35. Strader, C. D., Sigal, I. S., and Dixon, R. A. (1989) Am. J. Respir. Cell. Mol. Biol. 1, 81-86
36. Norregaard, L., Frederiksen, D., Nielsen, E., and Gether, U. (1998) EMBO J. 17, 4266-4273