Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4332-4336

  González Lpez, Marcos ^a   Welsh, Kate ^a   Finlay, Darren ^a   Ardecky, Robert J ^a   Ganji, Santhi Reddy ^a   Su, Ying ^a   Yuan, Hongbin ^a   Teriete, Peter ^a   MacE, Peter D ^a   Riedl, Stefan J ^a   Vuori, Kristiina ^a   Reed, John C ^a   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Monovalent Smac mimietics; Probe compounds; XIAP

Indexed keywords

SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TRIPEPTIDE DERIVATIVE; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CELL DEATH; DRUG BINDING; DRUG DESIGN; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DOMAIN;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BINDING SITES; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TNF-RELATED APOPTOSIS-INDUCING LIGAND; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79959871720     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.049     Document Type: Article

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