Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor

PLoS Genetics

Volumn 7, Issue 6, 2011, Pages

  Carroll, Sean Michael ^a   Ortlund, Eric A ^b   Thornton, Joseph W ^c  

^a HARVARD UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; GLUCOCORTICOID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FISH; GENE ISOLATION; GENE MUTATION; GLUCOCORTICOID RECEPTOR GENE; HYDROGEN BOND; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATOR GENE; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYLOGENY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; EVOLUTION, MOLECULAR; FISHES; GLUCOCORTICOIDS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; THERMODYNAMICS;

EID: 79959834622     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002117     Document Type: Article

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