Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses

PLoS Computational Biology

Volumn 7, Issue 6, 2011, Pages

  Barata, Teresa S ^a,b   Teo, Ian ^b   Brocchini, Steve ^a   Zloh, Mire ^a   Shaunak, Sunil ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CELL MEMBRANES; COMPUTATIONAL CHEMISTRY; CRYSTAL STRUCTURE; ELECTROSTATICS; GLUCOSAMINE; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MODELING; SURFACE TREATMENT;

CELL SURFACES; COMPLEX FORMATIONS; CRYSTALS STRUCTURES; CYTOKINE RESPONSE; GLYCOSYLATED; HYDROPHOBIC POCKETS; LIPOPOLYSACCHARIDES; PAMAM DENDRIMER; PROINFLAMMATORY CYTOKINES; SURFACE COMPLEX;

DENDRIMERS;

CARBOXYLIC ACID; DENDRIMER; GLUCOSAMINE; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; CYTOKINE; LY96 PROTEIN, HUMAN; PAMAM G3.5 DENDRIMER; TLR4 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; GLYCOSYLATION; HUMAN VERSUS ANIMAL COMPARISON; HYDROPHILICITY; MACROMOLECULE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; PROTEIN SYNTHESIS; PROTEIN TARGETING; STATIC ELECTRICITY; STRUCTURE ANALYSIS; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE; PROTEIN BINDING; RABBIT; REPRODUCIBILITY; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYTOKINES; DENDRIMERS; GLUCOSAMINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INFLAMMATION; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MICE; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; RABBITS; REPRODUCIBILITY OF RESULTS; TOLL-LIKE RECEPTOR 4;

EID: 79959822366     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002095     Document Type: Article

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