A network of hydrogen bonds on the surface of TLR2 controls ligand positioning and cell signaling

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6227-6234

  Kajava, Andrey V ^a   Vasselon, Thierry ^a,b  

^a Centre National de la Recherche Scientifique   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL MOIETY; CELL SIGNALING; CELLULAR RESPONSE; ECTODOMAIN; FUNCTIONAL SIGNALS; H-BOND NETWORK; HEAD GROUPS; INNATE IMMUNE RESPONSE; LIPOPEPTIDES; MICROBIAL PRODUCTS; PATTERN RECOGNITION RECEPTORS; SPECIFIC ORIENTATION; TERNARY COMPLEX;

CRYSTAL STRUCTURE; HYDROGEN BONDS; PATTERN RECOGNITION; SIGNALING;

LIGANDS;

HETERODIMER; MEMBRANE PROTEIN; PROTEIN PAM3CSK4; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; AMIDINE LYASE; CSK PROTEIN, HUMAN; LIGAND; MIXED FUNCTION OXIDASE; MULTIPROTEIN COMPLEX; ONCOPROTEIN; PAM PROTEIN, HUMAN; PROTEIN TYROSINE KINASE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLOW CYTOMETRY; GENE ACTIVATION; GENE MAPPING; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; CELL LINE; CHEMISTRY; METABOLISM; PROTEIN MULTIMERIZATION;

AMIDINE-LYASES; CELL LINE; HUMANS; HYDROGEN BONDING; LIGANDS; MIXED FUNCTION OXYGENASES; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

EID: 77949887383     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.063669     Document Type: Article

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