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Volumn 3, Issue 2, 2011, Pages 1691-1707

Epigenetics of estrogen receptor signaling: Role in hormonal cancer progression and therapy

Author keywords

Breast cancer; Epigenetics; Estrogen receptor; Histone modifications; Hormonal cancers

Indexed keywords

3 DEAZANEPLANOCIN A; 5 AZA 2' DEOXYCYTIDINE; ANTIESTROGEN; AROMATASE; AROMATASE INHIBITOR; AURORA B KINASE; DEPSIPEPTIDE; ENTINOSTAT; ESTROGEN; ESTROGEN RECEPTOR ALPHA; HISTONE; HISTONE DEACETYLASE; HISTONE METHYLTRANSFERASE; LETROZOLE; METHYLTRANSFERASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MIXED LINEAGE KINASE; PANOBINOSTAT; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN KINASE B; TAMOXIFEN; TRANSCRIPTION FACTOR EZH2; TRICHOSTATIN A; VORINOSTAT; ZEBULARINE;

EID: 79959745269     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3021691     Document Type: Review
Times cited : (71)

References (110)
  • 1
    • 30344479480 scopus 로고    scopus 로고
    • Coregulators in nuclear estrogen receptor action: From concept to therapeutic targeting
    • Hall, J.M.; McDonnell, D.P. Coregulators in nuclear estrogen receptor action: From concept to therapeutic targeting. Mol. Interv. 2005, 5, 343-357.
    • (2005) Mol. Interv , vol.5 , pp. 343-357
    • Hall, J.M.1    McDonnell, D.P.2
  • 2
    • 34548248572 scopus 로고    scopus 로고
    • Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state
    • Green, K.A.; Carroll, J.S. Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state. Nat. Rev. Cancer. 2007, 7, 713-722.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 713-722
    • Green, K.A.1    Carroll, J.S.2
  • 5
    • 0028283503 scopus 로고
    • Molecular mechanisms of action of steroid/thyroid receptor superfamily members
    • Tsai, M.J.; O'Malley, B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 1994, 63, 451-486.
    • (1994) Annu. Rev. Biochem , vol.63 , pp. 451-486
    • Tsai, M.J.1    O'Malley, B.W.2
  • 6
    • 1242351785 scopus 로고    scopus 로고
    • Novel estrogen receptor coregulators and signaling molecules in human diseases
    • Barnes, C.J.; Vadlamudi, R.K.; Kumar, R. Novel estrogen receptor coregulators and signaling molecules in human diseases. Cell Mol. Life Sci. 2004, 61, 281-291.
    • (2004) Cell Mol. Life Sci , vol.61 , pp. 281-291
    • Barnes, C.J.1    Vadlamudi, R.K.2    Kumar, R.3
  • 7
    • 0033400343 scopus 로고    scopus 로고
    • Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription
    • Collingwood, T.N.; Urnov, F.D.; Wolffe, A.P. Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription. J. Mol. Endocrinol. 1999, 23, 255-275.
    • (1999) J. Mol. Endocrinol , vol.23 , pp. 255-275
    • Collingwood, T.N.1    Urnov, F.D.2    Wolffe, A.P.3
  • 8
    • 0037204724 scopus 로고    scopus 로고
    • Connections and regulation of the human estrogen receptor
    • McDonnell, D.P.; Norris, J.D. Connections and regulation of the human estrogen receptor. Science 2002, 296, 1642-1644.
    • (2002) Science , vol.296 , pp. 1642-1644
    • McDonnell, D.P.1    Norris, J.D.2
  • 9
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: Cellular and molecular biology
    • McKenna, N.J.; Lanz, R.B.; O'Malley, B.W. Nuclear receptor coregulators: Cellular and molecular biology. Endocr. Rev. 1999, 20, 321-344.
    • (1999) Endocr. Rev , vol.20 , pp. 321-344
    • McKenna, N.J.1    Lanz, R.B.2    O'Malley, B.W.3
  • 10
    • 34548526743 scopus 로고    scopus 로고
    • Chromatin remodeling and cancer, part I: Covalent histone modifications
    • Wang, G.G.; Allis, C.D.; Chi, P. Chromatin remodeling and cancer, part I: Covalent histone modifications. Trends Mol. Med. 2007, 13, 363-372.
    • (2007) Trends Mol. Med , vol.13 , pp. 363-372
    • Wang, G.G.1    Allis, C.D.2    Chi, P.3
  • 13
    • 0035032345 scopus 로고    scopus 로고
    • A tale of histone modifications
    • REVIEWS0003
    • Grant, P.A. A tale of histone modifications. Genome Biol. 2001, 2, REVIEWS0003.
    • (2001) Genome Biol , vol.2
    • Grant, P.A.1
  • 14
    • 0028283503 scopus 로고
    • Molecular mechanisms of action of steroid/thyroid receptor superfamily members
    • Tsai, M.J.; O'Malley, B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 1994, 63, 451-486.
    • (1994) Annu. Rev. Biochem , vol.63 , pp. 451-486
    • Tsai, M.J.1    O'Malley, B.W.2
  • 15
    • 11244271837 scopus 로고    scopus 로고
    • Sin3: A flexible regulator of global gene expression and genome stability
    • Silverstein, R.A.; Ekwall, K. Sin3: A flexible regulator of global gene expression and genome stability. Curr. Genet. 2005, 47, 1-17.
    • (2005) Curr. Genet , vol.47 , pp. 1-17
    • Silverstein, R.A.1    Ekwall, K.2
  • 16
    • 17144416838 scopus 로고    scopus 로고
    • The clinical relevance of steroid hormone receptor corepressors
    • Kumar, R.; Gururaj, A.E.; Vadlamudi, R.K.; Rayala, S.K. The clinical relevance of steroid hormone receptor corepressors. Clin. Cancer Res. 2005, 11, 2822-2831.
    • (2005) Clin. Cancer Res , vol.11 , pp. 2822-2831
    • Kumar, R.1    Gururaj, A.E.2    Vadlamudi, R.K.3    Rayala, S.K.4
  • 19
    • 0037224484 scopus 로고    scopus 로고
    • Nongenomic actions of steroid hormones
    • Losel, R.; Wehling, M. Nongenomic actions of steroid hormones. Nat. Rev. Mol. Cell Biol. 2003, 4, 46-56.
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 46-56
    • Losel, R.1    Wehling, M.2
  • 22
    • 0036128068 scopus 로고    scopus 로고
    • The role of mitogen-activated protein (MAP) kinase in breast cancer
    • Santen R., Song, R.X.; McPherson, R.; Kumar, R.; Adam, L.; Jeng, M.H.; Yue, W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J. Steroid Biochem. Mol. Biol. 2002, 80, 239-256.
    • (2002) J. Steroid Biochem. Mol. Biol , vol.80 , pp. 239-256
  • 23
    • 33646390099 scopus 로고    scopus 로고
    • Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway
    • Espino, P.S.; Li, L.; He, S.; Yu, J.; Davie, J.R. Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway. Cancer Res. 2006, 66, 4610-4616.
    • (2006) Cancer Res , vol.66 , pp. 4610-4616
    • Espino, P.S.1    Li, L.2    He, S.3    Yu, J.4    Davie, J.R.5
  • 24
    • 78049329473 scopus 로고    scopus 로고
    • Mini review: Role of kinases and chromatin remodeling in progesterone signaling to chromatin
    • Vicent, G.P.; Nacht, A.S.; Zaurin, R.; Ballare, C.; Clausell, J.; Beato, M. Mini review: Role of kinases and chromatin remodeling in progesterone signaling to chromatin. Mol. Endocrinol. 2010, 24, 2088-2098.
    • (2010) Mol Endocrinol , vol.24 , pp. 2088-2098
    • Vicent, G.P.1    Nacht, A.S.2    Zaurin, R.3    Ballare, C.4    Clausell, J.5    Beato, M.6
  • 25
    • 52049084858 scopus 로고    scopus 로고
    • Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover
    • Li, C.; Liang, Y.Y.; Feng, X.H.; Tsai, S.Y.; Tsai, M.J.; O'Malley, B.W. Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol. Cell. 2008, 31, 835-849.
    • (2008) Mol. Cell , vol.31 , pp. 835-849
    • Li, C.1    Liang, Y.Y.2    Feng, X.H.3    Tsai, S.Y.4    Tsai, M.J.5    O'Malley, B.W.6
  • 26
    • 53249130976 scopus 로고    scopus 로고
    • Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
    • Yi, K.D.; Simpkins, J.W. Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection. Endocrinology 2008, 149, 5235-5243.
    • (2008) Endocrinology , vol.149 , pp. 5235-5243
    • Yi, K.D.1    Simpkins, J.W.2
  • 28
    • 0035964869 scopus 로고    scopus 로고
    • Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
    • Litt, M.D.; Simpson, M.; Gaszner, M.; Allis, C.D.; Felsenfeld, G. Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 2001, 293, 2453-2455.
    • (2001) Science , vol.293 , pp. 2453-2455
    • Litt, M.D.1    Simpson, M.2    Gaszner, M.3    Allis, C.D.4    Felsenfeld, G.5
  • 29
    • 0035839110 scopus 로고    scopus 로고
    • Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
    • Noma, K.; Allis, C.D.; Grewal, S.I. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 2001, 293, 1150-1155.
    • (2001) Science , vol.293 , pp. 1150-1155
    • Noma, K.1    Allis, C.D.2    Grewal, S.I.3
  • 31
    • 0032479171 scopus 로고    scopus 로고
    • PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation
    • Tang, J.; Gary, J.D.; Clarke, S.; Herschman, H.R. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. J. Biol. Chem. 1998, 273, 16935-16945
    • (1998) J. Biol. Chem , vol.273 , pp. 16935-16945
    • Tang, J.1    Gary, J.D.2    Clarke, S.3    Herschman, H.R.4
  • 32
    • 79959829510 scopus 로고    scopus 로고
    • Histone arginine methylation
    • doi:10.1016/j.febslet.2010.11.010
    • Di, L.A.; Bedford, M.T. Histone arginine methylation. FEBS Lett. 2010, doi:10.1016/j.febslet.2010.11.010
    • (2010) FEBS Lett
    • Di, L.A.1    Bedford, M.T.2
  • 33
    • 35348938519 scopus 로고    scopus 로고
    • JMJD6 is a histone arginine demethylase
    • Chang, B.; Chen, Y.; Zhao, Y.; Bruick, R.K. JMJD6 is a histone arginine demethylase. Science 2007, 318, 444-447.
    • (2007) Science , vol.318 , pp. 444-447
    • Chang, B.1    Chen, Y.2    Zhao, Y.3    Bruick, R.K.4
  • 35
    • 70249133329 scopus 로고    scopus 로고
    • Functional connection between deimination and deacetylation of histones
    • Denis, H.; Deplus, R.; Putmans, P.; Yamada, M.; Metivier, R.; Fuks, F. Functional connection between deimination and deacetylation of histones. Mol. Cell Biol. 2009, 29, 4982-4993.
    • (2009) Mol. Cell Biol , vol.29 , pp. 4982-4993
    • Denis, H.1    Deplus, R.2    Putmans, P.3    Yamada, M.4    Metivier, R.5    Fuks, F.6
  • 37
    • 79951578893 scopus 로고    scopus 로고
    • Protein arginine deiminase 4: A target for an epigenetic cancer therapy
    • Slack, J.L.; Causey, C.P.; Thompson, P.R. Protein arginine deiminase 4: A target for an epigenetic cancer therapy. Cell Mol. Life Sci. 2010, 68, 709-720.
    • (2010) Cell Mol. Life Sci , vol.68 , pp. 709-720
    • Slack, J.L.1    Causey, C.P.2    Thompson, P.R.3
  • 38
    • 0033520325 scopus 로고    scopus 로고
    • Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
    • Chen, H.; Lin, R.J.; Xie, W.; Wilpitz, D.; Evans, R.M. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 1999, 98, 675-686.
    • (1999) Cell , vol.98 , pp. 675-686
    • Chen, H.1    Lin, R.J.2    Xie, W.3    Wilpitz, D.4    Evans, R.M.5
  • 39
    • 66449088362 scopus 로고    scopus 로고
    • Estrogen Receptor (ER) Mediates Stimulatory Effects of Estrogen on Aromatase (CYP19) Gene Expression in Human Placenta
    • Kumar, P.; Kamat, A.; Mendelson, C.R. Estrogen Receptor (ER) Mediates Stimulatory Effects of Estrogen on Aromatase (CYP19) Gene Expression in Human Placenta. Mol. Endocrinol. 2009, 23, 784-793.
    • (2009) Mol. Endocrinol , vol.23 , pp. 784-793
    • Kumar, P.1    Kamat, A.2    Mendelson, C.R.3
  • 41
    • 0141785350 scopus 로고    scopus 로고
    • Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    • Frasor, J.; Danes, J.M.; Komm, B.; Chang, K.C.; Lyttle, C.R.; Katzenellen bogen, B.S. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: Insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 2003, 144, 4562-4574.
    • (2003) Endocrinology , vol.144 , pp. 4562-4574
    • Frasor, J.1    Danes, J.M.2    Komm, B.3    Chang, K.C.4    Lyttle, C.R.5    Katzenellen Bogen, B.S.6
  • 42
    • 0036682426 scopus 로고    scopus 로고
    • Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor
    • Levenson, A.S.; Svoboda, K.M.; Pease, K.M.; Kaiser, S.A.; Chen, B.; Simons, L.A.; Jovanovic, B.D.; Dyck, P.A.; Jordan, V.C. Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002, 62, 4419-4426.
    • (2002) Cancer Res , vol.62 , pp. 4419-4426
    • Levenson, A.S.1    Svoboda, K.M.2    Pease, K.M.3    Kaiser, S.A.4    Chen, B.5    Simons, L.A.6    Jovanovic, B.D.7    Dyck, P.A.8    Jordan, V.C.9
  • 43
    • 0141752761 scopus 로고    scopus 로고
    • Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta
    • Monroe, D.G.; Getz, B.J.; Johnsen, S.A.; Riggs, B.L.; Khosla, S.; Spelsberg, T.C. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta. J. Cell Biochem. 2003, 90, 315-326.
    • (2003) J. Cell Biochem , vol.90 , pp. 315-326
    • Monroe, D.G.1    Getz, B.J.2    Johnsen, S.A.3    Riggs, B.L.4    Khosla, S.5    Spelsberg, T.C.6
  • 44
    • 37249011323 scopus 로고    scopus 로고
    • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor
    • Hwang, C.; Giri, V.N.; Wilkinson, J.C.; Wright, C.W.; Wilkinson, A.S.; Cooney, K.A.; Duckett, C.S. EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. Breast Cancer Res. Treat. 2008, 107, 235-242.
    • (2008) Breast Cancer Res. Treat , vol.107 , pp. 235-242
    • Hwang, C.1    Giri, V.N.2    Wilkinson, J.C.3    Wright, C.W.4    Wilkinson, A.S.5    Cooney, K.A.6    Duckett, C.S.7
  • 45
    • 22744446856 scopus 로고    scopus 로고
    • Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer
    • Cancers 2011, 3,1703
    • Saji, S.; Kawakami, M.; Hayashi, S.; Yoshida, N.; Hirose, M.; Horiguchi, S.; Itoh, A.; Funata, N.; Schreiber, S.L.; Yoshida, M.; Toi, M. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 2005, 24, 4531-4539. Cancers 2011, 3,1703
    • (2005) Oncogene , vol.24 , pp. 4531-4539
    • Saji, S.1    Kawakami, M.2    Hayashi, S.3    Yoshida, N.4    Hirose, M.5    Horiguchi, S.6    Itoh, A.7    Funata, N.8    Schreiber, S.L.9    Yoshida, M.10    Toi, M.11
  • 46
    • 33745658056 scopus 로고    scopus 로고
    • Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor
    • Kim, M.Y.; Woo, E.M.; Chong, Y.T.; Homenko, D.R.; Kraus, W.L. Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. Mol. Endocrinol. 2006, 20, 1479-1493.
    • (2006) Mol. Endocrinol , vol.20 , pp. 1479-1493
    • Kim, M.Y.1    Woo, E.M.2    Chong, Y.T.3    Homenko, D.R.4    Kraus, W.L.5
  • 47
    • 77950896568 scopus 로고    scopus 로고
    • Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
    • Yao, Y.; Li, H.; Gu, Y.; Davidson, N.E.; Zhou, Q. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling. Carcinogenesis 2010, 31, 382-387.
    • (2010) Carcinogenesis , vol.31 , pp. 382-387
    • Yao, Y.1    Li, H.2    Gu, Y.3    Davidson, N.E.4    Zhou, Q.5
  • 49
    • 28144465120 scopus 로고    scopus 로고
    • Estrogen mediates phosphorylation of histone H3 in ovarian follicle and mammary epithelial tumor cells via the mitotic kinase, Aurora B
    • Ruiz-Cortes, Z.T.; Kimmins, S.; Monaco, L.; Burns, K.H.; Sassone-Corsi, P.; Murphy, B.D. Estrogen mediates phosphorylation of histone H3 in ovarian follicle and mammary epithelial tumor cells via the mitotic kinase, Aurora B. Mol. Endocrinol. 2005, 19, 2991-3000.
    • (2005) Mol. Endocrinol , vol.19 , pp. 2991-3000
    • Ruiz-Cortes, Z.T.1    Kimmins, S.2    Monaco, L.3    Burns, K.H.4    Sassone-Corsi, P.5    Murphy, B.D.6
  • 50
    • 77954837839 scopus 로고    scopus 로고
    • Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT
    • Bredfeldt, T.G.; Greathouse, K.L.; Safe, S.H.; Hung, M.C.; Bedford, M.T.; Walker, C.L. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol. Endocrinol. 2010, 24, 993-1006.
    • (2010) Mol. Endocrinol , vol.24 , pp. 993-1006
    • Bredfeldt, T.G.1    Greathouse, K.L.2    Safe, S.H.3    Hung, M.C.4    Bedford, M.T.5    Walker, C.L.6
  • 51
    • 46749144603 scopus 로고    scopus 로고
    • Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney
    • Hontz, A.E.; Li, S.A.; Salisbury, J.L.; Lingle, W.L.; Li, J.J. Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney. Adv. Exp. Med. Biol. 2008, 617, 411-418.
    • (2008) Adv. Exp. Med. Biol , vol.617 , pp. 411-418
    • Hontz, A.E.1    Li, S.A.2    Salisbury, J.L.3    Lingle, W.L.4    Li, J.J.5
  • 52
    • 78751683777 scopus 로고    scopus 로고
    • Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs
    • Madak-Erdogan, Z.; Lupien, M.; Stossi, F.; Brown, M.; Katzenellenbogen, B.S. Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol. Cell Biol. 2011, 31, 226-236.
    • (2011) Mol. Cell Biol , vol.31 , pp. 226-236
    • Madak-Erdogan, Z.1    Lupien, M.2    Stossi, F.3    Brown, M.4    Katzenellenbogen, B.S.5
  • 55
    • 71949085489 scopus 로고    scopus 로고
    • Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13
    • Ansari, K.I.; Kasiri, S.; Hussain, I.; Mandal, S.S. Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13. FEBS J. 2009, 276, 7400-7411.
    • (2009) FEBS J , vol.276 , pp. 7400-7411
    • Ansari, K.I.1    Kasiri, S.2    Hussain, I.3    Mandal, S.S.4
  • 56
    • 33744903415 scopus 로고    scopus 로고
    • Identification of the MLL2 complex as a coactivator for estrogen receptor alpha
    • Mo, R.; Rao, S.M.; Zhu, Y.J. Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. J. Biol. Chem. 2006, 281, 15714-15720.
    • (2006) J. Biol. Chem , vol.281 , pp. 15714-15720
    • Mo, R.1    Rao, S.M.2    Zhu, Y.J.3
  • 57
    • 67749114645 scopus 로고    scopus 로고
    • Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription
    • Kim, H.; Heo, K.; Kim, J.H.; Kim, K.; Choi, J.; An, W. Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J. Biol. Chem. 2009, 284, 19867-19877.
    • (2009) J. Biol. Chem , vol.284 , pp. 19867-19877
    • Kim, H.1    Heo, K.2    Kim, J.H.3    Kim, K.4    Choi, J.5    An, W.6
  • 60
    • 2642544592 scopus 로고    scopus 로고
    • Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    • Metivier, R.; Penot, G.; Hubner, M.R.; Reid, G.; Brand, H.; Kos, M.; Gannon, F. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 2003, 115, 751-763.
    • (2003) Cell , vol.115 , pp. 751-763
    • Metivier, R.1    Penot, G.2    Hubner, M.R.3    Reid, G.4    Brand, H.5    Kos, M.6    Gannon, F.7
  • 61
    • 39149092383 scopus 로고    scopus 로고
    • CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1
    • Frietze, S.; Lupien, M.; Silver, P.A.; Brown, M. CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res. 2008, 68, 301-306.
    • (2008) Cancer Res , vol.68 , pp. 301-306
    • Frietze, S.1    Lupien, M.2    Silver, P.A.3    Brown, M.4
  • 62
    • 78650233514 scopus 로고    scopus 로고
    • TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks
    • Yang, Y.; Lu, Y.; Espejo, A.; Wu, J.; Xu, W.; Liang, S.; Bedford, M.T. TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks. Mol. Cell. 2010, 40, 1016-1023.
    • (2010) Mol Cell , vol.40 , pp. 1016-1023
    • Yang, Y.1    Lu, Y.2    Espejo, A.3    Wu, J.4    Xu, W.5    Liang, S.6    Bedford, M.T.7
  • 64
    • 77953121401 scopus 로고    scopus 로고
    • PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity
    • Nair, S.S.; Nair, B.C.; Cortez, V.; Chakravarty, D.; Metzger, E.; Schule, R.; Brann, D.W.; Tekmal, R.R.; Vadlamudi, R.K. PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep. 2010, 11, 438-444.
    • (2010) EMBO Rep , vol.11 , pp. 438-444
    • Nair, S.S.1    Nair, B.C.2    Cortez, V.3    Chakravarty, D.4    Metzger, E.5    Schule, R.6    Brann, D.W.7    Tekmal, R.R.8    Vadlamudi, R.K.9
  • 67
    • 6044259839 scopus 로고    scopus 로고
    • Endocrine-resistant breast cancer: Underlying mechanisms and strategies for overcoming resistance
    • Kurebayashi, J. Endocrine-resistant breast cancer: Underlying mechanisms and strategies for overcoming resistance. Breast Cancer. 2003, 10, 112-119.
    • (2003) Breast Cancer , vol.10 , pp. 112-119
    • Kurebayashi, J.1
  • 68
    • 77149122714 scopus 로고    scopus 로고
    • Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment response
    • Pathiraja, T.N.; Stearns, V.; Oesterreich, S. Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment response. J. Mammary. Gland. Biol. Neoplasia. 2010, 15, 35-47.
    • (2010) J. Mammary. Gland. Biol. Neoplasia , vol.15 , pp. 35-47
    • Pathiraja, T.N.1    Stearns, V.2    Oesterreich, S.3
  • 69
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P.A.; Baylin, S.B. The epigenomics of cancer. Cell 2007, 128, 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 70
    • 32944482642 scopus 로고    scopus 로고
    • Novel mechanisms of resistance to endocrine therapy: Genomic and nongenomic considerations
    • Gururaj, A.E.; Rayala, S.K.; Vadlamudi, R.K.; Kumar, R. Novel mechanisms of resistance to endocrine therapy: Genomic and nongenomic considerations. Clin. Cancer Res. 2006, 12, 1001s-1007s.
    • (2006) Clin. Cancer Res , vol.12
    • Gururaj, A.E.1    Rayala, S.K.2    Vadlamudi, R.K.3    Kumar, R.4
  • 71
    • 28744431757 scopus 로고    scopus 로고
    • Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: Implicated role of growth factor signaling and estrogen receptor coregulators
    • Schiff, R.; Massarweh, S.A.; Shou, J.; Bharwani, L.; Arpino, G.; Rimawi, M.; Osborne, C.K. Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: Implicated role of growth factor signaling and estrogen receptor coregulators. Cancer Chemother. Pharmacol. 2005, 56 (Suppl. 1), 10-20.
    • (2005) Cancer Chemother. Pharmacol , vol.56 , Issue.SUPPL. 1 , pp. 10-20
    • Schiff, R.1    Massarweh, S.A.2    Shou, J.3    Bharwani, L.4    Arpino, G.5    Rimawi, M.6    Osborne, C.K.7
  • 76
    • 30544454697 scopus 로고    scopus 로고
    • The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype
    • Croonquist, P.A.; Van, N.B. The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype. Oncogene 2005, 24, 6269-6280.
    • (2005) Oncogene , vol.24 , pp. 6269-6280
    • Croonquist, P.A.1    Van, N.B.2
  • 77
    • 33644765912 scopus 로고    scopus 로고
    • Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    • Collett, K.; Eide, G.E.; Arnes, J.; Stefansson, I.M.; Eide, J.; Braaten, A.; Aas, T.; Otte, A.P.; Akslen, L.A. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin. Cancer Res. 2006, 12, 1168-1174.
    • (2006) Clin. Cancer Res , vol.12 , pp. 1168-1174
    • Collett, K.1    Eide, G.E.2    Arnes, J.3    Stefansson, I.M.4    Eide, J.5    Braaten, A.6    Aas, T.7    Otte, A.P.8    Akslen, L.A.9
  • 78
    • 78049307003 scopus 로고    scopus 로고
    • Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo
    • Hu, S.; Yu, L.; Li, Z.; Shen, Y.; Wang, J.; Cai, J.; Xiao, L.; Wang, Z. Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo. Cancer Biol. Ther. 2010, 10, 788-795.
    • (2010) Cancer Biol. Ther , vol.10 , pp. 788-795
    • Hu, S.1    Yu, L.2    Li, Z.3    Shen, Y.4    Wang, J.5    Cai, J.6    Xiao, L.7    Wang, Z.8
  • 79
    • 78650493658 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells
    • Li, H.; Cai, Q.; Godwin, A.K.; Zhang, R. Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol. Cancer Res. 2010, 8, 1610-1618.
    • (2010) Mol. Cancer Res , vol.8 , pp. 1610-1618
    • Li, H.1    Cai, Q.2    Godwin, A.K.3    Zhang, R.4
  • 81
    • 77955757491 scopus 로고    scopus 로고
    • The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth
    • Yang, J.; Jubb, A.M.; Pike, L.; Buffa, F.M.; Turley, H.; Baban, D.; Leek, R.; Gatter, K.C.; Ragoussis, J.; Harris, A.L. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res. 2010, 70, 6456-6466.
    • (2010) Cancer Res , vol.70 , pp. 6456-6466
    • Yang, J.1    Jubb, A.M.2    Pike, L.3    Buffa, F.M.4    Turley, H.5    Baban, D.6    Leek, R.7    Gatter, K.C.8    Ragoussis, J.9    Harris, A.L.10
  • 82
  • 83
    • 0035209689 scopus 로고    scopus 로고
    • Association of steroid receptor coactivator AIB1 with estrogen receptor-alpha in breast cancer cells
    • Azorsa, D.O.; Cunliffe, H.E.; Meltzer, P.S. Association of steroid receptor coactivator AIB1 with estrogen receptor-alpha in breast cancer cells. Breast Cancer Res. Treat. 2001, 70, 89-101.
    • (2001) Breast Cancer Res. Treat , vol.70 , pp. 89-101
    • Azorsa, D.O.1    Cunliffe, H.E.2    Meltzer, P.S.3
  • 84
    • 0033974086 scopus 로고    scopus 로고
    • Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer
    • Kurebayashi, J.; Otsuki, T.; Kunisue, H.; Tanaka, K.; Yamamoto, S.; Sonoo, H. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer. Clin. Cancer Res. 2000, 6, 512-518.
    • (2000) Clin. Cancer Res , vol.6 , pp. 512-518
    • Kurebayashi, J.1    Otsuki, T.2    Kunisue, H.3    Tanaka, K.4    Yamamoto, S.5    Sonoo, H.6
  • 85
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • Smith, C.L.; O'Malley, B.W. Coregulator function: A key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 2004, 25, 45-71.
    • (2004) Endocr. Rev , vol.25 , pp. 45-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 86
    • 24744446846 scopus 로고    scopus 로고
    • Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis
    • Kuang, S.Q.; Liao, L.; Wang, S.; Medina, D.; O'Malley, B.W.; Xu, J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005, 65, 7993-8002.
    • (2005) Cancer Res , vol.65 , pp. 7993-8002
    • Kuang, S.Q.1    Liao, L.2    Wang, S.3    Medina, D.4    O'Malley, B.W.5    Xu, J.6
  • 87
    • 1642349331 scopus 로고    scopus 로고
    • AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice
    • Kuang, S.Q.; Liao, L.; Zhang, H.; Lee, A.V.; O'Malley, B.W.; Xu, J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004, 64, 1875-1885
    • (2004) Cancer Res , vol.64 , pp. 1875-1885
    • Kuang, S.Q.1    Liao, L.2    Zhang, H.3    Lee, A.V.4    O'Malley, B.W.5    Xu, J.6
  • 89
    • 4243196028 scopus 로고    scopus 로고
    • Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis
    • Bagheri-Yarmand, R.; Talukder, A.H.; Wang, R.A.; Vadlamudi, R.K.; Kumar, R. Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Development. 2004, 131, 3469-3479.
    • (2004) Development , vol.131 , pp. 3469-3479
    • Bagheri-Yarmand, R.1    Talukder, A.H.2    Wang, R.A.3    Vadlamudi, R.K.4    Kumar, R.5
  • 90
    • 34250619620 scopus 로고    scopus 로고
    • Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
    • Vadlamudi, R.K.; Kumar, R. Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR. Nucl. Recept. Signal. 2007, 5, e004.
    • (2007) Nucl. Recept. Signal , vol.5
    • Vadlamudi, R.K.1    Kumar, R.2
  • 91
    • 34347208713 scopus 로고    scopus 로고
    • Oncogenic Potential of the Nuclear Receptor Coregulator Proline-, Glutamic Acid-, Leucine-Rich Protein 1/Modulator of the Nongenomic Actions of the Estrogen Receptor
    • Rajhans, R.; Nair, S.; Holden, A.H.; Kumar, R.; Tekmal, R.R.; Vadlamudi, R.K. Oncogenic Potential of the Nuclear Receptor Coregulator Proline-, Glutamic Acid-, Leucine-Rich Protein 1/Modulator of the Nongenomic Actions of the Estrogen Receptor. Cancer Res. 2007, 67, 5505-5512.
    • (2007) Cancer Res , vol.67 , pp. 5505-5512
    • Rajhans, R.1    Nair, S.2    Holden, A.H.3    Kumar, R.4    Tekmal, R.R.5    Vadlamudi, R.K.6
  • 92
    • 77950858916 scopus 로고    scopus 로고
    • The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype
    • Habashy, H.O.; Powe, D.G.; Rakha, E.A.; Ball, G.; Macmillan, R.D.; Green, A.R.; Ellis, I.O. The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype. Breast Cancer Res. Treat. 2009, 120, 603-12.
    • (2009) Breast Cancer Res. Treat , vol.120 , pp. 603-612
    • Habashy, H.O.1    Powe, D.G.2    Rakha, E.A.3    Ball, G.4    Macmillan, R.D.5    Green, A.R.6    Ellis, I.O.7
  • 93
    • 4143087257 scopus 로고    scopus 로고
    • Histone deacetylase inhibition and estrogen signalling in human breast cancer cells
    • Margueron, R.; Duong, V.; Castet, A.; Cavailles, V. Histone deacetylase inhibition and estrogen signalling in human breast cancer cells. Biochem. Pharmacol. 2004, 68, 1239-1246.
    • (2004) Biochem. Pharmacol , vol.68 , pp. 1239-1246
    • Margueron, R.1    Duong, V.2    Castet, A.3    Cavailles, V.4
  • 95
    • 67349237892 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induced modulation of anti-estrogen therapy
    • Thomas, S.; Munster, P.N. Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett. 2009, 280, 184-191.
    • (2009) Cancer Lett , vol.280 , pp. 184-191
    • Thomas, S.1    Munster, P.N.2
  • 96
    • 77957937450 scopus 로고    scopus 로고
    • Epigenetic modifications as therapeutic targets
    • Kelly, T.K.; De Carvalho, D.D.; Jones, P.A. Epigenetic modifications as therapeutic targets. Nat. Biotechnol. 2010, 28, 1069-1078.
    • (2010) Nat. Biotechnol , vol.28 , pp. 1069-1078
    • Kelly, T.K.1    de Carvalho, D.D.2    Jones, P.A.3
  • 97
    • 41949118169 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor SAHA induces ERalpha degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling
    • Yi, X.; Wei, W.; Wang, S.Y.; Du, Z.Y.; Xu, Y.J.; Yu, X.D. Histone deacetylase inhibitor SAHA induces ERalpha degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling. Biochem. Pharmacol. 2008, 75, 1697-1705.
    • (2008) Biochem. Pharmacol , vol.75 , pp. 1697-1705
    • Yi, X.1    Wei, W.2    Wang, S.Y.3    Du, Z.Y.4    Xu, Y.J.5    Yu, X.D.6
  • 98
    • 77954627516 scopus 로고    scopus 로고
    • The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression
    • Chen, S.; Ye, J.; Kijima, I.; Evans, D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc. Natl. Acad. Sci. USA 2010, 107, 11032-11037.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11032-11037
    • Chen, S.1    Ye, J.2    Kijima, I.3    Evans, D.4    The, H.D.A.C.5
  • 99
    • 79952237710 scopus 로고    scopus 로고
    • Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole
    • Sabnis, G.J.; Goloubeva, O.; Chumsri, S.; Nguyen, N.; Sukumar, S.; Brodie, A.M. Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole. Cancer Res. 2011, 71, 1893-1903.
    • (2011) Cancer Res , vol.71 , pp. 1893-1903
    • Sabnis, G.J.1    Goloubeva, O.2    Chumsri, S.3    Nguyen, N.4    Sukumar, S.5    Brodie, A.M.6
  • 100
    • 0037276902 scopus 로고    scopus 로고
    • The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells
    • Zhu, W.G.; Otterson, G.A. The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. Curr. Med. Chem. Anticancer Agents 2003, 3, 187-199.
    • (2003) Curr. Med. Chem. Anticancer Agents , vol.3 , pp. 187-199
    • Zhu, W.G.1    Otterson, G.A.2
  • 101
    • 44749085668 scopus 로고    scopus 로고
    • ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor
    • Fan, J.; Yin, W.J.; Lu, J.S.; Wang, L.; Wu, J.; Wu, F.Y.; Di, G.H.; Shen, Z.Z.; Shao, Z.M. ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. J. Cancer Res. Clin. Oncol. 2008, 134, 883-890
    • (2008) J. Cancer Res. Clin. Oncol , vol.134 , pp. 883-890
    • Fan, J.1    Yin, W.J.2    Lu, J.S.3    Wang, L.4    Wu, J.5    Wu, F.Y.6    Di, G.H.7    Shen, Z.Z.8    Shao, Z.M.9
  • 102
    • 77950867869 scopus 로고    scopus 로고
    • Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
    • Billam, M.; Sobolewski, M.D.; Davidson, N.E. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res. Treat. 2010, 120, 581-592.
    • (2010) Breast Cancer. Res Treat , vol.120 , pp. 581-592
    • Billam, M.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 105
    • 44249128891 scopus 로고    scopus 로고
    • Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells
    • Kondo, Y.; Shen, L.; Ahmed, S.; Boumber, Y.; Sekido, Y.; Haddad, B.R.; Issa, J.P. Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One 2008, 3, e2037.
    • (2008) PLoS One , vol.3
    • Kondo, Y.1    Shen, L.2    Ahmed, S.3    Boumber, Y.4    Sekido, Y.5    Haddad, B.R.6    Issa, J.P.7
  • 107
    • 56649103900 scopus 로고    scopus 로고
    • Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
    • Watanabe, H.; Soejima, K.; Yasuda, H.; Kawada, I.; Nakachi, I.; Yoda, S.; Naoki, K.; Ishizaka, A. Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells. Cancer Cell Int. 2008, 8, 15.
    • (2008) Cancer Cell Int , vol.8 , pp. 15
    • Watanabe, H.1    Soejima, K.2    Yasuda, H.3    Kawada, I.4    Nakachi, I.5    Yoda, S.6    Naoki, K.7    Ishizaka, A.8
  • 109
    • 79959726390 scopus 로고    scopus 로고
    • Potential Role of Pargyline in Overcoming Adaptive Resistance in Breast Cancer Cells
    • Cortez, V.; Nair, S.S.; Nair, B.; Tekmal, R.; Vadlamudi, R.K. Potential Role of Pargyline in Overcoming Adaptive Resistance in Breast Cancer Cells. Cancer Res. 2011, 69, 409.
    • (2011) Cancer Res , vol.69 , pp. 409
    • Corte, V.1    Nair, S.S.2    Nair, B.3    Tekmal, R.4    Vadlamud, R.K.5
  • 110
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J.; Yang, X.; Zhuang, L.; Jiang, X.; Chen, W.; Lee, P.L.; Karuturi, R.K.; Tan, P.B.; Liu, E.T.; Yu, Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007, 21, 1050-1063
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6    Karuturi, R.K.7    Tan, P.B.8    Liu, E.T.9    Yu, Q.10


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