Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth

Journal of Neurotrauma

Volumn 28, Issue 6, 2011, Pages 1063-1076

  Otsuka, Seiji ^a   Adamson, Crista ^a   Sankar, Venkatachalam ^a,c   Gibbs, Kurt M ^a   Kane Goldsmith, Noriko ^a   Ayer, Jennie ^a   Babiarz, Joanne ^a   Kalinski, Hagar ^b   Ashush, Hagit ^b   Alpert, Evgenia ^b   Lahav, Ron ^b   Feinstein, Elena ^b   Grumet, Martin ^a  

^a RUTGERS UNIVERSITY   (United States)

^b QBI Enterprises Ltd   (Israel)

^c UNIVERSITY OF MADRAS   (India)

Author keywords

lumbar puncture; macrophages; neuropathic pain; spinal cord injury; white matter sparing

Indexed keywords

CYANINE DYE 3; MESSENGER RNA; PROTEIN KINASE C GAMMA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CONTROLLED STUDY; FEMALE; FLUORESCENCE; GENE DELIVERY SYSTEM; HINDLIMB; HISTOPATHOLOGY; IMMUNOREACTIVITY; LOCOMOTION; LUMBAR PUNCTURE; MACROPHAGE; NERVE FIBER GROWTH; NONHUMAN; PYRAMIDAL TRACT; RAT; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SPINAL CORD CONTUSION; SPINAL CORD INJURY; TACTILE STIMULATION; THORAX INJURY; TREATMENT OUTCOME; WALKING; WHITE MATTER;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; HYPERALGESIA; INJECTIONS, SPINAL; NERVE REGENERATION; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SEROTONIN; SPINAL CORD INJURIES; UP-REGULATION;

EID: 79959715793     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2010.1568     Document Type: Article

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