Timing and duration of anti-α4β1 integrin treatment after spinal cord injury: Effect on therapeutic efficacy - Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 11, Issue 5, 2009, Pages 575-587

  Fleming, Jennifer C ^a,b,c   Bao, Feng ^a   Chen, Yuhua ^a   Hamilton, Eilis F ^a   Gonzalez Lara, Laura E ^a,b   Foster, Paula J ^a,b   Weaver, Lynne C ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c Victoria Research Laboratories   (Canada)

Author keywords

Functional recovery; Inflammation; Integrin; Neuroprotection; Oxidative damage; Spinal cord injury

Indexed keywords

ALPHA4 BETA1 INTEGRIN MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; MYELOPEROXIDASE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LIPID PEROXIDATION; LONG TERM CARE; MACROPHAGE; MALE; MICROGLIA; MONOCYTE; MOTOR PERFORMANCE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PAIN ASSESSMENT; RAT; SPINAL CORD INJURY; THERAPY DELAY; TISSUE PREPARATION; TREATMENT DURATION;

ANIMALS; ANTIBODIES, MONOCLONAL; DISEASE MODELS, ANIMAL; FEMALE; HYPERALGESIA; INTEGRIN ALPHA4BETA1; MACROPHAGES; MALE; MONOCYTES; MOTOR ACTIVITY; MYELIN SHEATH; MYELITIS; NEUROPROTECTIVE AGENTS; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 71849107535     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2009.6.SPINE08915     Document Type: Article

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