메뉴 건너뛰기




Volumn 30, Issue 25, 2010, Pages 8624-8636

Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORMALDEHYDE; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN; SHORT HAIRPIN RNA; TRYPTOPHAN HYDROXYLASE 2;

EID: 77954136703     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5389-09.2010     Document Type: Article
Times cited : (163)

References (74)
  • 1
    • 0035076328 scopus 로고    scopus 로고
    • A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist
    • Ackley MA, Hurley RW, Virnich DE, Hammond DL (2001) A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist. Pain 91:377-388.
    • (2001) Pain , vol.91 , pp. 377-388
    • Ackley, M.A.1    Hurley, R.W.2    Virnich, D.E.3    Hammond, D.L.4
  • 2
    • 0025925108 scopus 로고
    • Spinal 5-HT3 receptor-mediated antinociception: Possible release of GABA
    • Alhaider AA, Lei SZ, Wilcox GL (1991) Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J Neurosci 11:1881-1888.
    • (1991) J Neurosci , vol.11 , pp. 1881-1888
    • Alhaider, A.A.1    Lei, S.Z.2    Wilcox, G.L.3
  • 3
    • 0021288912 scopus 로고
    • Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
    • Basbaum AI, Fields HL (1984) Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338.
    • (1984) Annu Rev Neurosci , vol.7 , pp. 309-338
    • Basbaum, A.I.1    Fields, H.L.2
  • 4
    • 14044253360 scopus 로고    scopus 로고
    • Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive
    • DOI 10.1016/j.pain.2004.12.031
    • Buhler AV, Choi J, Proudfit HK, Gebhart GF (2005) Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive. Pain 114:285-294. (Pubitemid 40279111)
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 285-294
    • Buhler, A.V.1    Choi, J.2    Proudfit, H.K.3    Gebhart, G.F.4
  • 5
    • 0037096409 scopus 로고    scopus 로고
    • Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, but Does Not Initiate, Neuropathic Pain
    • Burgess SE, Gardell LR, Ossipov MH, Malan TP Jr, Vanderah TW, Lai J, Porreca F (2002) Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22:5129-5136. (Pubitemid 37465626)
    • (2002) Journal of Neuroscience , vol.22 , Issue.12 , pp. 5129-5136
    • Burgess, S.E.1    Gardell, L.R.2    Ossipov, M.H.3    Malan Jr., T.P.4    Vanderah, T.W.5    Lai, J.6    Porreca, F.7
  • 6
    • 36849060297 scopus 로고    scopus 로고
    • Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury
    • Carlson JD, Maire JJ, Martenson ME, Heinricher MM (2007) Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury. J Neurosci 27:13222-13231.
    • (2007) J Neurosci , vol.27 , pp. 13222-13231
    • Carlson, J.D.1    Maire, J.J.2    Martenson, M.E.3    Heinricher, M.M.4
  • 7
    • 58149472709 scopus 로고    scopus 로고
    • Purinergic receptor immunoreactivity in the rostral ventromedial medulla
    • Close LN, Cetas JS, Heinricher MM, Selden NR (2009) Purinergic receptor immunoreactivity in the rostral ventromedial medulla. Neuroscience 158:915-921.
    • (2009) Neuroscience , vol.158 , pp. 915-921
    • Close, L.N.1    Cetas, J.S.2    Heinricher, M.M.3    Selden, N.R.4
  • 8
    • 67649658025 scopus 로고    scopus 로고
    • Different mediation of descending pain facilitation and inhibition by spinal 5-HT-3 and 5-HT-7 receptors
    • Dogrul A, Ossipov MH, Porreca F (2009) Different mediation of descending pain facilitation and inhibition by spinal 5-HT-3 and 5-HT-7 receptors. Brain Res 1280:52-59.
    • (2009) Brain Res , vol.1280 , pp. 52-59
    • Dogrul, A.1    Ossipov, M.H.2    Porreca, F.3
  • 9
    • 34447632233 scopus 로고    scopus 로고
    • 3B receptor subunit in the central and peripheral nervous systems in rodents
    • DOI 10.1111/j.1460-9568.2007.05659.x
    • Doucet E, Latrémolière A, Darmon M, Hamon M, Emerit MB (2007) Immunolabelling of the 5-HT 3B receptor subunit in the central and peripheral nervous systems in rodents. Eur J Neurosci 26:355-366. (Pubitemid 47087607)
    • (2007) European Journal of Neuroscience , vol.26 , Issue.2 , pp. 355-366
    • Doucet, E.1    Latremoliere, A.2    Darmon, M.3    Hamon, M.4    Emerit, M.B.5
  • 10
    • 8844255512 scopus 로고    scopus 로고
    • Brainstem mechanisms of persistent pain following injury
    • Dubner R, Ren K (2004) Brainstem mechanisms of persistent pain following injury. J Orofacial Pain 18:299-305. (Pubitemid 39531543)
    • (2004) Journal of Orofacial Pain , vol.18 , Issue.4 , pp. 299-305
    • Dubner, R.1    Ren, K.2
  • 11
    • 0024349967 scopus 로고
    • Brainstem modulation of nociceptor-driven withdrawal reflexes
    • Fields HL, Heinricher MM (1989) Brainstem modulation of nociceptor-driven withdrawal reflexes. Ann NY Acad Sci 563:34-44.
    • (1989) Ann NY Acad Sci , vol.563 , pp. 34-44
    • Fields, H.L.1    Heinricher, M.M.2
  • 12
    • 33645392052 scopus 로고    scopus 로고
    • Central nervous system mechanisms of pain modulation
    • Ed 5 (McMahon SB, Koltzenburg M, eds), Philadelphia: Elsevier Churchill Livingstone
    • Fields HL, Basbaum AI, Heinricher MM (2006) Central nervous system mechanisms of pain modulation. In: Wall and Melzack's textbook of pain, Ed 5 (McMahon SB, Koltzenburg M, eds), pp 125-142. Philadelphia: Elsevier Churchill Livingstone.
    • (2006) Wall and Melzack's Textbook of Pain , pp. 125-142
    • Fields, H.L.1    Basbaum, A.I.2    Heinricher, M.M.3
  • 13
    • 2142761550 scopus 로고    scopus 로고
    • Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons
    • Finnegan TF, Li DP, Chen SR, Pan HL (2004) Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. J Pharmacol Exp Ther 309:476-483.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 476-483
    • Finnegan, T.F.1    Li, D.P.2    Chen, S.R.3    Pan, H.L.4
  • 14
    • 0033791063 scopus 로고    scopus 로고
    • Serotonergic raphe magnus cells that respond to noxious tail heat are not on or off cells
    • Gao K, Mason P (2000) Serotonergic raphe magnus cells that respond to noxious tail heat are not ON or OFF cells. J Neurophysiol 84:1719-1725.
    • (2000) J Neurophysiol , vol.84 , pp. 1719-1725
    • Gao, K.1    Mason, P.2
  • 15
    • 0032031560 scopus 로고    scopus 로고
    • Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia
    • Gao K, Chen DO, Genzen JR, Mason P (1998) Activation of serotonergic neurons in the raphe magnus is not necessary for morphine analgesia. J Neurosci 18:1860-1868. (Pubitemid 28103093)
    • (1998) Journal of Neuroscience , vol.18 , Issue.5 , pp. 1860-1868
    • Gao, K.1    Chen, D.O.2    Genzen, J.R.3    Mason, P.4
  • 16
    • 53149137817 scopus 로고    scopus 로고
    • Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn
    • Géranton SM, Fratto V, Tochiki KK, Hunt SP (2008) Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn. Mol Pain 4:35.
    • (2008) Mol Pain , vol.4 , pp. 35
    • Géranton, S.M.1    Fratto, V.2    Tochiki, K.K.3    Hunt, S.P.4
  • 17
    • 0025195844 scopus 로고
    • 5-HT3 receptors modulate spinal nociceptive reflexes
    • Glaum SR, Proudfit HK, Anderson EG (1990) 5-HT3 receptors modulate spinal nociceptive reflexes. Brain Res 510:12-16.
    • (1990) Brain Res , vol.510 , pp. 12-16
    • Glaum, S.R.1    Proudfit, H.K.2    Anderson, E.G.3
  • 18
    • 0034672678 scopus 로고    scopus 로고
    • An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT3 receptors in the anaesthetized rat
    • Green GM, Scarth J, Dickenson A (2000) An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT3 receptors in the anaesthetized rat. Pain 89:81-88.
    • (2000) Pain , vol.89 , pp. 81-88
    • Green, G.M.1    Scarth, J.2    Dickenson, A.3
  • 19
    • 5644256896 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    • Guo W, Wei F, Zou S, Robbins MT, Sugiyo S, Ikeda T, Tu JC, Worley PF, Dubner R, Ren K (2004) Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J Neurosci 24:9161-9173.
    • (2004) J Neurosci , vol.24 , pp. 9161-9173
    • Guo, W.1    Wei, F.2    Zou, S.3    Robbins, M.T.4    Sugiyo, S.5    Ikeda, T.6    Tu, J.C.7    Worley, P.F.8    Dubner, R.9    Ren, K.10
  • 20
    • 30644477580 scopus 로고    scopus 로고
    • Supraspinal brain-derived neurotrophic factor signaling: A novel mechanism for pain facilitation
    • Guo W, Robbins MT, Wei F, Zou S, Dubner R, Ren K (2006) Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for pain facilitation. J Neurosci 26:126-137.
    • (2006) J Neurosci , vol.26 , pp. 126-137
    • Guo, W.1    Robbins, M.T.2    Wei, F.3    Zou, S.4    Dubner, R.5    Ren, K.6
  • 21
    • 0021221003 scopus 로고
    • Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine
    • Hammond DL, Yaksh TL (1984) Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine. Brain Res 298:329-337.
    • (1984) Brain Res , vol.298 , pp. 329-337
    • Hammond, D.L.1    Yaksh, T.L.2
  • 22
    • 0021895370 scopus 로고
    • Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla
    • Hammond DL, Tyce GM, Yaksh TL (1985) Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J Physiol 359:151-162.
    • (1985) J Physiol , vol.359 , pp. 151-162
    • Hammond, D.L.1    Tyce, G.M.2    Yaksh, T.L.3
  • 23
    • 0003002165 scopus 로고    scopus 로고
    • Serotonin and its receptors in pain control
    • (Sawynok J, Cowan A, eds), New York: Wiley
    • Hamon M, Bourgoin S (1999) Serotonin and its receptors in pain control. In: Novel aspects of pain management: opioids and beyond (Sawynok J, Cowan A, eds), pp 203-228. New York: Wiley.
    • (1999) Novel Aspects of Pain Management: Opioids and Beyond , pp. 203-228
    • Hamon, M.1    Bourgoin, S.2
  • 24
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77-88.
    • (1988) Pain , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3    Flores, C.4    Joris, J.5
  • 25
    • 0027968011 scopus 로고
    • Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla
    • Heinricher MM, Morgan MM, Tortorici V, Fields HL (1994) Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience 63:279-288.
    • (1994) Neuroscience , vol.63 , pp. 279-288
    • Heinricher, M.M.1    Morgan, M.M.2    Tortorici, V.3    Fields, H.L.4
  • 26
    • 0033841549 scopus 로고    scopus 로고
    • Cornea-responsive medullary dorsal horn neurons: Modulation by local opioids and projections to thalamus and brain stem
    • Hirata H, Takeshita S, Hu JW, Bereiter DA (2000) Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem. J Neurophysiol 84:1050-1061.
    • (2000) J Neurophysiol , vol.84 , pp. 1050-1061
    • Hirata, H.1    Takeshita, S.2    Hu, J.W.3    Bereiter, D.A.4
  • 28
    • 0035313099 scopus 로고    scopus 로고
    • Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury
    • Hurley RW, Hammond DL (2001) Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci 21:2536-2545.
    • (2001) J Neurosci , vol.21 , pp. 2536-2545
    • Hurley, R.W.1    Hammond, D.L.2
  • 29
    • 0037466781 scopus 로고    scopus 로고
    • Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat
    • Hurley RW, Banfor P, Hammond DL (2003) Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Neuroscience 118:789-796.
    • (2003) Neuroscience , vol.118 , pp. 789-796
    • Hurley, R.W.1    Banfor, P.2    Hammond, D.L.3
  • 30
    • 35848939596 scopus 로고    scopus 로고
    • Role of TPH-2 in brain function: News from behavioral and pharmacologic studies
    • Invernizzi RW (2007) Role of TPH-2 in brain function: news from behavioral and pharmacologic studies. J Neurosci Res 85:3030-3035.
    • (2007) J Neurosci Res , vol.85 , pp. 3030-3035
    • Invernizzi, R.W.1
  • 31
    • 5044232714 scopus 로고    scopus 로고
    • Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats
    • DOI 10.1016/j.ejphar.2004.08.048, PII S0014299904010064
    • Jeong CY, Choi JI, Yoon MH (2004) Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. Eur J Pharmacol 502:205-211. (Pubitemid 39336486)
    • (2004) European Journal of Pharmacology , vol.502 , Issue.3 , pp. 205-211
    • Jeong, C.Y.1    Choi, J.I.2    Yoon, M.H.3
  • 32
    • 0020025141 scopus 로고
    • Failure of spinal cord serotonin depletion to alter analgesia elicited from the periaqueductal gray
    • Johannessen JN, Watkins LR, Carlton SM, Mayer DJ (1982) Failure of spinal cord serotonin depletion to alter analgesia elicited from the periaqueductal gray. Brain Res 237:373-386.
    • (1982) Brain Res , vol.237 , pp. 373-386
    • Johannessen, J.N.1    Watkins, L.R.2    Carlton, S.M.3    Mayer, D.J.4
  • 33
    • 1842455727 scopus 로고    scopus 로고
    • Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal
    • Johansen JP, Fields HL (2004) Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal. Nat Neurosci 7:398-403.
    • (2004) Nat Neurosci , vol.7 , pp. 398-403
    • Johansen, J.P.1    Fields, H.L.2
  • 34
    • 0032974181 scopus 로고    scopus 로고
    • Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity
    • Kalyuzhny AE, Wessendorf MW (1999) Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity. Neurosci 90:229-234.
    • (1999) Neurosci , vol.90 , pp. 229-234
    • Kalyuzhny, A.E.1    Wessendorf, M.W.2
  • 35
    • 34347215896 scopus 로고    scopus 로고
    • Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    • Kayser V, Elfassi IE, Aubel B, Melfort M, Julius D, Gingrich JA, Hamon M, Bourgoin S (2007) Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain 130:235-248.
    • (2007) Pain , vol.130 , pp. 235-248
    • Kayser, V.1    Elfassi, I.E.2    Aubel, B.3    Melfort, M.4    Julius, D.5    Gingrich, J.A.6    Hamon, M.7    Bourgoin, S.8
  • 36
    • 0033062034 scopus 로고    scopus 로고
    • TrkA, trkB, and trkC messenger RNA expression by bulbospinal cells of the rat
    • King VR, Michael GJ, Joshi RK, Priestley JV (1999) TrkA, trkB, and trkC messenger RNA expression by bulbospinal cells of the rat. Neuroscience 92:935-944.
    • (1999) Neuroscience , vol.92 , pp. 935-944
    • King, V.R.1    Michael, G.J.2    Joshi, R.K.3    Priestley, J.V.4
  • 37
    • 0034253658 scopus 로고    scopus 로고
    • Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat
    • DOI 10.1016/S0304-3959(00)00290-6, PII S0304395900002906
    • Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F (2000) Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain 87:265-273. (Pubitemid 30645875)
    • (2000) Pain , vol.87 , Issue.3 , pp. 265-273
    • Kovelowski, C.J.1    Ossipov, M.H.2    Sun, H.3    Lai, J.4    Malan Jr., T.P.5    Porreca, F.6
  • 38
    • 12344331520 scopus 로고    scopus 로고
    • Changes of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by bee venom-induced inflammatory pain
    • DOI 10.1016/j.neulet.2004.10.064, PII S0304394004013552
    • Liu XY, Wu SX, Wang YY, Wang W, Zhou L, Li YQ (2005) Changes of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by bee venom-induced inflammatory pain. Neurosci Lett 375:42-46. (Pubitemid 40139065)
    • (2005) Neuroscience Letters , vol.375 , Issue.1 , pp. 42-46
    • Liu, X.-Y.1    Wu, S.-X.2    Wang, Y.-Y.3    Wang, W.4    Zhou, L.5    Li, Y.-Q.6
  • 39
    • 33749509564 scopus 로고    scopus 로고
    • Serotonergic modulation of spinal sensory circuits
    • Lopez-Garcia JA (2006) Serotonergic modulation of spinal sensory circuits. Curr Top Med Chem 6:1987-1996.
    • (2006) Curr Top Med Chem , vol.6 , pp. 1987-1996
    • Lopez-Garcia, J.A.1
  • 40
    • 0037114977 scopus 로고    scopus 로고
    • Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes
    • Marinelli S, Vaughan CW, Schnell SA, Wessendorf MW, Christie MJ (2002) Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. J Neurosci 22:10847-10855. (Pubitemid 36005159)
    • (2002) Journal of Neuroscience , vol.22 , Issue.24 , pp. 10847-10855
    • Marinelli, S.1    Vaughan, C.W.2    Schnell, S.A.3    Wessendorf, M.W.4    Christie, M.J.5
  • 41
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • Millan MJ (2002) Descending control of pain. Prog Neurobiol 66:355-474.
    • (2002) Prog Neurobiol , vol.66 , pp. 355-474
    • Millan, M.J.1
  • 42
    • 0030980973 scopus 로고    scopus 로고
    • 8-OH-DPAT-induced spontaneous tail-flicks in the rat are facilitated by the selective serotonin (5-HT)(2C) agonist, RO 60-0175: Blockade of its actions by the novel 5-HT(2C) receptor antagonist SE 206,553
    • DOI 10.1016/S0028-3908(97)00071-3, PII S0028390897000713
    • Millan MJ, Girardon S, Bervoets K (1997) 8-OH-DPAT-induced spontaneous tail-flicks in the rat are facilitated by the selective serotonin (5-HT) 2C agonist, RO 60-0175: blockade of its actions by the novel 5-HT2C receptor antagonist SB 206,553. Neuropharmacology 36:743-745. (Pubitemid 27272120)
    • (1997) Neuropharmacology , vol.36 , Issue.4-5 , pp. 743-745
    • Millan, M.J.1    Girardon, S.2    Bervoets, K.3
  • 43
    • 3242682547 scopus 로고    scopus 로고
    • 3 receptor facilitates at-level mechanical allodynia following spinal cord injury
    • DOI 10.1016/j.pain.2004.03.040, PII S0304395904001824
    • Oatway MA, Chen Y, Weaver LC (2004) The 5-HT3 receptor facilitates mechanical allodynia following spinal cord injury. Pain 110:259-268. (Pubitemid 38953291)
    • (2004) Pain , vol.110 , Issue.1-2 , pp. 259-268
    • Oatway, M.A.1    Chen, Y.2    Weaver, L.C.3
  • 44
    • 0025141063 scopus 로고
    • Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro
    • Pan ZZ, Williams JT, Osborne PB (1990) Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro. J Physiol 427:519-532.
    • (1990) J Physiol , vol.427 , pp. 519-532
    • Pan, Z.Z.1    Williams, J.T.2    Osborne, P.B.3
  • 45
    • 0027251356 scopus 로고
    • Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro
    • DOI 10.1016/0306-4522(93)90263-F
    • Pan ZZ, Wessendorf MW, Williams JT (1993) Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro. Neuroscience 54:421-429. (Pubitemid 23153752)
    • (1993) Neuroscience , vol.54 , Issue.2 , pp. 421-429
    • Pan, Z.Z.1    Wessendorf, M.W.2    Williams, J.T.3
  • 46
    • 0030881279 scopus 로고    scopus 로고
    • Cellular mechanism for antianalgesic action of agonists of the kappa-opioid receptor
    • Pan ZZ, Tershner SA, Fields HL (1997) Cellular mechanism for antianalgesic action of agonists of the kappa-opioid receptor. Nature 389:382-385.
    • (1997) Nature , vol.389 , pp. 382-385
    • Pan, Z.Z.1    Tershner, S.A.2    Fields, H.L.3
  • 49
    • 0035958715 scopus 로고    scopus 로고
    • Response properties of neurons in the rostroventromedial medulla of neuropathic rats: Attempted modulation of responses by [1DMe] NPYF, a neuropeptide FF analogue
    • Pertovaara A, Keski-Vakkuri U, Kalmari J, Wei H, Panula P (2001) Response properties of neurons in the rostroventromedial medulla of neuropathic rats: attempted modulation of responses by [1DMe] NPYF, a neuropeptide FF analogue. Neuroscience 105:457-468.
    • (2001) Neuroscience , vol.105 , pp. 457-468
    • Pertovaara, A.1    Keski-Vakkuri, U.2    Kalmari, J.3    Wei, H.4    Panula, P.5
  • 51
    • 0036603005 scopus 로고    scopus 로고
    • Chronic pain and medullary descending facilitation
    • Porreca F, Ossipov MH, Gebhart GF (2002) Chronic pain and medullary descending facilitation. Trends Neurosci 25:319-325.
    • (2002) Trends Neurosci , vol.25 , pp. 319-325
    • Porreca, F.1    Ossipov, M.H.2    Gebhart, G.F.3
  • 52
    • 0028202756 scopus 로고
    • Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla
    • Potrebic SB, Fields HL, Mason P (1994) Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J Neurosci 14:1655-1665.
    • (1994) J Neurosci , vol.14 , pp. 1655-1665
    • Potrebic, S.B.1    Fields, H.L.2    Mason, P.3
  • 53
    • 33745728124 scopus 로고    scopus 로고
    • Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation
    • Rahman W, Suzuki R, Webber M, Hunt SP, Dickenson AH (2006) Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain 123:264-274.
    • (2006) Pain , vol.123 , pp. 264-274
    • Rahman, W.1    Suzuki, R.2    Webber, M.3    Hunt, S.P.4    Dickenson, A.H.5
  • 54
    • 0036844495 scopus 로고    scopus 로고
    • Descending modulation in persistent pain: An update
    • Ren K, Dubner R (2002) Descending modulation in persistent pain: an update. Pain 100:1-6.
    • (2002) Pain , vol.100 , pp. 1-6
    • Ren, K.1    Dubner, R.2
  • 55
    • 36248929894 scopus 로고    scopus 로고
    • Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: Role of BDNF-TrkB signaling and NMDA receptors
    • Ren K, Dubner R (2007) Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol Neurobiol 35:224-235.
    • (2007) Mol Neurobiol , vol.35 , pp. 224-235
    • Ren, K.1    Dubner, R.2
  • 56
    • 0036899904 scopus 로고    scopus 로고
    • Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    • Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5:1319-1326.
    • (2002) Nat Neurosci , vol.5 , pp. 1319-1326
    • Suzuki, R.1    Morcuende, S.2    Webber, M.3    Hunt, S.P.4    Dickenson, A.H.5
  • 57
    • 7644219835 scopus 로고    scopus 로고
    • Bad news from the brain: Descending 5-HT pathways that control spinal pain processing
    • Suzuki R, Rygh LJ, Dickenson AH (2004) Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 25:613-617.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 613-617
    • Suzuki, R.1    Rygh, L.J.2    Dickenson, A.H.3
  • 58
    • 34248226218 scopus 로고    scopus 로고
    • Descending serotonergic facilitation of spinal ERK activation and pain behavior
    • DOI 10.1016/j.febslet.2006.11.012, PII S0014579306013287
    • Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY (2006) Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS Lett 580:6629-6634. (Pubitemid 44827020)
    • (2006) FEBS Letters , vol.580 , Issue.28-29 , pp. 6629-6634
    • Svensson, C.I.1    Tran, T.K.2    Fitzsimmons, B.3    Yaksh, T.L.4    Hua, X.-Y.5
  • 59
    • 0021267603 scopus 로고
    • Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord
    • Vasko MR, Pang IH, Vogt M (1984) Involvement of 5-hydroxytryptamine- containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord. Brain Res 306:341-348.
    • (1984) Brain Res , vol.306 , pp. 341-348
    • Vasko, M.R.1    Pang, I.H.2    Vogt, M.3
  • 60
    • 0032981834 scopus 로고    scopus 로고
    • Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro
    • Vaughan CW, McGregor IS, Christie MJ (1999) Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. Br J Pharmacol 127:935-940.
    • (1999) Br J Pharmacol , vol.127 , pp. 935-940
    • Vaughan, C.W.1    McGregor, I.S.2    Christie, M.J.3
  • 61
    • 0037414862 scopus 로고    scopus 로고
    • Synthesis of serotonin by a second tryptophan hydroxylase isoform
    • DOI 10.1126/science.1078197
    • Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76. (Pubitemid 36042402)
    • (2003) Science , vol.299 , Issue.5603 , pp. 76
    • Walther, D.J.1    Peter, J.-U.2    Bashammakh, S.3    Hortnagl, H.4    Voits, M.5    Fink, H.6    Bader, M.7
  • 62
    • 0033535124 scopus 로고    scopus 로고
    • Mu- and δ-opioid receptor mRNAS are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla
    • DOI 10.1002/(SICI)1096-9861(19990208)404:2<183::AID-CNE4>3.0.CO;2-N
    • Wang H, Wessendorf MW (1999) Mu- and delta-opioid receptor mRNAs are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla. J Comp Neurol 404:183-196. (Pubitemid 29086544)
    • (1999) Journal of Comparative Neurology , vol.404 , Issue.2 , pp. 183-196
    • Wang, H.1    Wessendorf, M.W.2
  • 63
    • 0033023451 scopus 로고    scopus 로고
    • Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation
    • DOI 10.1016/S0304-3959(98)00212-7, PII S0304395998002127
    • Wei F, Dubner R, Ren K (1999a) Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. Pain 80:127-141. (Pubitemid 29151697)
    • (1999) Pain , vol.80 , Issue.1-2 , pp. 127-141
    • Wei, F.1    Dubner, R.2    Ren, K.3
  • 66
    • 0141856440 scopus 로고    scopus 로고
    • Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: A microelectroporation study in adult rodents
    • Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo M (2003) Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents. J Neurosci 23:8402-8409. (Pubitemid 37129657)
    • (2003) Journal of Neuroscience , vol.23 , Issue.23 , pp. 8402-8409
    • Wei, F.1    Xia, X.-M.2    Tang, J.3    Ao, H.4    Ko, S.5    Liauw, J.6    Qiu, C.-S.7    Zhuo, M.8
  • 67
    • 33751525119 scopus 로고    scopus 로고
    • Kappa opioid receptor (KOR) and GAD67 immunoreactivity are found in off and NEUTRAL cells in the rostral ventromedial medulla
    • Winkler CW, Hermes SM, Chavkin CI, Drake CT, Morrison SF, Aicher SA (2006) Kappa opioid receptor (KOR) and GAD67 immunoreactivity are found in OFF and NEUTRAL cells in the rostral ventromedial medulla. J Neurophysiol 96:3465-3473.
    • (2006) J Neurophysiol , vol.96 , pp. 3465-3473
    • Winkler, C.W.1    Hermes, S.M.2    Chavkin, C.I.3    Drake, C.T.4    Morrison, S.F.5    Aicher, S.A.6
  • 68
    • 0018352151 scopus 로고
    • Spinal serotonin terminal system mediates antinociception
    • Yaksh TL, Wilson PR (1979) Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther 208:446-453.
    • (1979) J Pharmacol Exp Ther , vol.208 , pp. 446-453
    • Yaksh, T.L.1    Wilson, P.R.2
  • 70
    • 77349122058 scopus 로고    scopus 로고
    • Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception
    • Zhang L, Hammond DL (2010) Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception. Pain 149:107-116.
    • (2010) Pain , vol.149 , pp. 107-116
    • Zhang, L.1    Hammond, D.L.2
  • 71
    • 3042722258 scopus 로고    scopus 로고
    • Tryptophan hydroxylase-2 controls brain synthesis
    • DOI 10.1126/science.1097540
    • Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217. (Pubitemid 38886729)
    • (2004) Science , vol.305 , Issue.5681 , pp. 217
    • Zhang, X.1    Beaulieu, J.-M.2    Sotnikova, T.D.3    Gainetdinov, R.R.4    Caron, M.G.5
  • 72
    • 33845423914 scopus 로고    scopus 로고
    • Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity
    • Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW 4th, Johnson RL, Deneris ES, Chen ZF (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci 26:12781-12788.
    • (2006) J Neurosci , vol.26 , pp. 12781-12788
    • Zhao, Z.Q.1    Scott, M.2    Chiechio, S.3    Wang, J.S.4    Renner, K.J.5    Gereau IV, R.W.6    Johnson, R.L.7    Deneris, E.S.8    Chen, Z.F.9
  • 74
    • 0025763631 scopus 로고
    • Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat
    • Zhuo M, Gebhart GF (1991) Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res 550:35-48.
    • (1991) Brain Res , vol.550 , pp. 35-48
    • Zhuo, M.1    Gebhart, G.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.