An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

Molecular Pain

Volumn 1, Issue , 2005, Pages

  Luo, Miaw Chyi ^a   Zhang, Dong Qin ^a   Ma, Shou Wu ^a   Huang, Yuan Yuan ^a   Shuster, Sam J ^b   Porreca, Frank ^a   Lai, Josephine ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b Neuromics   (United States)

Author keywords

Antinociception; Knockdown; Rat; RNA interference; Sensory neurons; Spinal cord

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; I FECT; LIPID; RNA; SMALL INTERFERING RNA; ALEXA FLUOR 546; DELTORPHIN II, ALA(2); DELTORPHIN II, ALA(2)-; DRUG DERIVATIVE; MESSENGER RNA; MU OPIATE RECEPTOR; NALTREXONE; NALTRINDOLE; OLIGOPEPTIDE; QUINOLINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; IN VIVO STUDY; LOW DRUG DOSE; LUMBAR SPINAL CORD; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PAIN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DENSITY; RNA INTERFERENCE; SPINAL GANGLION; THERMAL STIMULATION; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; INTRASPINAL DRUG ADMINISTRATION; LUMBAR VERTEBRA; METABOLISM; NERVE CELL; NOCICEPTIVE RECEPTOR; PAIN ASSESSMENT; PERIPHERAL NERVOUS SYSTEM; POSTERIOR HORN CELL; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; INJECTIONS, SPINAL; LUMBAR VERTEBRAE; NALTREXONE; NEURONS; NOCICEPTORS; OLIGOPEPTIDES; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM; POSTERIOR HORN CELLS; QUINOLINIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; RNA, MESSENGER; RNA, SMALL INTERFERING; SPINAL CORD;

EID: 33645519567     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-1-29     Document Type: Article

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