Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion

Journal of Neurotrauma

Volumn 25, Issue 4, 2008, Pages 334-349

  Iseda, Tsutomu ^a   Okuda, Tetsuhito ^a   Kane Goldsmith, Noriko ^a   Mathew, Marlon ^a   Ahmed, Sameer ^a   Chang, Yu Wen ^a   Young, Wise ^a   Grumet, Martin ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Axonal regeneration; Chondroitin sulfate; Gliosis; Proteoglycans; Secondary damage; Transection

Indexed keywords

CHONDROITIN ABC LYASE; GLYCOSAMINOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CONTUSION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; FEMALE; IMMUNOREACTIVITY; NERVE FIBER GROWTH; NONHUMAN; PROTEIN EXPRESSION; PYRAMIDAL TRACT; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY;

ANIMALS; AXONS; CHONDROITIN ABC LYASE; CHONDROITIN SULFATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, SPINAL; NERVE REGENERATION; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TIME FACTORS;

EID: 41449105151     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2007.0289     Document Type: Article

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