hChAT: A tool for the chemoenzymatic generation of potential acetyl/Butyrylcholinesterase inhibitors

ChemBioChem

Volumn 10, Issue 13, 2009, Pages 2191-2194

  Green, Keith D ^a   Fridman, Micha ^b   Garneau Tsodikova, Sylvie ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Acylation; Alzheimer's disease; Coenzyme A cosubstrates; Enzyme promiscuity; Inhibitors

Indexed keywords

ACETYLCHOLINE; CHOLINE; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE INHIBITOR; COENZYME A; DONEPEZIL; ECOTHIOPATE; EDROPHONIUM; GALANTAMINE; HEMICHOLINIUM 3; NEOSTIGMINE; PYRIDOSTIGMINE; RIVASTIGMINE; SERINE;

ACETYLATION; ADRENERGIC SYSTEM; ALZHEIMER DISEASE; ARTICLE; BIOSYNTHESIS; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; BUTYRYLCHOLINESTERASE; CHOLINE O-ACETYLTRANSFERASE; CHOLINESTERASE INHIBITORS; COENZYME A; HUMANS; KINETICS; RECOMBINANT PROTEINS;

EID: 70349405978     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900309     Document Type: Article

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