Redesign of cosubstrate specificity and identification of important residues for substrate binding to hChAT

Biochemistry

Volumn 49, Issue 29, 2010, Pages 6219-6227

  Green, Keith D ^b   Porter, Vanessa R ^a,b   Zhang, Yaru ^b,c   Garneau Tsodikova, Sylvie ^a,b,c  

^a Department of Medicinal Chemistry ^*  (United States)

^b Life Sciences Institute   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL TRANSFERASE; ACETYL-COA; ACTIVE SITE; ACYL-COA; ACYLTRANSFERASES; CARNITINE; CO-SUBSTRATE; PALMITOYLTRANSFERASE; REVERSIBLE FORMATION; SUBSTRATE BINDING; WILD TYPES;

ENZYMES;

SUBSTRATES;

ACYL COENZYME A; CARNITINE; CHOLINE ACETYLTRANSFERASE; CHOLINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CATALYSIS; CHOLINE; CHOLINE O-ACETYLTRANSFERASE; HUMANS; MOLECULAR SEQUENCE DATA; SUBSTRATE SPECIFICITY;

EUKARYOTA;

EID: 77954832316     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1007996     Document Type: Article

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