In situ phosphorylation of Akt and ERK1/2 in rat mammary gland, colon, and liver following treatment with human insulin and IGF-1

Toxicologic Pathology

Volumn 39, Issue 4, 2011, Pages 623-640

  Hvid, Henning ^a,b   Fels, Johannes J ^b   Kirk, Rikke K ^b   Thorup, Inger ^b   Jensen, Henrik E ^a   Hansen, Bo F ^b   Oleksiewicz, Martin B ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c Arsanis Inc   (Austria)

Author keywords

IGF 1; insulin; phosphorylated Akt; phosphorylated ERK1 2; rat mammary gland

Indexed keywords

INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RECOMBINANT HUMAN INSULIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; COLON; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; ENZYME REGULATION; EPITHELIUM BASAL CELL; ESTRUS CYCLE; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; MAMMARY GLAND; MAXIMUM PLASMA CONCENTRATION; MITOGENESIS; MITOSIS; MYOEPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SINGLE DRUG DOSE; STAINING; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BREAST; COLON; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIVER; MAMMARY GLANDS, ANIMAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

RATTUS;

EID: 79959523300     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311406936     Document Type: Article

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