Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling

Molecular and Cellular Biochemistry

Volumn 182, Issue 1-2, 1998, Pages 73-78

  Liu, Feng ^a   Roth, Richard A ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin receptor; SH2 domains; Tyrosine phosphorylation

Indexed keywords

GRB PROTEIN; INSULIN; INSULIN RECEPTOR; PLECKSTRIN; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; PROTEIN BINDING; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0031896438     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006899832614     Document Type: Review

References (43)

1. White MF, Kahn CR: The insulin signalling system. J Biol Chem 269(1): 1-4, 1994
2. Cheatham B, Kahn CR: Insulin action and the insulin signalling network. Endocrine Rev 16: 117-142, 1995
3. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu B, Calas B, Grigorescu F, Nishiyama M, Waterfield M, Kasuga M: Involvement of phosphoinositide 3-kinase in insulin- or IGF-I-induced membrane raffling. EMBO J 13: 2313-2321, 1994
4. Burgering BMT, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3OH kinase signal transduction. Nature 376: 599-602, 1995
5. Franke TF, Yang SI, Chan TO, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736, 1995
6. Kohn AD, Kovacina KS, Roth RA: Insulin stimulates the kinase activity of RACPK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14: 4288-4295, 1995
7. Kaliman P, Vinals F, Testar X, Palacin M, Zorzano A: Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J Biol Chem 271: 19146-19151, 1996
8. Evans J, Honer C, Womelsdorf B, Kaplan E, Bell P: The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA synthesis. Cell Sig 7: 365-376, 1995
9. Hara K, Yonezawa K, Sakaue H, Ando A, Kotani K, Kitamura Y, Ueda H, Stephens L, Jackson T, Hawkins P, Dhand R, Clark A, Holman G, Waterfield M, Kasuga M: 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci USA (91): 7415-7419, 1994
10. Martin S, Haruta T, Morris A, Klippel A, Williams L, Olefsky J: Activated phosphatidylinositol 3-kinase is sufficient to mediate acting rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem 271: 17605-17608, 1996
11. Skolnik EY, Lee C-H, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ Jr, Backer JM, Ullrich A, White MF, Schlessinger J: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated 1RS 1 and She: Implications for insulin control of ras signalling. EMBO J 12(5): 1929-1936, 1993
12. Skolnik E, Batzer A, Li N, Lee C, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J: The function of GRB2 in linking the insulin receptor to Ras signalling pathways. Science 260: 1953-1955, 1993
13. Yonezawa K, Ando A, Kaburagi Y, R. Y-H, Kitamura T, Hara K, Nakafuku M, Okabayashi Y, Kadowaki T, Kaziro Y, Kasuga M: Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors. J Biol Chem 269(6): 4634-4640, 1994
14. Kovacina KS, Roth RA: Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein. Biochem Biophys Res Comm 192: 1303-1311, 1993
15. Chang P, Le Marchand-Brastel Y, Cheathan L, Moller D: Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant n-iice. Implications for the regulation of glycogen synthase. J Biol Chem 270: 29928-29935, 1995
16. Denton R, Tavare J: Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. Eur J Biochem 227: 597-611, 1995
17. Sale E, Atkinson P, Sale G: Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J 14: 674-684, 1995
18. Zhang B, Berger J, Zhou G, Elbrecht A, Biswas S, White-Carrington S, Szalkowski D, Moller D: Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptory. J Biol Chem 271: 31771-31774, 1996
19. Patti M, Sun X, Bruening J, Araki E, Lipes M, White M, Kahn C: 4PS/ insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS- 1-deficient mice. J Biol Chem 270: 24670-24673, 1995
20. Sun X-J, Wang L-M, Zhang Y, Yenush L, Myers M, Glasheen E, Lane W, Pierce J, White M: Role of IRS-2 in insulin and cytokine signalling. Nature 377: 173-177, 1995
21. Tobe K, Tamemoto H, Yamauchi T, Aizawa S, Yazaki Y, Kadowaki T: Identification of a 190 kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J Biol Chem 270: 5698-5701, 1995
22. Myers MJ, Sun XJ, White MF: The IRS-1 signalling system. Trends Biochem Sci 19(7): 289-293, 1994
23. Liu F, Roth RA: Grb-IR: A SH2-domain-containing protein that binds to and inhibits insulin receptor function. Proc Natl Acad Sci USA 92: 1995
24. Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci USA 89: 8894-8898, 1992
25. Ooi J, Yajnik V, Immanuel D, Gordon M, Moskow JJ, Buchberg AM, Margolis B: The cloning of Grb 10 reveals a new family of SH2 domain proteins. Oncogene 10: 1610-1630, 1995
26. Daly R, Sanderson G, Janes P, Sutherland R: Cloning and characterization of Grb 14, a novel member of the Grb7 gene family. J Biol Chem 271: 12502-12510, 1996
27. Gagel R: Putting the bits and pieces of the RET proto-oncogene puzzle together. Bone 17: 13S-16S, 1995
28. Takahashi S, Uchida K, Nakagawa A, Miyake Y, Kainosho M, Matsuzaki K, Omura S: Biosynthesis of lactacystin. Jour Antibio 48: 1015-1020, 1995
29. O'Neill T, Rose T, Pillay T, Hotta K, Olefsky J, Gustafson T: Interaction of a GRB-IR splice variant (a human GRB 10 homolog) with the insulin and insulin-like growth factor 1 receptors. Evidence for a role in mitogenic signalling. J Biol Chem 271: 22506-22513, 1996
30. 29a. Frantz J, Giorgetti-Peraldi S, Ottinger E, Shoelson S: Human GRB-IRbeta/ GRB 10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem 272: 2659-2667, 1997
31. Margolis B: The GRB family of SH2 domain proteins. Prog Biophys Mol Biol 62: 223-244, 1994
32. Choi KY, Satterberg B, Lyons DM, Elion EA: Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78: 499-512, 1994
33. Marcus S, Polverino A, Barr M, Wigler M: Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc Natl Acad Sci USA 91: 7762-7766, 1994
34. Klauck T, Faux M, Labudda K, Langeberg L, Jaken S, Scott J: Coordination of three signalling enzymes by AKAP79, a mammalian scaffold protein. Science 271: 1589-1592, 1996
35. Faux M, Scott J: Molecular glue: Kinase anchoring and scaffold proteins. Cell 85: 9-12, 1996
36. Yokote K, Margolis B, Heldin C-H, Claesson-Welsh L: Grb7 is a downstream signalling component of platelet-derived growth factor α- and β-receptors. J Biol Chem 271: 30942-30949, 1996
37. Stein D, Wu J, Fuqua SAW, Roonprapunt C, Yajnik V, d' Eustachio P, Moskow JJ, Buchberg AM, Osborne CK, Margolis B: The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J 13: 1331-1340, 1994
38. Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith R, Riedel H: Interaction between the Grb 10 SH2 domain and the insulin receptor carboxyl terminus. J Biol Chem 271: 8882-8886, 1996
39. Pandey A, Liu X, Dixon J, Di Fiore P, Dixit V: Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adaptor protein GA7. J Biol Chem 271: 10607-10610, 1996
40. Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW: Evidence for the direct interaction of the insulin-like growth factor 1 receptor with IRS-l, Shc, and Grb10. Mol Endocrin 10: 631-641, 1996
41. Morrione A, Valentinis B, Li S, Ooi J, Margolis B, Baserga R: Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res 56: 3165-3167, 1996
42. Stein E, Cerretti D, Daniel T: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J Biol Chem 271: 23588-23593, 1996
43. Pandey A, Duan H, Di Fiore P, Dixit V: The Ret receptor protein tyrosine kinase associates with the SH2-containing adaptor protein Grb10. J Biol Chem 270: 21461-21463, 1995