Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor

Diabetologia

Volumn 40, Issue SUPPL. 2, 1997, Pages

  Slieker, L J ^a   Brooke, G S ^a   Dimarchi, R D ^a   Flora, D B ^a   Green, L K ^a   Hoffmann, J A ^a   Long, H B ^a   Fan, L ^a   Shields, J E ^a   Sundell, K L ^a   Surface, P L ^a   Chance, R E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Insulin; Insulin analogues; Insulin receptor; Insulin like growth factor I receptor; Mammary epithelial cells; Proliferation

Indexed keywords

INSULIN RECEPTOR;

AMINO ACID SEQUENCE; CELL PROLIFERATION; CONFERENCE PAPER; DIABETES MELLITUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FEMALE; HUMANS; INSULIN; MAMMARY GLANDS, ANIMAL; MOLECULAR SEQUENCE DATA; OSMOLAR CONCENTRATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN;

EID: 8544226918     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051402     Document Type: Conference Paper

References (44)

1. Berger M, Cüppers HJ, Hegner H, Jörgens H, Berchtold P (1982) Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 5: 77-91
2. Brange J, Owens DR, Kang S, Vølund A (1990) Monomeric insulins and their experimental and clinical implications. Diabetes Care 13: 923-954
3. Mosekilde E, Jensen KS, Binder C, Pramming S, Thorsteinsson B (1989) Modeling absorption kinetics of subcutaneous injected soluble insulin. J Pharmacokinet Biopharm 17: 67-87
4. Binder C (1983) A theoretical model for the absorption of soluble insulin. In: Brunetti P, Alberti KGMM, Albisser AM, Hepp KD, Massi Bendetti M (eds) Artificial systems for insulin delivery. Raven Press, New York, pp 53-57
5. DiMarchi RD, Mayer JP, Fan L et al. (1992) Synthesis of a fast-acting insulin based on structural homology with insulin-like growth factor I. In: Smith JA, Rivier JE (eds) Peptides: chemistry and biology. Proceedings of the Twelfth American Peptide Symposium. ESCOM, Leiden, pp 26-28
6. Heinemann L, Heise T, Jorgensen LN, Starke AAR (1993) Aclion profile of the rapid acting insulin analogue: human insulin B28 Asp. Diabet Med 10: 535-539
7. Heinemann L, Starke AAR, Heding L, Jensen I, Berger M (1990) Action profiles of fast onset insulin analogues. Diabetologia 33: 384-386
8. Pullen RA, Lindsay DG, Wood SP et al. (1976) Receptor-binding region of insulin. Nature 259: 369-373
9. Gammeltoft S (1984) Insulin receptors: binding kinetics and structure-function relationship of insulin. Physiol Rev 64: 1321-1378
10. Taylor R, Hetherington CS, Tolley S (1989) Receptor-binding and biological potency of despentapeptide insulin. Horm Metabol Res 21: 249-252
11. Gliemann J, Gammeltoft S (1974) The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells. Diabetologia 10: 105-113
12. Nakagawa SH, Tager HS (1987) Role of the COOH-terminal B-chain domain in insulin-receptor interactions. Identification of perturbations involving the insulin main chain. J Biol Chem 262: 12054-12058
13. Bi RC, Dauter Z, Dodson E, Dodson G, Giordano F, Reynolds C (1984) Insulin's structure as a modified and monomeric molecule. Biopolymers 23: 391-395
14. Baker EN, Blundell TL, Cutfield JF et al. (1988) The structure of 2Zn pig insulin crystals at 1.5 Å resolution. Phil Trans R Soc Lond. B. Biological Sciences 319: 369-456
15. Oh Y, Müller HL, Neely EK, Lamson G, Rosenfeld RG (1993) New concepts in insulin-like growth factor receptor physiology. Growth Regulation 3: 113-123
16. Chen ZZ, Schwartz GP, Zong L, Burke GT, Chanley JD, Katsoyannis PG (1988) Determinants of growth-promoting activity reside in the A-domain of insulin-like growth factor I. Biochemistry 27: 6105-6111
17. Cascieri MA, Chicchi GG, Appelbaum J, Green BG, Hayes NS, Bayne ML (1989) Structural analogs of human insulin-like growth factor (IGF) I with altered affinity for type 2 IGF receptors. J Biol Chem 264: 2199-2202
18. Bayne ML, Appelbaum J, Underwood D, Chicchi GG, Green BG, Hayes NS, Cascieri MA (1989) The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor. J Biol Chem 264: 11004-11008
19. Cara JF, Mirmira RG, Nakagawa SH, Tager HS (1990) An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the type I insulin-like growth factor and insulin receptors of placental plasma membranes. J Biol Chem 265: 17820-17825
20. Kubiak T, Cowburn D (1986) Enzymatic semisynthesis of porcine despentapeptide (B26-30) insulin using unprotected desoctapeptide (B23-30) insulin as a substrate. Int J Peptide Protein Res 27: 514-521
21. Long HB, Baker JC, Belagaje RM et al. (1992) Human insulin analogs with rapid onset and short duration of action. In: Smith JA, Rivier JA (eds) Peptides: chemistry and biology. Proceedings of the Twelfth American Peptide Symposium. ESCOM, Leiden, pp 88-90
22. Chance RE, Hoffmann JA, Kroeff EP et al. (1981) The production of human insulin using recombinant DNA technology and a new chain combination procedure. In: Rich DH, Gross E (eds) Peptides: synthesis-structure-function. Proceedings of the Seventh American Peptide Symposium. Pierce Chemical Company, Rockford, IL, pp 721-728
23. Frank BH, Beckage MJ, Willey KA (1983) High-performance liquid chromatographic preparation of single-site carrier-free pancreatic polypeptide hormone radiotracers. J Chromatography 266: 239-248
24. Gruppuso PA, Frank BH, Schwartz R (1988) Binding of proinsulin and proinsulin conversion intermediates to human placental insulin-like growth factor-I receptors. J Clin Endocrinol Metab 67: 194-197
25. Drejer K, Kruse V, Larsen UD, Hougaard P, Bjørn S, Gammeltoft S (1991) Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells. Diabetes 40: 1488-1495
26. Zeuzem S, Stahl E, Jungmann E, Zoltobrocki M, Schöffling K, Caspary WF (1990) In vitro activity of biosynthetic human diarginylinsulin. Diabetologia 33: 65-71
27. Schwartz GP, Burke GT, Katsoyannis PG (1987) A superactive insulin: [B10-aspartic acid]insulin(human). Proc Natl Acad Sci USA 84: 6408-6411
28. Munson PJ, Rodbard D (1980) LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107: 220-239
29. Jonas HA, Newman JD, Harrison LC (1986) An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proc Natl Acad Sci USA 83: 4124-4128
30. Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y (1993) Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification. Biochemistry 32: 13531-13536
31. De Meyts P, Christoffersen CT, Ursø B et al. (1993) Insulin potency as a mitogen is determined by the half-life of the insulin-receptor complex. Exp Clin Endocrinol 101: 22-23
32. Hansen BF, Danielsen GM, Drejer K et al. (1996) Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency. Biochem J 315: 271-279
33. 2]insulin (human). Proc Natl Acad Sci USA 86: 458-461
34. Zhang W, Gustafson TA, Rutter WJ, Johnson JD (1994) Positively charged side chains in the insulin-like growth factor-1 C-and D-regions determine receptor binding specificity. J Biol Chem 269: 10609-10613
35. Gustafson TA, Rutter WJ (1990) The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras. J Biol Chem 265: 18663-18667
36. Yip CC, Hsu H, Patel RG, Hawley DM, Maddux BA, Goldfine ID (1988) Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor a-subunit. Biochem Biophys Res Commun 157: 321-329
37. Schumacher R, Mosthaf L, Schlessinger J, Brandenburg D, Ullrich A (1991) Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. J Biol Chem 266: 19288-19295
38. Kjeldsen T, Andersen AS, Wiberg FC et al. (1991) The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc Natl Acad Sci USA 88: 4404-4408
39. Gammeltoft S, Drejer K (1991) Increased mitogenic potency of high affinity insulin analogues in mouse NIH 3T3 fibroblasts. J Cell Biochem [Suppl 15B]:54 (Abstract)
40. Bornfeldt KE, Gidlöf RA, Wasteson A, Lake M, Skottner A, Arnqvist HJ (1991) Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities. Diabetologia 34: 307-313
41. Drejer K (1992) The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab Rev 8: 259-286
42. Jørgensen LN, Dideriksen LH (1993) Preclinical studies of rapid-acting insulin analogues. In: Berger M, Gries FA (eds) Frontiers in insulin pharmacology. Thieme, Stuttgart New York, pp 110-117
43. Seipke G, Berchtold H, Geisen K, Hilgenfeld R, Rosskamp R (1995) A new insulin with prolonged action. Eur J Endocrinol 132 [Supp 1]:25 (Abstract)
44. Zimmerman J (1994) A 12-month chronic toxicity study of LY275585 (human insulin analog) administered subcutaneously to Fischer 344 rats. Diabetes 43[Suppl 1]:166A (Abstract)