A chromone analog inhibits TNF-α induced expression of cell adhesion molecules on human endothelial cells via blocking NF-κB activation

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2952-2962

  Kumar, Sarvesh ^a   Singh, Brajendra K ^b,c   Pandey, Anil K ^b   Kumar, Ajit ^d   Sharma, Sunil K ^b   Raj, Hanumantharao G ^d   Prasad, Ashok K ^b   Eycken, Erik Van der ^c   Parmar, Virinder S ^b   Ghosh, Balaram ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF DELHI   (India)

Author keywords

CAMs; Chromones; Endothelial cells; ICAM 1; NF B; TNF

Indexed keywords

ALCOHOL; ALLYL 3 (4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; ALLYL 3 (7 HYDROXY 4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; CELL ADHESION MOLECULE; CHROMONE DERIVATIVE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ETHYL 3 (4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; ETHYL 3 (7 HYDROXY 4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; ISOPROPYL 3 (4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; ISOPROPYL 3 (7 HYDROXY 4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; PROPYL 3 (4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; PROPYL 3 (7 HYDROXY 4 OXO 4H 1 BENZOPYRAN 3 YL)ACRYLATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CATALYSIS; DRUG INHIBITION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIPID PEROXIDATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BIOTRANSFORMATION; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; DRUG DESIGN; E-SELECTIN; ENDOTHELIAL CELLS; FLOW CYTOMETRY; HUMANS; INDICATORS AND REAGENTS; INTERCELLULAR ADHESION MOLECULE-1; LIPID PEROXIDATION; MICROSOMES, LIVER; NADP; NEUTROPHILS; NF-KAPPA B; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR RELA; TUBULIN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

RATTUS;

EID: 33947145669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.004     Document Type: Article

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