메뉴 건너뛰기




Volumn 110, Issue , 2011, Pages 107-139

TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade

Author keywords

Epidemiology; Missense; Mutation; Reassessment; Sequencing; Synonymous

Indexed keywords

PROTEIN P53;

EID: 79959428081     PISSN: 0065230X     EISSN: 0065230X     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386469-7.00005-0     Document Type: Chapter
Times cited : (62)

References (116)
  • 1
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • Aas T., Borresen A.L., Geisler S., Smith-Sorensen B., Johnsen H., Varhaug J.E., et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat. Med. 1996, 2:811-814.
    • (1996) Nat. Med. , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.L.2    Geisler, S.3    Smith-Sorensen, B.4    Johnsen, H.5    Varhaug, J.E.6
  • 3
    • 0027749169 scopus 로고
    • A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein
    • Bargonetti J., Manfredi J.J., Chen X., Marshak D.R., Prives C. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev. 1993, 7:2565-2574.
    • (1993) Genes Dev. , vol.7 , pp. 2565-2574
    • Bargonetti, J.1    Manfredi, J.J.2    Chen, X.3    Marshak, D.R.4    Prives, C.5
  • 4
    • 64049118136 scopus 로고    scopus 로고
    • From cancer genomes to cancer models: Bridging the gaps
    • Baudot A., Real F.X., Izarzugaza J.M., Valencia A. From cancer genomes to cancer models: Bridging the gaps. EMBO Rep. 2009, 10:359-366.
    • (2009) EMBO Rep. , vol.10 , pp. 359-366
    • Baudot, A.1    Real, F.X.2    Izarzugaza, J.M.3    Valencia, A.4
  • 5
    • 10744230945 scopus 로고    scopus 로고
    • P53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D., Gasco M., Hiller L., Sullivan A., Syed N., Trigiante G., et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003, 3:387-402.
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1    Gasco, M.2    Hiller, L.3    Sullivan, A.4    Syed, N.5    Trigiante, G.6
  • 6
    • 45349097133 scopus 로고    scopus 로고
    • Analysis of p53 mutation status in human cancer cell lines: A paradigm for cell line cross-contamination
    • Berglind H., Pawitan Y., Kato S., Ishioka C., Soussi T. Analysis of p53 mutation status in human cancer cell lines: A paradigm for cell line cross-contamination. Cancer Biol. Ther. 2008, 7:699-708.
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 699-708
    • Berglind, H.1    Pawitan, Y.2    Kato, S.3    Ishioka, C.4    Soussi, T.5
  • 7
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • Blandino G., Levine A.J., Oren M. Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 1999, 18:477-485.
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 8
    • 0032055501 scopus 로고    scopus 로고
    • Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
    • Brachmann R.K., Yu K., Eby Y., Pavletich N.P., Boeke J.D. Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations. EMBO J. 1998, 17:1847-1859.
    • (1998) EMBO J. , vol.17 , pp. 1847-1859
    • Brachmann, R.K.1    Yu, K.2    Eby, Y.3    Pavletich, N.P.4    Boeke, J.D.5
  • 11
    • 77955354374 scopus 로고    scopus 로고
    • In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
    • Broz D.K., Attardi L.D. In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 2010, 31:1311-1318.
    • (2010) Carcinogenesis , vol.31 , pp. 1311-1318
    • Broz, D.K.1    Attardi, L.D.2
  • 13
    • 42049091225 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • author reply, 1636
    • Campbell I.G., Qiu W., Polyak K., Haviv I. Breast-cancer stromal cells with TP53 mutations. N. Engl. J. Med. 2008, 358:1634-1635. author reply, 1636.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1634-1635
    • Campbell, I.G.1    Qiu, W.2    Polyak, K.3    Haviv, I.4
  • 14
    • 33646756222 scopus 로고    scopus 로고
    • Dissecting p53-dependent apoptosis
    • Chipuk J.E., Green D.R. Dissecting p53-dependent apoptosis. Cell Death Differ. 2006, 13:994-1002.
    • (2006) Cell Death Differ. , vol.13 , pp. 994-1002
    • Chipuk, J.E.1    Green, D.R.2
  • 15
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 1994, 265:346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 16
    • 0036107052 scopus 로고    scopus 로고
    • Time for a unified system of mutation description and reporting: A review of locus-specific mutation databases
    • Claustres M., Horaitis O., Vanevski M., Cotton R.G. Time for a unified system of mutation description and reporting: A review of locus-specific mutation databases. Genome Res. 2002, 12:680-688.
    • (2002) Genome Res. , vol.12 , pp. 680-688
    • Claustres, M.1    Horaitis, O.2    Vanevski, M.3    Cotton, R.G.4
  • 17
    • 0028939079 scopus 로고
    • Interhelical angles in the solution structure of the oligomerization domain of p53: Correction
    • Clore G.M., Omichinski J.G., Sakaguchi K., Zambrano N., Sakamoto H., Appella E., et al. Interhelical angles in the solution structure of the oligomerization domain of p53: Correction. Science 1995, 267:1515-1516.
    • (1995) Science , vol.267 , pp. 1515-1516
    • Clore, G.M.1    Omichinski, J.G.2    Sakaguchi, K.3    Zambrano, N.4    Sakamoto, H.5    Appella, E.6
  • 18
    • 77952238224 scopus 로고    scopus 로고
    • P53-family proteins and their regulators: Hubs and spokes in tumor suppression
    • Collavin L., Lunardi A., Del Sal G. p53-family proteins and their regulators: Hubs and spokes in tumor suppression. Cell Death Differ. 2010, 17:901-911.
    • (2010) Cell Death Differ. , vol.17 , pp. 901-911
    • Collavin, L.1    Lunardi, A.2    Del Sal, G.3
  • 19
    • 0029806936 scopus 로고    scopus 로고
    • Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
    • Denissenko M.F., Pao A., Tang M., Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 1996, 274:430-432.
    • (1996) Science , vol.274 , pp. 430-432
    • Denissenko, M.F.1    Pao, A.2    Tang, M.3    Pfeifer, G.P.4
  • 20
    • 0032951530 scopus 로고    scopus 로고
    • P73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como C.J., Gaiddon C., Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol. Cell. Biol. 1999, 19:1438-1449.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1438-1449
    • Di Como, C.J.1    Gaiddon, C.2    Prives, C.3
  • 21
    • 0036143771 scopus 로고    scopus 로고
    • A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
    • DiGiammarino E.L., Lee A.S., Cadwell C., Zhang W., Bothner B., Ribeiro R.C., et al. A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer. Nat. Struct. Biol. 2002, 9:12-16.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 12-16
    • DiGiammarino, E.L.1    Lee, A.S.2    Cadwell, C.3    Zhang, W.4    Bothner, B.5    Ribeiro, R.C.6
  • 23
    • 70350567735 scopus 로고    scopus 로고
    • 20years studying p53 functions in genetically engineered mice
    • Donehower L.A., Lozano G. 20years studying p53 functions in genetically engineered mice. Nat. Rev. Cancer 2009, 9:831-841.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 831-841
    • Donehower, L.A.1    Lozano, G.2
  • 24
    • 33748170994 scopus 로고    scopus 로고
    • Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences
    • Feldmeyer N., Schmeiser H.H., Muehlbauer K.R., Belharazem D., Knyazev Y., Nedelko T., et al. Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences. Mutat. Res. 2006, 608:163-168.
    • (2006) Mutat. Res. , vol.608 , pp. 163-168
    • Feldmeyer, N.1    Schmeiser, H.H.2    Muehlbauer, K.R.3    Belharazem, D.4    Knyazev, Y.5    Nedelko, T.6
  • 25
    • 17444390129 scopus 로고    scopus 로고
    • Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
    • Flores E.R., Sengupta S., Miller J.B., Newman J.J., Bronson R., Crowley D., et al. Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 2005, 7:363-373.
    • (2005) Cancer Cell , vol.7 , pp. 363-373
    • Flores, E.R.1    Sengupta, S.2    Miller, J.B.3    Newman, J.J.4    Bronson, R.5    Crowley, D.6
  • 26
    • 75549087826 scopus 로고    scopus 로고
    • COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer
    • Forbes S.A., Tang G., Bindal N., Bamford S., Dawson E., Cole C., et al. COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer. Nucleic Acids Res. 2010, 38:D652-D657.
    • (2010) Nucleic Acids Res. , vol.38
    • Forbes, S.A.1    Tang, G.2    Bindal, N.3    Bamford, S.4    Dawson, E.5    Cole, C.6
  • 27
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander P., Haupt Y., Prives C., Oren M. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell. Biol. 1996, 16:4961-4971.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 28
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
    • Gannon J.V., Greaves R., Iggo R., Lane D.P. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J. 1990, 9:1595-1602.
    • (1990) EMBO J. , vol.9 , pp. 1595-1602
    • Gannon, J.V.1    Greaves, R.2    Iggo, R.3    Lane, D.P.4
  • 29
    • 0028879677 scopus 로고
    • P53 point mutation and survival in colorectal cancer patients
    • Goh H.S., Yao J., Smith D.R. p53 point mutation and survival in colorectal cancer patients. Cancer Res. 1995, 55:5217-5221.
    • (1995) Cancer Res. , vol.55 , pp. 5217-5221
    • Goh, H.S.1    Yao, J.2    Smith, D.R.3
  • 30
    • 0030575866 scopus 로고    scopus 로고
    • Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
    • Gorina S., Pavletich N.P. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science 1996, 274:1001-1005.
    • (1996) Science , vol.274 , pp. 1001-1005
    • Gorina, S.1    Pavletich, N.P.2
  • 31
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994, 54:4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 34
    • 33947188719 scopus 로고    scopus 로고
    • Cancer: Drivers and passengers
    • Haber D.A., Settleman J. Cancer: Drivers and passengers. Nature 2007, 446:145-146.
    • (2007) Nature , vol.446 , pp. 145-146
    • Haber, D.A.1    Settleman, J.2
  • 35
    • 0025085667 scopus 로고
    • Different tumor-derived p53 mutants exhibit distinct biological activities
    • Halevy O., Michalovitz D., Oren M. Different tumor-derived p53 mutants exhibit distinct biological activities. Science 1990, 250:113-116.
    • (1990) Science , vol.250 , pp. 113-116
    • Halevy, O.1    Michalovitz, D.2    Oren, M.3
  • 37
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris S.L., Levine A.J. The p53 pathway: Positive and negative feedback loops. Oncogene 2005, 24:2899-2908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 38
    • 0028842340 scopus 로고
    • A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice
    • Harvey M., Vogel H., Morris D., Bradley A., Bernstein A., Donehower L.A. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat. Genet. 1995, 9:305-311.
    • (1995) Nat. Genet. , vol.9 , pp. 305-311
    • Harvey, M.1    Vogel, H.2    Morris, D.3    Bradley, A.4    Bernstein, A.5    Donehower, L.A.6
  • 39
    • 2442473751 scopus 로고    scopus 로고
    • P53: At the crossroads of molecular carcinogenesis and molecular epidemiology
    • Hofseth L.J., Robles A.I., Yang Q., Wang X.W., Hussain S.P., Harris C. p53: At the crossroads of molecular carcinogenesis and molecular epidemiology. Chest 2004, 125:83S-85S.
    • (2004) Chest , vol.125
    • Hofseth, L.J.1    Robles, A.I.2    Yang, Q.3    Wang, X.W.4    Hussain, S.P.5    Harris, C.6
  • 41
    • 0037209115 scopus 로고    scopus 로고
    • Splice mutations in the p53 gene: Case report and review of the literature
    • Holmila R., Fouquet C., Cadranel J., Zalcman G., Soussi T. Splice mutations in the p53 gene: Case report and review of the literature. Hum. Mutat. 2003, 21:101-102.
    • (2003) Hum. Mutat. , vol.21 , pp. 101-102
    • Holmila, R.1    Fouquet, C.2    Cadranel, J.3    Zalcman, G.4    Soussi, T.5
  • 42
    • 2342507856 scopus 로고    scopus 로고
    • The challenge of documenting mutation across the genome: The human genome variation society approach
    • Horaitis O., Cotton R.G. The challenge of documenting mutation across the genome: The human genome variation society approach. Hum. Mutat. 2004, 23:447-452.
    • (2004) Hum. Mutat. , vol.23 , pp. 447-452
    • Horaitis, O.1    Cotton, R.G.2
  • 43
    • 0000707647 scopus 로고    scopus 로고
    • Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases
    • Hussain S.P., Raja K., Amstad P.A., Sawyer M., Trudel L.J., Wogan G.N., et al. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:12770-12775.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 12770-12775
    • Hussain, S.P.1    Raja, K.2    Amstad, P.A.3    Sawyer, M.4    Trudel, L.J.5    Wogan, G.N.6
  • 46
    • 47649096991 scopus 로고    scopus 로고
    • Structural biology of the tumor suppressor p53
    • Joerger A.C., Fersht A.R. Structural biology of the tumor suppressor p53. Annu. Rev. Biochem. 2008, 77:557-582.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 557-582
    • Joerger, A.C.1    Fersht, A.R.2
  • 47
    • 70350565471 scopus 로고    scopus 로고
    • P53-A Jack of all trades but master of none
    • Junttila M.R., Evan G.I. p53-A Jack of all trades but master of none. Nat. Rev. Cancer 2009, 9:821-829.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 821-829
    • Junttila, M.R.1    Evan, G.I.2
  • 48
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • Kan Z., Jaiswal B.S., Stinson J., Janakiraman V., Bhatt D., Stern H.M., et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010, 466:869-873.
    • (2010) Nature , vol.466 , pp. 869-873
    • Kan, Z.1    Jaiswal, B.S.2    Stinson, J.3    Janakiraman, V.4    Bhatt, D.5    Stern, H.M.6
  • 49
    • 0037816165 scopus 로고    scopus 로고
    • Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
    • Kato S., Han S.Y., Liu W., Otsuka K., Shibata H., Kanamaru R., et al. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:8424-8429.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 8424-8429
    • Kato, S.1    Han, S.Y.2    Liu, W.3    Otsuka, K.4    Shibata, H.5    Kanamaru, R.6
  • 52
    • 69349098834 scopus 로고    scopus 로고
    • Stem cells: The promises and perils of p53
    • Krizhanovsky V., Lowe S.W. Stem cells: The promises and perils of p53. Nature 2009, 460:1085-1086.
    • (2009) Nature , vol.460 , pp. 1085-1086
    • Krizhanovsky, V.1    Lowe, S.W.2
  • 53
  • 54
    • 13644260907 scopus 로고    scopus 로고
    • Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    • Lang G.A., Iwakuma T., Suh Y.A., Liu G., Rao V.A., Parant J.M., et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004, 119:861-872.
    • (2004) Cell , vol.119 , pp. 861-872
    • Lang, G.A.1    Iwakuma, T.2    Suh, Y.A.3    Liu, G.4    Rao, V.A.5    Parant, J.M.6
  • 55
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu J.I., Dumont P., Hafey M., Murphy M.E., George D.L. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 2004, 6:443-450.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 56
    • 70349442548 scopus 로고    scopus 로고
    • The first 30years of p53: Growing ever more complex
    • Levine A.J., Oren M. The first 30years of p53: Growing ever more complex. Nat. Rev. Cancer 2009, 9:749-758.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 57
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin J., Chen J., Elenbaas B., Levine A.J. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 1994, 8:1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 58
    • 16844384191 scopus 로고    scopus 로고
    • P53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors
    • Liu Z., Muehlbauer K.R., Schmeiser H.H., Hergenhahn M., Belharazem D., Hollstein M.C. p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. Cancer Res. 2005, 65:2583-2587.
    • (2005) Cancer Res. , vol.65 , pp. 2583-2587
    • Liu, Z.1    Muehlbauer, K.R.2    Schmeiser, H.H.3    Hergenhahn, M.4    Belharazem, D.5    Hollstein, M.C.6
  • 59
    • 0346455759 scopus 로고    scopus 로고
    • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
    • Liu G., Parant J.M., Lang G., Chau P., Chavez-Reyes A., El-Naggar A.K., et al. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat. Genet. 2004, 36:63-68.
    • (2004) Nat. Genet. , vol.36 , pp. 63-68
    • Liu, G.1    Parant, J.M.2    Lang, G.3    Chau, P.4    Chavez-Reyes, A.5    El-Naggar, A.K.6
  • 60
    • 20244375365 scopus 로고    scopus 로고
    • UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin
    • Luo J.L., Tong W.M., Yoon J.H., Hergenhahn M., Koomagi R., Yang Q., et al. UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. Cancer Res. 2001, 61:8158-8163.
    • (2001) Cancer Res. , vol.61 , pp. 8158-8163
    • Luo, J.L.1    Tong, W.M.2    Yoon, J.H.3    Hergenhahn, M.4    Koomagi, R.5    Yang, Q.6
  • 61
    • 0035905749 scopus 로고    scopus 로고
    • Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: A new biomedical research tool
    • Luo J.L., Yang Q., Tong W.M., Hergenhahn M., Wang Z.Q., Hollstein M. Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: A new biomedical research tool. Oncogene 2001, 20:320-328.
    • (2001) Oncogene , vol.20 , pp. 320-328
    • Luo, J.L.1    Yang, Q.2    Tong, W.M.3    Hergenhahn, M.4    Wang, Z.Q.5    Hollstein, M.6
  • 62
    • 52949096084 scopus 로고    scopus 로고
    • Next-generation DNA sequencing methods
    • Mardis E.R. Next-generation DNA sequencing methods. Annu. Rev. Genom. Hum. Genet. 2008, 9:387-402.
    • (2008) Annu. Rev. Genom. Hum. Genet. , vol.9 , pp. 387-402
    • Mardis, E.R.1
  • 63
    • 0034063604 scopus 로고    scopus 로고
    • A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
    • Marin M.C., Jost C.A., Brooks L.A., Irwin M.S., O'Nions J., Tidy J.A., et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 2000, 25:47-54.
    • (2000) Nat. Genet. , vol.25 , pp. 47-54
    • Marin, M.C.1    Jost, C.A.2    Brooks, L.A.3    Irwin, M.S.4    O'Nions, J.5    Tidy, J.A.6
  • 64
    • 0035824070 scopus 로고    scopus 로고
    • Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma
    • Marrogi A.J., Khan M.A., van Gijssel H.E., Welsh J.A., Rahim H., Demetris A.J., et al. Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J. Natl. Cancer Inst. 2001, 93:1652-1655.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1652-1655
    • Marrogi, A.J.1    Khan, M.A.2    van Gijssel, H.E.3    Welsh, J.A.4    Rahim, H.5    Demetris, A.J.6
  • 65
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • McLendon R., Friedman A., Bigner D., Van Meir E.G., Brat D.J., Mastrogianakis M., et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
    • McLendon, R.1    Friedman, A.2    Bigner, D.3    Van Meir, E.G.4    Brat, D.J.5    Mastrogianakis, M.6
  • 67
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-The next generation
    • Metzker M.L. Sequencing technologies-The next generation. Nat. Rev. Genet. 2010, 11:31-46.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 68
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson M., Gabriel S., Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat. Rev. Genet. 2010, 11:685-696.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 69
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz D., Halevy O., Oren M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 1990, 62:671-680.
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 71
    • 0028877982 scopus 로고
    • Flexibility: The key to p53 function?
    • Milner J. Flexibility: The key to p53 function?. Trends Biochem. Sci. 1995, 20:49-51.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 49-51
    • Milner, J.1
  • 73
    • 10944236962 scopus 로고    scopus 로고
    • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
    • Olive K.P., Tuveson D.A., Ruhe Z.C., Yin B., Willis N.A., Bronson R.T., et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004, 119:847-860.
    • (2004) Cell , vol.119 , pp. 847-860
    • Olive, K.P.1    Tuveson, D.A.2    Ruhe, Z.C.3    Yin, B.4    Willis, N.A.5    Bronson, R.T.6
  • 74
    • 0027994037 scopus 로고
    • Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
    • Ory K., Legros Y., Auguin C., Soussi T. Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J. 1994, 13:3496-3504.
    • (1994) EMBO J. , vol.13 , pp. 3496-3504
    • Ory, K.1    Legros, Y.2    Auguin, C.3    Soussi, T.4
  • 75
    • 37349101054 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations and nodal metastases
    • Patocs A., Zhang L., Xu Y., Weber F., Caldes T., Mutter G.L., et al. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N. Engl. J. Med. 2007, 357:2543-2551.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2543-2551
    • Patocs, A.1    Zhang, L.2    Xu, Y.3    Weber, F.4    Caldes, T.5    Mutter, G.L.6
  • 76
    • 0027771333 scopus 로고
    • The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
    • Pavletich N.P., Chambers K.A., Pabo C.O. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev. 1993, 7:2556-2564.
    • (1993) Genes Dev. , vol.7 , pp. 2556-2564
    • Pavletich, N.P.1    Chambers, K.A.2    Pabo, C.O.3
  • 78
  • 80
    • 0026356298 scopus 로고
    • Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens
    • Puisieux A., Lim S., Groopman J., Ozturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 1991, 51:6185-6189.
    • (1991) Cancer Res. , vol.51 , pp. 6185-6189
    • Puisieux, A.1    Lim, S.2    Groopman, J.3    Ozturk, M.4
  • 81
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    • Raycroft L., Wu H.Y., Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 1990, 249:1049-1051.
    • (1990) Science , vol.249 , pp. 1049-1051
    • Raycroft, L.1    Wu, H.Y.2    Lozano, G.3
  • 84
    • 42049118522 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • author reply, 1636
    • Roukos D.H. Breast-cancer stromal cells with TP53 mutations. N. Engl. J. Med. 2008, 358. author reply, 1636.
    • (2008) N. Engl. J. Med. , vol.358
    • Roukos, D.H.1
  • 88
    • 0037047345 scopus 로고    scopus 로고
    • The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
    • Shimizu H., Burch L.R., Smith A.J., Dornan D., Wallace M., Ball K.L., et al. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J. Biol. Chem. 2002, 277:28446-28458.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28446-28458
    • Shimizu, H.1    Burch, L.R.2    Smith, A.J.3    Dornan, D.4    Wallace, M.5    Ball, K.L.6
  • 89
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006, 314:268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5    Barber, T.D.6
  • 90
    • 35748963522 scopus 로고    scopus 로고
    • Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL
    • Sot B., Freund S.M., Fersht A.R. Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J. Biol. Chem. 2007, 282:29193-29200.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29193-29200
    • Sot, B.1    Freund, S.M.2    Fersht, A.R.3
  • 91
    • 78049348695 scopus 로고    scopus 로고
    • The history of p53. A perfect example of the drawbacks of scientific paradigms
    • Soussi T. The history of p53. A perfect example of the drawbacks of scientific paradigms. EMBO Rep 2010, 11:822-826.
    • (2010) EMBO Rep , vol.11 , pp. 822-826
    • Soussi, T.1
  • 92
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumours to evaluate clinical outcome
    • Soussi T., Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat. Rev. Cancer 2001, 1:233-240.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 93
    • 0037217682 scopus 로고    scopus 로고
    • Significance of TP53 mutations in human cancer: A critical analysis of mutations at CpG dinucleotides
    • Soussi T., Beroud C. Significance of TP53 mutations in human cancer: A critical analysis of mutations at CpG dinucleotides. Hum. Mutat. 2003, 21:192-200.
    • (2003) Hum. Mutat. , vol.21 , pp. 192-200
    • Soussi, T.1    Beroud, C.2
  • 94
    • 0024312638 scopus 로고
    • Evolutionary conservation of the biochemical properties of p53: Specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70
    • Soussi T., Caron de Fromentel C., Sturzbecher H.W., Ullrich S., Jenkins J., May P. Evolutionary conservation of the biochemical properties of p53: Specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70. J. Virol. 1989, 63:3894-3901.
    • (1989) J. Virol. , vol.63 , pp. 3894-3901
    • Soussi, T.1    Caron de Fromentel, C.2    Sturzbecher, H.W.3    Ullrich, S.4    Jenkins, J.5    May, P.6
  • 95
    • 0033986412 scopus 로고    scopus 로고
    • P53 website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis
    • Soussi T., Dehouche K., Beroud C. p53 website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis. Hum. Mutat. 2000, 15:105-113.
    • (2000) Hum. Mutat. , vol.15 , pp. 105-113
    • Soussi, T.1    Dehouche, K.2    Beroud, C.3
  • 96
    • 30144433850 scopus 로고    scopus 로고
    • Locus-specific mutation databases: Pitfalls and good practice based on the p53 experience
    • Soussi T., Ishioka C., Claustres M., Beroud C. Locus-specific mutation databases: Pitfalls and good practice based on the p53 experience. Nat. Rev. Cancer 2006, 6:83-90.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 83-90
    • Soussi, T.1    Ishioka, C.2    Claustres, M.3    Beroud, C.4
  • 97
    • 11344252796 scopus 로고    scopus 로고
    • Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations
    • Soussi T., Kato S., Levy P.P., Ishioka C. Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum. Mutat. 2005, 25:6-17.
    • (2005) Hum. Mutat. , vol.25 , pp. 6-17
    • Soussi, T.1    Kato, S.2    Levy, P.P.3    Ishioka, C.4
  • 99
    • 35148826938 scopus 로고    scopus 로고
    • Shaping genetic alterations in human cancer: The p53 mutation paradigm
    • Soussi T., Wiman K.G. Shaping genetic alterations in human cancer: The p53 mutation paradigm. Cancer Cell 2007, 12:303-312.
    • (2007) Cancer Cell , vol.12 , pp. 303-312
    • Soussi, T.1    Wiman, K.G.2
  • 100
    • 42049121114 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • author reply, 1636
    • Soussi Zander C., Soussi T. Breast-cancer stromal cells with TP53 mutations. N. Engl. J. Med. 2008, 358:1635. author reply, 1636.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1635
    • Soussi Zander, C.1    Soussi, T.2
  • 102
    • 20044381123 scopus 로고    scopus 로고
    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    • Stephens P., Edkins S., Davies H., Greenman C., Cox C., Hunter C., et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat. Genet. 2005, 37:590-592.
    • (2005) Nat. Genet. , vol.37 , pp. 590-592
    • Stephens, P.1    Edkins, S.2    Davies, H.3    Greenman, C.4    Cox, C.5    Hunter, C.6
  • 103
    • 0033559256 scopus 로고    scopus 로고
    • A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
    • Stommel J.M., Marchenko N.D., Jimenez G.S., Moll U.M., Hope T.J., Wahl G.M. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking. EMBO J. 1999, 18:1660-1672.
    • (1999) EMBO J. , vol.18 , pp. 1660-1672
    • Stommel, J.M.1    Marchenko, N.D.2    Jimenez, G.S.3    Moll, U.M.4    Hope, T.J.5    Wahl, G.M.6
  • 105
    • 0027940573 scopus 로고
    • Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2
    • Thukral S.K., Blain G.C., Chang K.K., Fields S. Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2. Mol. Cell. Biol. 1994, 14:8315-8321.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8315-8321
    • Thukral, S.K.1    Blain, G.C.2    Chang, K.K.3    Fields, S.4
  • 106
    • 33745893223 scopus 로고    scopus 로고
    • Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice
    • Tong W.M., Lee M.K., Galendo D., Wang Z.Q., Sabapathy K. Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice. Int. J. Cancer 2006, 119:745-749.
    • (2006) Int. J. Cancer , vol.119 , pp. 745-749
    • Tong, W.M.1    Lee, M.K.2    Galendo, D.3    Wang, Z.Q.4    Sabapathy, K.5
  • 107
    • 0027292296 scopus 로고
    • The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer
    • Tornaletti S., Rozek D., Pfeifer G.P. The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. Oncogene 1993, 8:2051-2057.
    • (1993) Oncogene , vol.8 , pp. 2051-2057
    • Tornaletti, S.1    Rozek, D.2    Pfeifer, G.P.3
  • 108
    • 0037220167 scopus 로고    scopus 로고
    • The TP53 gene, tobacco exposure, and lung cancer
    • Toyooka S., Tsuda T., Gazdar A.F. The TP53 gene, tobacco exposure, and lung cancer. Hum. Mutat. 2003, 21:229-239.
    • (2003) Hum. Mutat. , vol.21 , pp. 229-239
    • Toyooka, S.1    Tsuda, T.2    Gazdar, A.F.3
  • 109
    • 0035837312 scopus 로고    scopus 로고
    • Characterization of germline TP53 splicing mutations and their genetic and functional analysis
    • Varley J.M., Attwooll C., White G., McGown G., Thorncroft M., Kelsey A.M., et al. Characterization of germline TP53 splicing mutations and their genetic and functional analysis. Oncogene 2001, 20:2647-2654.
    • (2001) Oncogene , vol.20 , pp. 2647-2654
    • Varley, J.M.1    Attwooll, C.2    White, G.3    McGown, G.4    Thorncroft, M.5    Kelsey, A.M.6
  • 111
    • 0027744051 scopus 로고
    • P53 domains: Identification and characterization of two autonomous DNA-binding regions
    • Wang Y., Reed M., Wang P., Stenger J.E., Mayr G., Anderson M.E., et al. p53 domains: Identification and characterization of two autonomous DNA-binding regions. Genes Dev. 1993, 7:2575-2586.
    • (1993) Genes Dev. , vol.7 , pp. 2575-2586
    • Wang, Y.1    Reed, M.2    Wang, P.3    Stenger, J.E.4    Mayr, G.5    Anderson, M.E.6
  • 112
    • 2442648882 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine phosphatome in colorectal cancers
    • Wang Z., Shen D., Parsons D.W., Bardelli A., Sager J., Szabo S., et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 2004, 304:1164-1166.
    • (2004) Science , vol.304 , pp. 1164-1166
    • Wang, Z.1    Shen, D.2    Parsons, D.W.3    Bardelli, A.4    Sager, J.5    Szabo, S.6
  • 113
    • 0034576495 scopus 로고    scopus 로고
    • P63 and P73: P53 mimics, menaces and more
    • Yang A., McKeon F. P63 and P73: P53 mimics, menaces and more. Nat. Rev. Mol. Cell Biol. 2000, 1:199-207.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 199-207
    • Yang, A.1    McKeon, F.2
  • 114
    • 42049093400 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • author reply, 1636
    • Zalcman G., Bergot E., Hainaut P. Breast-cancer stromal cells with TP53 mutations. N. Engl. J. Med. 2008, 358:1635. author reply, 1636.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1635
    • Zalcman, G.1    Bergot, E.2    Hainaut, P.3
  • 116
    • 33746012703 scopus 로고    scopus 로고
    • Mutational analysis of the p53 core domain L1 loop
    • Zupnick A., Prives C. Mutational analysis of the p53 core domain L1 loop. J. Biol. Chem. 2006, 281:20464-20473.
    • (2006) J. Biol. Chem. , vol.281 , pp. 20464-20473
    • Zupnick, A.1    Prives, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.