Deconstruction of lignocellulosic biomass to fuels and chemicals

Annual Review of Chemical and Biomolecular Engineering

Volumn 2, Issue , 2011, Pages 121-145

  Chundawat, Shishir P S ^a,b   Beckham, Gregg T ^c,d,e   Himmel, Michael E ^c,f   Dale, Bruce E ^a,b  

^a USA   (United States)

^b Michigan State University   (United States)

^c NATIONAL RENEWABLE ENERGY LABORATORY   (United States)

^d Department of Geology and Geological Engineering   (United States)

^e a partnership between the University of Colorado Boulder   (United States)

^f OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

biofuels; enzymatic hydrolysis; heterogeneous catalysis; thermochemical pretreatment

Indexed keywords

BIOCHEMICAL CONVERSION; CELL WALLS; CO-OPTIMIZATION; LENGTH SCALE; LIGNOCELLULOSIC BIOMASS; PLANT CELL WALL; PRE-TREATMENT; PRE-TREATMENTS; RENEWABLE RESOURCE; SOLUBLE SUGARS; SUPERIOR CATALYSTS; THERMOCHEMICAL CONVERSION; THERMOCHEMICAL PRETREATMENT; TRANSPORTATION FUELS;

BIOCHEMICAL FUEL CELLS; BIOFUELS; CATALYSIS; CATALYSTS; PHENOLS; PLANT CELL CULTURE; SUGARS;

ENZYMATIC HYDROLYSIS;

BIOFUEL; CELLULASE; CELLULOSE; FUNGAL PROTEIN; LIGNIN; ORGANIC COMPOUND;

BIOMASS; CATALYSIS; CELL WALL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HISTOLOGY; HYDROLYSIS; METABOLISM; PLANT; PROTEIN TERTIARY STRUCTURE; REVIEW; TRICHODERMA;

BIOFUELS; BIOMASS; CATALYSIS; CELL WALL; CELLULASES; CELLULOSE; FUNGAL PROTEINS; HYDROLYSIS; LIGNIN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANIC CHEMICALS; PLANTS; PROTEIN STRUCTURE, TERTIARY; TRICHODERMA;

EID: 79959386497     PISSN: 19475438     EISSN: None     Source Type: Journal    
DOI: 10.1146/annurev-chembioeng-061010-114205     Document Type: Article

References (150)

1. Himmel M, Ding S, Johnson D, Adney W, Nimlos M, et al. 2007. Biomass recalcitrance: Engineering plants and enzymes for biofuels production. Science 315:804-7
2. Solomon BD. 2010. Biofuels and sustainability. Ann. N. Y. Acad. Sci. 1185:119-34
3. Aden A, Foust T. 2009. Technoeconomic analysis of the dilute sulfuric acid and enzymatic hydrolysis process for the conversion of corn stover to ethanol. Cellulose 16:535-45
4. Richard TL. 2010. Challenges in scaling up biofuels infrastructure. Science 329:793-96
5. Laser M, Larson E, Dale B, Wang M, Greene N, Lynd LR. 2009. Comparative analysis of efficiency, environmental impact, and process economics for mature biomass refining scenarios. Biofuels Bioprod. Biorefining 3:247-70
6. Mosier N, Wyman C, Dale B, Elander R, Lee YY, et al. 2005. Features of promising technologies for pretreatment of lignocellulosic biomass. Bioresour. Technol. 96:673-86 (Pubitemid 39592889)
7. da Costa Sousa L, Chundawat SPS, Balan V, Dale BE. 2009. "Cradle-to-grave" assessment of existing lignocellulose pretreatment technologies. Curr. Opin. Biotechnol. 20:339-47
8. Jeoh T, Ishizawa CI, Davis MF, Himmel ME, AdneyWS, Johnson DK. 2007. Cellulase digestibility of pretreated biomass is limited by cellulose accessibility. Biotechnol. Bioeng. 98:112-22 (Pubitemid 47325828)
9. Atsumi S, Cann AF, ConnorMR, Shen CR, Smith KM, et al. 2008. Metabolic engineering of Escherichia coli for 1-butanol production. Metab. Eng. 10:305-11
10. Steen EJ, Kang YS, Bokinsky G, Hu ZH, Schirmer A, et al. 2010. Microbial production of fatty-acidderived fuels and chemicals from plant biomass. Nature 463:559-62
11. Huber GW, Chheda JN, Barrett CJ, Dumesic JA. 2005. Production of liquid alkanes by aqueous-phase processing of biomass-derived carbohydrates. Science 308:1446-50 (Pubitemid 40791294)
12. Bond JQ, Alonso DM, Wang D, West RM, Dumesic JA. 2010. Integrated catalytic conversion of γ-valerolactone to liquid alkenes for transportation fuels. Science 327:1110-14
13. Cosgrove DJ. 2005. Growth of the plant cell wall. Nat. Rev. Mol. Cell Biol. 6:850-61 (Pubitemid 41568734)
14. Pauly M, Keegstra K. 2008. Cell wall carbohydrates and their modifications as a resource for biofuels. Plant J. 54:559-68 (Pubitemid 351678047)
15. O'Sullivan AC. 1997. Cellulose: The structure slowly unravels. Cellulose 4:173-207 (Pubitemid 127508792)
16. Somerville C, Bauer S, Brininstool G, Facette M, Hamann T, et al. 2004. Toward a systems approach to understanding plant cell walls. Science 306:2206-11 (Pubitemid 40024448)
17. Nishiyama Y, Kim U-J, Kim D-Y, Katsumata KS, May RP, Langan P. 2003. Periodic disorder along ramie cellulose microfibrils. Biomacromolecules 4:1013-17 (Pubitemid 36939471)
18. Zhou W, Hao ZQ, Xu Y, Schuttler HB. 2009. Cellulose hydrolysis in evolving substrate morphologies II: Numerical results and analysis. Biotechnol. Bioeng. 104:275-89
19. Nishiyama Y, Langan P, Chanzy H. 2002. Crystal structure and hydrogen-bonding system in cellulose Iβfrom synchrotron X-ray and neutron fiber diffraction. J. Am. Chem. Soc. 124:9074-82 (Pubitemid 34847668)
20. Wada M, Ike M, Tokuyasu K. 2010. Enzymatic hydrolysis of cellulose I is greatly accelerated via its conversion to the cellulose II hydrate form. Polym. Degrad. Stab. 95:543-48
21. Wada M, Chanzy H, NishiyamaY,Langan P. 2004. Cellulose IIII crystal structure and hydrogen bonding by synchrotron X-ray and neutron fiber diffraction. Macromolecules 37:8548-55
22. Igarashi K, Wada M, Samejima M. 2007. Activation of crystalline cellulose to cellulose IIII results in efficient hydrolysis by cellobiohydrolase. FEBS J. 274:1785-92 (Pubitemid 46426914)
23. Gardiner ES, Sarko A. 1985. Packing analysis of carbohydrates and polysaccharides. 16. The crystal structures of celluloses IVI and IVII. Can. J. Chem. 63:173-80
24. Chundawat S. 2009. Ultrastructural and physicochemical modifications within ammonia treated lignocellulosic cell walls and their influence on enzymatic digestibility. Ph.D. thesis. Michigan State Univ., East Lansing
25. Schulze E. 1891. Zur Kenntnis der chemischen Zusammensetzung der pflanzlichen Zellmem. Ber. Dtsch. Chem. Ges. 24:2277-87
26. Ebringerová A, Hromádková Z, Heinze T. 2005. Hemicellulose. In Polysaccharides I: Structure, Characterisation and Use, ed. T Heinze, pp. 1-67. Berlin/Heidelberg: Springer
27. Fengel D, Wegener G. 1989. Wood: Chemistry, Ultrastructure, Reactions. Berlin: Walter de Gruyter. 613 pp.
28. Jeffries TW. 1994. Biodegradation of lignin and hemicelluloses. In Biochemistry of Microbial Degradation, ed. C Ratledge, pp. 233-77, Dordrecht, Netherlands: Kluwer Academic Publishers
29. Grabber J. 2005. How do lignin composition, structure, and cross-linking impact degradability? A review of cell wall model studies. Crop Sci. 45:820-31 (Pubitemid 40670262)
30. Boerjan W, Ralph J, Baucher M. 2003. Lignin biosynthesis. Annu. Rev. Plant Biol. 54:519-46 (Pubitemid 37400004)
31. McCann MC, Bush M, Milioni D, Sado P, Stacey NJ, et al. 2001. Approaches to understanding the functional architecture of the plant cell wall. Phytochemistry 57:811-21 (Pubitemid 32607030)
32. Carpita NC. 1996. Structure and biogenesis of the cell walls of grasses. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47:445-76
33. Bidlack J, Malone M, Benson R. 1992. Molecular structure and component integration of secondary cell walls in plants. Proc. Okla. Acad. Sci. 72:51-56
34. Nakashima J,Mizuno T, Takabe K, Fujita M, SaikiH. 1997. Direct visualization of lignifying secondary wall thickenings in Zinnia elegans cells in culture. Plant Cell Physiol. 38:818-27 (Pubitemid 27347765)
35. Viamajala S, Selig M, Vinzant T, Tucker M, Himmel M, et al. 2006. Catalyst transport in corn stover internodes elucidating transport mechanisms using Direct Blue-I. Appl. Biochem. Biotech. 130:509-27 (Pubitemid 43791480)
36. Himmel M, ed. 2008. Biomass Recalcitrance: Deconstructing the Plant Cell Wall for Bioenergy. Oxford, UK: Blackwell
37. Ding S, Himmel M. 2006. The maize primary cell wall microfibril: A new model derived from direct visualization. J. Agric. Food Chem. 54:597-606 (Pubitemid 43274091)
38. McCann MC,Wells B, Roberts K. 1990. Direct visualization of cross-links in the primary plant cell wall. J. Cell Sci. 96:323-34
39. Carpita N, Sabularse D, Montezinos D, Delmer D. 1979. Determination of the pore size of cell walls of living plant cells. Science 205:1144-47
40. Ralph J. 2010. Hydroxycinnamates in lignification. Phytochem. Rev. 9:65-83
41. Hatfield RD, Ralph J, Grabber JH. 1999. Cell wall cross-linking by ferulates and diferulates in grasses. J. Sci. Food Agric. 79:403-7 (Pubitemid 29150585)
42. Shevchenko SM, Bailey GW. 1996. The mystery of the lignin-carbohydrate complex: A computational approach. J. Mol. Struct. 364:197-208 (Pubitemid 126369690)
43. Saeman JF. 1945. Kinetics of wood saccharification-hydrolysis of cellulose and decomposition of sugars in dilute acid at high temperature. Ind. Eng. Chem. 37:43-52
44. Pingali SV, Urban VS, Heller WT, McGaughey J, O'Neill H, et al. 2010. Breakdown of cell wall nanostructure in dilute acid pretreated biomass. Biomacromolecules 11:2329-35
45. Chundawat SPS, Balan V, Sousa L, Dale BE. 2010. Thermochemical pretreatment of lignocellulosic biomass. In Bioalcohol Production: Biochemical Conversion of Lignocellulosic Biomass, ed. K Waldron. Cambridge, UK: Woodhead Publishing
46. Wyman CE,Dale BE, Elander RT, HoltzappleM, Ladisch MR, et al. 2009. Comparative sugar recovery and fermentation data following pretreatment of poplar wood by leading technologies. Biotechnol. Prog. 25:333-39
47. Wyman CE, Dale BE, Elander RT, Holtzapple MT, Ladisch MR, Lee YY. 2005. Comparative sugar recovery data from laboratory scale application of leading pretreatment technologies to corn stover. Bioresour. Technol. 96:2026-32 (Pubitemid 41174572)
48. Eggeman T, Elander RT. 2005. Process and economic analysis of pretreatment technologies. Bioresour. Technol. 96:2019-25 (Pubitemid 41169796)
49. Lloyd TA, Wyman CE. 2005. Combined sugar yields for dilute sulfuric acid pretreatment of corn stover followed by enzymatic hydrolysis of the remaining solids. Bioresour. Technol. 96:1967-77 (Pubitemid 41174566)
50. Öhgren K, Bura R, Saddler J, Zacchi G. 2007. Effect of hemicellulose and lignin removal on enzymatic hydrolysis of steam pretreated corn stover. Bioresour. Technol. 98:2503-10 (Pubitemid 46453471)
51. Mosier N, Hendrickson R, Ho N, Sedlak M, Ladisch MR. 2005. Optimization of pH controlled liquid hot water pretreatment of corn stover. Bioresour. Technol. 96:1986-93 (Pubitemid 41174568)
52. Liu C, Wyman CE. 2005. Partial flow of compressed-hot water through corn stover to enhance hemicellulose sugar recovery and enzymatic digestibility of cellulose. Bioresour. Technol. 96:1978-85 (Pubitemid 41174567)
53. Chundawat SPS, Vismeh R, Sharma L, Humpula J, Sousa L, et al. 2010. Multifaceted characterization of cell wall decomposition products formed during ammonia fiber expansion (AFEX) and dilute-acid based pretreatments. Bioresour. Technol. 101:8429-38
54. Teymouri F, Laureano-Perez L, Alizadeh H, Dale BE. 2005. Optimization of the ammonia fiber explosion (AFEX) treatment parameters for enzymatic hydrolysis of corn stover. Bioresour. Technol. 96:2014-18 (Pubitemid 41174571)
55. Kim TH, Lee YY. 2005. Pretreatment and fractionation of corn stover by ammonia recycle percolation process. Bioresour. Technol. 96:2007-13 (Pubitemid 41174570)
56. Gupta R, Lee YY. 2010. Investigation of biomass degradation mechanism in pretreatment of switchgrass by aqueous ammonia and sodium hydroxide. Bioresour. Technol. 101:8185-91
57. Kim S, Holtzapple MT. 2005. Lime pretreatment and enzymatic hydrolysis of corn stover. Bioresour. Technol. 96:1994-2006 (Pubitemid 41174569)
58. Swatloski RP, Spear SK, Holbrey JD, Rogers RD. 2002. Dissolution of cellulose with ionic liquids. J. Am. Chem. Soc. 124:4974-75
59. Zhao H, Jones CL, Baker GA, Xia S, Olubajo O, Person VN. 2009. Regenerating cellulose from ionic liquids for an accelerated enzymatic hydrolysis. J. Biotechnol. 139:47-54
60. Singh S, Simmons BA,VogelKP. 2009. Visualization of biomass solubilization and cellulose regeneration during ionic liquid pretreatment of switchgrass. Biotechnol. Bioeng. 104:68-75
61. Li C, Knierim B, Manisseri C, Arora R, Scheller HV, et al. 2010. Comparison of dilute acid and ionic liquid pretreatment of switchgrass: Biomass recalcitrance, delignification and enzymatic saccharification. Bioresour. Technol. 101:4900-6
62. Sellin M, Ondruschka B, Stark A. 2010. Hydrogen bond acceptor properties of ionic liquids and their effect on cellulose solubility. In Cellulose Solvents: For Analysis, Shaping and Chemical Modification, ed.TF Liebert, TJ Heinze, KJ Edgar, pp. 121-35. Washington, D.C.: American Chemical Society
63. Liu H, Sale KL, Holmes BM, Simmons BA, Singh S. 2010. Understanding the interactions of cellulose with ionic liquids: A molecular dynamics study. J. Phys. Chem. B 114:4293-301
64. Nguyen T-AD, Kim K-R, Han SJ, ChoHY, Kim JW, et al. 2010. Pretreatment of rice straw with ammonia and ionic liquid for lignocellulose conversion to fermentable sugars. Bioresour. Technol. 101:7432-38
65. Datta S, Holmes B, Park JI, Chen Z, Dibble DC, et al. 2010. Ionic liquid tolerant hyperthermophilic cellulases for biomass pretreatment and hydrolysis. Green Chem. 12:338-45
66. Zhang Y-HP, Ding S-Y,Mielenz JR, Cui J-B, Elander RT, et al. 2007. Fractionating recalcitrant lignocellulose at modest reaction conditions. Biotechnol. Bioeng. 97:214-23 (Pubitemid 46852918)
67. Zhu Z, SathitsuksanohN, Vinzant T, Schell DJ, McMillan JD, Zhang YHP. 2009. Comparative study of corn stover pretreated by dilute acid and cellulose solvent-based lignocellulose fractionation: Enzymatic hydrolysis, supramolecular structure, and substrate accessibility. Biotechol. Bioeng. 103:715-24
68. Ishizawa CI, Davis MF, Schell DF, Johnson DK. 2007. Porosity and its effect on the digestibility of dilute sulfuric acid pretreated corn stover. J. Agric. Food Chem. 55:2575-81 (Pubitemid 46623752)
69. Grabber JH, Hatfield RD, Ralph J. 1998. Diferulate cross-links impede the enzymatic degradation of non-lignified maize walls. J. Sci. Food Agric. 77:193-200 (Pubitemid 28278743)
70. Ralph J, Quideau S, Grabber JH, Hatfield RD. 1994. Identification and synthesis of new ferulic acid dehydrodimers present in grass cell walls. J. Chem. Soc. Perkin Trans. 1:3485-98
71. Kumar R, Mago G, Balan V, Wyman CE. 2009. Physical and chemical characterizations of corn stover and poplar solids resulting from leading pretreatment technologies. Bioresour. Technol. 100:3948-62
72. Lee YY, Wu Z, Torget RW. 2000. Modeling of countercurrent shrinking-bed reactor in dilute-acid total-hydrolysis of lignocellulosic biomass. Bioresour. Technol. 71:29-39 (Pubitemid 29423749)
73. Brunecky R, Vinzant TB, Porter SE, Donohoe BS, Johnson DK, Himmel ME. 2009. Redistribution of xylan in maize cell walls during dilute acid pretreatment. Biotechnol. Bioeng. 102:1537-43
74. Arora R, Manisseri C, Li C, Ong M, Scheller H, et al. 2010. Monitoring and analyzing process streams towards understanding ionic liquid pretreatment of switchgrass (Panicum virgatum L.). BioEnergy Res. 3:134-45
75. Chundawat SPS, Donohoe BS, Sousa LdC, Elder T, Agarwal UP, et al. 2011. Multi-scale visualization and characterization of plant cell wall deconstruction during thermochemical pretreatment. Energy Environ. Sci. 4:973-84
76. Donohoe B, Decker S, Tucker M, Himmel M, Vinzant T. 2008. Visualizing lignin coalescence and migration through maize cell walls following thermochemical pretreatment. Biotechnol. Bioeng. 101:913-25
77. Cetinkol OP, Dibble DC, Cheng G, Kent MS, Knierim B, et al. 2010. Understanding the impact of ionic liquid pretreatment on eucalyptus. Biofuels 1:33-46
78. Donohoe BS, Selig MJ, Viamajala S, Vinzant TB, Adney WS, Himmel ME. 2009. Detecting cellulase penetration into corn stover cell walls by immuno-electron microscopy. Biotechnol. Bioeng. 103:480-89
79. Selig M, Viamajala S, Decker S, Tucker M, Himmel M, Vinzant T. 2007. Deposition of lignin droplets produced during dilute acid pretreatment of maize stems retards enzymatic hydrolysis of cellulose. Biotechnol. Prog. 23:1333-39 (Pubitemid 350261868)
80. KimH, Ralph J. 2010. Solution-state 2DNMRof ball-milled plant cell wall gels in DMSO-d6/pyridined5. Org. Biomol. Chem. 8:576-91
81. Haas TJ, Nimlos MR, Donohoe BS. 2009. Real-time and post-reaction microscopic structural analysis of biomass undergoing pyrolysis. Energy Fuels 23:3810-17
82. Park S, Baker J, Himmel M, Parilla P, Johnson D. 2010. Cellulose crystallinity index: Measurement techniques and their impact on interpreting cellulase performance. Biotechnol. Biofuels 3:10
83. Zhang A, Lu F, Sun R-C, Ralph J. 2010. Isolation of cellulolytic enzyme lignin from wood preswollen/dissolved in dimethyl sulfoxide/N-methylimidazole. J. Agric. Food Chem. 58:3446-50
84. Hamilton TJ, Dale BE, Ladisch MR, Tsao GT. 1984. Effect of ferric tartrate/sodium hydroxide solvent pretreatment on enzyme hydrolysis of cellulose in corn residue. Biotechnol. Bioeng. 26:781-87 (Pubitemid 14063347)
85. Dadi AP, Varanasi S, Schall CA. 2006. Enhancement of cellulose saccharification kinetics using an ionic liquid pretreatment step. Biotechnol. Bioeng. 95:904-10 (Pubitemid 44863208)
86. PilathHM, Nimlos MR,Mittal A,HimmelME, Johnson DK. 2010. Glucose reversion reaction kinetics. J. Agric. Food Chem. 58:6131-40
87. Lynd LR,Weimer PJ, van Zyl W, Pretorius IS. 2002. Microbial cellulose utilization: Fundamentals and biotechnology. Microbiol. Mol. Biol. Rev. 66:506-77 (Pubitemid 35005827)
88. Bayer EA, Belaich JP, Shoham Y, Lamed R. 2004. The cellulosomes: Multienzyme machines for degradation of plant cell wall polysaccharides. Annu. Rev. Microbiol. 58:521-54 (Pubitemid 39551996)
89. Wilson DB. 2009. Cellulases and biofuels. Curr. Opin. Biotechnol. 20:295-99
90. Lantz SE, Goedegebuur F, Hommes R, Kaper T, Kelemen BR, et al. 2010. Hypocrea jecorina Cel6A protein engineering. Biotechnol. Biofuels 3:20
91. Heinzelman P, Snow CD, Wu I, Nguyen C, Villalobos A, et al. 2009. A family of thermostable fungal cellulases created by structure-guided recombination. Proc. Natl. Acad. Sci. USA 106:5610-15
92. Harris PV, Welner D, McFarland KC, Re E, Navarro Poulsen J-C, et al. 2010. Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: Structure and function of a large, enigmatic family. Biochemistry 49:3305-16
93. Reese E. 1976. History of cellulase program at US Army Natick Development Center. Proc. Biotechnol. Bioeng. Symp. 6:9-20
94. Martinez D, BerkaRM, HenrissatB, SaloheimoM,Arvas M, et al. 2008. Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina). Nat. Biotechnol. 26:553-60 (Pubitemid 351668043)
95. Koivula A, Kinnari T, Harjunpaa V, Ruohonen L, Teleman A, et al. 1998. Tryptophan 272: An essential determinant of crystalline cellulose degradation by Trichoderma reesei cellobiohydrolase Cel6A. FEBS Lett. 429:341-46 (Pubitemid 28300388)
96. von Ossowski I, Stahlberg J, Koivula A, Piens K, Becker D, et al. 2003. Engineering the exo-loop of Trichoderma reesei cellobiohydrolase, Cel7A. A comparison with Phanerochaete chrysosporium Cel7D. J. Mol. Biol. 333:817-29 (Pubitemid 37268020)
97. Koivula A, Ruohonen L, Wohlfahrt G, Reinikainen T, Teeri TT, et al. 2002. The active site of cellobiohydrolase Cel6A from Trichoderma reesei: The roles of aspartic acids D221 and D175. J. Am. Chem. Soc. 124:10015-24 (Pubitemid 34919737)
98. Barnett CB, Wilkinson KA, Naidoo KJ. 2010. Pyranose ring transition state is derived from cellobiohydrolase I induced conformational stability and glycosidic bond polarization. J. Am. Chem. Soc. 132:12800-3
99. Levine SE, Fox JM, Blanch HW, Clark DS. 2010. A mechanistic model of the enzymatic hydrolysis of cellulose. Biotechnol. Bioeng. 107:37-51
100. Heinzelman P, SnowCD, SmithMA, Yu XL,Kannan A, et al. 2009.SCHEMArecombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability. J. Biol. Chem. 284:26229-33
101. Linder M, Lindeberg G, Reinikainen T, Teeri TT, Pettersson G. 1995. The difference in affinity between two fungal cellulose-binding domains is dominated by a single amino acid substitution. FEBS Lett. 372:96-98
102. Rouvinen J, Bergfors T, Teeri T, Knowles JKC, Jones TA. 1990. Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei. Science 249:380-86
103. Adney WS, Jeoh T, Beckham GT, Chou YC, Baker JO, et al. 2009. Probing the role of N-linked glycans in the stability and activity of fungal cellobiohydrolases by mutational analysis. Cellulose 16:699-709
104. DivneC, Stahlberg J, Teeri TT, Jones TA. 1998. High-resolution crystal structures reveal how a cellulose chain is bound in the 50 Å long tunnel of cellobiohydrolase I from Trichoderma reesei. J. Mol. Biol. 275:309-25 (Pubitemid 28030006)
105. HarrisonMJ, Nouwens AS, Jardine DR, Zachara NE, Gooley AA, et al. 1998. Modified glycosylation of cellobiohydrolase I from a high cellulase-producing mutant strain of Trichoderma reesei. Eur. J. Biochem. 256:119-27 (Pubitemid 28399103)
106. Karkehabadi S, Hansson H, Kim S, Piens K, Mitchinson C, Sandgren M. 2008. The first structure of a glycoside hydrolase family 61 member, Cel61B from Hypocrea jecorina, at 1.6 Å resolution. J. Mol. Biol. 383:144-54
107. Kleywegt GJ, Zou JY, Divne C, Davies GJ, Sinning I, et al. 1997. The crystal structure of the catalytic core domain of endoglucanase I from Trichoderma reesei at 3.6 angstrom resolution, and a comparison with related enzymes. J. Mol. Biol. 272:383-97 (Pubitemid 27410052)
108. Kraulis PJ, Clore GM, Nilges M, Jones TA, Pettersson G, et al. 1989. Determination of the threedimensional solution structure of the C-terminal domain of cellobiohydrolase I from Trichoderma reesei. A study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry 28:7241-57
109. Linder M, Teeri TT. 1996. The cellulose-binding domain of themajor cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose. Proc. Natl. Acad. Sci. USA 93:12251-55 (Pubitemid 26367128)
110. Srisodsuk M, Reinikainen T, Penttila M, Teeri TT. 1993. Role of the interdomain linker peptide of Trichoderma reesei cellobiohydrolase I in its interactionwith crystalline cellulose. J. Biol.Chem. 268:20756-61 (Pubitemid 23292244)
111. Jeoh T, Michener W, Himmel ME, Decker SR, Adney WS. 2008. Implications of cellobiohydrolase glycosylation for use in biomass conversion. Biotechnol. Biofuels 1:10
112. Stals I, Sandra K, Geysens S, Contreras R, Van Beeumen J, Claeyssens M. 2004. Factors influencing glycosylation of Trichoderma reesei cellulases. I: Postsecretorial changes of the O- and N-glycosylation pattern of Cel7A. Glycobiology 14:713-24 (Pubitemid 39161978)
113. Santa-Maria M, Jeoh T. 2010. Molecular-scale investigations of cellulose microstructure during enzymatic hydrolysis. Biomacromolecules 11:2000-7
114. Beckham GT, Matthews JF, Bomble YJ, Bu L, Adney WS, et al. 2010. Identification of amino acids responsible for processivity in a Family 1 carbohydrate-binding module from a fungal cellulase. J. Phys. Chem. B 114:1447-53
115. Bu L, Beckham GT, Crowley MF, Chang CH, Matthews JF, et al. 2009. The energy landscape for the interaction of the Family 1 carbohydrate-binding module and the cellulose surface is altered by hydrolyzed glycosidic linkages. J. Phys. Chem. B 113:10994-1002
116. Boraston AB, Bolam DN, Gilbert HJ, Davies GJ. 2004. Carbohydrate-binding modules: Fine-tuning polysaccharide recognition. Biochem. J. 382:769-81 (Pubitemid 39312891)
117. Lehtio J, Sugiyama J, Gustavsson M, Fransson L, Linder M, Teeri TT. 2003. The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules. Proc. Natl. Acad. Sci. USA 100:484-89 (Pubitemid 36126077)
118. Nishiyama Y, Sugiyama J, Chanzy H, Langan P. 2003. Crystal structure and hydrogen bonding system in cellulose 1a from synchrotron X-ray and neutron fiber diffraction. J. Am. Chem. Soc. 125:14300-6 (Pubitemid 37452368)
119. Creagh AL, Ong E, Jervis E, Kilburn DG, Haynes CA. 1996. Binding of the cellulose-binding domain of exoglucanase Cex from Cellulomonas fimi to insoluble microcrystalline cellulose is entropically driven. Proc. Natl. Acad. Sci. USA 93:12229-34 (Pubitemid 26367124)
120. Takashima S,Ohno M, Hidaka M, Nakamura A, Masaki H. 2007. Correlation between cellulose binding and activity of cellulose-binding domain mutants of Humicola grisea cellobiohydrolase 1. FEBS Lett. 581:5891-96 (Pubitemid 50009359)
121. Carrard G, Koivula A, Soderlund H, Beguin P. 2000. Cellulose-binding domains promote hydrolysis of different sites on crystalline cellulose. Proc. Natl. Acad. Sci. USA 97:10342-47
122. Kim ES, LeeHJ, Bang WG,Choi IG, KimKH. 2009. Functional characterization of a bacterial expansin from Bacillus subtilis for enhanced enzymatic hydrolysis of cellulose. Biotechnol. Bioeng. 102:1342-53
123. Saloheimo M, Paloheimo M, Hakola S, Pere J, Swanson B, et al. 2002. Swollenin, a Trichoderma reesei proteinwith sequence similarity to the plant expansins, exhibits disruption activity on cellulosicmaterials. Eur. J. Biochem. 269:4202-11 (Pubitemid 35026007)
124. DinN,Gilkes NR, Tekant B, Miller RC Jr, Warren RAJ, Kilburn DG. 1991. Non-hydrolytic disruption of cellulose fibres by the binding domain of a bacterial cellulase. Nat. Biotechnol. 9:1096-99
125. Vaaje-Kolstad G, Horn SJ, van Aalten DMF, Synstad B, Eijsink VGH. 2005. The non-catalytic chitinbinding protein CBP21 from Serratia marcescens is essential for chitin degradation. J. Biol. Chem. 280:28492-97 (Pubitemid 41105749)
126. Nimlos MR, Matthews JF, Crowley MF, Walker RC, Chukkapalli G, et al. 2007. Molecular modeling suggests induced fit of Family I carbohydrate-binding modules with a broken-chain cellulose surface. Prot. Eng. Des. Select. 20:179-87 (Pubitemid 351321299)
127. Igarashi K, Koivula A, WadaM, Kimura S, Penttila M, Samejima M. 2009. High speed atomic force microscopy visualizes processive movement of Trichoderma reesei cellobiohydrolase I on crystalline cellulose. J. Biol. Chem. 284:36186-90
128. Vuong TV, Wilson DB. 2009. Processivity, synergism, and substrate specificity of Thermobifida fusca Cel6B. Appl. Environ. Microbiol. 75:6655-61
129. Horn SJ, Sikorski P, Cederkvist JB, Vaaje-KolstadG, Sorlie M, et al. 2006. Costs and benefits of processivity in enzymatic degradation of recalcitrant polysaccharides. Proc. Natl. Acad. Sci. USA 103:18089-94 (Pubitemid 44871617)
130. Zakariassen H, Aam BB, Horn SJ, Varum KM, Sorlie M, Eijsink VGH. 2009. Aromatic residues in the catalytic center of chitinase A from Serratia marcescens affect processivity, enzyme activity, and biomass converting efficiency. J. Biol. Chem. 284:10610-17
131. Gao J, Ma S, Major DT, Nam K, Pu J, Truhlar DG. 2006. Mechanisms and free energies of enzymatic reactions. Chem. Rev. 106:3188-209 (Pubitemid 44376932)
132. Deng Y, Roux B. 2009. Computations of standard binding free energies with molecular dynamics simulations. J. Phys. Chem. B 113:2234-46
133. Gruno M, Valjamae P, Pettersson G, Johansson G. 2004. Inhibition of the Trichoderma reesei cellulases by cellobiose is strongly dependent on the nature of the substrate. Biotechnol. Bioeng. 86:503-11 (Pubitemid 38679768)
134. Peters B, BeckhamGT, Trout BL. 2007. Extensions to the likelihood maximization approach for finding reaction coordinates. J. Chem. Phys. 127:034109
135. BeckhamGT, Bomble YJ, Matthews JF, ReschMG, Yarbrough JM, et al. 2010. TheO-glycosylated linker from the Trichoderma reesei Family 7 cellulase is a flexible, disordered protein. Biophys. J. 99(11):3773-81
136. Zhang YHP, Lynd LR. 2004. Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems. Biotechnol. Bioeng. 88:797-824 (Pubitemid 40003769)
137. Movagarnejad K, Sohrabi M, Kaghazchi T, Vahabzadeh F. 2000. A model for the rate of enzymatic hydrolysis of cellulose in heterogeneous solid-liquid systems. Biochem. Eng. J. 4:197-206 (Pubitemid 30020219)
138. Bansal P, Hall M, Realff MJ, Lee JH, Bommarius AS. 2009. Modeling cellulase kinetics on lignocellulosic substrates. Biotechnol. Adv. 27:833-48
139. Zhang YHP, Lynd LR. 2006. A functionally based model for hydrolysis of cellulose by fungal cellulase. Biotechnol. Bioeng. 94:888-98 (Pubitemid 44186896)
140. Jalak J, Valjamae P. 2010. Mechanism of initial rapid rate retardation in cellobiohydrolase catalyzed cellulose hydrolysis. Biotechnol. Bioeng. 106:871-83
141. ZhangYHP,HimmelME, Mielenz JR. 2006. Outlook for cellulase improvement: Screening and selection strategies. Biotechnol. Adv. 24:452-81 (Pubitemid 44082013)
142. Korkegian A, Black ME, Baker D, Stoddard BL. 2005. Computational thermostabilization of an enzyme. Science 308:857-60 (Pubitemid 40629266)
143. Prescher JA, Bertozzi CR. 2006. Chemical technologies for probing glycans. Cell 126:851-54 (Pubitemid 44310782)
144. Lynd LR, van Zyl WH, McBride JE, Laser M. 2005. Consolidated bioprocessing of cellulosic biomass: An update. Curr. Opin. Biotechnol. 16:577-83 (Pubitemid 41393839)
145. Lau MW, Dale BE. 2009. Cellulosic ethanol production from AFEX-treated corn stover using Saccharomyces cerevisiae 424A(LNH-ST). Proc. Natl. Acad. Sci. USA 106:1368-73
146. Lau M, Gunawan C, Dale B. 2009. The impacts of pretreatment on the fermentability of pretreated lignocellulosic biomass: A comparative evaluation between ammonia fiber expansion and dilute acid pretreatment. Biotechnol. Biofuels 2:30
147. Atsumi S, Liao JC. 2008. Metabolic engineering for advanced biofuels production from Escherichia coli. Curr. Opin. Biotechnol. 19:414-19
148. Roman-Leshkov Y, Barrett CJ, Liu ZY, Dumesic JA. 2007. Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates. Nature 447:982-85 (Pubitemid 46975757)
149. Lu YL, Warner R, Sedlak M, Ho N, Mosier NS. 2009. Comparison of glucose/xylose cofermentation of poplar hydrolysates processed by different pretreatment technologies. Biotechnol. Prog. 25:349-56
150. Zhong L, Matthews JF, Crowley MF, Rignall T, Talon C, et al. 2008. Interactions of the complete cellobiohydrolase I from Trichodera reesei with microcrystalline cellulose Iβ. Cellulose 15:261-73