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We thank K. Roberts for thoughtful suggestions. This work was supported by grants from the U.S. Department of Energy (DE-FG02-03ER20133) and the NSF (MCB 0114562). T.H. and S.V. were recipients of fellowships from the Deutche Forschungsgemeinschaft. S.P. was the recipient of a fellowship from the Carl Tryggers Foundation (CTS 03258). H.Y. was supported by a fellowship from the NIH Stanford Training Program in Genomics.
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