Organ targeted prenatal gene therapy-how far are we?

Prenatal Diagnosis

Volumn 31, Issue 7, 2011, Pages 720-734

  Mehta, Vedanta ^a   Abi Nader, Khalil ^a   Waddington, Simon ^a   David, Anna L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Congenital disease; Fetal gene therapy; Ultrasound; Vector

Indexed keywords

ADENOVIRUS VECTOR; ALPHA GLOBIN; ALPHA GLUCOSIDASE; BETA GALACTOSIDASE; BETA GLUCURONIDASE; BILIRUBIN; BLOOD CLOTTING FACTOR 7; COMPLEMENTARY DNA; DYSTROPHIN; ELONGATION FACTOR 1ALPHA; ENHANCED GREEN FLUORESCENT PROTEIN; FIBROBLAST GROWTH FACTOR 10; FLUOROCARBON; GREEN FLUORESCENT PROTEIN; KALININ; LENTIVIRUS VECTOR; LEVO IDURONIDASE; LUCIFERASE; MICRORNA; NITRIC OXIDE DONOR; PARVOVIRUS VECTOR; RECOMBINANT BLOOD CLOTTING FACTOR 9; RETROVIRUS VECTOR; SILDENAFIL; SURVIVAL MOTOR NEURON PROTEIN; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNINDEXED DRUG; VASCULOTROPIN;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ALPHA LEVO IDURONIDASE DEFICIENCY; AMNION FLUID; ARTERY BLOOD FLOW; BLOOD BRAIN BARRIER; BLOOD DISEASE; BONE MARROW; BRAIN DAMAGE; BRAIN HEMORRHAGE; BREATHING MECHANICS; CARDIOVASCULAR SYSTEM; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CELL PROTECTION; CENTRAL NERVOUS SYSTEM; CHILDHOOD DISEASE; CYSTIC ADENOMATOID MALFORMATION; CYSTIC FIBROSIS; DUCHENNE MUSCULAR DYSTROPHY; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME DEFICIENCY; EPIDERMIS; EPIDERMIS CELL; EPIDERMOLYSIS BULLOSA; EX VIVO GENE TRANSFER; FETOSCOPY; FETUS LUNG; FIRST TRIMESTER PREGNANCY; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC DISORDER; GENODERMATOSIS; GERM CELL; GERM LINE GENE THERAPY; GESTATIONAL AGE; GLOBIN GENE; HEART MUSCLE; HEMATOPOIETIC SYSTEM; HEMOPHILIA B; HERPES SIMPLEX VIRUS; HUMAN; HUMORAL IMMUNITY; HYPOBETALIPOPROTEINEMIA; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; LEBER CONGENITAL AMAUROSIS; LIVER; LIVER DISEASE; LIVER NECROSIS; LUNG HYPOPLASIA; LUNG INJURY; LUNG PARENCHYMA; MORBIDITY; MORTALITY; MOTOR PERFORMANCE; MUCOPOLYSACCHARIDOSIS; MUSCLE CELL; MUSCLE WEAKNESS; NONHUMAN; ORNITHINE TRANSCARBAMYLASE DEFICIENCY; PERICARDIUM; PERITONEAL CAVITY; PLACENTA CIRCULATION; PLACENTA INSUFFICIENCY; POSTNATAL CARE; PRENATAL CARE; PRENATAL DIAGNOSIS; PRENATAL GENE THERAPY; PRENATAL SCREENING; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PSEUDOTYPING; REPORTER GENE; RETROVIRUS; REVIEW; RNA BINDING; SENSE ORGAN; STEM CELL; STEM CELL GENE THERAPY; TROPISM; UMBILICAL VEIN; UNINEPHRECTOMY; UROGENITAL SYSTEM; VIRUS REPLICATION; VISION; X LINKED SEVERE COMBINED IMMUNODEFICIENCY;

ANIMALS; EMBRYONIC STEM CELLS; FEMALE; FETAL THERAPIES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC DISEASES, INBORN; HUMANS; ORGAN SPECIFICITY; PREGNANCY;

EID: 79959349503     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2787     Document Type: Review

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