Fetal gene transfer using lentiviral vectors: In vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys

Human Gene Therapy

Volumn 17, Issue 12, 2006, Pages 1254-1261

  Tarantal, Alice F ^a,b,c   Lee, C Chang I ^a,b   Jimenez, Daniel F ^a,b   Cherry, Simon R ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [4 FLUORO 3 (HYDROXYMETHYL)BUTYL]GUANINE F 18; CONTRAST MEDIUM; FIREFLY LUCIFERASE; HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE; LENTIVIRUS VECTOR; THYMIDINE KINASE; VESICULAR STOMATITIS VIRUS GLYCOPROPTEIN; VIRUS ENZYME; VIRUS GLYCOPROTEIN;

ABDOMEN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; DIAPHRAGM; ECHOGRAPHY; FETUS; FETUS CIRCULATION; FLUORESCENCE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; GESTATION PERIOD; HUMAN IMMUNODEFICIENCY VIRUS 1; IMAGE ANALYSIS; IMAGING; IMAGING SYSTEM; IN VIVO STUDY; LENTIVIRINAE; MACACA; MICROPET IMAGING; NEWBORN; NONHUMAN; OMENTUM; PERINATAL PERIOD; PERITONEUM; POLYMERASE CHAIN REACTION; PROCESS DEVELOPMENT; PROCESS MONITORING; PROMOTER REGION; PROTEIN EXPRESSION; TECHNIQUE; TRANSGENE; ULTRASOUND; VIRUS GENE;

ANIMALS; ANIMALS, NEWBORN; FEMALE; FETAL THERAPIES; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HIV-1; LENTIVIRUS; LUCIFERASES, FIREFLY; MACACA FASCICULARIS; MEMBRANE GLYCOPROTEINS; OPTICS; POSITRON-EMISSION TOMOGRAPHY; PREGNANCY; THYMIDINE KINASE; VIRAL ENVELOPE PROTEINS;

ANIMALIA; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA FASCICULARIS; VESICULAR STOMATITIS VIRUS;

EID: 33845788246     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2006.17.1254     Document Type: Article

References (30)

1. BENVENISTE, H., FOWLER, J.S., ROONEY, W.D., MOLLER, D.H., BACKUS, W.W., WARNER, D.A., CARTER, P., KING, P., SCHARF, B., ALEXOFF, D.A., MA, Y., VASKA, P., SCHLYER, D., and VOLKOW, N.D. (2003). Maternal-fetal in vivo imaging: A combined PET and MRI study. J. Nucl. Med. 44, 1522-1530.
2. 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates. J. Nucl. Med. 46, 312-320.
3. BREMER, C., NTZIACHRISTOS, V., and WEISSLEDER, R. (2003). Optical-based molecular imaging: Contrast agents and potential medical applications. Eur. Radiol. 13, 231-243.
4. CHERRY, S.R. (2004). In vivo molecular and genomic imaging: New challenges for imaging physics. Phys. Med. Biol. 49, R13-R48.
5. CHERRY, S.R., and GAMBHIR, S.S. (2001). Use of positron emission tomography in animal research. ILAR J. 42, 219-232.
6. CONTAG, C.H., and BACHMANN, M.H. (2002). Advances in in vivo bioluminescence imaging of gene expression. Annu. Rev. Biomed. Eng. 4, 235-260.
7. DE, A., LEWIS, X.Z., and GAMBHIR, S.S. (2003). Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice. Mol. Ther. 7, 681-691.
8. GAMBHIR, S.S., BARRIO, J.R., PHELPS, M.E., IYER, M., NAMAVARI, M., SATYAMURTHY, N., WU, L., GREEN, L.A., BAUER, E., MACLAREN, D.C., NGUYEN, K., BERK, A.J., CHERRY, S.R., and HERSCHMAN, H.R. (1999). Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. U.S.A. 96, 2333-2338.
9. GAMBHIR, S.S., BAUER, E., BLACK, M.E., LIANG, Q., KOKORIS, M.S., BARRIO, J.R., IYER, M., NAMAVARI, M., PHELPS, M.E., and HERSCHMAN, H.R. (2000a). A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Natl. Acad. Sci. U.S.A. 97, 2785-2790.
10. GAMBHIR, S.S., HERSCHMAN, H.R., CHERRY, S.R., BARRIO, J.R., SATYAMURTHY, N., TOYOKUNI, T., PHELPS, M.E., LARSON, S.M., BALATONI, J., FINN, R., SADELAIN, M., TJUVAJEV, J., and BLASBERG, R. (2000b). Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2, 118-138.
11. JIMENEZ, D.F., LEE, C.I., O'SHEA, C.E., KOHN, D.B., and TARANTAL, A.F. (2005). HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys. Gene Ther. 12, 821-830.
12. LEE, C.C., JIMENEZ, D.F., KOHN, D.B., and TARANTAL, A.F. (2005). Fetal gene transfer using lentiviral vectors and the potential for germ cell transduction in rhesus monkeys (Macaca mulatta). Hum. Gene Ther. 16, 417-425.
13. MIN, J.J., and GAMBHIR, S.S. (2004). Gene therapy progress and prospects: Noninvasive imaging of gene therapy in living subjects. Gene Ther. 11, 115-125.
14. PHELPS, M.E. (2000a), Inaugural article: Positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. U.S.A. 97, 9226-9233.
15. PHELPS, M.E. (2000b). PET: The merging of biology and imaging into molecular imaging. J. Nucl. Med. 41, 661-681.
16. RAY, P., WU, A.M., and GAMBHIR, S.S. (2003). Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Res. 63, 1160-1165.
17. SADIKOT, R.T., and BLACKWELL, T.S. (2005). Bioluminescence imaging. Proc. Am. Thorac. Soc. 2, 537-540, 511-532.
18. TAI, Y.C., RUANGMA, A., ROWLAND, D., SIEGEL, S., NEWPORT, D.F., CHOW, P.L., and LAFOREST, R. (2005). Performance evaluation of the microPET focus: A third-generation microPET scanner dedicated to animal imaging. J. Nucl. Med. 46, 455-463.
19. TARANTAL, A.F. (1990). Interventional ultrasound in pregnant macaques: Embryonic/fetal applications. J. Med. Primatol. 19, 47-58.
20. TARANTAL, A.F. (2005). Ultrasound imaging in rhesus (Macaca mulatta) and long-tailed (Macaca fascicularis) macaques: Reproductive and research applications. In The Laboratory Primate. S. Wolfe-Coote, ed. (Elsevier Academic Press, San Diego, CA) pp. 317-352.
21. TARANTAL, A.F., and GARGOSKY, S.E. (1995). Characterization of the insulin-like growth factor (IGF) axis in the serum of maternal and fetal macaques (Macaca fascicularis and Macaca mulatta). Growth Regul. 5, 190-198.
22. TARANTAL, A.F., and HENDRICKX, A.G. (1988a). Prenatal growth in the cynomolgus and rhesus macaque (Macaca fascicularis and Macaca mulatta): A comparison by ultrasonography. Am. J. Primatol. 15, 310-323.
23. TARANTAL, A.F., and HENDRICKX, A.G. (1988b). Use of ultrasound for early pregnancy detection in the rhesus and cynomolgus macaque (Macaca mulatta and Macaca fascicularis). J. Med. Primatol. 17, 105-112.
24. TARANTAL, A.F., and HENDRICKX, A.G. (1989). Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus macaque (Macaca fascicularis). I. Neonatal/infant observations. Teratology 39, 137-147.
25. TARANTAL, A.F., O'ROURKE, J.P., CASE, S.S., NEWBOUND, G.C., LI, J., LEE, C.I., BASKIN, C.R., KOHN, D.B., and BUNNELL, B.A. (2001a). Rhesus monkey model for fetal gene transfer: Studies with retroviral-based vector systems. Mol. Ther. 3, 128-138.
26. TARANTAL, A.F., LEE, C.I., EKERT, J.E., MCDONALD, R., KOHN, D.B., PLOPPER, C.G., CASE, S.S., and BUNNELL, B.A. (2001b). Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): Lung-targeting approaches. Mol. Ther. 4, 614-621.
27. TARANTAL, A.F., MCDONALD, R.J., JIMENEZ, D.F., LEE, C.C., O'SHEA, C.E., LEAPLEY, A.C., WON, R.H., PLOPPER, C.G., LUTZKO, C., and KOHN, D.B. (2005). Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): Safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery. Mol. Ther. 12, 87-98.
28. 18F]FHBG: A reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J. Nucl. Med. 42, 1225-1234.
29. YU, Y., ANNALA, A.J., BARRIO, J.R., TOYOKUNI, T., SATYAMURTHY, N., NAMAVARI, M., CHERRY, S.R., PHELPS, M.E., HERSCHMAN, H.R., and GAMBHIR, S.S. (2000). Quantification of target gene expression by imaging reporter gene expression in living animals. Nat. Med. 6, 933-937.
30. ZHAO, H., DOYLE, T.C., COQUOZ, O., KALISH, F., RICE, B.W., and CONTAG, C.H. (2005). Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo. J. Biomed. Opt. 10, 41210.