Correction of sickle cell disease in transgenic mouse models by gene therapy

Science

Volumn 294, Issue 5550, 2001, Pages 2368-2371

  Pawliuk, R ^a   Westerman, K A ^a   Fabry, M E ^a   Payen, E ^a   Tighe, R ^a   Bouhassira, E E ^a   Acharya, S A ^a   Ellis, J ^a   London, I M ^a   Eaves, C J ^a   Humphries, R K ^a   Beuzard, Y ^a   Nagel, R L ^a   Leboulch, P ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; DEHYDRATION; GENES; POLYMERIZATION; PROTEINS; TRANSPLANTATION (SURGICAL);

SICKLE CELL DISEASES (SCD);

DISEASE CONTROL;

BETA GLOBULIN; IMMUNOGLOBULIN;

DISEASE; GENE; MUTATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GENE THERAPY; MOUSE; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; SICKLE CELL ANEMIA; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; DISEASE MODELS, ANIMAL; ERYTHROCYTES; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GLOBINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HEMOGLOBIN, SICKLE; HIV-1; HUMANS; LENTIVIRUS; LOCUS CONTROL REGION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXYHEMOGLOBINS; RNA, MESSENGER; THALASSEMIA; TRANSDUCTION, GENETIC; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 0035861452     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1065806     Document Type: Article

References (35)