Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus

Gene Therapy

Volumn 4, Issue 9, 1997, Pages 883-890

  Douar, A M ^a,b   Adebakin, S ^a   Themis, M ^a   Pavirani, A ^c   Cook, T ^a   Coutelle, C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GÉNÉTHON   (France)

^c TRANSGENE S A   (France)

Author keywords

Foetal targeting; Gene therapy; Viral vectors

Indexed keywords

BETA GALACTOSIDASE; VIRUS VECTOR;

ADENOVIRUS; AMNION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYSTIC FIBROSIS; ENZYME ACTIVITY; FETUS; GENE TARGETING; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; TRANSGENE; VIRUS RECOMBINANT;

EID: 0030867444     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300498     Document Type: Article

References (24)

1. Douar AM, Themis M, Coutelle C. Foetal somatic gene therapy. Hum Mol Reprod 1996; 2: 633-641.
2. Brace RA. Progress towards understanding the regulation of amniotic fluid volume: water and solute fluxes in and through the fetal membranes. Placenta 1995; 16: 1-18.
3. Badalian SS, Chao CR, Fox HE, Timor TI. Fetal breathing-related nasal fluid flow velocity in uncomplicated pregnancies. Am J Obstet Gynecol 1993; 169, 563-567.
4. Gaillard D et al. Immunohistochemical localization of cystic fibrosis transmembrane conductance regulator in human fetal airway and digestive mucosa. Pediatr Res 1994; 36: 137-143.
5. Tizzano EF et al. Regional expression of CFTR in developing human respiratory tissues. Am J Respir Cell Mol Biol 1994; 10: 355-362.
6. Trezise AE et al. Expression of the cystic fibrosis gene in human foetal tissues. Hum Mol Genet 1993; 2: 212-218.
7. Coutelle C, Douar AM, Colledge WH, Froster U. The challenge of fetal gene therapy. Nature Med 1995; 1: 864-866.
8. Sekhon HS, Larson EJ. In utero gene transfer into pulmonary epithelium. Nature Med 1995; 1: 1201-1203
9. Pitt BR et al. Retrovirus-mediated gene transfer in lungs of living fetal sheep. Gene Therapy 1995; 2: 344-350.
10. McCray PJ et al. Adenovirus-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo. J. Clin Invest 1995; 95: 2620-2632.
11. Holzinger A et al. Intra-amniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues. Pediatr Res 1995; 38: 844-850.
12. Grossman M et al Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 6: 335-341.
13. Rill DR et al. Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumongenic cells. Blood 1994; 84: 380-383.
14. Blaese RM et al. T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science 1995; 270: 475-480.
15. Welsh RJ, Cooper NR, Jensen FC, Oldstone MB. Human serum lyses RNA tumor viruses. Nature 1975; 257: 612-614.
16. Russel DW, Berger MS, Miller AD. The effects of human serum and cerebrospinal fluid on retroviral vectors and packaging cell lines Hum Gene Ther 1995; 6: 635-641.
17. Cosset F-L et al. High-titer packaging cells producing recombi- nant retroviruses resistant to human serum. J Virol 1995; 69: 7430-7436.
18. Douar AM et al. Effect of amniotic fluid on cationic lipid mediated transfection and retroviral infection. Gene Therapy 1996; 3: 789-796.
19. Vincent MC et al. Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero. Hum Gene Ther 1995; 6: 1019-1028.
20. Fassati A, Wells DJ, Walsh FS, Dickson G. Transplantation of retroviral producer cells for in vivo gene transfer into mouse skeletal muscle. Hum Gene Ther 1996; 7: 595-602.
21. Jones SN et al. Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice J Biol Chem 1990; 265: 14684-14690.
22. Papaioannou VE. In utero manipulations. Postimplantation Mammalian Embryos. A Practical Approach. JRL Press: Oxford, WA, 1990, pp 61-80.
23. Yee JK et al. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci USA 1994; 91: 9564-9568.
24. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.