In Vivo Delivery of Recombinant Viruses to the Fetal Murine Cochlea: Transduction Characteristics and Long-Term Effects on Auditory Function

Molecular Therapy

Volumn 14, Issue 3, 2006, Pages 328-335

  Bedrosian, Jeffrey C ^a,b   Gratton, Michael Anne ^b   Brigande, John V ^c   Tang, Waixing ^a   Landau, Jessica ^b   Bennett, Jean ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

adeno associated virus; cochlea; gene transfer; hair cells; hearing loss; in utero therapy; mouse model

Indexed keywords

LENTIVIRUS VECTOR; PARVOVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SPECIFICITY; COCHLEA; COCHLEAR NERVE; CONGENITAL DEAFNESS; CONTROLLED STUDY; EMBRYO; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; FETUS; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HAIR CELL; HEARING TEST; IN VIVO STUDY; MOUSE; MOUSE STRAIN; NONHUMAN; SAFETY; SEROTYPE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

ANIMALS; CELL DIFFERENTIATION; COCHLEA; DEPENDOVIRUS; FEMALE; FETUS; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HAIR CELLS, INNER; HAIR CELLS, OUTER; HEARING LOSS, SENSORINEURAL; LENTIVIRUS; MICE; MICROINJECTIONS; TRANSDUCTION, GENETIC; UTERUS;

LENTIVIRUS; MURINAE;

EID: 33746865345     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.04.003     Document Type: Article

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