Cytoskeletal protein kinases: Titin and its relations in mechanosensing

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 1, 2011, Pages 119-134

  Gautel, Mathias ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Autophagy; Connectin; Mechanical strain sensor; Mechanobiology; MURF; Myomesin; Myosin light chain kinase; Nbr1; Obscurin; p62 SQSTM1; Sarcomere; Telethonin TCAP; Titin; Twitchin

Indexed keywords

ACTIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CELL ENZYME; CONNECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN; MYOSIN LIGHT CHAIN KINASE; PROTEIN DAPK1; PROTEIN DRAK2; PROTEIN KINASE; PROTEIN MURF2; PROTEIN P62; PROTEIN SQSTM1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HEART MUSCLE CELL; HUMAN; MATRIX ATTACHMENT REGION; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN REFOLDING; PROTEIN UNFOLDING; REVIEW; SKELETAL MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; CYTOSKELETAL PROTEINS; CYTOSKELETON; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MYOSIN-LIGHT-CHAIN KINASE; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN UNFOLDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79958862768     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0946-1     Document Type: Review

References (142)

1. I Agarkova JC Perriard 2005 The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere Trends Cell Biol 15 477 85 16061384 1:CAS:528:DC%2BD2MXpvFenu7k%3D (Pubitemid 41253467)
2. I Agarkova E Ehler S Lange R Schoenauer JC Perriard 2003 M-band: a safeguard for sarcomere stability? J Muscle Res Cell Motil 24 191 203 14609030 1:CAS:528:DC%2BD3sXnslSns7s%3D (Pubitemid 37323621)
3. N Akiyama Y Ohnuki Y Kunioka Y Saeki T Yamada 2006 Transverse stiffness of myofibrils of skeletal and cardiac muscles studied by atomic force microscopy J Physiol Sci 56 145 151 16839448 (Pubitemid 46955926)
4. P Amodeo MA Castiglione Morelli G Strazzullo P Fucile M Gautel A Motta 2001 Kinase recognition by calmodulin: modeling the interaction with the autoinhibitory region of human cardiac titin kinase J Mol Biol 306 81 95 11178895 1:CAS:528:DC%2BD3MXhtFKrtL0%3D (Pubitemid 33027734)
5. SV Avrova NS Shelud'ko YS Borovikov S Galler 2009 Twitchin of mollusc smooth muscles can induce "catch"-like properties in human skeletal muscle: support for the assumption that the "catch" state involves twitchin linkages between myofilaments J Comp Physiol B 179 945 50 19543896 1:CAS:528:DC%2BD1MXht1OgtLrK
6. Backues SK and Klionsky DJ (2010) Autophagy gets in on the regulatory act. J Mol Cell Biol (in press)
7. K Barany A Rokolya M Barany 1990 Stretch activates myosin light chain kinase in arterial smooth muscle Biochem Biophys Res Commun 173 164 171 2256911 1:CAS:528:DyaK3MXitFGktQ%3D%3D
8. D Barsyte-Lovejoy A Galanis A Clancy AD Sharrocks 2004 ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif Biochem J 381 693 9 15132737 1:CAS:528:DC%2BD2cXlvFGqu74%3D (Pubitemid 39120478)
9. GM Benian JE Kiff N Neckelmann DG Moerman RH Waterston 1989 Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans Nature 342 45 50 2812002 1:CAS:528:DyaK3cXivFCr (Pubitemid 19271116)
10. GM Benian A Ayme-Southgate TL Tinley 1999 The genetics and molecular biology of the titin/connectin-like proteins of invertebrates Rev Physiol Biochem Pharmacol 138 235 68 10396143 1:CAS:528:DyaK1MXktVejsbo%3D
11. O Bergmann RD Bhardwaj S Bernard S Zdunek F Barnabe-Heider S Walsh J Zupicich K Alkass BA Buchholz H Druid S Jovinge J Frisen 2009 Evidence for cardiomyocyte renewal in humans Science 324 98 102 19342590 1:CAS:528: DC%2BD1MXjvVajsbc%3D
12. M Bertz M Wilmanns M Rief 2009 The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk Proc Natl Acad Sci USA 106 13307 133310 19622741 1:CAS:528:DC%2BD1MXhtVOitr%2FE
13. S Bialik A Kimchi 2010 Lethal weapons: DAP-kinase, autophagy and cell death DAP-kinase regulates autophagy Curr Opin Cell Biol 22 199 205 20005690 1:CAS:528:DC%2BC3cXks1Srur4%3D
14. J Boudeau D Miranda-Saavedra GJ Barton DR Alessi 2006 Emerging roles of pseudokinases Trends Cell Biol 16 443 52 16879967 1:CAS:528:DC%2BD28XptFChsbo%3D (Pubitemid 44293399)
15. TM Butler MJ Siegman 2011 A force-activated kinase in a catch smooth muscle J Muscle Res Cell Motil 31 349 358 21286791 1:CAS:528: DC%2BC3MXitlejs7o%3D
16. TM Butler SU Mooers SR Narayan MJ Siegman 2010 The N-terminal region of twitchin binds thick and thin contractile filaments: redundant mechanisms of catch force maintenance J Biol Chem 285 40654 65 20971853 1:CAS:528: DC%2BC3cXhsFynsL3L
17. B Cariou D Perdereau K Cailliau E Browaeys-Poly V Bereziat M Vasseur-Cognet J Girard AF Burnol 2002 The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta Mol Cell Biol 22 6959 6970 12242277 1:CAS:528:DC%2BD38XnsFKitr0%3D
18. L Carlsson J-G Yu M Moza O Carpen L-E Thornell 2007 Myotilin: a prominent marker of myofibrillar remodelling Neuromuscul Disord 17 61 68 17056257 (Pubitemid 46201768)
19. JY Chan M Takeda LE Briggs ML Graham JT Lu N Horikoshi EO Weinberg H Aoki N Sato KR Chien H Kasahara 2008 Identification of cardiac-specific myosin light chain kinase Circ Res 102 571 80 18202317 1:CAS:528:DC%2BD1cXjtVerurs%3D (Pubitemid 351416756)
20. Crowther LM, Wang SC, Eriksson NA, Myers S, Murray L and Muscat GE (2010) chicken ovalbumin upstream promoter-transcription factor II regulates nuclear receptor, myogenic and metabolic gene expression in skeletal muscle cells. Physiol Genomics (in press)
21. KS Dai CC Liew 2001 A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain J Biol Chem 276 23992 23999 11283016 1:CAS:528:DC%2BD3MXltVWisrg%3D
22. C Däpp S Schmutz H Hoppeler M Flück 2004 Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle Physiol Genomics 20 97 107 15479860
23. I de Diego J Kuper N Bakalova P Kursula M Wilmanns 2010 Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex Sci Signal 3 ra6 10.1126/scisignal.2000552 20103772
24. PP de Tombe RJ Solaro 2000 Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failure Ann Biomed Eng 28 991 1001 11144684 (Pubitemid 32085385)
25. MT Diaz-Meco J Moscat 2001 MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling Mol Cell Biol 21 1218 27 11158308 1:CAS:528:DC%2BD3MXovVCnsQ%3D%3D (Pubitemid 32114970)
26. H Dietz F Berkemeier M Bertz M Rief 2006 Anisotropic deformation response of single protein molecules Proc Natl Acad Sci USA 103 12724 8 16908850 1:CAS:528:DC%2BD28XptVyntLc%3D (Pubitemid 44298628)
27. D Dinev BW Jordan B Neufeld JD Lee D Lindemann UR Rapp S Ludwig 2001 Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells EMBO Rep 2 829 34 11520859 1:CAS:528: DC%2BD3MXns1WgtbY%3D (Pubitemid 32982752)
28. A Duran M Serrano M Leitges JM Flores S Picard JP Brown J Moscat MT Diaz-Meco 2004 The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis Dev Cell 6 303 9 14960283 1:CAS:528:DC%2BD2cXhs1Slsro%3D (Pubitemid 38190368)
29. AC Durieux D Desplanches D Freyssenet M Fluck 2007 Mechanotransduction in striated muscle via focal adhesion kinase Biochem Soc Trans 35 1312 3 17956339 1:CAS:528:DC%2BD2sXht1eru7fP (Pubitemid 350206488)
30. E Ehler M Gautel 2008 The sarcomere and sarcomerogenesis Adv Exp Med Biol 642 1 14 19181089 1:CAS:528:DC%2BC3cXhtlemtrbL
31. GP Farman EJ Allen D Gore TC Irving PP de Tombe 2007 Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae Biophys J 92 L73 5 17293398 1:CAS:528:DC%2BD2sXkvVSmt70%3D
32. A Fukuzawa S Idowu M Gautel 2005 Complete human gene structure of obscurin: implications for isoform generation by differential splicing J Muscle Res Cell Motil 26 427 34 16625316 1:CAS:528:DC%2BD28XmsVSjsrc%3D
33. A Fukuzawa S Lange MR Holt A Vihola V Carmignac A Ferreiro AB Udd M Gautel 2008 Interactions with titin and myomesin target obscurin and its small homologue, obscurin-like 1, to the sarcomeric M-band: implications for hereditary myopathies J Cell Sci 121 1841 1851 18477606 1:CAS:528: DC%2BD1cXotVygurg%3D (Pubitemid 351943377)
34. D Funabara C Hamamoto K Yamamoto A Inoue M Ueda R Osawa S Kanoh DJ Hartshorne S Suzuki S Watabe 2007 Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch J Exp Biol 210 4399 410 18055628 1:CAS:528:DC%2BD1cXhslOjsr8%3D
35. M Gautel 2008 The sarcomere and the nucleus: functional links to hypertrophy, atrophy and sarcopenia Adv Med Biol Exp 642 176 191 1:CAS:528:DC%2BC3cXhtlemtrfF
36. M Gautel 2010 The sarcomeric cytoskeleton: who picks up the strain? Curr Opin Cell Biol 23 39 46 21190822
37. M Gautel M Castiglione-Morelli M Pfuhl A Motta A Pastore 1995 A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase Eur J Biochem 230 752 759 7607248 1:CAS:528:DyaK2MXmtlSqtrk%3D
38. F Grater J Shen H Jiang M Gautel H Grubmuller 2005 Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations Biophys J 88 790 804 15531631 (Pubitemid 40975919)
39. D Greene T Garcia B Sutton KM Gernert GM Benian AF Oberhauser 2008 Single-molecule force spectroscopy reveals a stepwise unfolding of C. elegans giant protein kinase domains Biophys J 95 1360 1370 18390597 1:CAS:528:DC%2BD1cXovFWhtbg%3D
40. K Haglund I Dikic 2005 Ubiquitylation and cell signaling EMBO J 24 3353 9 16148945 1:CAS:528:DC%2BD2MXhtVKns7zO (Pubitemid 41486773)
41. SK Hanks T Hunter 1995 Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification FASEB J 9 576 96 7768349 1:CAS:528:DyaK2MXmt1ajsbc%3D
42. V Hatch G Zhi L Smith JT Stull R Craig W Lehman 2001 Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction J Cell Biol 154 611 7 11481347 1:CAS:528:DC%2BD3MXlvVGkuro%3D (Pubitemid 34286165)
43. RS Haworth F Cuello TJ Herron G Franzen JC Kentish M Gautel M Avkiran 2004 Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function Circ Res 95 1091 1099 15514163 1:CAS:528:DC%2BD2cXpvVGmtbs%3D (Pubitemid 39557896)
44. T Hayashi T Arimura M Itoh-Satoh K Ueda S Hohda N Inagaki M Takahashi H Hori M Yasunami H Nishi Y Koga H Nakamura M Matsuzaki BY Choi SW Bae CW You KH Han JE Park R Knoll M Hoshijima KR Chien A Kimura 2004 Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy J Am Coll Cardiol 44 2192 201 15582318 1:CAS:528:DC%2BD2cXhtVCktLrP (Pubitemid 39576040)
45. J Heierhorst B Kobe SC Feil MW Parker GM Benian KR Weiss BE Kemp 1996 Ca2+/S100 regulation of giant protein kinases Nature 380 636 9 8602266 1:CAS:528:DyaK28XisVeguro%3D
46. 2+/S100- dependent protein kinases Eur J Biochem 242 454 459 9022668 1:CAS:528: DyaK2sXlsFOgtg%3D%3D
47. LJ Holt K Siddle 2005 Grb10 and Grb14: enigmatic regulators of insulin action-and more? Biochem J 388 393 406 15901248 1:CAS:528:DC%2BD2MXks1GlsLY%3D (Pubitemid 40839916)
48. F Hong BD Haldeman OA John PD Brewer YY Wu S Ni DP Wilson MP Walsh JE Baker CR Cremo 2009 Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes J Mol Biol 390 879 92 19477187 1:CAS:528:DC%2BD1MXosV2nsrY%3D
49. R Horowits RJ Podolsky 1987 The positional stability of thick filaments in activated skeletal muscle depends on sarcomere length: evidence for the role of titin filaments J Cell Biol 105 2217 2223 3680378 1:CAS:528: DyaL1cXjsFClsg%3D%3D (Pubitemid 18019071)
50. M Hoshijima 2006 Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures Am J Physiol Heart Circ Physiol 290 H1313 1325 16537787 1:CAS:528:DC%2BD28Xks1Sgu7Y%3D
51. S-H Hu MW Parker JY Lei MCJ Wilce GM Benian BE Kemp 1994 Insights into autoregulation from the crystal structure of twitchin kinase Nature 369 581 584 8202162 1:CAS:528:DyaK2cXlsFajur8%3D (Pubitemid 24192530)
52. HE Huxley AR Faruqi M Kress J Bordas MH Koch 1982 Time-resolved X-ray diffraction studies of the myosin layer-line reflections during muscle contraction J Mol Biol 158 637 84 6981706 1:CAS:528:DyaL38XltVOru7c%3D (Pubitemid 12044690)
53. M Ikura GM Clore AM Gronenborn G Zhu CB Klee A Bax 1992 Solution structure of a calmodulin-target peptide complex by multi-dimensional NMR Science 256 632 638 1585175 1:CAS:528:DyaK38XltVKlsr0%3D
54. Johansen T, Lamark T (2011) Selective autophagy mediated by autophagic adapter proteins. Autophagy 7
55. I Joung JL Strominger J Shin 1996 Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain Proc Natl Acad Sci USA 93 5991 5995 8650207 1:CAS:528:DyaK28Xjs1Ojsb8%3D
56. KE Kamm JT Stull 2001 Dedicated myosin light chain kinases with diverse cellular functions J Biol Chem 276 4527 4530 11096123 1:CAS:528: DC%2BD3MXhtlOqsL0%3D
57. V Kirkin T Lamark YS Sou G Bjorkoy JL Nunn JA Bruun E Shvets DG McEwan TH Clausen P Wild I Bilusic JP Theurillat A Overvatn T Ishii Z Elazar M Komatsu I Dikic T Johansen 2009 A role for NBR1 in autophagosomal degradation of ubiquitinated substrates Mol Cell 33 505 16 19250911 1:CAS:528: DC%2BD1MXltFSnu7k%3D
58. B Kobe J Heierhorst SC Feil MW Parker GB Benian KR Weiss BE Kemp 1996 Giant protein kinases: domain interactions and structural basis of autoregulation EMBO J 15 6810 6821 9003756 1:CAS:528:DyaK2sXosFejsQ%3D%3D (Pubitemid 27023251)
59. M Komatsu S Waguri M Koike YS Sou T Ueno T Hara N Mizushima J Iwata J Ezaki S Murata J Hamazaki Y Nishito S Iemura T Natsume T Yanagawa J Uwayama E Warabi H Yoshida T Ishii A Kobayashi M Yamamoto Z Yue Y Uchiyama E Kominami K Tanaka 2007 Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 1149 63 18083104 1:CAS:528:DC%2BD1cXksFGnsg%3D%3D (Pubitemid 350235021)
60. A Kontrogianni-Konstantopoulos MA Ackermann AL Bowman SV Yap RJ Bloch 2009 Muscle giants: molecular scaffolds in sarcomerogenesis Physiol Rev 89 1217 67 19789381 1:CAS:528:DC%2BD1MXhtlyqs7rN
61. M Kruger WA Linke 2009 Titin-based mechanical signalling in normal and failing myocardium J Mol Cell Cardiol 46 490 498 19639676
62. DS Kudryashov OV Stepanova EL Vilitkevich TA Nikonenko ES Nadezhdina NA Shanina TJ Lukas LJ Van Eldik DM Watterson VP Shirinsky 2004 Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain Exp Cell Res 298 407 417 15265689 1:CAS:528: DC%2BD2cXlvVWhtr0%3D (Pubitemid 38950858)
63. S Labeit B Kolmerer 1995 Titins: giant proteins in charge of muscle ultrastructure and elasticity Science 270 293 296 7569978 1:CAS:528: DyaK2MXoslehs7Y%3D
64. S Labeit M Gautel A Lakey J Trinick 1992 Towards a molecular understanding of titin EMBO J 11 1711 1716 1582406 1:CAS:528:DyaK3sXisV2qsbk%3D
65. S Lange F Xiang A Yakovenko A Vihola P Hackman E Rostkova J Kristensen B Brandmeier G Franzen B Hedberg LG Gunnarsson SM Hughes S Marchand T Sejersen I Richard L Edstrom E Ehler B Udd M Gautel 2005 The kinase domain of titin controls muscle gene expression and protein turnover Science 308 1599 1603 15802564 1:CAS:528:DC%2BD2MXltFems7s%3D (Pubitemid 40807503)
66. S Lange E Ehler M Gautel 2006 From A to Z and back? Multicompartment proteins in the sarcomere Trends Cell Biol 16 11 18 16337382 1:CAS:528:DC%2BD28XksVanug%3D%3D (Pubitemid 43077090)
67. R Ledvora K Barany D VanderMeulen J Barron M Barany 1983 Stretch-induced phosphorylation of the 20,000-dalton light chain of myosin in arterial smooth muscle J Biol Chem 258 14080 14083 6417135 1:CAS:528:DyaL3sXlvFagtLc%3D (Pubitemid 14217929)
68. EH Lee J Hsin M Sotomayor G Comellas K Schulten 2009 Discovery through the computational microscope Structure 17 1295 306 19836330 1:CAS:528: DC%2BD1MXht1ymsrfJ
69. WA Linke M Kruger 2010 The giant protein titin as an integrator of myocyte signaling pathways Physiol Bethesda 25 186 98 1:CAS:528: DC%2BC3cXpsFOhsr8%3D
70. G Manning DB Whyte R Martinez T Hunter S Sudarsanam 2002 The protein kinase complement of the human genome Science 298 1912 34 12471243 1:CAS:528:DC%2BD38Xpt1Wisb0%3D (Pubitemid 35425239)
71. J Mao H Luo B Han R Bertrand J Wu 2009 Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation J Immunol 182 4762 70 19342653 1:CAS:528:DC%2BD1MXjvFOjtbY%3D
72. SL Marcus CJ Winrow JP Capone RA Rachubinski 1996 A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor J Biol Chem 271 27197 200 8910285 1:CAS:528:DyaK28XmvVWntbc%3D (Pubitemid 26367263)
73. FK Mardakheh M Yekezare LM Machesky JK Heath 2009 Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling J Cell Biol 187 265 77 19822672 1:CAS:528:DC%2BD1MXhtlalsLbI
74. CD Markert MP Meaney KA Voelker RW Grange HW Dalley JK Cann M Ahmed B Bishwokarma SJ Walker SX Yu M Brown MW Lawlor AH Beggs MK Childers 2010 Functional muscle analysis of the Tcap knockout mouse Hum Mol Genet 19 2268 2283 20233748 1:CAS:528:DC%2BC3cXlvVWksL4%3D
75. K Maruyama 1976 Connectin, an elastic protein from myofibrils J Biochem 80 405 407 1002676 1:CAS:528:DyaE28XltFygsLc%3D
76. E Masiero M Sandri 2010 Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles Autophagy 6 307 309 20104028 1:CAS:528: DC%2BC3cXot1ehtr0%3D
77. P Mason S Bayol PT Loughna 1999 The novel sarcomeric protein telethonin exhibits developmental and functional regulation Biochem Biophys Res Commun 257 699 703 10208846 1:CAS:528:DyaK1MXisVaiu74%3D (Pubitemid 29301505)
78. O Mayans P Van der Ven M Wilm A Mues P Young DO Fürst M Wilmanns M Gautel 1998 Structural basis of the activation of the titin kinase domain during myofibrillogenesis Nature 395 863 869 9804419 1:CAS:528:DyaK1cXntlKjsbg%3D (Pubitemid 28503420)
79. MS McElhinny K Kakinuma H Sorimachi S Labeit CC Gregorio 2002 Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1 J Cell Biol 157 125 136 11927605 1:CAS:528:DC%2BD38Xis1Knsb4%3D (Pubitemid 34847835)
80. ES Moreira TJ Wiltshire G Faulkner A Nilforoushan M Vainzof OT Suzuki G Valle R Reeves M Zatz MR Passos-Bueno DE Jenne 2000 Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin Nat Genet 24 163 6 10655062 1:CAS:528:DC%2BD3cXhtFCgsbY%3D (Pubitemid 30094717)
81. K Mukherjee M Sharma R Jahn MC Wahl TC Sudhof 2010 Evolution of CASK into a Mg2+-sensitive kinase Sci Signal 3 ra33 20424264
82. AJ Murton D Constantin PL Greenhaff 2008 The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy Biochim Biophys Acta 1782 730 43 18992328 1:CAS:528:DC%2BD1cXhsVCntb%2FJ
83. SA Myers SC Wang GE Muscat 2006 The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism J Biol Chem 281 24149 60 16803904 1:CAS:528: DC%2BD28Xot1eqsrg%3D (Pubitemid 44274189)
84. K Nakamura AJ Kimple DP Siderovski GL Johnson 2010 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation J Biol Chem 285 2077 89 19903815 1:CAS:528:DC%2BC3cXjsVSqsg%3D%3D
85. RL Nicol N Frey G Pearson M Cobb J Richardson EN Olson 2001 Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy EMBO J 20 2757 67 11387209 1:CAS:528:DC%2BD3MXksFGrsbo%3D (Pubitemid 32938559)
86. WMJ Obermann M Gautel F Steiner P Van der Ven K Weber DO Fürst 1996 The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein and the 250 kD carboxy-terminal region of titin by immunoelectron microscopy J Cell Biol 134 1441 1453 8830773 1:CAS:528: DyaK28Xls1yktL0%3D (Pubitemid 26318017)
87. Ochala J, Gustafson A-M, Lano Diez M, Renaud G, Li M, Aare S, Qaisar R, Banduseela VC, Hedstrom Y, Tang X, Dworkin B, Ford GC, Nair S, Perera S, Gautel M, Larsson L (2011) Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms. J Physiol (in press)
88. K Okada T Yanagawa E Warabi K Yamastu J Uwayama K Takeda H Utsunomiya H Yoshida J Shoda T Ishii 2009 The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice Hepatol Res 39 490 500 19207582 1:CAS:528:DC%2BD1MXhsFemsbnL
89. KT O'Neil WF DeGrado 1990 How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices Trends Biochem Sci 15 59 64 2186516 (Pubitemid 20036857)
90. S Pankiv TH Clausen T Lamark A Brech J-A Bruun H Outzen A Overvatn G Bjorkoy T Johansen 2007 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J Biol Chem 282 24131 24145 17580304 1:CAS:528:DC%2BD2sXoslOntb0%3D (Pubitemid 47328003)
91. I Park J Chung CT Walsh Y Yun JL Strominger J Shin 1995 Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region Proc Natl Acad Sci USA 92 12338 42 8618896 1:CAS:528:DyaK28Xhtl2mtw%3D%3D
92. S Perera MR Holt BS Mankoo M Gautel 2011 Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover Dev Biol 351 46 61 21185285 1:CAS:528:DC%2BC3MXhvFehs7w%3D [Epub ahead of print Dec 22, 2010]
93. S Pernigo A Fukuzawa M Bertz M Holt M Rief RA Steiner M Gautel 2010 Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex Proc Natl Acad Sci USA 107 2908 2913 20133654 1:CAS:528:DC%2BC3cXis1Clt7k%3D
94. G Piazzesi M Reconditi M Linari L Lucii P Bianco E Brunello V Decostre A Stewart DB Gore TC Irving M Irving V Lombardi 2007 Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size Cell 131 784 95 18022371 1:CAS:528:DC%2BD2sXhsVSgurvM (Pubitemid 350103598)
95. V Pizon A Iakovenko PFM Van der Ven RA Kelly C Fatu DO Fürst E Karsenti M Gautel 2002 Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein J Cell Sci 115 4469 4482 12414993 1:CAS:528:DC%2BD38XpvVSqtL0%3D (Pubitemid 36004408)
96. EM Puchner HE Gaub 2009 Force and function: probing proteins with AFM-based force spectroscopy Curr Opin Struct Biol 19 605 14 19822417 1:CAS:528:DC%2BD1MXht1ylsLrI
97. E Puchner A Alexandrovich AL Kho U Hensen LV Schäfer B Brandmeier F Gräter H Grubmuller HE Gaub M Gautel 2008 Mechanoenzymatics of titin kinase Proc Natl Acad Sci USA 105 13385 13390 18765796 1:CAS:528:DC%2BD1cXhtFChs73K
98. A Puls S Schmidt F Grawe S Stabel 1997 Interaction of protein kinase C zeta with ZIP, a novel protein kinase C- binding protein Proc Natl Acad Sci USA 94 6191 6 9177193 1:CAS:528:DyaK2sXjvFCntb0%3D
99. PL Puri Z Wu P Zhang LD Wood KS Bhakta J Han JR Feramisco M Karin JY Wang 2000 Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells Genes Dev 14 574 584 10716945 1:CAS:528:DC%2BD3cXitFWrsrg%3D (Pubitemid 30159776)
100. M Rabiller M Getlik S Kluter A Richters S Tuckmantel JR Simard D Rauh 2010 Proteus in the world of proteins: conformational changes in protein kinases Arch Pharm Weinheim 343 193 206 20336692 1:CAS:528:DC%2BC3cXjvFaku7s%3D
101. CA Rabiner RE Mains BA Eipper 2005 Kalirin: a dual rho guanine nucleotide exchange factor that is so much more than the sum of its many parts Neuroscientist 11 148 160 15746383 1:CAS:528:DC%2BD2MXjtFyjs7k%3D (Pubitemid 40388497)
102. T Rajakulendran F Sicheri 2010 Allosteric protein kinase regulation by pseudokinases: insights from STRAD Sci Signal 3 pe8 20197543
103. P Rellos AC Pike FH Niesen E Salah WH Lee F von Delft S Knapp 2010 Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation PLoS Biol 8 e1000426 20668654
104. M Rief M Gautel F Oesterhelt JM Fernandez HE Gaub 1997 Reversible unfolding of individual titin Ig-domains by AFM Science 276 1109 1112 9148804 1:CAS:528:DyaK2sXjt12qtLc%3D (Pubitemid 27218118)
105. MW Russell MO Raeker KA Korytkowski KJ Sonneman 2002 Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases Gene 282 237 46 11814696 1:CAS:528:DC%2BD38XnvFSnug%3D%3D (Pubitemid 34117580)
106. MN Sack DL Disch HA Rockman DP Kelly 1997 A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program Proc Natl Acad Sci USA 94 6438 43 9177236 1:CAS:528:DyaK2sXjvFGhsrk%3D (Pubitemid 27270703)
107. T Sadikot CR Hammond MB Ferrari 2010 Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance Dev Dyn 239 1124 1135 20235223 1:CAS:528:DC%2BC3cXltl2qu7k%3D
108. M Sandri 2008 Signaling in muscle atrophy and hypertrophy Physiol Bethesda 23 160 70 1:CAS:528:DC%2BD1cXosFKhtLY%3D
109. L Sanz P Sanchez MJ Lallena MT Diaz-Meco J Moscat 1999 The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation EMBO J 18 3044 3053 10356400 1:CAS:528:DyaK1MXktFCjtb8%3D (Pubitemid 29255613)
110. L Sanz MT Diaz-Meco H Nakano J Moscat 2000 The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway EMBO J 19 1576 86 10747026 1:CAS:528:DC%2BD3cXislymt7s%3D (Pubitemid 30182165)
111. R Schröder A Iakovenko J Reimann A Mues C Bönnemann J Matten M Gautel 2001 Early and selective downregulation of telethonin in neurogenic atrophy J Muscle Res Cell Motil 22 259 264 11763198 (Pubitemid 33082006)
112. ML Seibenhener T Geetha MW Wooten 2007 Sequestosome 1/p62-more than just a scaffold FEBS Lett 581 175 9 17188686 1:CAS:528:DC%2BD2sXnslyrsw%3D%3D (Pubitemid 46096472)
113. K Seipel S O'Brien E Iannotti Q Medley M Streuli 2001 Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization J Cell Sci 114 389 399 11148140 1:CAS:528:DC%2BD3MXht1Kgurg%3D (Pubitemid 32149580)
114. JR Sellers MD Pato 1984 The binding of smooth muscle myosin light chain kinase and phosphatases to actin and myosin J Biol Chem 259 7740 6 6330077 1:CAS:528:DyaL2cXksFSksbw%3D (Pubitemid 14081188)
115. VT Skamnaki DJ Owen ME Noble ED Lowe G Lowe NG Oikonomakos LN Johnson 1999 Catalytic mechanism of phosphorylase kinase probed by mutational studies Biochemistry 38 14718 30 10545198 1:CAS:528:DyaK1MXmsFaquro%3D
116. JA Spencer S Eliazer RL Ilaria Jr JA Richardson EN Olson 2000 Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein J Cell Biol 150 771 84 10953002 1:CAS:528: DC%2BD3cXmtVemu7s%3D (Pubitemid 30663414)
117. T Sudo M Maruyama H Osada 2000 p62 functions as a p38 MAP kinase regulator Biochem Biophys Res Commun 269 521 5 10708586 1:CAS:528: DC%2BD3cXhsFKhsL0%3D (Pubitemid 30440333)
118. L Sun ZJ Chen 2004 The novel functions of ubiquitination in signaling Curr Opin Cell Biol 16 119 126 15196553 1:CAS:528:DC%2BD2cXjslWktLg%3D (Pubitemid 38757287)
119. G Tasca M Mirabella A Broccolini M Monforte M Sabatelli GL Biscione G Piluso F Gualandi PA Tonali B Udd E Ricci 2010 An Italian case of hereditary myopathy with early respiratory failure (HMERF) not associated with the titin kinase domain R279W mutation Neuromuscul Disord 20 730 4 20708934
120. SS Taylor AP Kornev 2010 Protein kinases: evolution of dynamic regulatory proteins Trends Biochem Sci 36 65 77 10.1016/j.tibs.2010.09.006 20971646
121. SS Taylor AP Kornev 2010 Yet another "active" pseudokinase, Erb3 Proc Natl Acad Sci USA 107 8047 8 20421461 1:CAS:528:DC%2BC3cXmtVKgs7g%3D
122. SS Taylor E Radzio-Andzelm 1994 Three protein kinase structures define a common motif Structure 2 345 55 8081750 1:CAS:528:DyaK2MXivVKhsg%3D%3D
123. L Tskhovrebova J Trinick 2003 Titin: properties and family relationships Nat Rev Mol Cell Biol 4 679 89 14506471 1:CAS:528:DC%2BD3sXnsVKqsL0%3D (Pubitemid 37082183)
124. M Valiev J Yang JA Adams SS Taylor JH Weare 2007 Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations J Phys Chem B 111 13455 64 17983217 1:CAS:528:DC%2BD2sXht1Gmt77O (Pubitemid 350241477)
125. V Vogel 2006 Mechanotransduction involving multimodular proteins: converting force into biochemical signals Annu Rev Biophys Biomol Struct 35 459 88 16689645 1:CAS:528:DC%2BD28XmtFSksrw%3D (Pubitemid 43877387)
126. K Wang J McClure A Tu 1979 Titin: major myofibrillar components of striated muscle Proc Natl Acad Sci USA 76 3698 3702 291034 1:CAS:528: DyaE1MXlsFejtbg%3D (Pubitemid 9246443)
127. X Wang AJ Merritt J Seyfried C Guo ES Papadakis KG Finegan M Kayahara J Dixon RP Boot-Handford EJ Cartwright U Mayer C Tournier 2005 Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway Mol Cell Biol 25 336 345 15601854 (Pubitemid 40039823)
128. S Waters K Marchbank E Solomon C Whitehouse M Gautel 2009 Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover FEBS Lett 583 1846 52 19427866 1:CAS:528:DC%2BD1MXnt1Okt74%3D
129. S Weinert N Bergmann X Luo B Erdmann M Gotthardt 2006 M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere J Cell Biol 173 559 70 16702235 1:CAS:528:DC%2BD28XltVaqtr4%3D (Pubitemid 43765202)
130. B Weitkamp K Jurk G Beinbrech 1998 Projectin-thin filament interactions and modulation of the sensitivity of the actomyosin ATPase to calcium by projectin kinase J Biol Chem 273 19802 8 9677413 1:CAS:528:DyaK1cXlt1Ciur4%3D (Pubitemid 28367042)
131. C Whitehouse J Chambers K Howe M Cobourne P Sharpe E Solomon 2002 NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube Eur J Biochem 269 538 45 11856312 1:CAS:528:DC%2BD38XhtVyhu7o%3D (Pubitemid 34128011)
132. CA Whitehouse S Waters K Marchbank A Horner NW McGowan JV Jovanovic GM Xavier TG Kashima MT Cobourne GO Richards PT Sharpe TM Skerry AE Grigoriadis E Solomon 2010 Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity Proc Natl Acad Sci USA 107 12913 8 20616007 1:CAS:528:DC%2BC3cXpsVCrs7s%3D
133. SA Wickstrom A Lange E Montanez R Fassler 2010 The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J 29 281 91 20033063
134. MS Willis C Ike L Li DZ Wang DJ Glass C Patterson 2007 Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo Circ Res 100 456 9 17272810 1:CAS:528:DC%2BD2sXitFyltr0%3D (Pubitemid 46673255)
135. MS Willis M Zungu C Patterson 2010 Cardiac muscle ring finger-1-friend or foe? Trends Cardiovasc Med 20 12 6 20685572 1:CAS:528:DC%2BC3cXntVyrtr0%3D
136. MW Wooten ML Seibenhener V Mamidipudi MT Diaz-Meco PA Barker J Moscat 2001 The atypical protein kinase C-interacting protein p62 Is a scaffold for NF-kB activation by nerve growth factor J Biol Chem 276 7709 7712 11244088 1:CAS:528:DC%2BD3MXitFKhtL4%3D
137. CX Yang HQ Chen C Chen WP Yu WC Zhang YJ Peng WQ He DM Wei X Gao MS Zhu 2006 Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase Cell Res 16 367 376 16617332 1:CAS:528:DC%2BD28XjsV2gtLk%3D
138. LH Ye K Hayakawa H Kishi M Imamura A Nakamura T Okagaki T Takagi A Iwata T Tanaka K Kohama 1997 The structure and function of the actin-binding domain of myosin light chain kinase of smooth muscle J Biol Chem 272 32182 9 9405419 1:CAS:528:DyaK1cXis1Crug%3D%3D (Pubitemid 28011893)
139. P Young E Ehler M Gautel 2001 Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly J Cell Biol 154 123 136 11448995 1:CAS:528:DC%2BD3MXltF2ltbo%3D (Pubitemid 34289283)
140. E Zalckvar H Berissi L Mizrachy Y Idelchuk I Koren M Eisenstein H Sabanay R Pinkas-Kramarski A Kimchi 2009 DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy EMBO Rep 10 285 92 19180116 1:CAS:528:DC%2BD1MXhtFOqt7k%3D
141. A Zetser E Gredinger E Bengal 1999 p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor J Biol Chem 274 5193 5200 9988769 1:CAS:528: DyaK1MXhsFSlt78%3D
142. P Zou N Pinotsis S Lange Y-H Song A Popov I Mavridis O Mayans M Gautel M Wilmanns 2006 Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk Nature 439 229 233 16407954 1:CAS:528:DC%2BD28XislKhtg%3D%3D (Pubitemid 43083147)