Evolution of CASK into a Mg2+-sensitive kinase

Science Signaling

Volumn 3, Issue 119, 2010, Pages

  Mukherjee, Konark ^a,d   Sharma, Manu ^a   Jahn, Reinhard ^b   Wahl, Markus C ^c   Södhof, Thomas C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; MAGNESIUM ION; MAGNESIUM; PROTEIN KINASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; PHYLOGENY; PRIORITY JOURNAL; BIOCATALYSIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; PROTEIN CONFORMATION;

ANIMALIA;

BIOCATALYSIS; CELL LINE; EVOLUTION, MOLECULAR; HUMANS; MAGNESIUM; MODELS, MOLECULAR; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN KINASES;

EID: 77953834740     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000800     Document Type: Article

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56. Acknowledgments: We thank members of the Südhof and Jahn laboratories for discussions and R. Lührmann for providing access to crystallography equipment. We are grateful to the support by the staff of beam line BL14.2 (BESSY) for help during collection of diffraction data. Funding: This work was supported by a grant from the National Institute of Mental Health (R37 MH52804-08 to T. C. S.) and the Max-Planck-Society. M. S. is a Human Frontier Long Term Fellow. Author contributions: K. M., M. S., and M. C. W. designed and performed the experiments, analyzed data, and wrote the manuscript. R. J. designed the experiments. T. C. S. designed the experiments, analyzed data, and wrote the manuscript. Accession numbers: Atomic coordinates have been deposited with the PDB; accession numbers are 3MFR, 3MFS, 3MFT, and 3MFU.