Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations

Biophysical Journal

Volumn 88, Issue 2, 2005, Pages 790-804

  Gräter, Frauke ^a,b   Shen, Jianhua ^b   Jiang, Hualiang ^b   Gautel, Mathias ^c   Grubmüller, Helmut ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN; MUSCLE PROTEIN; PHOSPHOTRANSFERASE; TITIN KINASE; UNCLASSIFIED DRUG; PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FORCE; GEOMETRY; MECHANICAL STRESS; MOLECULAR DYNAMICS; MUSCLE CELL; PROTEIN DOMAIN; SENSOR; SIGNAL TRANSDUCTION; SIMULATION; TENSION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ELASTICITY; EVALUATION; MECHANICS; METHODOLOGY; PROTEIN CONFORMATION; STIMULATION; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE; VALIDATION STUDY;

COMPUTER SIMULATION; ELASTICITY; ENZYME ACTIVATION; MECHANICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUSCLE PROTEINS; PHYSICAL STIMULATION; PROTEIN CONFORMATION; PROTEIN KINASES; STRESS, MECHANICAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18844398202     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.052423     Document Type: Article

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