Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

Journal of Cell Biology

Volumn 157, Issue 1, 2002, Pages 125-136

  McElhinny, Abigail S ^a   Kakinuma, Kazumi ^d   Sorimachi, Hiroyuki ^d   Labeit, Siegfried ^c   Gregorio, Carol C ^a,b,e  

^a Department of Cell Biology and Anatomy ^*  (United States)

^b University of Arizona   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cardiac myocyte; GMEB 1; MURF 1; SUMO 3; Titin

Indexed keywords

BINDING PROTEIN; CONNECTIN; GLUCOCORTICOID MODULATORY ELEMENT BINDING PROTEIN 1; ISOPEPTIDASE T 3; MUSCLE PROTEIN; MUSCLE SPECIFIC RING FINGER 1 PROTEIN; PEPTIDASE; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME 9; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MYOFILAMENT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SARCOMERE; THIN FILAMENT;

ANIMALS; CARBON-NITROGEN LYASES; CELL NUCLEUS; CELLS, CULTURED; CHICK EMBRYO; DNA-BINDING PROTEINS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; INDICATORS AND REAGENTS; LIGASES; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; MUSCLE PROTEINS; MYOCARDIUM; MYOFIBRILS; PROTEIN KINASES; RATS; SARCOMERES; TRANSCRIPTION FACTORS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 0036544533     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200108089     Document Type: Article

References (57)

1. Taxol induces postmitotic myoblasts to assemble interdigitating microtubule-myosin arrays that exclude actin filaments
2. The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
3. Identification of ubiquitin ligases required for skeletal muscle atrophy
4. RING domains: Master builders of molecular scaffolds?
5. Molecular tools for the study of titin's differential expression
6. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain
7. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain
8. Ubch9 conjugates SUMO but not ubiquitin
9. Myofibrillogenesis in the developing chicken heart: Assembly of Z-disk, M-line and the thick filaments
10. Molecular analysis of protein assembly in muscle development
11. RING for destruction?
12. Elastic filaments in situ in cardiac muscle: Deep-etch replica analysis in combination with selective removal of actin and myosin filaments
13. Myogenesis in the mouse embryo: Differential onset of expression of myogenic proteins and the involvement of titin in myofibfil assembly
14. Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction
15. To the heart of myofibril assembly
16. Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: Tropomodulin requires tropomyosin for assembly
17. 2 terminus of titin spans the Z-disc: Its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity
18. Muscle assembly: A titanic achievement?
19. A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies
20. Hormonal regulation of myosin heavy chain and alpha-actin gene expression in cultured fetal rat heart myocytes
21. Independent assembly of 1.6m long bipolar MHC filaments and I-Z-I bodies
22. Studies of the interaction between titin and myosin
23. Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family
24. Cloned rat cardiac titin class I and class II motifs
25. The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer
26. Dynamics of actin and assembly of connectin (titin) during myofibrillogenesis in embryonic chick cardiac muscle cells in vitro
27. Titins, giant proteins in charge of muscle ultrastructure and elasticity
28. Towards a molecular understanding of titin
29. The giant protein titin: Emerging roles in physiology and pathophysiology
30. Actin-titin interaction in cardiac myofibrils: Probing a physiological role
31. I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure
32. Connectin, an elastic protein of muscle
33. Probing the functional roles of titin ligands in cardiac myofibril assembly and maintenance
34. SUMO-nonclassical ubiquitin
35. SUMO, ubiquitin's mysterious cousin
36. Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin
37. The structure of the sarcomeric M band: Localization of defined domains of myomesin, M protein, and the 250-kD carboxy terminal region of titin by immunoelectron microscopy
38. Molecular structure of the sarcomeric M band: Mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin
39. Assembly of thick, thin, and titin filaments in chick precardiac explants
40. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
41. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
42. Fishing out proteins that bind ro titin
43. Differential distribution of subsets of myofibrillar proteins in cardiac nonstriated and striared myo fibrils
44. Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: Implications for the nature of vertebrate Z-discs
45. Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein
46. Use of T7 RNA polymerase to direct expression of cloned genes
47. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
48. Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein
49. Titin and nebulin protein rulers in muscle?
50. Titin: A molecular control freak
51. Integration of titin into the sarcomeres of cultured differentiating human skeletal muscle cells
52. Titin: Major myofibrillar components of striated muscle
53. Does titin regulate the length of muscle thick filaments?
54. Molecular structure of the sarcomeric Z-disk: Two types of titin interactions lead to an asymmetrical sorting of alpha-actinin
55. Cloning and characterization of a novel binding factor (GMEB-2) of the glucocorticoid modulatory element
56. Genomic organization of human GMEB-1 and rat GMEB-2: Structural conservation of two multifunctional proteins
57. Ability of the glucocorticoid modulatory element to modify glucocorticoid receptor transactivation indicates parallel pathways for the expression of glucocorticoid modulatory element and glucocorticoid response element activities