The blood brain barrier

Neuroimmune Pharmacology

Volumn , Issue , 2008, Pages 21-38

  Banks, William A ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Active transport; Adsorptive endocytosis and transcytosis; Brain endothelial cell; Cytokine; Endothelin; Facilitated diffusion; Immune cell; Neurovascular unit; Transmembrane diffusion

Indexed keywords

EID: 79958855558     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-72573-4_4     Document Type: Chapter

References (226)

1. Al-Sarraf H, Phillip L (2003) Effect of hypertension on the integrity of blood brain and blood CSF barriers, cerebral blood flow and CSF secretion in the rat. Brain Res 975:179-188.
2. Alafaci C, Salpietro G, Grasso G, Sfacteria A, Passalacqua M, Morabito A, Tripodo E, Calapai G, Buemi M, Tomasello F (2000) Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage. Eur J Pharmacol 406:219-225.
3. Arimura A (1992) Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research. Regul Pept 37:287-303.
4. Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Bales RA, Ethisham A, Greenberg RN, Berger JR (2004) Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia. J Neurovirol 10:223-232.
5. Ayre SG, Skaletski B, Mosnaim AD (1989) Blood-brain barrier passage of azidothymidine in rats: Effect of insulin. Res Comm Chem Path Pharmacol 63:45-52.
6. Baba M, Oishi R, Saeki K (1988) Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of mu opioid receptors in mice. Naunyn-Schmied Arch Pharmacol 37:423-428.
7. Balabanov R, Dore-Duffy P (1998) Role of the CNS microvascular pericyte in the blood-brain barrier. J Neurosci Res 53:637-644.
8. Baldwin SA, Fugaccia I, Brown DR, Brown LV, Scheff SW (1996) Blood-brain barrier breach following cortical contusion in the rat. J Neurosurg 85:476-481.
9. Balin BJ, Broadwell RD, Salcman M, el-Kalliny M (1986) Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251:260-280.
10. Ban E, Milon G, Prudhomme N, Fillion G, Haour F (1991) Receptors for interleukin-1 (and ?) in mouse brain: Mapping and neuronal localization in hippocampus. Neuroscience 43:21-30.
11. Banks WA (2004) Are the extracellular pathways a conduit for the delivery of therapeutics to the brain? Curr Pharm Des 10:1365-1370.
12. Banks WA, Broadwell RD (1994) Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin and albumin: Pharmacokinetic and morphological assessments. J Neurochem 62:2404-2419.
13. Banks WA, Farr SA, La Scola ME, Morley JE (2001) Intravenous human interleukin-1impairs memory processing in mice: Dependence on blood-brain barrier transport into posterior division of the septum. J Pharmacol Exp Ther 299:536-541.
14. Banks WA, Jumbe NL, Farrell CL, Niehoff ML, Heatherington A (2004a) Passage of erythropoietic agents across the blood-brain barrier: A comparison of human and murine erythropoietin and the analog Darbopoetin alpha. Eur J Pharmacol 505:93-101.
15. Banks WA, Kastin AJ (1989) Inhibition of the brain to blood transport system for enkephalins and Tyr-MIF-1 in mice addicted or genetically predisposed to drinking ethanol. Alcohol 6:53-57.
16. Banks WA, Kastin AJ (1990) Editorial Review: Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol 259:E1-E10.
17. Banks WA, Kastin AJ (1992) The interleukins-1?,-1 ?, and-2 do not disrupt the murine blood-brain barrier. Int J Immunopharmac 14:629-636.
18. Banks WA, Kastin AJ (1994) Brain-to-blood transport of peptides and the alcohol withdrawal syndrome. In: Models of Neuropeptide Action (Strand FL, Beckwith B, Chronwall B, Sandman CA, eds), pp 108-118. New York, NY: New York Academy of Sciences.
19. Banks WA, Kastin AJ, Akerstrom V (1997) HIV-1 protein gp120 crosses the blood-brain barrier: Role of adsorptive endocytosis. Life Sci 61:L119-L125.
20. Banks WA, Kastin AJ, Arimura A (1998a) Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. Exp Neurol 151:116-123.
21. Banks WA, Kastin AJ, Brennan JM, Vallance KL (1999) Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp Neurol 156:165-171.
22. Banks WA, Kastin AJ, Ehrensing CA (1994) Transport of bloodborne interleukin-1across the endothelial blood-spinal cord barrier of mice. J Physiol (London) 479:257-264.
23. Banks WA, Kastin AJ, Ehrensing CA (1998b) Diurnal uptake of circulating interleukin-1by brain, spinal cord, testis and muscle. Nim 5:36-41.
24. Banks WA, Kastin AJ, Fischman AJ, Coy DH, Strauss SL (1986) Carrier-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am J Physiol 251:E477-E482.
25. Banks WA, Kastin AJ, Komaki G, Arimura A (1993) Passage of pituitary adenylate cyclase activating polypeptide 1-27 and pituitary adenylate cyclase activating polypeptide 1-38 across the blood-brain barrier. J Pharmacol Exp Ther 267:690-696.
26. Banks WA, Niehoff ML, Zalcman S (2004b) Permeability of the mouse blood-brain barrier to murine interleukin-2: Predominance of a saturable efflux system. Brain Behav and Immun 18:434-442.
27. Banks WA, Ortiz L, Plotkin SR, Kastin AJ (1991) Human interleukin (IL) 1?, murine IL-1and murine IL-1are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259:988-996.
28. Banks WA, Pagliari P, Nakaoke R, Morley JE (2005a) Effects of a behaviorally active antibody on the brain uptake and clearance of amyloid beta proteins. Peptides 26:287-294.
29. Banks WA, Robinson SM, Nath A (2005b) Permeability of the bloodbrain barrier to HIV-1 Tat. Exp Neurol 193:218-227.
30. Banks WA, Robinson SM, Verma S, Morley JE (2003) Efflux of human and mouse amyloid proteins 1-40 and 1-42 from brain: Impairment in a mouse model of Alzheimer's disease. Neuroscience 121:487-492.
31. Banks WA, Robinson SM, Wolf KM, Bess JW, Jr., Arthur LO (2004c) Binding, internalization, and membrane incorporation of human immunodeficiency virus-1 at the blood-brain barrier is differentially regulated. Neuroscience 128:143-153.
32. Banks WA, Terrell B, Farr SA, Robinson SM, Nonaka N, Morley JE (2002) Transport of amyloid protein antibody across the blood-brain barrier in an animal model of Alzheimer's disease. Peptides 23:2223-2226.
33. Barten DM, Ruddle NH (1994) Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis. J Neuroimmunol 51:123-133.
34. Begley DJ (2004) ABC transporters and the blood-brain barrier. Curr Pharm Des 10:1295-1312.
35. Bernards CM (1999) Epidural and intrathecal drug movement. In: Spinal Drug Delivery (Yaksh TL, ed), pp 239-252. New York: Elsevier.
36. Bjorbaek C, Elmquist JK, Michl P, Ahima RS, van Beuren A, McCall AL, Flier JS (1998) Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139:3485-3491.
37. Blasberg RG (1977) Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion. Cancer Treatment Reports 61:625-631.
38. Bonhomme-Faivre L, Pelloquin A, Tardivel S, Urien S, Mathieu MC, Castagne V, Lacour B, Farinotti R (2002) Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice. Anit-Cancer Drugs 13:51-57.
39. Boulton M, Flessner M, Armstrong D, Mohamed R, Hay J, Johnston M (1999) Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat. Am J Physiology 276: R818-R823.
40. Bradbury M (1979) The Concept of a Blood-Brain Barrier. New York: John Wiley and Sons Ltd.
41. Brightman MW, Reese TS (1969) Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 40:648-677.
42. Broadwell RD (1989) Transcytosis of macromolecules through the blood-brain barrier: A cell biological perspective and critical appraisal. Acta Neuropathol (Berl) 79:117-128.
43. Broadwell RD (1993) Endothelial cell biology and the enigma of transcytosis through the blood-brain barrier. Adv Exp Med Biol 331:137-141.
44. Broadwell RD, Balin BJ, Salcman M (1988) Transcytotic pathway for blood-borne protein through the blood-brain barrier. Proc Natl Acad Sci USA 85:632-636.
45. Broadwell RD, Banks WA (1993) Cell biological perspective for the transcytosis of peptides and proteins through the mammalian blood-brain fluid barriers. In: The Blood-Brain Barrier (Pardridge WM, ed), pp 165-199. New York: Raven Press, Ltd.
46. Broadwell RD, Sofroniew MV (1993) Serum proteins bypass the blood-brain barrier for extracellular entry to the central nervous system. Exp Neurol 120:245-263.
47. Brown RC, Davis TP (2002) Calcium modulation of adherens tight junction function: A potential mechanism for blood-brain barrier disruption after stroke. Stroke 33:1706-1711.
48. Butter C, Baker D, O'Neill JK, Turk JL (1991) Mononuclear cell trafficking and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice. J Neurol Sci 104:9-12.
49. Cangiano C, Cardelli-Cangiano P, Cascino A, Patrizi MA, Barberini F, Rossi F, Capocaccia L, Strom R (1983) On the stimulation by insulin of tryptophan transport across the blood-brain barrier. Biochem Int 7:617-627.
50. Cashion MF, Banks WA, Bost KL, Kastin AJ (1999) Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res 822:26-33.
51. Castagne V, Bonhomme-Faivre L, Urien S, Reguiga MD, Soursac M, Gimenez F, Farinotti R (2004) Effect of recombinant interleukin-2 pretreatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice. Drug Metab Dispos 32:168-171.
52. Catalan RE, Martinez AM, Aragones MD, Miguel BG, Robles A (1988) Insulin action on brain microvessels; effect on alkaline phosphatase. Biochem Biophys Res Commun 150:583-590.
53. Chang SL, Felix B, Jiang Y, Fiala M (2001) Actions of endotoxin and morphine. Adv Exp Med Biol 493:187-196.
54. Chao CC, Gekker G, Sheng WS, Hu S, Tsang M, Peterson PK (1994) Priming effect of morphine on the production of tumor necrosis factor-alpha by microglia: Implications in respiratory burst activity and human immunodeficiency virus-1 expression. J Pharmacol Exp Ther 269:198-203.
55. Chehade JM, Hass MJ, Mooradian AD (2002) Diabetes-related changes in rat cerebral occlusin and zonula occludens-1 (ZO-1) expression. Neurochem Res 27:249-252.
56. Chen G, Castro WL, Chow HH, Reichlin S (1997) Clearance of 125 I-labelled interleukin-6 from brain into blood following intracerebroventricular injection in rats. Endocrinology 138:4830-4836.
57. Chen G, Reichlin S (1998) Clearance of [125I]-tumor necrosis factor-from the brain into the blood after intracerebroventricular injection into rats. NeuroImmunoModulation 5:261-269.
58. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM (2001) Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol 116:62-73.
59. Chou S, Dix RD (1989) Viral infections and the blood-brain barrier. In: Implications of the Blood-Brain Barrier and Its Manipulation, Volume 2: Clinical Aspects (Neuwelt EA, ed), pp 449-468. New York: Plenum Publishing Corporation.
60. Cornford EM, Braun LD, Oldendorf WH, Hill MA (1982) Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults. Am J Physiol 243:C161-C168.
61. Cosby SL, Brankin B (1995) Measles virus infection of cerebral endothelial cells and effect on their adhesive properties. Vet Microbiol 44:135-139.
62. Cserr HF (1984) Convection of brain interstitial fluid. In: Hydrocephalus (Shapiro K, Marmarou A, Portnoy H, eds), pp 59-68. New York: Raven Press.
63. Cserr HF, Berman BJ (1978) Iodide and thiocyanate efflux from brain following injection into rat caudate nucleus. Am J Physiol 4:F331-F337.
64. Cserr HF, Knopf PM (1992) Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view. Immunol Today 13:507-512
65. Cunningham ET, Jr., Wada E, Carter DB, Tracey DE, Battey JF, De Souza EB (1992) In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J Neurosci 12:1101-1114.
66. Davson H, Segal MB (1996a) Blood-brain-CSF relations. Physiology of the CSF and Blood-Brain Barriers, pp 257-302. Boca Raton: CRC Press.
67. Davson H, Segal MB (1996b) Ontogenetic aspects of the cerebrospinal system. Physiology of the CSF and Blood-Brain Barriers, pp 607-662. Boca Rataon: CRC Press, Inc.
68. Davson H, Segal MB (1996c) Special aspects of the blood-brain barrier. Physiology of the CSF and Blood-Brain Barriers, pp 303-485. Boca Raton: CRC Press.
69. Davson H, Segal MB (1996d) Special aspects of the blood-brain barrier. Physiology of the CSF and Blood-Brain Barriers, pp 303-485. Boca Raton: CRC Press.
70. Davson H, Segal MB (1996e) The proteins and other macromolecules of the CSF. Physiology of the CSF and the Blood-Brain Barrier, pp 573-606. Boca Raton: CRC Press.
71. de la Torre JC, Mussivand T (1993) Can disturbed brain microcirculation cause Alzheimer's disease? Neurological Research 15:146-153.
72. de Lange EC, Bouw MR, Mandema JW, Danhof M, De Boer AG, Breimer DD (1995) Application of intracerebral microdialysis to study regional distribution kinetics of drug in rat brain. Br J Pharmacol 116:2538-2544.
73. de Lange ECM, Bouw MR, Danhof M, De Boer AG, Breimer DD (1993) Application of intracerebral microdialysis to study regional distribution kinetics of atenolol and acetaminophen in rat brain. The Use of Intracerebral Microdialysis to Study the Blood-Brain Barrier Transport Characteristics of Drugs (thesis, Leiden/Amsterdam Center for Drug Research) Sinteur, Leiden, pp. 93-106.
74. De Vries HE, Moor AC, Blom-Roosemalen MC, De Boer AG, Breimer DD, van Berkel TJ, Kuiper J (1994) Lymphocyte adhesion to brain capillary endothelial cells in vitro. J Neuroimmunol 52:1-8.
75. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43:333-344.
76. Deli MA, Abraham CR, Kataoka Y, Niwa M (2005) Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology. Cell Mol Neurobiol 25:59-127.
77. DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295:2264.
78. Didier N, Banks WA, Creminon C, Dereuddre-Bosquet N, Mabondzo A (2002) Endothelin-1 production at the in-vitro blood-brain barrier during HIV infection. Neuroreport 13:1179-1183.
79. Drach J, Gsur A, Hamilton G, Zhao S, Angerler J, Fiegl M, Zojer N, Raderer M, Haberl I, Andreeff M, Huber H (1996) Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes. Blood 88:1747-1754.
80. Drion N, Lemaire M, Lefauconnier JM, Scherrmann JM (1996) Role of p-glycoprotein in the blood-brain transport of colchicine and vinblastine. J Neurochem 67:1688-1693.
81. Dziegielewska KM, Hinds LA, Mollgard K, Reynolds ML, Saunders NR (1988) Blood-brain, blood-cerebrospinal fluid and cerebrospinal fluid-brain barriers in a marsupial (MACROPUS EUGENII) during development. J Physiol 403:307-388.
82. Ehrenreich H, Hasselblatt M, Dembowski C, Depek L, Lewczuk P, Stiefel M, Rustenbeck H-H, Breiter N, Jacob S, Knerlich F, Bohn M, Poser W, Rither E, Kochen M, Gefeller O, Gleiter C, Wessel TC, De Ryck M, Itri L, Prange H, Cerami A, Brines M, Siren A-L (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Molecular Medicine 8:495-505.
83. Elferink RPJO, Zadina JE (2001) MDR1 P-glycoprotein transports endogenous opioid peptides. Peptides 22:2015-2020.
84. Engelhardt B, Wolburg H (2004) Minireview: Transendothelial migration of leukocytes: Through the front door or around the side of the house? Eur J Pharmacol 34:2955-2963.
85. Erbyraktar S, Grasso G, Sfacteria A, Xie QW, Coleman T, Kreilgaard M, Torup L, Sager T, Erbayraktar Z, Gokmen N, Yilmaz O, Ghezzi P, Villa P, Fratelli M, Casagrande S, Leist M, Helboe L, Gerwein J, Christensen S, Geist MA, Pedersen LO, Cerami-Hand C, Wuerth JP, Cerami A, Brines M (2003) Asialoerythropoietin is a nonerythropoiectic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci USA 100:6741-6746.
86. Fabry Z, Fitzsimmons KM, Herlein JA, Moninger TO, Dobbs MB, Hart MN (1993) Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J Neuroimmunol 47:23-34.
87. Faraci FM, Heistad DD (1998) Regulation of the cerebral circulation: Role of endothelium and potassium channels. Physiol Rev 78:53-97.
88. Farr SA, Banks WA, Uezu K, Sano A, Gaskin FS, Morley JE (2003) Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice. Life Sci 73:555-562.
89. Fellay J, Marzolini C, Meaden ER, Black DJ, Buclin T, Chave J-P, Decosterd LA, Furrer H, Opravil M, Pantaleo G, Retelska D, Ruiz L, Schinkel AH, Vernazza P, Eap CB, Telenti A (2002) Response of antiretrovial treatment in HIV-1 infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetic study. Lancet 359:30-36.
90. Ferguson AV (1991) The area postrema: A cardiovascular control centre at the blood-brain interface? Can J PhysiolPharmacol 69:1026-1034.
91. Ghersi-Egea JF, Gorevic PD, Ghiso J, Frangione B, Patlak CS, Fenstermacher JD (1996) Fate of cerebrospinal fluid-borne amyloid ?-peptide: Rapid clearance into blood and appreciable accumulation by cerebral arteries. J Neurochem 67:880-883.
92. Glynn SL, Yazdanian M (1998) In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J Pharm Sci 87:306-310.
93. Grammas P, Caspers ML (1991) The effect of aluminum on muscarinic receptors in isolated cerebral microvessels. Res Comm Chem Path Pharmacol 72:69-79.
94. Greenwood J, Bamforth S, Wang Y, Devine L (1995) The bloodretinal barrier in immune-mediated diseases of the retina. In: New Concepts of a Blood-Brain Barrier (Greenwood J, Begley DJ, Segal MB, eds), pp 315-326. New York: Plenum Press.
95. Gross PM, Weindl A (1987) Peering through the windows of the brain. J Cereb Blood Flow Metab 7:663-672.
96. Gutierrez EG, Banks WA, Kastin AJ (1993) Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J Neuroimmunol 47:169-176.
97. Hardebo JE, Owman C (1990) Enzymatic barrier mechanisms for neurotransmitter monoamines and their precursors at the bloodbrain barrier. In: Pathophysiology of the Blood-Brain Barrier (Johansson BB, Owman C, Widner H, eds), pp. 41-55.Amsterdam: Elsevier.
98. Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Muller-Tillmanns B, Lemke U, Henke K, Moritz E, Garcia E, Wollmer MA, Umbricht D, de Quervain DJ, Hofmann M, Maddalena A, Papassotiropoulos A, Nitsch RM (2003) Antibodies against betaamyloid slow cognitive decline in Alzheimer's disease. Neuron 38:547-554.
99. Hofman F, Chen P, Incardona F, Zidovetzki R, Hinton DR (1999) HIV-tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J Neuroimmunol 94:28-39.
100. Huber JD, Hau VS, Borg L, Campos CR, Egleton RD, Davis TP (2002) Blood-brain barrier tight junctions are altered during a 72-h exposure to lamba-carrageenan-induced inflammatory pain. Am J Physiol 283:H1531-H1537.
101. Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HTJ, Nixon RA, Mercken M, Bergeron C, Fraser PE, George-Hyslop P, Westaway D (2000) A peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease. Nature 408:979-982.
102. Johanson CE (1988) The choroid plexus-arachnoid membrane-cerebrospinal fluid system. In: Neuromethods; The Neuronal Microenvironment (Boulton AA, Baker GB, Walz W, eds), pp 33-104. Clifton, NJ: The Humana Press.
103. Johansson BB (1989) Hypertension and the blood-brain barrier. In: Implications of the Blood-Brain Barrier and its Manipulation, Volume 2: Clinical Aspects (Neuwelt EA, ed), pp 389-410. New York: Plenum Publishing Co.
104. Johnson AK, Gross PM (1993) Sensory circumventricular organs and brain homeostatic pathways. FASEB J 7:678-686.
105. Jones PM, Robinson ICAF (1982) Differential clearance of neurophysin and neurohypophysial peptides from the cerebrospinal fluid in conscious guinea pigs. Neuroendocrinology 34:297-302.
106. Juhler M, Barry DI, Offner H, Konat G, Klinken L, Paulson OB (1984) Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Res 302:347-355.
107. Kalaria RN, Harik SI (1989) Increased alpha 2-and beta 2-adrenergic receptors in cerebral microvessels in Alzheimer disease. Neurosci Lett 106:233-238.
108. Kalaria RN, Mitchell MJ, Harik SI (1987) Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proc Natl Acad Sci USA 84:3521-3525.
109. Kastin AJ, Akerstrom V (2001) Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73:237-242.
110. Kastin AJ, Akerstrom V, Pan W (2000) Activation of urocortin transport into brain by leptin. Peptides 21:1811-1817.
111. Kastin AJ, Fasold MB, Zadina JE (2002) Endomorphins, Metenkephalin, Tyr-MIF-1 and the P-glycoprotein efflux system. Drug Metab Dispos 30:231-234.
112. Kety SS (1987) Cerebral circulation and its measurement by inert diffusible tracers. In: Encyclopedia of Neuroscience, Volume I (Adelman G, ed), pp 206-208. Boston: Birkhuser.
113. Khan NA, DiCello F, Nath A, Kim KS (2003) Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. J Neurovirology 9:584-593.
114. King M, Su W, Chang A, Zuckerman A, Pasternak GW (2001) Transport of opioids from the brain to the periphery by P-glycoprotein: Peripheral actions of central drugs. Nature Neuroscience 4:221-222.
115. Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A (1997) A crucial role for B cells in neuroinvasive scrapie. Nature 390:687-690.
116. Knopf PM, Cserr HF, Nolan SC, Wu TY, Harling-Berg CJ (1995) Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain. Neuropathol Appl Neurobiol 21:175-18
117. Koenig H, Trout JJ, Goldstone AD, Lu CY (1992) Capillary NMDA receptors regulate blood-brain barrier function and breakdown. Brain Res 588:297-303.
118. Koyanagi Y, Tanaka Y, Kira J, Ito M, Hioki K, Misawa N, Kawano Y, Yamasaki K, Tanaka R, Suzuki Y, Ueyama Y, Terada E, Tanaka T, Myasaka M, Kobayashi T, Kumazawa Y, Yamamoto N (1997) Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain. J Virol 71:2417-2424.
119. Kozlowski GP, Sterzl I, Nilaver G (1992) Localization patterns for immunoglobulins and albumins in the brain suggest diverse mechanisms for their transport across the blood-brain barrier (BBB) In: Progress in Brain Research (Ermisch A, Landgraf R, Rühle HJ, eds), pp 149-154. Amsterdam: Elsevier.
120. Krizbai IA, Deli MA, Pestenacz A, Siklose L, Szabo CA, Andras I, Joo F (1998) Expression of glutamate receptors on cultured cerebral endothelial cells. J Neurosci Res 54:814-819.
121. LeBel CP (1999) Spinal Delivery of neurotrophins and related molecules. In: Spinal Drug Delivery (Yaksh TL, ed), pp 543-554. Amsterdam: Elsevier.
122. Lee CGL, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang KT, Ambudkar SV, Pastan I, Dey S (1998) HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 37:3594-3601.
123. Lee YW, Hennig B, Fiala M, Kim KS, Toborek M (2001) Cocaine activates redox-regulated transcription factors and induces TNFalpha expression in human brain endothelial cells. Brain Res 920:125-133.
124. Levin VA (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23:682-684.
125. Lossinsky AS, Pluta R, Song MJ, Badmajew V, Moretz RC, Wisniewski HM (1991) Mechanisms of inflammatory cell attachment in chronic relapsing experimental allergic encephalomyelitis: A scanning and high-voltage electron microscopic study of the injured mouse blood-brain barrier. Microvasc Res 41:299-310.
126. Lossinsky AS, Vorbrodt AW, Wisniewski HM (1983) Ultracytochemical studies of vesicular and canalicular transport structures in the injured mammalian blood-brain barrier. Acta Neuropathol (Berl) 61:239-245.
127. LÜscher W, Potschka H (2002) Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 30:7-14.
128. Male D (1995) The blood-brain barrier-No barrier to a determined lymphocyte. In: New Concepts of a Blood-Brain Barrier (Greenwood J, Begley DJ, Segal MB, eds), pp 311-314. New York: Plenum Press.
129. Mandi Y, Ocsovszki I, Szabo D, Nagy Z, Nelson J, Molnar J (1998) Nitric oxide production and MDR expression by human brain endothelial cells. Anticancer Res 18:3049-3052.
130. Maness LM, Kastin AJ, Farrell CL, Banks WA (1998) Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 139:4556-4562.
131. Marsh M (1984) The entry of enveloped viruses into cells by endocytosis. Biochem J 218:1-10.
132. Martins JM, Banks WA, Kastin AJ (1997) Acute modulation of the active carrier-mediated brain to blood transport of corticotropinreleasing hormone. Am J Physiol 272:E312-E319.
133. Martins JM, Kastin AJ, Banks WA (1996) Unidirectional specific and modulated brain to blood transport of corticotropin-releasing hormone. Neuroendocrinology 63:338-348.
134. Masereeuw R, Jaehde U, Langemeijer MWE, De Boer AG, Breimer DD (1994) In vivo and in vitro transport of zidovudine (AZT) across the blood-brain barrier and the effects of transport inhibitors. Pharm Res 11:324-330.
135. Mayhan WG, Heistad DD (1985) Permeability of blood-brain barrier to various sized molecules. Am J Physiology 248:H712-H718.
136. McCarthy TJ, Banks WA, Farrell CL, Adamu S, Derdeyn CP, Snyder AZ, LaForest R, Litzinger DC, Martin D, LeBel CP, Welch MJ (2002) Positron emission tomography shows that intrathecal leptin reaches the hypothalamus in baboons. J Pharmacol Exp Ther 307:878-883.
137. McLay RN, Kimura M, Banks WA, Kastin AJ (1997) Granulocytemacrophage colony-stimulating factor crosses the blood-brain and blood-spinal cord barriers. Brain 120:2083-2091.
138. McQuay HJ, Sullivan AF, Smallman K, Dickenson AH (1989) Intrathecal opioids, potency and lipophilicity. Pain 36:111-115.
139. Mealey KL, Bentjen SA, Gay JM, Cantor GH (2001) Ivermectin sensitivity is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11:727-733.
140. Megyeri P, Abraham CS, Temesvari P, Kovacs J, Vas T, Speer CP (1992) Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Neurosci Lett 148:137-140.
141. Mellman I, Fuchs R, Helenius A (1986) Acidification of the endocytic and exocytic pathways. Ann Rev Biochem 55:663-700.
142. Minami T, Okazaki J, Kawabata A, Kuroda R, Okazaki Y (1998) Penetration of cisplatin into mouse brain by lipopolysccharide. Toxicology 130:107-113.
143. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW (2000) A peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408:982-985.
144. Moser KV, Reindl M, Blasig I, Humpel C (2004) Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammatiion. Brain Res 1017:53-60.
145. Muldoon LL, Pagel MA, Kroll RA, Roman-Goldstein S, Jones RS, Neuwelt EA (1999) A physiological barrier distal to the anatomical blood-brain barrier in a model of transvascular delivery. Am J Neuroradiol 20:217-222.
146. Nakaoke R, Ryerse JS, Niwa M, Banks WA (2005) Human immunodeficiency virus type 1 transport across the in vitro mouse brain endothelial cell monolayer. Exp Neurol 193:101-109.
147. Nath A, Conant K, Chen P, Scott C, Major EO (1999) Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: A hit and run phenomenon. J Biol Chem 274:17098-17102.
148. Nelson PK, Masters LT, Zagzag D, Kelly PJ (1999) Angiographic abnormalities in progressive multifocal leukoencephalopathy: An explanation based on neuropathologic findings. Am J Neuroradiol 20:487-494.
149. Nonaka N, Hileman SM, Shioda S, Vo P, Banks WA (2004) Effect of lipopolysaccharide on leptin transport across the blood-brain barrier. Brain Res 1016:58-65.
150. Nonaka N, Shioda S, Banks WA (2005) Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier. Experimental Neurology 191:137-144.
151. Nottet HS, Persidsky Y, Sasseville VG, Nukuna AN, Bock P, Zhai QH, Sharer LR, McComb RD, Swindells S, Soderland C, Gendelman HE (1996) Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J Immunol 156:1284-1295.
152. Oehmichen M, Gruninger H, Wietholter H, Gencic M (1979) Lymphatic efflux of intracerebrally injected cells. Acta Neuropathol 45:61-65.
153. Oldendorf WH (1971) Brain uptake of radio-labelled amino acids, amines and hexoses after arterial injection. Am J Physiol 221:1629-1639.
154. Oldendorf WH (1974) Lipid solubility and drug penetration of the blood-brain barrier. Proc Soc Exp Biol Med 147:813-816.
155. Osburg B, Peiser C, Domling D, Schomburg L, Ko YT, Voight K, Bickel U (2002) Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat. Am J Physiol 283:E899-E908.
156. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998a) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553-1561.
157. Pan W, Banks WA, Kastin AJ (1997a) BBB permeability to ebiratide and TNF in acute spinal cord injury. Exp Neurol 146:367-373.
158. Pan W, Banks WA, Kastin AJ (1997b) Permeability of the bloodbrain barrier and blood-spinal cord barriers to interferons. J Neuroimmunol 76:105-111.
159. Pan W, Banks WA, Kastin AJ (1998b) Permeability of the bloodbrain barrier to neurotrophins. Brain Res 788:87-94.
160. Pan W, Banks WA, Kennedy MK, Gutierrez EG, Kastin AJ (1996) Differential permeability of the BBB in acute EAE: Enhanced transport of TNF-. Am J Physiol 271:E636-E642.
161. Pan W, Cornelissen G, Halberg F, Kastin AJ (2002) Selected contributions: Circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord. J Appl Physiol 92:1357-1362.
162. Pan W, Kastin AJ (2001a) Changing the chemokine gradient: CINC1 crosses the blood-brain barrier. J Neuroimmunol 115:64-70.
163. Pan W, Kastin AJ (2001b) Increase in TNF alpha transport after SCI is specific for time, region, and type of lesion. Exp Neurol 170:357-363.
164. Pan W, Kastin AJ (2002) TNF transport across the blood-brain barrier is abolished in receptor knockout mice. Exp Neurol 174:193-200.
165. Pan W, Kastin AJ, Pick CG (2005) The staircase test in mice after spinal cord injury. Int J Neuroprotect Neuroregen 1:32-37.
166. Pan W, Kastin AJ, Rigai T, McLay R, Pick CG (2003a) Increased hippocampal uptake of tumor necrosis factor alpha and behavioral changes in mice. Exp Brain Res 149:195-199.
167. Pan W, Zadina JE, Harlan RE, Weber JT, Banks WA, Kastin AJ (1997c) Tumor necrosis factor-?: A neuromodulator in the CNS. Neurosci Biobehav Rev 21:603-613.
168. Pan W, Zhang L, Liao J, Csernus B, Kastin AJ (2003b). Selective increase in TNF alpha permeation across the blood-spinal cord barrier after SCI. J Neuroimmunol 134:111-117.
169. Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, Bock P, Gendelman HE, Fiala M (1997) A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol 158:3499-3510.
170. Persidsky Y, Zheng J, Miller D, Gendelman HE (2000) Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia. J Leukoc Biol 68:413-422.
171. Peruzzo B, Pastor FE, Blazquez JL, Schobitz K, Pelaez B, Amat P, Rodriguez EM (2000) A second look at the barriers of the medial basal hypothalamus. Exp Brain Res 132:10-26.
172. Plotkin SR, Banks WA, Kastin AJ (1996) Comparison of saturable transport and extracellular pathways in the passage of interleukin-1across the blood-brain
173. Plotkin SR, Banks WA, Kastin AJ (1998) Enkephalin, PPE, mRNA, and PTS-1 in alcohol withdrawal seizure-prone and-resistant mice. Alcohol 15:25-31.
174. Poduslo JF, Curran GL (1996) Permeability at the blood-brain barrier and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Mol Brain Res 36:280-286.
175. Pollay M, Davson H (1963) The passage of certain substances out of the cerebrospinal fluid. Brain 86:137-150.
176. Pozzilli C, Bernardi S, Mansi L, Picozzi P, Iannotti F, Alfano B, Bozzao L, Lenzi GL, Salvatore M, Conforti P, Fieschi C (1988) Quantitative assessment of the blood-brain barrier permeability in multiple sclerosis using 68-Ga-EDTA and positron emission tomography. J Neurol Neurosurg Psych 51:1058-1062.
177. Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24:224-237.
178. Rapoport SI (1976) Blood Brain Barrier in Physiology and Medicine. Raven Press, New York.
179. Rapoport SI, Ohata M, London ED (1981) Cerebral blood flow and glucose utilization following opening of the blood-brain barrier and during maturation of the rat brain. Fed Proc 40:2322-2325.
180. Raub TJ, Audus KL (1990) Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers. J Cell Sci 97:127-138.
181. Reese TS, Karnovsky MJ (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 34: 207-217.
182. Rethelyi M (1984) Diffusional barrier around the hypothalamic arcuate nucleus in the rat. Brain Res 307:355-358.
183. Reyes TM, Fabry Z, Coe CL (1999) Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli. Brain Res 851:215-220.
184. Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Saheki A, Tsuji A (1994) In vivo evidence for ATP-dependent and p-glycoproteinmediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol 48:1989-1992.
185. Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL (1998) Chemokines and receptors in HIV encephalitis. AIDS 12:1021-1026.
186. Sands MS, Vogler C, Kyle JW, Grubb JH, Levy B, Galvin N, Sly WS, Birkenmeier EH (1994) Enzyme replacement therapy for murine mucopolysaccharidosis type VII. J Clin Invest 93:2324-2331.
187. Schiffenbauer J, Streit WJ, Butfiloski E, LaBow M, Edward C, Moldawer 3rd LL (2000) The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type 1 receptor. Clin Immunol 95:117-125.
188. Schweighardt B, Atwood WJ (2001) Virus receptors in the human central nervous system. J Neurovirol 7:187-195.
189. Shafer RA, Murphy S (1997) Activated astrocytes induce nitric oxide synthase-2 in cerebral endothelium via tumor necrosis factor alpha. GLIA 21:370-379.
190. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer's amyloid-1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106:1489-1499.
191. Shimura T, Tabata S, Ohnishi T, Terasaki T, Tsuji A (1991) Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier. J Pharmacol Exp Ther 258:459-465.
192. Shyng SL, Huber MT, Harris EC (1993) A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastome cells. Biol Chem 268:15922-15928.
193. Simpson JE, Newcombe J, Cuzner ML, Woodrofe MN (1998) Expression of monocyte chemoattractant protein-1 and other betachemokines by resident glia and inflammatory cells in multiple sclerosis. J Neuroimmunol 84:238-249.
194. Somogyvari-Vigh A, Pan W, Reglodi D, Kastin AJ, Arimura A (2000) Effect of middle cerebral artery occulsion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat. Regul Pept 91:89-95.
195. Spector R, Lorenzo AV (1974) The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicylic acid and iodide. J Pharmacol Exp Ther 188:55-65.
196. Stein U, Walther W, Shoemaker RH (1996) Modulation of mdr1 expression by cytokines in human colon carcinoma cells: An approach for reversal of multidrug resistance. British Journal of Cancer 74:1384-1391.
197. Takasawa M, Terasaki T, Suzuki H, Sugiyama Y (1997) In vivo evidence for carrier-mediated efflux transport of 3'azido-3'deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J Pharmacol Exp Ther 281:369-375.
198. Tanzi RE, Moir RD, Wagner SL (2004) Clearance of Alzheimer's Abeta peptide: The many roads to perdition. Neuron 43:608.
199. Taylor EM (2002) The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clinical Pharmacokinetics 41:81-92.
200. Terasaki T, Takakuwa S, Saheki A, Moritani S, Shimura T, Tabata S, Tsuji A (1992) Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the bloodbrain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells. Pharm Res 9:529-534.
201. Theron D, de Lagerie SB, Tardivel S, Pelerin H, Demeuse P, Mercier C, Mabondzo A, Farinotti R, Lacour B, Roux F, Gimenez F (2003) Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalized rat brain capillary endothelial cell line, GPNT. Biochem Pharmacol 66:579-587.
202. Thomas SA (2004) Anti-HIV drug distribution to the central nervous system. Current Pharmaceutical Design 10:1313-1324.
203. Urayama A, Grubb JH, Sly WS, Banks WA (2004) Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc Natl Acad Sci USA 101:12663.
204. Vadeboncoeur N, Segura M, Al-Numani D, Vanier G, Gottschalk M (2003) Proinflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2. FEMS Immunology and Medical Microbiology 35:49-58.
205. van Dam AM, De Vries HE, Kuiper J, Zijlstra FJ, De Boer AG, Tilders FJH, Berkenbosch F (1996) Interleukin-1 receptors on rat brain endothelial cells: A role in neuroimmune interaction? FASEB J 10:351-356.
206. Verma S, Nakaoke R, Dohgu S, Banks WA (2006) Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide. Brain Behav Immun. 20:449-545.
207. Vidal EL, Patel NA, Wu G, Fiala M, Chang SL (1998) Interleukin-1 induces the expression of mu opioid receptors in endothelial cells. Immunopharmacology 38:261-266.
208. Villegas JC, Broadwell RD (1993) Transcytosis of protein through the mammalian cerebral epithelium and endothelium: II. Adsorptive transcytosis of WGA-HRP and the blood-brain and brainblood barriers. J Neurocytol 22:67-80.
209. Vogler C, Levy B, Galvin NJ, Thorpe C, Sands MS, Barker JE, Baty J, Birkenmeier EH, Sly WS (1999) Enzyme replacement in murine mucopolysaccharidosis type VII: Neuronal and glial response to beta-glucuronidase requires early initiation of enzyme replacement therapy. Pediatr Res 45:838-844.
210. Vorbrodt AW (1994) Glycoconjugates and anionic sites in the bloodbrain barrier. In: Glycobiology and the Brain (Nicolini M, Zatta PF, eds), pp 37-62. Oxford: Pergamon Press.
211. Vorbrodt AW, Dobrogowska DH, Ueno M, Lossinsky AS (1995) Immunocytochemical studies of protamine-induced blood-brain barrier opening to endogenous albumin. Acta Neuropathol (Berl) 89:491-499.
212. Vorbrodt AW, Trowbridge RS (1991) Ultrastructural study of transcellular transport of native and cationized albumin in cultured sheep brain microvascular endothelium. J Neurocytol 20: 998-1006.
213. Walsh RJ, Slaby FJ, Posner BI (1987) A receptor-mediated mechanism for the transport of prolactin from blood to cerebrospinal fluid. Endocrinology 120:1846-1850.
214. Wang Y, Sawchuck RJ (1995) Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion. J Pharm Sci 7:871-876.
215. Westergren I, Johansson BB (1993) Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: A comparison between protamine, poly-L-lysine and poly-L-arginine. Acta Physiol Scand 149:99-104.
216. Widner H, Jonsson BA, Hallstadius L, Wingardh K, Strand SE, Johansson BB (1987) Scintigraphic method to quantify the passage from brain parenchyma to the deep cervical lymph nodes in the rat. Eur J Nucl Med 13:456-461.
217. Williams KC, Hickey WF (1995) Traffic of hematogenous cells through the central nervous system. Curr Top Microbiol Immunol 202:221-245.
218. Wilson JF, Anderson S, Snook G, Llewellyn KD (1984) Quantification of the permeability of the blood-CSF barrier to ?-MSH in the rat. Peptides 5:681-685.
219. Wolburg H, Wolburg-Buchholz K, Engelhardt B (2005) Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol 109:181-190.
220. Wu D, Clement JG, Pardridge WM (1998) Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat. Brain Res 791:313-316.
221. Xaio H, Banks WA, Niehoff ML, Morley JE (2001) Effect of LPS on the permeability of the blood-brain barrier to insulin. Brain Res 896:36-42.
222. Yamada S, DePasquale M, Patlak CS, Cserr HF (1991) Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol 261:H1197-H1204.
223. Yeagle P (1987) Transport. The Membranes of Cells. Academic Press, Inc., Orlando, pp. 191-215.
224. Zalcman SS (2001) Interleukin-2 potentiates novelty-and GBR 12909-induced exploratory activity. Brain Res 899:1-9.
225. Zalcman SS (2002) Interleukin-2-induced increases in climbing behavior: Inhibition by dopamine D-1 and D-2 receptor antagonists. Brain Res 944:157-164.
226. Zambenedetti P, Giordano R, Zatta P (1996) Indentification of lectin binding sites in the rat brain. Glycoconjugate Journal 13:341-346.