Selective increase in TNFα permeation across the blood-spinal cord barrier after SCI

Journal of Neuroimmunology

Volumn 134, Issue 1-2, 2003, Pages 111-117

  Pan, Weihong ^a,b   Zhang, Lihua ^a,b   Liao, Jie ^a,b   Csernus, Balazs ^a,b   Kastin, Abba J ^a,b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Blood spinal cord barrier; Cytokines; IL1 ; Neuroregeneration; Spinal cord injury; TNF ; Transport system

Indexed keywords

ALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BROWN SEQUARD SYNDROME; CONTROLLED STUDY; DISEASE MODEL; FUNCTIONAL DISEASE; GAIT; ISOTOPE LABELING; LUMBAR SPINAL CORD; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TRANSPORT; SENSORIMOTOR FUNCTION; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; UPREGULATION;

ALBUMINS; ANIMALS; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; INTERLEUKIN-1; LUMBAR VERTEBRAE; MALE; MICE; MICE, INBRED ICR; NERVE REGENERATION; PROTEIN TRANSPORT; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0037219053     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00426-5     Document Type: Article

References (35)

1. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human interleukin (IL)1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259:1991;988-996.
2. Banks W.A., Kastin A.J., Arimura A. Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotrophin PACAP. Exp. Neurol. 151:1998;116-123.
3. Banks W.A., Farr S.A., La Scola M.E., Morley J.E. Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exp. Ther. 299:2001;536-541.
4. Berman J.W., Guida M.P., Warren J., Amat J., Brosnan C.F. Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. J. Immunol. 156:1996;3017-3023.
5. Bethea J.R., Nagashima H., Acosta M.C., Briceno C., Gomez F., Marcillo A.E., Loor K., Green J., Dietrich W.D. Systemically administered interleukin-10 reduces tumor necrosis factor production and significantly improves functional recovery following traumatic spinal cord injury in rats. J. Neurotrauma. 16:1999;851-863.
6. Gutierrez E.G., Banks W.A., Kastin A.J. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47:1993;169-176.
7. Hayashi M., Ueyama T., Nemoto K., Tamaki T., Senba E. Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. J. Neurotrauma. 17:2000;203-218.
8. Hayes K.C., Hull T.C., Delaney G.A., Potter P.J., Sequeira K.A., Campbell K., Popovich P.G. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J. Neurotrauma. 19:2002;753-761.
9. Hughes J.T. Disorders of the spine and spinal cord. Adams J.H., Duchen L.W. Greenfield's Neuropathology. 1992;1083-1089 Oxford Univ. Press, New York.
10. Jaeger C.B., Blight A.R. Spinal cord compression injury in guinea pigs: structural changes of endothelium and its perivascular cell associations after blood-brain barrier breakdown and repair. Exp. Neurol. 144:1997;381-399.
11. Kim W.K., Kan Y., Ganea D., Hart R.P., Gozes I., Jonakait G.M. Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway. J. Neurosci. 20:2000;3622-3630.
12. Kim G.-M., Xu J., Xu J., Song S.-K., Yan P., Ku G., Xu X.M., Hsu C.Y. Tumor necrosis factor receptor deletion reduces nuclear factor-κB activation, cellular inhibition of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J. Neurosci. 21:2001;6617-6625.
13. Klusman I., Schwab M.E. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 762:1997;173-184.
14. Kronke M., Schutze S., Scheurich P., Meichle A., Hensel G., Thoma B., Kruppa G., Pfizenmaier K. Tumor necrosis factor signal transduction. Cell. Signal. 2:1990;1-8.
15. Lee Y.B., Yune T.Y., Baik S.Y., Shin Y.H., Du S., Rhim H., Lee E.B., Kim Y.C., Shin M.L., Markelonis G.J., Oh T.H. Role of tumor necrosis factor-α in neuronal and glial apoptosis after spinal cord injury. Exp. Neurol. 166:2000;190-195.
16. Lotan M., Solomon A., Ben-Bassat S., Schwartz M. Cytokines modulate the inflammatory response and change permissiveness to neuronal adhesion in injured mammalian central nervous system. Exp. Neurol. 126:1994;284-290.
17. Noble L.J., Wrathall J.R. The blood-spinal cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat. Brain Res. 424:1987;177-188.
18. Pan W., Kastin A.J. Increase in TNFα transport after SCI is specific for time, region, and type of lesion. Exp. Neurol. 170:2001;357-363.
19. Pan W., Kastin A.J. TNFα transport across the blood-brain barrier is abolished in receptor knockout mice. Exp. Neurol. 174:2002;193-200.
20. Pan W., Kastin A.J. Transport of cytokines and neurotrophins across the BBB and their regulation after spinal cord injury. Shanker H., Westman J. Blood-Spinal Cord and Brain Barriers in Health and Disease. 2002;Academic Press, San Diego. (in press).
21. Pan W., Banks W.A., Kennedy M.K., Gutierrez E.G., Kastin A.J. Differential permeability of the BBB in acute EAE: enhanced transport of TNF-α Am. J. Physiol. 271:1996;E636-E642.
22. Pan W., Banks W.A., Kastin A.J. BBB permeability to ebiratide and TNFα in acute spinal cord injury. Exp. Neurol. 146:1997;367-373.
23. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain and blood-spinal cord barriers to interferons. J. Neuroimmunol. 76:1997;105-111.
24. Pan W., Zadina J.E., Harlan R.E., Weber J.T., Banks W.A., Kastin A.J. Tumor necrosis factor α: a neuromodulator in the CNS. Neurosci. Biobehav. Rev. 21:1997;603-613.
25. Pan W., Kastin A.J., Bell R.L., Olson R.D. Upregulation of tumor necrosis factor α transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neurosci. 19:1999;3649-3655.
26. Pan W., Kastin A.J., Brennan J.M. Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J. Neuroimmunol. 106:2000;172-180.
27. Peschon J.J., Torrance D.S., Stocking K.L., Glaccum M.B., Otten C., Willis C.R., Charrier K., Morrissey P.J., Ware C.B., Mohler K.M. TNFα receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J. Immunol. 160:1998;943-952.
28. Popovich P.G., Horner P.J., Mullin B.B., Stokes B.T. A quantitative spatial analysis of the blood-spinal cord barrier: I. Permeability changes after experimental spinal contusion injury. Exp. Neurol. 142:1996;258-275.
29. Scherbel U., Raghupathi R., Nakamura M., Saatman K.E., Trojanowski J.Q., Neugebauer E., Marino M.W., McIntosh T.K. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc. Natl. Acad. Sci. U. S. A. 96:1999;8721-8726.
30. Schwartz M., Solomon A., Lavie V., Ben-Bassat S., Belkin M., Cohen A. Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res. 545:1991;334-338.
31. Smith R.A., Baglioni C. The active form of tumor necrosis factor is a trimer. J. Biol. Chem. 262:1987;6951-6954.
32. Tanno H., Nockels R.P., Pitts L.H., Noble L.J. Breakdown of the blood-brain barrier after fluid percussive brain injury in the rat: Part 1: Distribution and time course of protein extravasation. J. Neurotrauma. 9:1992;21-32.
33. Wang C.X., Nuttin B., Heremans H., Dom R., Gybels J. Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J. Neuroimmunol. 69:1996;151-156.
34. Xu J., Fan G., Chen S., Wu Y., Xu X.M., Hsu C.Y. Methylprednisolone inhibition of TNF-alpha expression and NF-κB activation after spinal cord injury in rats. Brain Res. Mol. Brain Res. 59:1998;135-142.
35. Yan P., Li Q., Kim G.M., Xu J., Hsu C.Y., Xu X.M. Cellular localization of tumor necrosis factor-alpha following acute spinal cord injury in adult rats. J. Neurotrauma. 18:2001;563-568.