메뉴 건너뛰기




Volumn 17, Issue 4, 2011, Pages 279-285

Lung cancer and its association with chronic obstructive pulmonary disease: Update on nexus of epigenetics

Author keywords

chromatin; chronic obstructive pulmonary disease; epigenetics; histones; lung cancer; methylation

Indexed keywords

ANTIOXIDANT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DEATH ASSOCIATED PROTEIN KINASE; DNA BINDING PROTEIN; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; GROWTH FACTOR; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; HISTONE DEMETHYLASE; HISTONE H3; HISTONE H4; HISTONE METHYLTRANSFERASE; KETONE; METHYL CPG BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINE DERIVED NITROSAMINE KETONE; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN P16; PROTEIN P300; PROTEIN P53; SIRTUIN 1; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79958820786     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e3283477533     Document Type: Review
Times cited : (44)

References (75)
  • 1
    • 0038677958 scopus 로고    scopus 로고
    • Low lung function and incident lung cancer in the United States: Data from the First National Health and Nutrition Examination Survey follow-up
    • DOI 10.1001/archinte.163.12.1475
    • Mannino DM, Aguayo SM, Petty TL, et al. Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up. Arch Intern Med 2003; 163:1475-1480. (Pubitemid 36758921)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.12 , pp. 1475-1480
    • Mannino, D.M.1    Aguayo, S.M.2    Petty, T.L.3    Redd, S.C.4
  • 2
    • 68849111316 scopus 로고    scopus 로고
    • Current concepts on the role of inflammation in COPD and lung cancer
    • Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009; 9:375-383.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 375-383
    • Yao, H.1    Rahman, I.2
  • 3
    • 0036532026 scopus 로고    scopus 로고
    • Histone modifications in transcriptional regulation
    • DOI 10.1016/S0959-437X(02)00279-4
    • Berger SL. Histone modifications in transcriptional regulation. Curr Opin Genet Dev 2002; 12:142-148. (Pubitemid 34219485)
    • (2002) Current Opinion in Genetics and Development , vol.12 , Issue.2 , pp. 142-148
    • Berger, S.L.1
  • 4
    • 36448949026 scopus 로고    scopus 로고
    • Multivalent engagement of chromatin modifications by linked binding modules
    • DOI 10.1038/nrm2298, PII NRM2298
    • Ruthenburg AJ, Li H, Patel DJ, et al. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol 2007; 8:983-994. (Pubitemid 350174643)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 983-994
    • Ruthenburg, A.J.1    Li, H.2    Patel, D.J.3    David, A.C.4
  • 5
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • DOI 10.1038/nature05915, PII NATURE05915
    • Berger SL. The complex language of chromatin regulation during transcription. Nature 2007; 447:407-412. (Pubitemid 46816746)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 407-412
    • Berger, S.L.1
  • 6
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: Tying it all together
    • Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int J Biochem Cell Biol 2009; 41:87-95.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 87-95
    • Guil, S.1    Esteller, M.2
  • 7
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • DOI 10.1038/nrg2045, PII NRG2045
    • Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8:253-262. (Pubitemid 46439287)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 8
    • 4544250024 scopus 로고    scopus 로고
    • Gene-promoter hypermethylation as a biomarker in lung cancer
    • DOI 10.1038/nrc1432
    • Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 2004; 4:707-717. (Pubitemid 39215069)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.9 , pp. 707-717
    • Belinsky, S.A.1
  • 9
    • 0345357773 scopus 로고    scopus 로고
    • Gene Silencing in Cancer in Association with Promoter Hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349:2042-2054. (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 10
    • 77954086478 scopus 로고    scopus 로고
    • Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    • This study provides evidence that cigarette smoke mediates 'cancer-associated' epigenomic alterations in cultured human lung epithelial cells. Thus, in-vitro studies may have significant impact on delineating the early epigenetic mechanisms regulating gene expression during pulmonary carcinogenesis
    • Liu F, Killian JK, Yang M, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 2010; 29:3650-3664. This study provides evidence that cigarette smoke mediates 'cancer-associated' epigenomic alterations in cultured human lung epithelial cells. Thus, in-vitro studies may have significant impact on delineating the early epigenetic mechanisms regulating gene expression during pulmonary carcinogenesis.
    • (2010) Oncogene , vol.29 , pp. 3650-3664
    • Liu, F.1    Killian, J.K.2    Yang, M.3
  • 11
    • 77955015091 scopus 로고    scopus 로고
    • Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer
    • Lin RK, Wu CY, Chang JW, et al. Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res 2010; 70:5807-5817.
    • (2010) Cancer Res , vol.70 , pp. 5807-5817
    • Lin, R.K.1    Wu, C.Y.2    Chang, J.W.3
  • 12
    • 76649112380 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
    • This study provides cell, animal, and clinical evidence that NNK induces DNA methyltransferase 1 via AKT/GSK3β/βTrCP/hnRNP-U signaling pathway to demonstrate the mechanism in smoking-mediated lung cancer
    • Lin RK, Hsieh YS, Lin P, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest 2010;120:521-532. This study provides cell, animal, and clinical evidence that NNK induces DNA methyltransferase 1 via AKT/GSK3β/βTrCP/hnRNP-U signaling pathway to demonstrate the mechanism in smoking-mediated lung cancer.
    • (2010) J Clin Invest , vol.120 , pp. 521-532
    • Lin, R.K.1    Hsieh, Y.S.2    Lin, P.3
  • 13
    • 0037068329 scopus 로고    scopus 로고
    • DNA methylation analysis: A powerful new tool for lung cancer diagnosis
    • DOI 10.1038/sj.onc.1205605
    • Tsou JA, Hagen JA, Carpenter CL, et al. DNA methylation analysis: a powerful new tool for lung cancer diagnosis. Oncogene 2002; 21:5450-5461. (Pubitemid 34983481)
    • (2002) Oncogene , vol.21 , Issue.35 REV. ISS. 3 , pp. 5450-5461
    • Tsou, J.A.1    Hagen, J.A.2    Carpenter, C.L.3    Laird-Offringa, I.A.4
  • 15
    • 0035967107 scopus 로고    scopus 로고
    • Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer
    • DOI 10.1038/sj.onc.1204302
    • Kim DH, Nelson HH, Wiencke JK, et al. Promoter methylation of DAP-kinase: association with advanced stage in nonsmall cell lung cancer. Oncogene 2001; 20:1765-1770. (Pubitemid 32368022)
    • (2001) Oncogene , vol.20 , Issue.14 , pp. 1765-1770
    • Kim, D.-H.1    Nelson, H.H.2    Wiencke, J.K.3    Christiani, D.C.4    Wain, J.C.5    Mark, E.J.6    Kelsey, K.T.7
  • 17
    • 0035870282 scopus 로고    scopus 로고
    • p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in nonsmall cell lung cancer
    • Kim DH, Nelson HH, Wiencke JK, et al. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in nonsmall cell lung cancer. Cancer Res 2001; 61:3419-3424.
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3
  • 18
    • 0034666334 scopus 로고    scopus 로고
    • Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers
    • Kersting M, Friedl C, Kraus A, et al. Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol 2000; 18:3221-3229.
    • (2000) J Clin Oncol , vol.18 , pp. 3221-3229
    • Kersting, M.1    Friedl, C.2    Kraus, A.3
  • 19
    • 0032763520 scopus 로고    scopus 로고
    • DNA methylation and expression of p16(INK4A) gene in pulmonary adenocarcinoma and anthracosis in background lung
    • Hou M, Morishita Y, Iljima T, et al. DNA methylation and expression of p16(INK4A) gene in pulmonary adenocarcinoma and anthracosis in background lung. Int J Cancer 1999; 84:609-613.
    • (1999) Int J Cancer , vol.84 , pp. 609-613
    • Hou, M.1    Morishita, Y.2    Iljima, T.3
  • 20
    • 0030830914 scopus 로고    scopus 로고
    • DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: Its association with smoking history
    • Eguchi K, Kanai Y, Kobayashi K, et al. DNA hypermethylation at the D17S5 locus in nonsmall cell lung cancers: its association with smoking history. Cancer Res 1997; 57:4913-4915. (Pubitemid 27469002)
    • (1997) Cancer Research , vol.57 , Issue.21 , pp. 4913-4915
    • Eguchi, K.1    Kanai, Y.2    Kobayashi, K.3    Hirohashi, S.4
  • 21
    • 74549167140 scopus 로고    scopus 로고
    • Methylation induced gene silencing of HtrA3 in smoking-related lung cancer
    • Beleford D, Liu Z, Rattan R, et al. Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. Clin Cancer Res 2010; 16:398-409.
    • (2010) Clin Cancer Res , vol.16 , pp. 398-409
    • Beleford, D.1    Liu, Z.2    Rattan, R.3
  • 22
    • 50549093259 scopus 로고    scopus 로고
    • CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes
    • Takeshita M, Koga T, Takayama K, et al. CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes. Int J Cancer 2008; 123:1623-1630.
    • (2008) Int J Cancer , vol.123 , pp. 1623-1630
    • Takeshita, M.1    Koga, T.2    Takayama, K.3
  • 23
    • 77149130202 scopus 로고    scopus 로고
    • Molecular characterization of chronic obstructive pulmonary disease-related nonsmall cell lung cancer through aberrant methylation and alterations of EGFR signaling
    • This study identifies two genes (IL-12Rb2 and Wif-1) from a panel of 12 for which promoter hypermethylation was significantly associated with COPD when compared to non-COPD study participants. It is one of the few studies that examine methylation events specifically associated with COPD in NSCLC patients
    • Suzuki M, Wada H, Yoshino M, et al. Molecular characterization of chronic obstructive pulmonary disease-related nonsmall cell lung cancer through aberrant methylation and alterations of EGFR signaling. Ann Surg Oncol 2010; 17:878-888. This study identifies two genes (IL-12Rb2 and Wif-1) from a panel of 12 for which promoter hypermethylation was significantly associated with COPD when compared to non-COPD study participants. It is one of the few studies that examine methylation events specifically associated with COPD in NSCLC patients.
    • (2010) Ann Surg Oncol , vol.17 , pp. 878-888
    • Suzuki, M.1    Wada, H.2    Yoshino, M.3
  • 24
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • Wang R, An J, Ji F, et al. Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem Biophys Res Commun 2008; 373:151-154.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3
  • 25
    • 33845926895 scopus 로고    scopus 로고
    • A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    • Shames DS, Girard L, Gao B, et al. A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med 2006; 3:e486.
    • (2006) PLoS Med , vol.3
    • Shames, D.S.1    Girard, L.2    Gao, B.3
  • 27
    • 39449091629 scopus 로고    scopus 로고
    • Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer
    • DOI 10.1158/0008-5472.CAN-07-5782
    • Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res 2008; 68:1037-1045. (Pubitemid 351272221)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 1037-1045
    • Luxen, S.1    Belinsky, S.A.2    Knaus, U.G.3
  • 29
    • 54749135818 scopus 로고    scopus 로고
    • Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
    • Shivapurkar N, Stastny V, Okumura N, et al. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res 2008; 68:7448-7456.
    • (2008) Cancer Res , vol.68 , pp. 7448-7456
    • Shivapurkar, N.1    Stastny, V.2    Okumura, N.3
  • 30
    • 77249099223 scopus 로고    scopus 로고
    • CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression
    • Zelko IN, Mueller MR, Folz RJ. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. Free Radic Biol Med 2010; 48:895-904.
    • (2010) Free Radic Biol Med , vol.48 , pp. 895-904
    • Zelko, I.N.1    Mueller, M.R.2    Folz, R.J.3
  • 31
    • 78349241777 scopus 로고    scopus 로고
    • Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers
    • This study demonstrates a significant association between smokers with CpG methylation at the p16 and GATA4 genes and lowered lung function when compared to smokers without these epigenetic changes. It is one of the few studies that examine methylation events specifically associated with COPD particularly in response to wood smoke
    • Sood A, Petersen H, Blanchette CM, et al. Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. Am J Respir Crit Care Med 2010; 182:1098-1104. This study demonstrates a significant association between smokers with CpG methylation at the p16 and GATA4 genes and lowered lung function when compared to smokers without these epigenetic changes. It is one of the few studies that examine methylation events specifically associated with COPD particularly in response to wood smoke.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1098-1104
    • Sood, A.1    Petersen, H.2    Blanchette, C.M.3
  • 33
    • 0038544188 scopus 로고    scopus 로고
    • Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases
    • Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol 2003; 36:95-109. (Pubitemid 36836261)
    • (2003) Journal of Biochemistry and Molecular Biology , vol.36 , Issue.1 , pp. 95-109
    • Rahman, I.1
  • 37
    • 0033200205 scopus 로고    scopus 로고
    • The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
    • DOI 10.1093/emboj/18.17.4779
    • Thomson S, Clayton AL, Hazzalin CA, et al. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J 1999; 18:4779-4793. (Pubitemid 29415531)
    • (1999) EMBO Journal , vol.18 , Issue.17 , pp. 4779-4793
    • Thomson, S.1    Clayton, A.L.2    Hazzalin, C.A.3    Rose, S.4    Barratt, M.J.5    Mahadevan, L.C.6
  • 38
    • 77449109789 scopus 로고    scopus 로고
    • Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
    • Bedford DC, Kasper LH, Fukuyama T, et al. Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics 2010; 5:9-15.
    • (2010) Epigenetics , vol.5 , pp. 9-15
    • Bedford, D.C.1    Kasper, L.H.2    Fukuyama, T.3
  • 39
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • DOI 10.1126/science.1062374
    • Chen L, Fischle W, Verdin E, et al. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001; 293:1653-1657. (Pubitemid 32807844)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1653-1657
    • Chen, L.-F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 40
    • 77949321456 scopus 로고    scopus 로고
    • Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications
    • This study demonstrates a novel role of PKCz in cigarette smoke/aldehyde-mediated and LPS-mediated inflammatory response and chromatin modifications in the lungs. These findings also provide new insights on the molecular mechanisms underlying the pathogenesis of chronic lung diseases
    • Yao H, Hwang JW, Moscat J, et al. Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem 2010; 285:5405-5416. This study demonstrates a novel role of PKCz in cigarette smoke/aldehyde-mediated and LPS-mediated inflammatory response and chromatin modifications in the lungs. These findings also provide new insights on the molecular mechanisms underlying the pathogenesis of chronic lung diseases.
    • (2010) J Biol Chem , vol.285 , pp. 5405-5416
    • Yao, H.1    Hwang, J.W.2    Moscat, J.3
  • 43
    • 50149094330 scopus 로고    scopus 로고
    • Adenovirus small e1a alters global patterns of histone modification
    • Horwitz GA, Zhang K, McBrian MA, et al. Adenovirus small e1a alters global patterns of histone modification. Science 2008; 321:1084-1085.
    • (2008) Science , vol.321 , pp. 1084-1085
    • Horwitz, G.A.1    Zhang, K.2    McBrian, M.A.3
  • 44
    • 70349311616 scopus 로고    scopus 로고
    • Histone acetyl transferases as emerging drug targets
    • Dekker FJ, Haisma HJ. Histone acetyl transferases as emerging drug targets. Drug Discov Today 2009; 14:942-948.
    • (2009) Drug Discov Today , vol.14 , pp. 942-948
    • Dekker, F.J.1    Haisma, H.J.2
  • 45
    • 67650409769 scopus 로고    scopus 로고
    • Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
    • Tjeertes JV, Miller KM, Jackson SP. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J 2009; 28:1878-1889.
    • (2009) EMBO J , vol.28 , pp. 1878-1889
    • Tjeertes, J.V.1    Miller, K.M.2    Jackson, S.P.3
  • 46
    • 63349102653 scopus 로고    scopus 로고
    • Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke
    • Adenuga D, Yao H, March TH, et al. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol 2009; 40:464-473.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 464-473
    • Adenuga, D.1    Yao, H.2    March, T.H.3
  • 47
    • 33745728358 scopus 로고    scopus 로고
    • Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    • Yang SR, Chida AS, Bauter MR, et al. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol 2006; 291:L46-L57.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Yang, S.R.1    Chida, A.S.2    Bauter, M.R.3
  • 48
    • 70349324812 scopus 로고    scopus 로고
    • A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
    • Nakamaru Y, Vuppusetty C, Wada H, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 2009; 23:2810-2819.
    • (2009) FASEB J , vol.23 , pp. 2810-2819
    • Nakamaru, Y.1    Vuppusetty, C.2    Wada, H.3
  • 49
    • 42649146208 scopus 로고    scopus 로고
    • SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    • DOI 10.1164/rccm.200708-1269OC
    • Rajendrasozhan S, Yang SR, Kinnula VL, et al. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177:861-870. (Pubitemid 351600664)
    • (2008) American Journal of Respiratory and Critical Care Medicine , vol.177 , Issue.8 , pp. 861-870
    • Rajendrasozhan, S.1    Yang, S.-R.2    Kinnula, V.L.3    Rahman, I.4
  • 50
    • 78650176368 scopus 로고    scopus 로고
    • Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
    • Important finding showing that loss of HDAC2 is a critical factor in inhaled toxicant-mediated lung inflammation especially in regulating the anti-inflammatory effects of glucocorticoids in mouse lungs. This may have implications for devising better therapies for steroid insensitive patients to treat chronic lung diseases
    • Adenuga D, Caito S, Yao H, et al. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochem Biophys Res Commun 2010; 403:452-456. Important finding showing that loss of HDAC2 is a critical factor in inhaled toxicant-mediated lung inflammation especially in regulating the anti-inflammatory effects of glucocorticoids in mouse lungs. This may have implications for devising better therapies for steroid insensitive patients to treat chronic lung diseases.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 452-456
    • Adenuga, D.1    Caito, S.2    Yao, H.3
  • 52
    • 51249121642 scopus 로고    scopus 로고
    • Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2
    • Meja KK, Rajendrasozhan S, Adenuga D, et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol 2008; 39:312-323.
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 312-323
    • Meja, K.K.1    Rajendrasozhan, S.2    Adenuga, D.3
  • 53
    • 4544322261 scopus 로고    scopus 로고
    • Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
    • DOI 10.1002/ijc.20395
    • Osada H, Tatematsu Y, Saito H, et al. Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients. Int J Cancer 2004; 112:26-32. (Pubitemid 39249488)
    • (2004) International Journal of Cancer , vol.112 , Issue.1 , pp. 26-32
    • Osada, H.1    Tatematsu, Y.2    Saito, H.3    Yatabe, Y.4    Mitsudomi, T.5    Takahashi, T.6
  • 55
    • 66349120902 scopus 로고    scopus 로고
    • Histone arginine methylations: Their roles in chromatin dynamics and transcriptional regulation
    • Litt M, Qiu Y, Huang S. Histone arginine methylations: their roles in chromatin dynamics and transcriptional regulation. Biosci Rep 2009; 29:131-141.
    • (2009) Biosci Rep , vol.29 , pp. 131-141
    • Litt, M.1    Qiu, Y.2    Huang, S.3
  • 57
    • 77955757491 scopus 로고    scopus 로고
    • The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth
    • This study highlights that histone demethylase JMJD2B is regulated by both estrogen receptor a and hypoxia-inducible factor 1a, and drives breast cancer cell proliferation in normoxia and hypoxia. Thus, targeting histone demethylase in hypoxic condition which occurs in lung cancer may be crucial
    • Yang J, Jubb AM, Pike L, et al. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res 2010; 70:6456-6466. This study highlights that histone demethylase JMJD2B is regulated by both estrogen receptor a and hypoxia-inducible factor 1a, and drives breast cancer cell proliferation in normoxia and hypoxia. Thus, targeting histone demethylase in hypoxic condition which occurs in lung cancer may be crucial.
    • (2010) Cancer Res , vol.70 , pp. 6456-6466
    • Yang, J.1    Jubb, A.M.2    Pike, L.3
  • 58
    • 73549088729 scopus 로고    scopus 로고
    • Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth
    • This study demonstrates that loss of JMJD1A is sufficient to reduce tumor growth in vivo, and histone demethylation plays a significant role in modulating growth within the tumor microenvironment
    • Krieg AJ, Rankin EB, Chan D, et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol 2010; 30:344-353. This study demonstrates that loss of JMJD1A is sufficient to reduce tumor growth in vivo, and histone demethylation plays a significant role in modulating growth within the tumor microenvironment.
    • (2010) Mol Cell Biol , vol.30 , pp. 344-353
    • Krieg, A.J.1    Rankin, E.B.2    Chan, D.3
  • 59
    • 77952795537 scopus 로고    scopus 로고
    • Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
    • This study highlights that hyperoxia leads to induction of global as well as gene-specific H3K4me3 in normal human bronchial epithelial cells and human lung carcinoma cells, which plays a vital role in hyperoxia-induced altered gene expression and tumor progression
    • Zhou X, Sun H, Chen H, et al. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res 2010; 70:4214-4221. This study highlights that hyperoxia leads to induction of global as well as gene-specific H3K4me3 in normal human bronchial epithelial cells and human lung carcinoma cells, which plays a vital role in hyperoxia-induced altered gene expression and tumor progression.
    • (2010) Cancer Res , vol.70 , pp. 4214-4221
    • Zhou, X.1    Sun, H.2    Chen, H.3
  • 60
    • 77949468885 scopus 로고    scopus 로고
    • Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: Involvement in the proliferation of cancer cells through the E2F/RB pathway
    • Hayami S, Yoshimatsu M, Veerakumarasivam A, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 2010; 9:59.
    • (2010) Mol Cancer , vol.9 , pp. 59
    • Hayami, S.1    Yoshimatsu, M.2    Veerakumarasivam, A.3
  • 63
    • 34248631385 scopus 로고    scopus 로고
    • The role of histone deacetylases (HDACs) in human cancer
    • DOI 10.1016/j.molonc.2007.01.001, PII S1574789107000026
    • Ropero S, Esteller M. The role of histone deacetylases (HDACs) in human cancer. Mol Oncol 2007; 1:19-25. (Pubitemid 46776612)
    • (2007) Molecular Oncology , vol.1 , Issue.1 , pp. 19-25
    • Ropero, S.1    Esteller, M.2
  • 64
    • 51049100212 scopus 로고    scopus 로고
    • Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition
    • Shan B, Yao TP, Nguyen HT, et al. Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J Biol Chem 2008; 283:21065-21073.
    • (2008) J Biol Chem , vol.283 , pp. 21065-21073
    • Shan, B.1    Yao, T.P.2    Nguyen, H.T.3
  • 65
    • 66049146095 scopus 로고    scopus 로고
    • Genetic dissection of histone deacetylase requirement in tumor cells
    • Haberland M, Johnson A, Mokalled MH, et al. Genetic dissection of histone deacetylase requirement in tumor cells. Proc Natl Acad Sci U S A 2009; 106:7751-7755.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7751-7755
    • Haberland, M.1    Johnson, A.2    Mokalled, M.H.3
  • 66
    • 77956341931 scopus 로고    scopus 로고
    • Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
    • This study describes the importance of HDAC1 and HDAC2 in DNA-damage response by promoting double-strand break repair. Findings from this study provides better insights on the radio-sensitizing effects of HDAC inhibitors against cancer therapy
    • Miller KM, Tjeertes JV, Coates J, et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol 2010; 17:1144-1151. This study describes the importance of HDAC1 and HDAC2 in DNA-damage response by promoting double-strand break repair. Findings from this study provides better insights on the radio-sensitizing effects of HDAC inhibitors against cancer therapy.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1144-1151
    • Miller, K.M.1    Tjeertes, J.V.2    Coates, J.3
  • 67
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • Kouzarides T. Chromatin modifications and their function. Cell 2007; 128:693-705. (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 68
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005; 37:391-400.
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3
  • 69
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: Targeting chromatin modifications
    • Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009; 8:1409-1420.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 70
    • 77956929100 scopus 로고    scopus 로고
    • Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis
    • Tessema M, Klinge DM, Yingling CM, et al. Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene 2010; 29:5159-5170.
    • (2010) Oncogene , vol.29 , pp. 5159-5170
    • Tessema, M.1    Klinge, D.M.2    Yingling, C.M.3
  • 71
    • 35148873511 scopus 로고    scopus 로고
    • Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by down-regulation of DNMT3B
    • Liu H, Zhou Y, Boggs SE, et al. Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by down-regulation of DNMT3B. Oncogene 2007; 26:5900-5910.
    • (2007) Oncogene , vol.26 , pp. 5900-5910
    • Liu, H.1    Zhou, Y.2    Boggs, S.E.3
  • 72
    • 33846990844 scopus 로고    scopus 로고
    • Current perspectives on histone demethylases
    • Shanghai
    • Tian X, Fang J. Current perspectives on histone demethylases. Acta Biochim Biophys Sin (Shanghai) 2007; 39:81-88.
    • (2007) Acta Biochim Biophys Sin , vol.39 , pp. 81-88
    • Tian, X.1    Fang, J.2
  • 73
    • 77950868547 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
    • Lim S, Janzer A, Becker A, et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 2010; 31:512-520.
    • (2010) Carcinogenesis , vol.31 , pp. 512-520
    • Lim, S.1    Janzer, A.2    Becker, A.3
  • 74
    • 73149117308 scopus 로고    scopus 로고
    • Targeting histone demethylases in cancer therapy
    • Grant S. Targeting histone demethylases in cancer therapy. Clin Cancer Res 2009; 15:7111-7113.
    • (2009) Clin Cancer Res , vol.15 , pp. 7111-7113
    • Grant, S.1
  • 75
    • 77955480504 scopus 로고    scopus 로고
    • Epigenetics and environmental lung disease
    • Schwartz DA. Epigenetics and environmental lung disease. Proc Am Thorac Soc 2010; 7:123-125.
    • (2010) Proc Am Thorac Soc , vol.7 , pp. 123-125
    • Schwartz, D.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.