ANTINEOPLASTIC ACTIVITY;
CANCER INHIBITION;
COLON TUMOR;
DEMETHYLATION;
DRUG POTENTIATION;
ENZYME INHIBITION;
EPIGENETICS;
GENE EXPRESSION;
HUMAN;
IN VITRO STUDY;
IN VIVO STUDY;
NOTE;
PRIORITY JOURNAL;
AMINES;
ANTINEOPLASTIC AGENTS;
DNA METHYLATION;
EPIGENESIS, GENETIC;
GENE SILENCING;
HISTONE DEMETHYLASES;
HISTONES;
HUMANS;
MODELS, BIOLOGICAL;
NEOPLASMS;
SIGNAL TRANSDUCTION;
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes
Huang Y, Murray Stewart T, Wu Y, et al. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin Cancer Res 2009;15:7217-28.
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer
Belinsky SA, Klinge DM, Stidley CA, et al. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res 2003;63:7089-93.
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006;66:6361-9.
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
Polo JM, Dell'Oso T, Ranuncolo SM, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 2004;10:1329-35.
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
Fiskus W, Wang Y, Sreekumar A, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 2009;114:2733-43.